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Pesquisa : B01.300.381.385 [Categoria DeCS]
Referências encontradas : 57 [refinar]
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[PMID]:28236408
[Au] Autor:Ge HX; Zhang J; Qian K; Yu BY; Chen XP
[Ad] Endereço:Department of Pharmacy, Huzhou University, Huzhou 313000, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis.
[So] Source:Chin J Nat Med;14(10):783-788, 2016 Oct.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
[Mh] Termos MeSH primário: Alcaloides de Berberina/síntese química
Alcaloides de Berberina/metabolismo
Gliocladium/metabolismo
Glicosídeos/síntese química
Glicosídeos/metabolismo
[Mh] Termos MeSH secundário: Alcaloides de Berberina/química
Biotransformação
Catálise
Glicosídeos/química
Glicosilação
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (Glycosides); 19716-69-9 (protoberberine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:26481382
[Au] Autor:Xu SH; DU CH; Zhang J; Yu BY
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Glycosylation and sulfation of emodin by Gliocladium deliquescens NRRL 1086.
[So] Source:Chin J Nat Med;13(10):796-800, 2015 Oct.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The present study was designed to explore the substrate scope and biocatalytic capability of Gliocladium deliquescens NRRL 1086 on phenolic natural products. Emodin was subjected to the fermentation culture of Gliocladium deliquescens NRRL 1086 according to the standard two-stage protocol. The biotransformation process was monitored by HPLC-DAD-MS, the main product was isolated by column chromatography, and the structure was elucidated on the basis of NMR spectroscopy. Emodin could be fully metabolized by Gliocladium deliquescens NRRL 1086, resulting in high yield of emodin 6-O-ß-D-glucopyranoside and small amount of sulfated product. In conclusion, our results may provide a convenient method to prepare emodin 6-O-ß-D-glucopyranoside and the microbe catalyzed glucosylation/sulfation will give an inspiration to pharmacokinetic model studies in vitro.
[Mh] Termos MeSH primário: Emodina/metabolismo
Fermentação
Gliocladium/metabolismo
Glucosídeos/metabolismo
Extratos Vegetais/metabolismo
[Mh] Termos MeSH secundário: Reatores Biológicos
Biotransformação
Glicosilação
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Estrutura Molecular
Fenóis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (6''-O-glucopyranoside); 0 (Glucosides); 0 (Phenols); 0 (Plant Extracts); KA46RNI6HN (Emodin)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151020
[Lr] Data última revisão:
151020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151021
[St] Status:MEDLINE


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[PMID]:24827395
[Au] Autor:Li XZ; Chen G; Wang HF; Hua HM; Pei YH
[Ad] Endereço:a Department of Pharmacy , Affiliated Hospital of Yanbian University , Yanji 133000 , China.
[Ti] Título:Synthesis and bioactivity of diketopiperazine PJ147 and its derivatives from Gliocladium sp. YUP08.
[So] Source:J Asian Nat Prod Res;16(7):764-9, 2014.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Concise total synthesis of diketopiperazine PJ147, obtained from mycelium of Gliocladium sp. YUP08, has been achieved in seven steps with 43.5% overall yield. Biological evaluation of PJ147 exhibited strong inhibiting activity against A375-S2, Hela, P388, A-549, HL-60, and BEL-7420 cell lines. Thus, eight derivatives of PJ147 with high water solubility were also synthesized to facilitate the in vivo bioassay of this kind of diketopiperazines.
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Dicetopiperazinas/isolamento & purificação
Dicetopiperazinas/farmacologia
Gliocladium/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Dicetopiperazinas/síntese química
Dicetopiperazinas/química
Ensaios de Seleção de Medicamentos Antitumorais
Células HL-60
Células HeLa
Seres Humanos
Estrutura Molecular
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Diketopiperazines); 0 (PJ 147)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140731
[Lr] Data última revisão:
140731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140516
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2014.916283


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[PMID]:24617266
[Au] Autor:Wang Y; Hu P; Li E; Liu X; Che Y; Liu G
[Ti] Título:[Genetic transformation of the fungus Gliocladium sp. mediated by Agrobacterium tumefaciens].
[So] Source:Wei Sheng Wu Xue Bao;53(11):1233-9, 2013 Nov 04.
[Is] ISSN:0001-6209
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To construct a transformation system in Gliocladium sp. 6.102, a Cordyceps-colonizing fungus producing a variety of epipolythiodioxopiperazine (ETP) compounds with drug potentials. METHODS: Agrobacterium tumefaciens-mediated transformation (ATMT) was used to transform Gliocladium sp. 6.102. The factors of bacterial cell concentration, co-cultivation time, pH and acetosyringone concentration were optimized. RESULTS; A total of 50 -100 transformants per 10(6) fungal conidia was obtained via the optimal ATMT method. The genes encoding hygromycin B phosphotase and enhanced green fluorescent protein (EGFP) were transferred into Gliocladium sp. by the optimal ATMT method. The marker genes were successfully expressed and stably maintained in the transgenic fungus. CONCLUSION: A transformation system was established for Gliocladium sp. 6.102 and this system may be useful to identify ETP biosynthetic genes in Gliocladium.
[Mh] Termos MeSH primário: Agrobacterium tumefaciens/genética
Gliocladium/genética
Transformação Genética
[Mh] Termos MeSH secundário: Antibióticos Antineoplásicos/biossíntese
Gliocladium/efeitos dos fármacos
Gliocladium/crescimento & desenvolvimento
Proteínas de Fluorescência Verde/genética
Testes de Sensibilidade Microbiana
Piperazinas
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Piperazines); 0 (enhanced green fluorescent protein); 0 (epipolythiodiketopiperazine); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140312
[Lr] Data última revisão:
140312
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140313
[St] Status:MEDLINE


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[PMID]:23851004
[Au] Autor:Mueller A; Schlink U; Wichmann G; Bauer M; Graebsch C; Schüürmann G; Herbarth O
[Ad] Endereço:UFZ Helmholtz Centre for Environmental Research, Division Health Science, Permoserstr. 15, 04318 Leipzig, Germany. a.mueller@ufz.de
[Ti] Título:Individual and combined effects of mycotoxins from typical indoor moulds.
[So] Source:Toxicol In Vitro;27(6):1970-8, 2013 Sep.
[Is] ISSN:1879-3177
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mycotoxins patulin, gliotoxin and sterigmatocystin can be produced by common indoor moulds and enter the human body via inhalation of mycotoxin containing spores and particulates. There are various studies about the individual effects of these mycotoxins, but a lack of knowledge about their effects in mixtures. The aim of this study was to evaluate combined effects on the singe celled organism Tetrahymena pyriformis. Using the MIXTOX model (EU project NOMIRACLE) synergistic or antagonistic effects with dose level deviation or dose ratio dependent deviation were analyzed. The most toxic compound gliotoxin (EC50 0.37 µM) and patulin (EC50 9.3 µM) as shown by the MIXTOX model acted synergistic, caused by similar mode of actions. Within the combination with sterigmatocystin (maximum inhibition of 45% at 12.5 µM) antagonistic effects were observed with switch to synergism if the toxicity of the mixture is mainly caused by sterigmatocystin. In the end the MIXTOX model was applicable for the prediction of combined effects of toxic compounds.
[Mh] Termos MeSH primário: Gliotoxina/toxicidade
Modelos Biológicos
Patulina/toxicidade
Esterigmatocistina/toxicidade
Tetrahymena pyriformis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Interações Medicamentosas
Gliocladium
Gliotoxina/administração & dosagem
Patulina/administração & dosagem
Esterigmatocistina/administração & dosagem
Tetrahymena pyriformis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
10048-13-2 (Sterigmatocystin); 67-99-2 (Gliotoxin); 95X2BV4W8R (Patulin)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:130820
[Lr] Data última revisão:
130820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130716
[St] Status:MEDLINE


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[PMID]:23199480
[Au] Autor:Ge HX; Zhang J; Chen L; Kou JP; Yu BY
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24# Tongjia Xiang Street, Nanjing 210009, China.
[Ti] Título:Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity.
[So] Source:Bioorg Med Chem;21(1):62-9, 2013 Jan 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To discover new inhibitors on tissue factor procoagulant activity, 21 tetrahydroprotoberberines were screened on the model of human THP-1 cells stimulated by lipopolysaccharide. Among these tetrahydroprotoberberines, several unique compounds were synthesized through microbial transformation: compound 6 (l-corydalmine) was obtained through regio-selective demethylation by Streptomyces griseus ATCC 13273, whereas compounds 4a, 4b, 5h, and 5i were microbial glycosylation products by Gliocladium deliquescens NRRL1086. The bioassay results showed that compounds 3 (tetrahydroberberine), 10 (tetrahydroberberrubine), and 5f (cinnamyl ester of 5) and 5i (glycosidic product of 5), exhibited the most potential effects, with IC(50) values of 8.35, 6.75, 3.75, and 8.79 nM, respectively. The preliminary structure and activity relationship analysis revealed that the 2,3-methylenedioxy group of the A ring was essential for the strong inhibitory effects, and the R configuration of the chiral center C-14 showed higher activity than S-form products. The formation of fatty acid or aromatic acid esters of compound 5, except the cinnamyl esters, would weaken its effects. It is also interesting to note that the glycosylation of tetrahydroprotoberberines will maintain and even enhance the inhibitory effects. Because of the importance of glycochemistry in new drug discovery and development, this deserves further exploration and may provide some guide on the semi-synthesis of tetrahydroprotoberberines as tissue factor pathway inhibitors. Our findings also provide some potential leading compounds for tissue factor-related diseases, such as cancer and cardiovascular diseases.
[Mh] Termos MeSH primário: Alcaloides de Berberina/química
Alcaloides de Berberina/farmacologia
Tromboplastina/antagonistas & inibidores
[Mh] Termos MeSH secundário: Alcaloides de Berberina/metabolismo
Linhagem Celular
Gliocladium/metabolismo
Glicosilação
Seres Humanos
Streptomyces griseus/metabolismo
Relação Estrutura-Atividade
Tromboplastina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Berberine Alkaloids); 728C74FB5Z (berbine); 9035-58-9 (Thromboplastin)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121204
[St] Status:MEDLINE


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[PMID]:22825674
[Au] Autor:Martínez-Ramírez JA; Voigt K; Peters FT
[Ad] Endereço:Institute of Forensic Medicine, Jena University Hospital, Jena, Germany.
[Ti] Título:Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis.
[So] Source:Anal Bioanal Chem;404(5):1339-59, 2012 Sep.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:It is well-known that cadavers may be colonized by microorganisms, but there is limited information if or to what extent these microbes are capable of metabolizing drugs or poisons, changing the concentrations and metabolic pattern of such compounds in postmortem samples. The aim of the present study was to develop a fungal biotransformation system as an in vitro model to investigate potential postmortem metabolism by fungi. Five model drugs (amitriptyline, metoprolol, mirtazapine, promethazine, and zolpidem) were each incubated with five model fungi known to colonize cadavers (Absidia repens, Aspergillus repens, Aspergillus terreus, Gliocladium viride, and Mortierella polycephala) and with Cunninghamella elegans (positive control). Incubations were performed in Sabouraud medium at 25 °C for 5 days. After centrifugation, a part of the supernatants was analyzed by liquid chromatography-tandem mass spectrometry with product ion scanning. Another part was analyzed by full scan gas chromatography-mass spectrometry after extraction and derivatization. All model drugs were metabolized by the control fungus resulting in two (metoprolol) to ten (amitriptyline) metabolites. Of the model fungi, only Abs. repens and M. polycephala metabolized the model drugs: amitriptyline was metabolized to six and five, metoprolol to two and two, mirtazapine to five and three, promethazine to six and nine, and zolpidem to three and four metabolites, respectively. The main metabolic reactions were demethylation, oxidation, and hydroxylation. The presented in vitro model is applicable to studying drug metabolism by fungi colonizing cadavers.
[Mh] Termos MeSH primário: Absidia/metabolismo
Aspergillus/metabolismo
Gliocladium/metabolismo
Mortierella/metabolismo
Preparações Farmacêuticas/metabolismo
Espectrometria de Massas por Ionização por Electrospray/métodos
[Mh] Termos MeSH secundário: Amitriptilina/metabolismo
Biotransformação
Cadáver
Cromatografia Líquida/métodos
Cromatografia Gasosa-Espectrometria de Massas/métodos
Hidroxilação
Metilação
Metoprolol/metabolismo
Mianserina/análogos & derivados
Mianserina/metabolismo
Oxirredução
Prometazina/metabolismo
Piridinas/metabolismo
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Pyridines); 1806D8D52K (Amitriptyline); 250PJI13LM (Mianserin); 7K383OQI23 (zolpidem); A051Q2099Q (mirtazapine); FF28EJQ494 (Promethazine); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:160512
[Lr] Data última revisão:
160512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120725
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-012-6212-3


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[PMID]:22588247
[Au] Autor:Ge HX; Zhang J; Dong Y; Cui K; Yu BY
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24# Tong Jia Xiang St, Nanjing, 21009, PR China.
[Ti] Título:Unique biocatalytic resolution of racemic tetrahydroberberrubine via kinetic glycosylation and enantio-selective sulfation.
[So] Source:Chem Commun (Camb);48(49):6127-9, 2012 Jun 21.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this communication, we document a facile kinetic glycosylation resolution of racemic tetrahydroberberrubine. We also demonstrate that the enantiomeric excess of the resolved products is increased via a second resolution of the minor product of the first glycosylation resolution. This provides a rare example of tandem kinetic resolution of racemates.
[Mh] Termos MeSH primário: Berberina/química
Berberina/metabolismo
Gliocladium/metabolismo
Sulfatases/metabolismo
Sulfatos/metabolismo
[Mh] Termos MeSH secundário: Berberina/análogos & derivados
Biocatálise
Glicosilação
Cinética
Modelos Moleculares
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Sulfates); 0I8Y3P32UF (Berberine); EC 3.1.6.- (Sulfatases)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120517
[St] Status:MEDLINE
[do] DOI:10.1039/c2cc32175k


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[PMID]:22189862
[Au] Autor:Ge HX; Zhang J; Kai C; Liu JH; Yu BY
[Ad] Endereço:Department of Chemistry, Huzhou Teachers College, Huzhou, Zhejiang Province, People's Republic of China.
[Ti] Título:Regio- and enantio-selective glycosylation of tetrahydroprotoberberines by Gliocladium deliquescens NRRL1086 resulting in unique alkaloidal glycosides.
[So] Source:Appl Microbiol Biotechnol;93(6):2357-64, 2012 Mar.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The microbial transformation of a series of tetrahydroprotoberberines (THPBs, 1-5) by Gliocladium deliquescens NRRL1086 was investigated. In this research, the novel glycosylation of tetrahydroberberrubine (1) was observed with fast rate and high regio- and enantio-selectivity. One pair of unique enantiomorphic alkaloidal glycosides T-1 and T-2 was isolated and their structures were elucidated unambiguously by HR-MS, CD, 1D and 2D NMR spectrum. It is interesting that different amounts of glucose in the potato broth medium could influence the ratio of T-1 and T-2; in the 1.5% glucose medium, the ratio was about 15:1 and the yield of the S-form product T-1 may reach the theoretical maximum yield of about 50% which could provide one practical method to prepare the enantiomerically pure product and one alternative resolution method of tetrahydroberberrubine. The preliminary enzymatic research by using sodium dodecyl sulfate (SDS) and imidazole as glycosyltransferase and glycosidase inhibitors revealed that glycosyltransferase may contribute to glycosylation process. This is the first successful approach to glycosylation of tetrahydroprotoberberines.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Alcaloides de Berberina/química
Alcaloides de Berberina/metabolismo
Gliocladium/metabolismo
Glicosídeos/metabolismo
[Mh] Termos MeSH secundário: Biotransformação
Glicosilação
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Berberine Alkaloids); 0 (Glycosides); 728C74FB5Z (berbine)
[Em] Mês de entrada:1206
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111223
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-011-3795-0


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[PMID]:22117164
[Au] Autor:Koolen HH; Soares ER; Silva FM; Souza AQ; Medeiros LS; Filho ER; Almeida RA; Ribeiro IA; Pessoa Cdo Ó; Morais MO; Costa PM; Souza AD
[Ad] Endereço:Departamento de Química, Universidade Federal do Amazonas, Av. Gal. Rodrigo Otávio, Manaus, Amazonas, Brazil. hector_ferreira86@yahoo.com.br
[Ti] Título:An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera.
[So] Source:Nat Prod Res;26(21):2013-9, 2012 Nov.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at a concentration of 43.4 µM.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides/farmacologia
Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Dicetopiperazinas/química
Gliocladium/química
Strychnos/microbiologia
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Antineoplásicos/farmacologia
Linhagem Celular Tumoral/efeitos dos fármacos
Ácido Cítrico/isolamento & purificação
Dicetopiperazinas/isolamento & purificação
Relação Dose-Resposta a Droga
Endófitos/química
Ergosterol/análogos & derivados
Ergosterol/isolamento & purificação
Gliocladium/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Micrococcus luteus/efeitos dos fármacos
Estrutura Molecular
Peptídeos Cíclicos/química
Peptídeos Cíclicos/isolamento & purificação
Fitosteróis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Diketopiperazines); 0 (Peptides, Cyclic); 0 (Phytosterols); 0 (cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether); 2968PHW8QP (Citric Acid); 516-37-0 (cerevisterol); UG9TN81TGH (ergosterol-5,8-peroxide); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:120925
[Lr] Data última revisão:
120925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111126
[St] Status:MEDLINE



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