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  1 / 11443 MEDLINE  
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[PMID]:29216817
[Au] Autor:Nivala O; Faccio G; Arvas M; Permi P; Buchert J; Kruus K; Mattinen ML
[Ad] Endereço:VTT Technical Research Centre of Finland, Ltd., P.O. Box 1000, FI-02044, Espoo, Finland. outi.nivala@helsinki.fi.
[Ti] Título:Characterization of sulfhydryl oxidase from Aspergillus tubingensis.
[So] Source:BMC Biochem;18(1):15, 2017 12 08.
[Is] ISSN:1471-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized. In addition, basic functions of most of the SOX enzymes reported so far are not fully understood. In particular, the physiological role of secreted fungal SOXs is unclear. RESULTS: The recently identified SOX from Aspergillus tubingensis (AtSOX) was produced, purified and characterized in the present work. AtSOX had a pH optimum of 6.5, and showed a good pH stability retaining more than 80% of the initial activity in a pH range 4-8.5 within 20 h. More than 70% of the initial activity was retained after incubation at 50 °C for 20 h. AtSOX contains a non-covalently bound flavin cofactor. The enzyme oxidised a sulfhydryl group of glutathione to form a disulfide bond, as verified by nuclear magnetic resonance spectroscopy. AtSOX preferred glutathione as a substrate over cysteine and dithiothreitol. The activity of the enzyme was totally inhibited by 10 mM zinc sulphate. Peptide- and protein-bound sulfhydryl groups in bikunin, gliotoxin, holomycin, insulin B chain, and ribonuclease A, were not oxidised by the enzyme. Based on the analysis of 33 fungal genomes, SOX enzyme encoding genes were found close to nonribosomal peptide synthetases (NRPS) but not with polyketide synthases (PKS). In the phylogenetic tree, constructed from 25 SOX and thioredoxin reductase sequences from IPR000103 InterPro family, AtSOX was evolutionary closely related to other Aspergillus SOXs. Oxidoreductases involved in the maturation of nonribosomal peptides of fungal and bacterial origin, namely GliT, HlmI and DepH, were also evolutionary closely related to AtSOX whereas fungal thioreductases were more distant. CONCLUSIONS: AtSOX (55 kDa) is a fungal secreted flavin-dependent enzyme with good stability to both pH and temperature. A Michaelis-Menten behaviour was observed with reduced glutathione as a substrate. Based on the location of SOX enzyme encoding genes close to NRPSs, SOXs could be involved in the secondary metabolism and act as an accessory enzyme in the production of nonribosomal peptides.
[Mh] Termos MeSH primário: Aspergillus/enzimologia
Oxirredutases/metabolismo
[Mh] Termos MeSH secundário: Dissulfetos
Estabilidade Enzimática
Glutationa/metabolismo
Concentração de Íons de Hidrogênio
Oxirredutases/química
Oxirredutases/genética
Oxirredutases/isolamento & purificação
Peptídeo Sintases
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Disulfides); EC 1.- (Oxidoreductases); EC 1.8.3.- (sulfhydryl oxidase); EC 6.3.2.- (Peptide Synthases); EC 6.3.2.- (non-ribosomal peptide synthase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s12858-017-0090-4


  2 / 11443 MEDLINE  
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[PMID]:28562088
[Au] Autor:Yoshida S; Suzuki T; Furuno H; Aboshi T; Murayama T; Koseki T; Shiono Y
[Ad] Endereço:a Faculty of Agriculture, Department of Food, Life, and Environmental Science , Yamagata University , Yamagata , Japan.
[Ti] Título:Spectroscopic characterisation of two polyketide metabolites from Cylindrocarpon sp. from driftwood.
[So] Source:Nat Prod Res;32(1):60-64, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined using a variety of spectroscopic methods. Compound 2 exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Aspergillus clavatus F 318a at a concentration of 50 µg per disk.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Hypocreales/química
Policetídeos/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antifúngicos/química
Aspergillus/efeitos dos fármacos
Japão
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Staphylococcus aureus/efeitos dos fármacos
Estereoisomerismo
Madeira/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Polyketides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1332616


  3 / 11443 MEDLINE  
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[PMID]:28494651
[Au] Autor:Liu F; Chen G; Zhang LH; Liu B; Chen S; Hua H; Bai J; Wang HF; Pei YH
[Ad] Endereço:a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
[Ti] Título:Isolation and structure elucidation of a new compound from the fungus Aspergillus flavipes PJ03-11.
[So] Source:Nat Prod Res;32(1):30-35, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new diphenyl ether 3-methylpentyl-2, 4-dichloroasterrate (2), along with a known diphenyl ether butyl 2, 4-dichloroasterrate (1) were isolated from the metabolites of a wetland fungus Aspergillus flavipes. PJ03-11. The structures of 1 and 2 were determined by extensive NMR and HR-ESI-MS experiments. Compounds 1 and 2 showed weak cytotoxic activity, but both of them showed no antimicrobial activity.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Aspergillus/química
Hidroxibenzoatos/farmacologia
Éteres Fenílicos/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Antineoplásicos/química
Antineoplásicos/farmacologia
Cristalografia por Raios X
Avaliação Pré-Clínica de Medicamentos/métodos
Células HL-60
Seres Humanos
Hidroxibenzoatos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Éteres Fenílicos/química
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Hydroxybenzoates); 0 (Phenyl Ethers)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1326490


  4 / 11443 MEDLINE  
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[PMID]:29251479
[Au] Autor:Thiyagarajan S; Bavya M; Jamal A
[Ti] Título:Isolation of marine fungi Aspergillus sp. and its in vitro antifouling activity against marine bacteria.
[So] Source:J Environ Biol;37(5):895-903, 2016 09.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Biofouling is considered as a main issue of concern in aquatic environment causing severe economic loss and pollution. The aim of the present study was to isolate marine fungus antagonistic to biofouling bacteria and to define antifouling compounds present in it. Using standard plate method five predominant biofouling bacteria viz., Methylococcus sp., Flavobacterium sp., Marinococcus sp., Serratia sp. and Pseudomonas sp. were isolated from marine solid substances on Zobell's agar. Tolerance range of these bacteria to NaCl was 2-10%. Isolation of fungi from mangrove and estuarine sediments and their screening identified Aspergillus sp. EF4 as a potential isolate. This isolate caused inhibition of all the five test bacterial cultures measuring zone diameters respectively of 11, 16, 12, 13 and 11mm.? Subsequent to submerged fermentation using shaking flask method this fungus produced bioactive compounds within 5 days. The culture parameters optimized were raffinose as carbon source, yeast extract as lone nitrogen source, pH up to 9.0 and temperature up to 40?C. Antifouling compounds of culture filtrate were separated and detected by a three-step procedure involving thin layer chromatography, bioautography and preparative TLC. The in vitro assay involving glass slide-wooden stick-biofilm method revealed that these compounds could cause inhibition and destruction of bacteria to an extent of 2.16 x 104 CFU ml-1 and 2.46 x 104 CFU ml-1 respectively while growth of bacteria in control beaker was enumerated to be 4.41 x 104 CFU ml-1. High performance liquid chromatography of culture filtrate indicated probable principal antifouling compound as Fumonisin B2. Isolation of antagonistic marine fungus from Indian coast and detection of its antifouling compound would help in planning effective strategies for controlling biofouling in marine environment.
[Mh] Termos MeSH primário: Antibiose
Aspergillus/fisiologia
Bactérias/classificação
Incrustação Biológica
[Mh] Termos MeSH secundário: Organismos Aquáticos
Fenômenos Fisiológicos Bacterianos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  5 / 11443 MEDLINE  
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[PMID]:28457835
[Au] Autor:Tetz G; Cynamon M; Hendricks G; Vikina D; Tetz V
[Ad] Endereço:TGV-inhalonix, 303 5th Avenue #2012, New York, NY 10016, USA. Electronic address: tets@tgvlabs.com.
[Ti] Título:In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp.
[So] Source:Int J Antimicrob Agents;50(1):47-54, 2017 Jul.
[Is] ISSN:1872-7913
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0.06 µg/mL to 0.5 µg/mL. It was also highly effective against pre-formed 48-h-old biofilms formed by yeasts and moulds. The half-minimal biofilm eradication concentration (MBEC ) was equal to the MFC. The minimum biofilm eradication concentration to eliminate 90% of biofilms (MBEC ) varied from 1 × to 4 × MFC. Scanning electron microscopy revealed morphological changes accompanied by the release of intracellular material from the fungal cells following exposure to Mul-1867. Furthermore, an increased concentration of nucleic acids was found in the medium after 5 min and 20 min of Mul-1867 treatment, indicating leakage of cytoplasmic contents. Overall, these data indicate that Mul-1867 may be a promising inhaled antifungal agent for the treatment and prevention of fungal respiratory infections.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus/efeitos dos fármacos
Candida/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aspergilose/microbiologia
Aspergillus/isolamento & purificação
Aspergillus/fisiologia
Biofilmes/efeitos dos fármacos
Candida/isolamento & purificação
Candida/fisiologia
Candidíase/microbiologia
Meios de Cultura/química
DNA Fúngico/análise
Seres Humanos
Testes de Sensibilidade Microbiana
Viabilidade Microbiana/efeitos dos fármacos
Microscopia Eletrônica de Varredura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Culture Media); 0 (DNA, Fungal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 11443 MEDLINE  
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[PMID]:29346411
[Au] Autor:Loeffert ST; Vanhems P; Tissot E; Dananché C; Cassier P; Bénet T; Perraud M; Thibaudon M; Gustin MP
[Ad] Endereço:Laboratoire des Pathogènes Emergents-Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, France, Université de Lyon 1, France.
[Ti] Título:Evaluation of Hirst-type spore traps in outdoor Aspergillaceae monitoring during large demolition work in hospital.
[So] Source:PLoS One;13(1):e0191135, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Demolition can generate fungal spore suspensions in association with various adverse health effects, such as high risk of invasive aspergillosis in immunocompromised patients. One block of Edouard Herriot Hospital was entirely demolished. The aim of the present study was to evaluate Hirst-type spore traps utility in monitoring outdoor Aspergillaceae (Aspergillus spp. + Penicillium spp.) spores in part of Edouard Herriot Hospital (Lyon, France) undergoing major demolition. Three periods were scheduled in 2015: (A) Gutting of building and asbestos removal, (B) Demolition of floors, (C) Excavation and earthwork. Outdoor Aspergillaceae fungal load was monitored by cultivable (Air Ideal®, bioMérieux) and non-cultivable methods (Lanzoni VPPS-2000, Analyzair®, Bologna, Italy). Differences of Aspergillaceae recorded with Hirst-type spore traps were observed between Gerland and Edouard Herriot Hospital. Differences between Aspergillaceae were recorded between day time and night time at Gerland and Edouard Herriot Hospital. Daily paired differences between Aspergillaceae recorded with non-cultivable methodology at Edouard Herriot Hospital and in an area without demolition work were significant in Period A vs Period B (p = 10-4) and Period A vs Period C (p = 10-4). Weak correlation of daily Aspergillaceae recorded by both methods at Edouard Herriot Hospital was significant only for Period C (r = 0.26, p = 0.048, n = 58). Meteorological parameters and type of demolition works were found to heavily influenced Aspergillaceae dispersion. Non-cultivable methodology is a promising tool for outdoor Aspergillaceae scrutiny during major demolition work in hospital, helping infection control staff to rapidly implement control measures.
[Mh] Termos MeSH primário: Aspergillus/isolamento & purificação
Monitoramento Ambiental/métodos
Hospitais
Penicillium/isolamento & purificação
Esporos Fúngicos/isolamento & purificação
[Mh] Termos MeSH secundário: Microbiologia do Ar
Aspergillus/fisiologia
França
Penicillium/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191135


  7 / 11443 MEDLINE  
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[PMID]:29207242
[Au] Autor:Sobolev V; Arias R; Goodman K; Walk T; Orner V; Faustinelli P; Massa A
[Ad] Endereço:National Peanut Research Laboratory, Agricultural Research Service, United States Department of Agriculture , P.O. Box 509, Dawson, Georgia 39842, United States.
[Ti] Título:Suppression of Aflatoxin Production in Aspergillus Species by Selected Peanut (Arachis hypogaea) Stilbenoids.
[So] Source:J Agric Food Chem;66(1):118-126, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aspergillus flavus is a soil fungus that commonly invades peanut seeds and often produces carcinogenic aflatoxins. Under favorable conditions, the fungus-challenged peanut plant produces and accumulates resveratrol and its prenylated derivatives in response to such an invasion. These prenylated stilbenoids are considered peanut antifungal phytoalexins. However, the mechanism of peanut-fungus interaction has not been sufficiently studied. We used pure peanut stilbenoids arachidin-1, arachidin-3, and chiricanine A to study their effects on the viability of and metabolite production by several important toxigenic Aspergillus species. Significant reduction or virtually complete suppression of aflatoxin production was revealed in feeding experiments in A. flavus, Aspergillus parasiticus, and Aspergillus nomius. Changes in morphology, spore germination, and growth rate were observed in A. flavus exposed to the selected peanut stilbenoids. Elucidation of the mechanism of aflatoxin suppression by peanut stilbenoids could provide strategies for preventing plant invasion by the fungi that produce aflatoxins.
[Mh] Termos MeSH primário: Aflatoxinas/metabolismo
Arachis/química
Aspergillus/efeitos dos fármacos
Aspergillus/metabolismo
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Aspergillus/crescimento & desenvolvimento
Hemiterpenos/farmacologia
Esterigmatocistina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Hemiterpenes); 0 (Stilbenes); 0 (arachidin-1); 0 (arachidin-3); 0 (chiricanine A); 10048-13-2 (Sterigmatocystin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04542


  8 / 11443 MEDLINE  
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[PMID]:28467895
[Au] Autor:Wiemann P; Perevitsky A; Lim FY; Shadkchan Y; Knox BP; Landero Figueora JA; Choera T; Niu M; Steinberger AJ; Wüthrich M; Idol RA; Klein BS; Dinauer MC; Huttenlocher A; Osherov N; Keller NP
[Ad] Endereço:Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA.
[Ti] Título:Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.
[So] Source:Cell Rep;19(5):1008-1021, 2017 May 02.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive aspergillosis and demonstrate that host and fungal responses inextricably connect copper and reactive oxygen intermediate (ROI) mechanisms. Loss of the copper-binding transcription factor AceA yields an Aspergillus fumigatus strain displaying increased sensitivity to copper and ROI in vitro, increased intracellular copper concentrations, decreased survival in challenge with murine alveolar macrophages (AMΦs), and reduced virulence in a non-neutropenic murine model. ΔaceA survival is remediated by dampening of host ROI (chemically or genetically) or enhancement of copper-exporting activity (CrpA) in A. fumigatus. Our study exposes a complex host/microbe multifactorial interplay that highlights the importance of host immune status and reveals key targetable A. fumigatus counter-defenses.
[Mh] Termos MeSH primário: Aspergillus/metabolismo
Cobre/metabolismo
Interações Hospedeiro-Patógeno
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Aspergillus/genética
Aspergillus/patogenicidade
Proteínas de Transporte/genética
Proteínas de Transporte/metabolismo
Células Cultivadas
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Macrófagos/microbiologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos ICR
ATPases do Tipo-P/genética
ATPases do Tipo-P/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Fungal Proteins); 0 (Reactive Oxygen Species); 0 (Transcription Factors); 0 (copper-binding protein); 789U1901C5 (Copper); EC 3.6.3.- (P-type ATPases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  9 / 11443 MEDLINE  
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[PMID]:27770423
[Au] Autor:Milton RD
[Ad] Endereço:Department of Chemistry, University of Utah, 315 S 1400 E, Rm 2020, Salt Lake City, UT, 84112, USA. rm7745@hotmail.co.uk.
[Ti] Título:FAD-Dependent Glucose Dehydrogenase Immobilization and Mediation Within a Naphthoquinone Redox Polymer.
[So] Source:Methods Mol Biol;1504:193-202, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electrochemically-active polymers (redox polymers) are useful tools for simultaneous immobilization and electron transfer of enzymes at electrode surfaces, which also serve to increase the localized concentration of the biocatalyst. The properties of the employed redox couple must be compatible with the target biocatalyst from both an electrochemical (potential) and biochemical standpoint. This chapter details the synthesis of a naphthoquinone-functionalized redox polymer (NQ-LPEI) that is used to immobilize and electronically communicate with flavin adenine dinucleotide-dependent glucose dehydrogenase (FAD-GDH), yielding an enzymatic bioanode that is able to deliver large catalytic current densities for glucose oxidation at a relatively low associated potential.
[Mh] Termos MeSH primário: Aspergillus/enzimologia
Enzimas Imobilizadas/química
Glucose 1-Desidrogenase/química
Naftoquinonas/química
Polímeros/química
[Mh] Termos MeSH secundário: Aspergillus/química
Aspergillus/metabolismo
Técnicas Biossensoriais
Técnicas Eletroquímicas
Transporte de Elétrons
Enzimas Imobilizadas/metabolismo
Flavina-Adenina Dinucleotídeo/metabolismo
Glucose/metabolismo
Glucose 1-Desidrogenase/metabolismo
Modelos Moleculares
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzymes, Immobilized); 0 (Naphthoquinones); 0 (Polymers); 146-14-5 (Flavin-Adenine Dinucleotide); EC 1.1.1.47 (Glucose 1-Dehydrogenase); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  10 / 11443 MEDLINE  
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[PMID]:29261466
[Au] Autor:Neyaz Z; Mohindra N; Bhatnagar A; Marak RSK
[Ad] Endereço:From the Departments of Radiodiagnosis (Z.N., N.M.), Plastic Surgery (A.B.), and Microbiology (R.S.K.M.), Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow, Uttar Pradesh, India 226014.
[Ti] Título:Case 249: Intramuscular Mycetoma.
[So] Source:Radiology;286(1):353-359, 2018 Jan.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:History A 21-year-old man presented with swelling of the medial aspect of the left thigh of 1-month duration. There was no history of fever or penetrating injury in the left thigh. The patient had undergone renal transplantation 7 years earlier and had been taking immunosuppressants since transplantation. He had undergone two surgeries at the same site in the medial aspect of the left thigh in the past 3 years for a similar problem. At physical examination, there was swelling in the medial aspect of the left thigh, with mild tenderness. A surgical scar was noted anterior to the swelling ( Fig 1 ). No redness or discharging sinus was present. Laboratory results were as follows: hemoglobin level, 11.3 g/dL (normal range, 13.8-17.2 g/dL); white blood cell count, 9.7 × 10 /L (normal range, [4-11] × 10 /L); neutrophil, 75% (normal range, 48%-77%); lymphocyte, 22% (normal range, 10%-24%); eosinophil, 1% (normal range, 0.3%- 7%); monocyte, 1% (normal range, 0.6%-10%); serum creatinine level, 1.3 mg/dL (114.9 µmol/L) (normal range, 0.5-1.6 mg/dL [44.2-141.4 µmol/L]); and serum glucose (random) level, 82 mg/dL (4.5 mmol/L) (normal range, 79-140 mg/dL [4.4-7.8 mmol/L]). Radiography of the left thigh showed soft-tissue swelling in the medial aspect of the left thigh, without underlying bone involvement (not shown). Ultrasonography (US) and magnetic resonance (MR) imaging of the left thigh were performed. [Figure: see text].
[Mh] Termos MeSH primário: Aspergilose
Micetoma
Coxa da Perna
[Mh] Termos MeSH secundário: Adulto
Aspergillus/isolamento & purificação
Seres Humanos
Hospedeiro Imunocomprometido
Masculino
Coxa da Perna/diagnóstico por imagem
Coxa da Perna/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017152807



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