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[PMID]:29388829
[Au] Autor:Wrench C; Belchamber KBR; Bercusson A; Shah A; Barnes PJ; Armstrong-James D; Donnelly LE
[Ad] Endereço:1 Airway Disease, National Heart and Lung Institute Imperial College London London, United Kingdom and.
[Ti] Título:Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages.
[So] Source:Am J Respir Cell Mol Biol;58(2):271-273, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aspergillus fumigatus/imunologia
Macrófagos Alveolares/imunologia
Doença Pulmonar Obstrutiva Crônica/imunologia
Fumar/efeitos adversos
Esporos Fúngicos/imunologia
[Mh] Termos MeSH secundário: Fator Estimulador de Colônias de Granulócitos e Macrófagos/imunologia
Seres Humanos
Fator Estimulador de Colônias de Macrófagos/imunologia
Fumar/imunologia
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
81627-83-0 (Macrophage Colony-Stimulating Factor); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0351LE


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[PMID]:29202140
[Au] Autor:Nawrot U; Sulik-Tyszka B; Kurzyk E; Mroczynska M; Wlodarczyk K; Wróblewska M; Basak GW; Brillowska-Dabrowska A
[Ad] Endereço:Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
[Ti] Título:Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods.
[So] Source:Acta Biochim Pol;64(4):631-634, 2017.
[Is] ISSN:1734-154X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the ß-tubulin gene, out of them seventeen isolates showed wild-type cyp51A sequence and three were positive for the mutation TR34/L98H. All isolates were tested for the susceptibility to itraconazole (ITZ), voriconazole (VOR) and posaconasole (POS) using microdilution methods, according to EUCAST and CLSI protocols, as well as using Etest. The results of microdilution and Etests were analysed separately according to clinical breakpoints (CBP) defined by EUCAST version 7.0 and epidemiological cut off values (ECV). Etest as well as reference methods excellently recognised the WT isolates, which were susceptible to all tested triazoles, regardless of the method and CBP or ECV criteria used. The Etest recognized three non-WT isolates as resistant or intermediately sensitive to ITZ and POS and one as resistant to VOR. The categorical concordance between Etests and EUCAST and Etests and the CLSI method ranged from 90 to 100%. The interpretation of the results obtained from routine A. fumigatus Etests requires great caution. The use of the confirmative examinations with reference AST methods as well as with molecular tests is recommended.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus fumigatus/efeitos dos fármacos
Sistema Enzimático do Citocromo P-450/genética
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Farmacorresistência Fúngica/efeitos dos fármacos
Proteínas Fúngicas/genética
[Mh] Termos MeSH secundário: Aspergillus fumigatus/genética
Farmacorresistência Fúngica/genética
Itraconazol/farmacologia
Testes de Sensibilidade Microbiana/métodos
Polimorfismo Genético
Triazóis/farmacologia
Voriconazol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fungal Proteins); 0 (Triazoles); 304NUG5GF4 (Itraconazole); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.14.- (cytochrome P-450 CYP51A, Aspergillus); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.18388/abp.2017_1571


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[PMID]:29390575
[Au] Autor:Yao Y; Zhou H; Shen Y; Yang Q; Ye J; Lu G; Fu Y; Lou H; Yu Y; Zhou J
[Ad] Endereço:Department of Respiratory.
[Ti] Título:Evaluation of a commercial quantitative Aspergillus fumigatus-specific IgM assay for the diagnosis of invasive pulmonary aspergillosis.
[So] Source:Medicine (Baltimore);96(51):e9436, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Invasive pulmonary aspergillosis (IPA) is a common fungal infection with high mortality rates in immunocompromised patients. Early diagnosis of IPA is still challenging because of its nonspecific clinical symptoms and radiological presentations.To evaluate the clinical value of a commercial Aspergillus fumigates-specific IgM antibody assay in diagnosis of IPA, a multicenter prospective study was performed in 12 hospitals in Zhejiang Province, China, from January 1 to December 31, 2016.A total of 59 patients were enrolled in this study, including 30 IPA and 29 non-IPA patients. The sensitivities of IgM assay were 30.0%, 26.7%, 23.3%, and 20.0%, and the specificities were 79.3%, 86.2%, 86.2%, and 96.6% at the cutoff values of 50, 60, 70 and 80 AU/mL, respectively. The area under the curve of the IgM assay revealed by the receiver-operating characteristic analysis was 0.511 in the IPA cases. This study is the first to evaluate the clinical performance of a commercial A. fumigatus-specific IgM antibody assay that uses envelopes galactomannan extracted from A. fumigatus as the sole antigen in diagnosis of IPA.In conclusion, the A. fumigatus-specific IgM antibody assay has limited value and should not be a prior recommendation for IPA diagnosis.
[Mh] Termos MeSH primário: Aspergillus fumigatus/imunologia
Imunoglobulina M/imunologia
Aspergilose Pulmonar/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Aspergilose Pulmonar/imunologia
Aspergilose Pulmonar/microbiologia
Kit de Reagentes para Diagnóstico
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Immunoglobulin M); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009436


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[PMID]:28471497
[Au] Autor:Jacob CO; Yu N; Yoo DG; Perez-Zapata LJ; Barbu EA; Kaplan MJ; Purmalek M; Pingel JT; Idol RA; Dinauer MC
[Ad] Endereço:University of Southern California School of Medicine, Los Angeles.
[Ti] Título:Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.
[So] Source:Arthritis Rheumatol;69(8):1647-1660, 2017 08.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We have previously established that the gene for neutrophil cytosolic factor 2 (NCF-2) predisposes to lupus, and we have identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. We undertook this study to investigate the relationship between reduced leukocyte NADPH oxidase activity and immune dysregulation associated with systemic lupus erythematosus (SLE). METHODS: We generated NCF-2-null mice, in which NADPH oxidase activity is absent, on the nonautoimmune C57BL/6 (B6) mouse background and on the NZM 2328 mouse background, a polygenic model in which mice spontaneously develop lupus. Clinical disease, serology, and immunopathology were evaluated. RESULTS: NCF-2-null mice on the B6 background were susceptible to Aspergillus fumigatus pneumonia characteristic of chronic granulomatous disease, but did not develop systemic lupus disease. In contrast, NCF-2-null and even NCF-2-haploinsufficient mice on the NZM 2328 background developed accelerated full-blown lupus with significantly accelerated lupus kidney disease. This was characterized by more rapid development of hyperactive B cell and T cell immune compartments, increased expression of type I interferon-responsive genes, and generation of neutrophil extracellular traps, which were observed even in the absence of NADPH oxidase activity. CONCLUSION: Just as patients with chronic granulomatous disease who lack NADPH oxidase rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease. This establishes an interaction between reduced oxidase activity and other lupus-predisposing genes, paralleling human SLE-associated variants predicted to have only reduced NADPH oxidase activity.
[Mh] Termos MeSH primário: Haploinsuficiência/genética
Lúpus Eritematoso Sistêmico/genética
Nefrite Lúpica/genética
NADPH Oxidases/genética
[Mh] Termos MeSH secundário: Animais
Aspergillus fumigatus
Linfócitos B/imunologia
Catelicidinas/imunologia
Progressão da Doença
Ensaio de Imunoadsorção Enzimática
Armadilhas Extracelulares/imunologia
Regulação da Expressão Gênica/imunologia
Predisposição Genética para Doença
Doença Granulomatosa Crônica/genética
Interferon Tipo I/genética
Interferon Tipo I/imunologia
Rim/imunologia
Rim/patologia
Lúpus Eritematoso Sistêmico/imunologia
Nefrite Lúpica/imunologia
Nefrite Lúpica/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Aspergilose Pulmonar/genética
Reação em Cadeia da Polimerase em Tempo Real
Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cathelicidins); 0 (Interferon Type I); 0 (cathelicidin antimicrobial peptide); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.1 (Ncf2 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/art.40141


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[PMID]:29310381
[Au] Autor:Liu X; Yang J; Ma W
[Ad] Endereço:Department of Pulmonary Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
[Ti] Título:Primary cutaneous aspergillosis caused by Aspergillus.fumigatus in an immunocompetent patient: A case report.
[So] Source:Medicine (Baltimore);96(48):e8916, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary cutaneous aspergillosis in immunocompromised patients has been well described in extensive investigations. However, in immunocompetent hosts, primary cutaneous infection of aspergillus occurs rarely, and remains poorly characterized. PATIENT CONCERNS: We present a case of primary cutaneous aspergillosis manifested by erythematous plague covered with flava eschar. DIAGNOSES: The patient was diagnosed with primary cutaneous aspergillosis. INTERVENTIONS: Treatments with oral itraconazole at a dose of 75 mg/d and local wound care with ciclopirox olamine ointment were administered. OUTCOMES: After half a month, a partial resolution and a decrease in tenderness indicated gradual improvement, and a complete remission was achieved 2 months later. LESSONS: Primary cutaneous aspergillosis could occur in immunocompetent hosts. The initial lesions may appear in different forms, including macules, papules, nodules, or plaques. Repeated biopsy of a skin lesion for both culture and histopathology is needed.
[Mh] Termos MeSH primário: Aspergilose/tratamento farmacológico
Aspergillus fumigatus
Dermatomicoses/tratamento farmacológico
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Criança
Dermatomicoses/patologia
Seres Humanos
Imunocompetência
Itraconazol/uso terapêutico
Masculino
Piridonas/uso terapêutico
Pele/efeitos dos fármacos
Pele/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Pyridones); 19W019ZDRJ (ciclopirox); 304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008916


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[PMID]:29245249
[Au] Autor:Cho SY; Lee DG; Choi JK; Lee HJ; Kim SH; Park SH; Choi SM; Choi JH; Yoo JH; Park YJ; Lee JW
[Ad] Endereço:aDivision of Infectious Diseases, Department of Internal MedicinebVaccine Bio Research InstitutecThe Catholic Blood and Marrow Transplantation CentredDepartment of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
[Ti] Título:Characteristics of culture-positive invasive pulmonary aspergillosis in patients with hematologic diseases: Comparison between Aspergillus fumigatus and non-fumigatus Aspergillus species.
[So] Source:Medicine (Baltimore);96(49):e8841, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While the epidemiology and clinical differences of various Candida spp. has been relatively well-identified, data regarding invasive aspergillosis (IA) caused by different Aspergillus spp. are insufficient.We aimed to determine the epidemiology of culture-positive invasive pulmonary aspergillosis (IPA) and to compare the characteristics and outcomes of Aspergillus fumigatus IPA with those of non-fumigatus IPA in patients with hematologic diseases. All consecutive cases of IPA from 2011 to 2015 were reviewed retrospectively.There were 430 proven/probable IPA and 76 culture-positive proven/probable IPA. Excluding cases of multiple species of fungi or cases having difficulties in species-level identification, 41 A fumigatus and 22 non-fumigatus IPA (Aspergillus flavus [n = 11], Aspergillus niger [n = 6], and Aspergillus terreus [n = 5]) were compared. There were no significant differences in baseline characteristics between the 2 groups. However, disseminated IA was more common in non-fumigatus IPA (2.4% vs 18.2%; P = .046). Paranasal sinus (PNS) involvement was more common in non-fumigatus IPA. There was a trend towards higher peak serum galactomannan values in non-fumigatus IPA than in A fumigatus IPA group (median 1.33 [interquartile 0.98-3.29] vs 0.97 [0.66-1.97]; P = .084). Clinical response and mortality did not differ between groups.The culture-positive rate of proven/probable IPA was 17.7%, of which non-fumigatus Aspergillus accounted for about one-third. Disseminated IA, especially involving the PNS, was more frequent in non-fumigatus IPA than in A fumigatus IPA.
[Mh] Termos MeSH primário: Aspergillus fumigatus
Aspergillus
Doenças Hematológicas/microbiologia
Aspergilose Pulmonar Invasiva/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Doenças Hematológicas/sangue
Seres Humanos
Aspergilose Pulmonar Invasiva/sangue
Masculino
Mananas/sangue
Meia-Idade
Seios Paranasais/microbiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mannans); 11078-30-1 (galactomannan)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008841


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[PMID]:29073277
[Au] Autor:Luo Z; Fan Y; Li Q; Han B; Liu Y; Li S; Qiu H; Pang Z
[Ad] Endereço:College of Light Industry and Food Engineering, Guangxi University, Nanning, China.
[Ti] Título:Isolation, purification and characterization of 5'-phosphodiesterase from Aspergillus fumigatus.
[So] Source:PLoS One;12(10):e0186011, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and 5'-adenosine monophosphate. In this study, a 5'-PDE was newly isolated and purified from Aspergillus fumigatus. Following purification, this enzyme exhibited a specific activity of 1036.76 U/mg protein, a molecular weight of 9.5 kDa, and an optimal temperature and pH for enzyme activity of 60°C and 5.0, respectively. However, its activity was partially inhibited by Fe3+, Cu2+, and Zn2+, but slightly improved by the presence of K+ and Na+. Additionally, chemical-modification experiments were also applied to investigate the structural information of 5'-PDE, in which the residues containing carboxyl and imidazole groups were essential for enzyme activity based on their localization in the 5'-PDE active site. Furthermore, purified 5'-PDE could specifically catalyze the synthesis of ribonucleotides with a Vmax 0.71 mmol/mg·min and a KM of 13.60 mg/mL.
[Mh] Termos MeSH primário: Aspergillus fumigatus/enzimologia
Diester Fosfórico Hidrolases/isolamento & purificação
[Mh] Termos MeSH secundário: Catálise
Hidrólise
Peso Molecular
Diester Fosfórico Hidrolases/química
Diester Fosfórico Hidrolases/metabolismo
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.1.4.- (Phosphoric Diester Hydrolases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186011


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[PMID]:29045457
[Au] Autor:Mulligan JK; Pasquini WN; Carroll WW; Williamson T; Reaves N; Patel KJ; Mappus E; Schlosser RJ; Atkinson C
[Ad] Endereço:Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America.
[Ti] Título:Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.
[So] Source:PLoS One;12(10):e0186374, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be vitamin D3 (VD3) deficient, which is associated with more severe disease and increased polyp size. To gain mechanistic insights into these observational studies, we examined the impact of VD3 deficiency on inflammation and VD3 metabolism in an Aspergillus fumigatus (Af) mouse model of chronic rhinosinusitis (Af-CRS). METHODS: Balb/c mice were fed control or VD3 deficient diet for 4 weeks. Mice were then sensitized with intraperitoneal Af, and one week later given Af intranasally every three days for four weeks while being maintained on control or VD3 deficient diet. Airway function, sinonasal immune cell infiltrate and sinonasal VD3 metabolism profiles were then examined. RESULTS: Mice with VD3 deficiency had increased Penh and sRaw values as compared to controls as well as exacerbated changes in sRaw when coupled with Af-CRS. As compared to controls, VD3 deficient and Af-CRS mice had reduced sinonasal 1α-hydroxylase and the active VD3 metabolite, 1,25(OH)2D3. Differential analysis of nasal lavage samples showed that VD3 deficiency alone and in combination with Af-CRS profoundly upregulated eosinophil, neutrophil and lymphocyte numbers. VD3 deficiency exacerbated increases in monocyte-derived dendritic cell (DC) associated with Af-CRS. Conversely, T-regulatory cells were decreased in both Af-CRS mice and VD3 deficient mice, though coupling VD3 deficiency with Af-CRS did not exacerbate CD4 or T-regulatory cells numbers. Lastly, VD3 deficiency had a modifying or exacerbating impact on nasal lavage levels of IFN-γ, IL-6, IL-10 and TNF-α, but had no impact on IL-17A. CONCLUSIONS: VD3 deficiency causes changes in sinonasal immunity, which in many ways mirrors the changes observed in Af-CRS mice, while selectively exacerbating inflammation. Furthermore, both VD3 deficiency and Af-CRS were associated with altered sinonasal VD3 metabolism causing reductions in local levels of the active VD3 metabolite, 1,25(OH)2D3, even with adequate circulating levels.
[Mh] Termos MeSH primário: Colecalciferol/metabolismo
Inflamação/metabolismo
Pólipos Nasais/metabolismo
Rinite/metabolismo
Sinusite/metabolismo
[Mh] Termos MeSH secundário: Animais
Aspergillus fumigatus/patogenicidade
Contagem de Células Sanguíneas
Dieta
Suplementos Nutricionais
Modelos Animais de Doenças
Eosinófilos/patologia
Seres Humanos
Inflamação/dietoterapia
Inflamação/patologia
Linfócitos/patologia
Camundongos
Lavagem Nasal
Pólipos Nasais/dietoterapia
Pólipos Nasais/patologia
Neutrófilos/patologia
Rinite/dietoterapia
Rinite/patologia
Sinusite/dietoterapia
Sinusite/patologia
Linfócitos T Reguladores/metabolismo
Linfócitos T Reguladores/patologia
Deficiência de Vitamina D/metabolismo
Deficiência de Vitamina D/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1C6V77QF41 (Cholecalciferol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186374


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[PMID]:28973595
[Au] Autor:Miceli MH; Kauffman CA
[Ad] Endereço:Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor.
[Ti] Título:Aspergillus Galactomannan for Diagnosing Invasive Aspergillosis.
[So] Source:JAMA;318(12):1175-1176, 2017 Sep 26.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aspergillus fumigatus
Líquido da Lavagem Broncoalveolar/química
Hospedeiro Imunocomprometido
Técnicas Imunoenzimáticas
Aspergilose Pulmonar Invasiva/diagnóstico
Mananas/análise
[Mh] Termos MeSH secundário: Idoso
Aspergillus fumigatus/isolamento & purificação
Biópsia
Líquido da Lavagem Broncoalveolar/microbiologia
Granulomatose com Poliangiite/complicações
Granulomatose com Poliangiite/tratamento farmacológico
Seres Humanos
Masculino
Mananas/sangue
Sensibilidade e Especificidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mannans); 11078-30-1 (galactomannan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10661


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[PMID]:28923131
[Au] Autor:Wang F; Zhang C; Jiang Y; Kou C; Kong Q; Long N; Lu L; Sang H
[Ad] Endereço:1​Department of Dermatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, PR China.
[Ti] Título:Innate and adaptive immune response to chronic pulmonary infection of hyphae of Aspergillus fumigatus in a new murine model.
[So] Source:J Med Microbiol;66(10):1400-1408, 2017 Oct.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The pathogenesis of chronic pulmonary aspergillosis (CPA) has seldom been studied due partly to a lack of animal models. Since hypha is the main morphology colonizing the airway in CPA, it's critical to study the immune reaction to chronic pulmonary infection of hyphae of Aspergillus fumigatus, which also has seldom been studied in vivo before. METHODOLOGY: We established a novel murine model of chronic pulmonary infection of hyphae by challenging immunocompetent mice with tightly-structured hyphae balls intratracheally, and described the ensuing immunoreaction to hyphae and conidia, and the pathogenesis of CPA. RESULTS: Our experiment proved that the hyphae balls could induce a chronic pulmonary infection for 28 days with a considerable recrudescence at day 28 post-infection. Lungs infected with hyphae balls were remarkable for the many neutrophils and macrophages that flooded into airway lumens, with peribronchiolar infiltration of leukocytes. There was a transient increase of Th2 cells and Th17 cells at day 7 post-infection in the lung tissue. In contrast, lungs infected with conidia showed no peribronchiolar infiltration of leukocytes, but an influx of a great number of macrophages, and a much less number of neutrophils in the lumen. Besides, conidia activated the co-response of Th1, Th2 and Th17 cells with an increase of Treg cells in the lung tissue (quite different from most previous studies). CONCLUSION: We established a new murine model of chronic infection of hyphae to mimic the formation of CPA, and provide a new marker for different immune responses to hyphae and conidia.
[Mh] Termos MeSH primário: Imunidade Adaptativa/fisiologia
Aspergillus fumigatus/imunologia
Hifas/imunologia
Imunidade Inata/fisiologia
Aspergilose Pulmonar/imunologia
[Mh] Termos MeSH secundário: Animais
Feminino
Camundongos
Camundongos Endogâmicos C57BL
Linfócitos T
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000590



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