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  1 / 2145 MEDLINE  
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Vicentini, Adriana Pardini
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[PMID]:29342162
[Au] Autor:Dantas KC; Freitas RS; da Silva MV; Criado PR; Luiz ODC; Vicentini AP
[Ad] Endereço:Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil.
[Ti] Título:Comparison of diagnostic methods to detect Histoplasma capsulatum in serum and blood samples from AIDS patients.
[So] Source:PLoS One;13(1):e0190408, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although early and rapid detection of histoplasmosis is essential to prevent morbidity and mortality, few diagnostic tools are available in resource-limited areas, especially where it is endemic and HIV/AIDS is also epidemic. Thus, we compared conventional and molecular methods to detect Histoplasma capsulatum in sera and blood from HIV/AIDS patients. METHODOLOGY: We collected a total of 40 samples from control volunteers and patients suspected of histoplasmosis, some of whom were also infected with other pathogens. Samples were then analyzed by mycological, serological, and molecular methods, and stratified as histoplasmostic with (group I) or without AIDS (group II), uninfected (group III), and infected with HIV and other pathogens only (group IV). All patients were receiving treatment for histoplasmosis and other infections at the time of sample collection. RESULTS: Comparison of conventional methods with nested PCR using primers against H. capsulatum 18S rRNA (HC18S), 5.8S rRNA ITS (HC5.8S-ITS), and a 100 kDa protein (HC100) revealed that sensitivity against sera was highest for PCR with HC5.8S-ITS, followed by immunoblotting, double immunodiffusion, PCR with HC18S, and PCR with HC100. Specificity was equally high for double immunodiffusion, immunoblotting and PCR with HC100, followed for PCR with HC18S and HC5.8-ITS. Against blood, sensitivity was highest for PCR with HC5.8S-ITS, followed by PCR with HC18S, Giemsa staining, and PCR with HC100. Specificity was highest for Giemsa staining and PCR with HC100, followed by PCR with HC18S and HC5.8S-ITS. PCR was less efficient in patients with immunodeficiency due to HIV/AIDS and/or related diseases. CONCLUSION: Molecular techniques may detect histoplasmosis even in cases with negative serology and mycology, potentially enabling early diagnosis.
[Mh] Termos MeSH primário: Infecções por HIV/sangue
Histoplasma/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190408


  2 / 2145 MEDLINE  
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[PMID]:29287097
[Au] Autor:López LF; Muñoz CO; Cáceres DH; Tobón ÁM; Loparev V; Clay O; Chiller T; Litvintseva A; Gade L; González Á; Gómez BL
[Ad] Endereço:Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.
[Ti] Título:Standardization and validation of real time PCR assays for the diagnosis of histoplasmosis using three molecular targets in an animal model.
[So] Source:PLoS One;12(12):e0190311, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histoplasmosis is considered one of the most important endemic and systemic mycoses worldwide. Until now few molecular techniques have been developed for its diagnosis. The aim of this study was to develop and evaluate three real time PCR (qPCR) protocols for different protein-coding genes (100-kDa, H and M antigens) using an animal model. Fresh and formalin-fixed and paraffin-embedded (FFPE) lung tissues from BALB/c mice inoculated i.n. with 2.5x106 Histoplasma capsulatum yeast or PBS were obtained at 1, 2, 3, 4, 8, 12 and 16 weeks post-infection. A collection of DNA from cultures representing different clades of H. capsulatum (30 strains) and other medically relevant pathogens (36 strains of related fungi and Mycobacterium tuberculosis) were used to analyze sensitivity and specificity. Analytical sensitivity and specificity were 100% when DNAs from the different strains were tested. The highest fungal burden occurred at first week post-infection and complete fungal clearance was observed after the third week; similar results were obtained when the presence of H. capsulatum yeast cells was demonstrated in histopathological analysis. In the first week post-infection, all fresh and FFPE lung tissues from H. capsulatum-infected animals were positive for the qPCR protocols tested except for the M antigen protocol, which gave variable results when fresh lung tissue samples were analyzed. In the second week, all qPCR protocols showed variable results for both fresh and FFPE tissues. Samples from the infected mice at the remaining times post-infection and uninfected mice (controls) were negative for all protocols. Good agreement was observed between CFUs, histopathological analysis and qPCR results for the 100-kDa and H antigen protocols. We successfully standardized and validated three qPCR assays for detecting H. capsulatum DNA in fresh and FFPE tissues, and conclude that the 100-kDa and H antigen molecular assays are promising tests for diagnosing this mycosis.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Genes Fúngicos
Histoplasmose/diagnóstico
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Animais
DNA Fúngico/genética
DNA Fúngico/isolamento & purificação
Histoplasma/genética
Histoplasmose/genética
Pulmão/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Mycobacterium tuberculosis/genética
Mycobacterium tuberculosis/isolamento & purificação
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190311


  3 / 2145 MEDLINE  
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[PMID]:28953979
[Au] Autor:English BC; Van Prooyen N; Örd T; Örd T; Sil A
[Ad] Endereço:Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America.
[Ti] Título:The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum.
[So] Source:PLoS Pathog;13(9):e1006589, 2017 Sep.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability of intracellular pathogens to manipulate host-cell viability is critical to successful infection. Some pathogens promote host-cell survival to protect their replicative niche, whereas others trigger host-cell death to facilitate release and dissemination of the pathogen after intracellular replication has occurred. We previously showed that the intracellular fungal pathogen Histoplasma capsulatum (Hc) uses the secreted protein Cbp1 to actively induce apoptosis in macrophages; interestingly, cbp1 mutant strains are unable to kill macrophages and display severely reduced virulence in the mouse model of Hc infection. To elucidate the mechanism of Cbp1-induced host-cell death, we performed a comprehensive alanine scanning mutagenesis and identified all amino acid residues that are required for Cbp1 to trigger macrophage lysis. Here we demonstrate that Hc strains expressing lytic CBP1 alleles activate the integrated stress response (ISR) in infected macrophages, as indicated by an increase in eIF2α phosphorylation as well as induction of the transcription factor CHOP and the pseudokinase Tribbles 3 (TRIB3). In contrast, strains bearing a non-lytic allele of CBP1 fail to activate the ISR, whereas a partially lytic CBP1 allele triggers intermediate levels of activation. We further show that macrophages deficient for CHOP or TRIB3 are partially resistant to lysis during Hc infection, indicating that the ISR is critical for susceptibility to Hc-mediated cell death. Moreover, we show that CHOP-dependent macrophage lysis is critical for efficient spread of Hc infection to other macrophages. Notably, CHOP knockout mice display reduced macrophage apoptosis and diminished fungal burden and are markedly resistant to Hc infection. Together, these data indicate that Cbp1 is required for Hc to induce the ISR and mediate a CHOP-dependent virulence pathway in the host.
[Mh] Termos MeSH primário: Apoptose/imunologia
Genes Fúngicos/genética
Histoplasma/metabolismo
Histoplasmose/microbiologia
Macrófagos/metabolismo
Fator de Transcrição CHOP/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Ligação ao Cálcio/metabolismo
Células Cultivadas
Citoplasma/metabolismo
Feminino
Interações Hospedeiro-Patógeno/imunologia
Macrófagos/microbiologia
Camundongos
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium-Binding Proteins); 147336-12-7 (Transcription Factor CHOP)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006589


  4 / 2145 MEDLINE  
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[PMID]:28930505
[Au] Autor:Romano K; Pazo V; Qian X; Vaidya A; Maguire JH
[Ti] Título:The Road Less Traveled.
[So] Source:N Engl J Med;377(12):e16, 2017 Sep 21.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Histoplasma/isolamento & purificação
Histoplasmose/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Lavagem Broncoalveolar
Diagnóstico Diferencial
Feminino
Histoplasma/fisiologia
Histoplasmose/complicações
Histoplasmose/tratamento farmacológico
Seres Humanos
Itraconazol/uso terapêutico
Estágios do Ciclo de Vida
Pulmão/diagnóstico por imagem
Pulmão/patologia
Linfonodos/microbiologia
Linfonodos/patologia
Linfadenopatia/diagnóstico por imagem
Linfadenopatia/etiologia
Tomografia Computadorizada por Raios X
Viagem
[Pt] Tipo de publicação:INTERACTIVE TUTORIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMimc1616026


  5 / 2145 MEDLINE  
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[PMID]:28797398
[Au] Autor:Patterson J; Graham D; George A; Will M; Sutter D
[Ad] Endereço:Department of Pediatrics, San Antonio Military Medical Center, JBSA Fort Sam Houston, TX.
[Ti] Título:Right Middle Lobe Collapse and Pleural Effusion in an 18-Year-Old Man.
[So] Source:Chest;152(2):e33-e38, 2017 Aug.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 18-year-old African American male subject presented to an acute care clinic with 3 days of productive cough, chills, pleuritic right chest pain, sore throat with hoarseness, congestion, and intermittent shortness of breath. He recently relocated to Texas from Georgia to undergo basic military training. He denied any other recent travel or contact with persons with pulmonary TB or other respiratory illnesses. His medical history was significant for glucose-6-phosphate dehydrogenase deficiency and sickle cell trait.
[Mh] Termos MeSH primário: Histoplasmose/diagnóstico
Pneumopatias Fúngicas/diagnóstico
Mediastinite/microbiologia
Derrame Pleural/microbiologia
Atelectasia Pulmonar/microbiologia
Esclerose/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Histoplasma
Histoplasmose/diagnóstico por imagem
Seres Humanos
Pneumopatias Fúngicas/diagnóstico por imagem
Masculino
Mediastinite/diagnóstico por imagem
Derrame Pleural/diagnóstico por imagem
Atelectasia Pulmonar/diagnóstico por imagem
Esclerose/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


  6 / 2145 MEDLINE  
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[PMID]:28783875
[Au] Autor:Horwath MC; Bell-Horwath TR; Lescano V; Krishnan K; Merino EJ; Deepe GS
[Ad] Endereço:Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, 333 Burnet Avenue, Cincinnati, OH, 45229, USA.
[Ti] Título:Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1.
[So] Source:Chembiochem;18(20):2069-2078, 2017 Oct 18.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ferrostatin-1 (Fer-1) is a lipophilic antioxidant that effectively blocks ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. During many infections, both pathogens and host cells are subjected to oxidative stress, but the occurrence of ferroptosis had not been investigated. We examined ferroptosis in macrophages infected with the pathogenic yeast Histoplasma capsulatum. Unexpectedly, Fer-1 not only reduced the death of macrophages infected in vitro, but inhibited the growth of H. capsulatum and related species Paracoccidioides lutzii and Blastomyces dermatitidis at concentrations under 10 µm. Other antioxidant ferroptosis inhibitors, including liproxstatin-1, did not prevent fungal growth or reduce macrophage death. Structural analysis revealed a potential similarity of Fer-1 to inhibitors of fungal sterol synthesis, and ergosterol content of H. capsulatum decreased more than twofold after incubation with Fer-1. Strikingly, additional Fer-1 analogues with slight differences from Fer-1 had limited impact on fungal growth. In conclusion, the ferroptosis inhibitor Fer-1 has unexpected antifungal potency distinct from its antiferroptotic activity.
[Mh] Termos MeSH primário: Antifúngicos/química
Antifúngicos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Cicloexilaminas/química
Cicloexilaminas/farmacologia
Interações Hidrofóbicas e Hidrofílicas
Fenilenodiaminas/química
Fenilenodiaminas/farmacologia
[Mh] Termos MeSH secundário: Histoplasma/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antioxidants); 0 (Cyclohexylamines); 0 (Phenylenediamines); 0 (ferrostatin-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700105


  7 / 2145 MEDLINE  
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[PMID]:28719316
[Au] Autor:Samayoa B; Roy M; Cleveland AA; Medina N; Lau-Bonilla D; Scheel CM; Gomez BL; Chiller T; Arathoon E
[Ad] Endereço:Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala, Guatemala, Guatemala.
[Ti] Título:High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala.
[So] Source:Am J Trop Med Hyg;97(1):42-48, 2017 Jul.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients ≥ 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for . Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases.
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/mortalidade
Síndrome de Imunodeficiência Adquirida/mortalidade
Coinfecção/mortalidade
Infecções por HIV/mortalidade
Histoplasmose/complicações
Histoplasmose/mortalidade
[Mh] Termos MeSH secundário: Infecções Oportunistas Relacionadas com a AIDS/complicações
Síndrome de Imunodeficiência Adquirida/complicações
Adulto
Idoso
Idoso de 80 Anos ou mais
Causas de Morte
Estudos de Coortes
Coinfecção/complicações
Feminino
Guatemala
Infecções por HIV/complicações
Histoplasma/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Mortalidade
Estudos Prospectivos
Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0009


  8 / 2145 MEDLINE  
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[PMID]:28240390
[Au] Autor:Wang P; Kenyon C; de Hoog S; Guo L; Fan H; Liu H; Li Z; Sheng R; Yang Y; Jiang Y; Zhang L; Xu Y
[Ad] Endereço:Division of Clinical Microbiology, P.U.M.C.H., Beijing, China.
[Ti] Título:A novel dimorphic pathogen, Emergomyces orientalis (Onygenales), agent of disseminated infection.
[So] Source:Mycoses;60(5):310-319, 2017 May.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A novel dimorphic fungus, Emergomyces orientalis sp. nov. a close relative of systemic pathogens in the family Ajellomycetaceae (Blastomyces, Histoplasma). The fungus is reported in a 64-year-old male from Shanxi, China. The patient developed disseminated skin lesions, productive cough with fever and showed nodular opacities in his left lung on chest radiography. The patient had no identified cause of immunodeficiency apart from type-2 diabetes mellitus. Clinical, histopathological and mycological characteristics of the agent are given, and its phylogenetic position is determined with multilocus sequence data.
[Mh] Termos MeSH primário: Infecções Fúngicas Invasivas/diagnóstico
Infecções Fúngicas Invasivas/microbiologia
Onygenales/isolamento & purificação
Onygenales/patogenicidade
Filogenia
[Mh] Termos MeSH secundário: Blastomyces/genética
China
DNA Ribossômico
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/microbiologia
Febre/etiologia
Febre/microbiologia
Histoplasma/genética
Seres Humanos
Pulmão/diagnóstico por imagem
Pulmão/microbiologia
Pulmão/patologia
Masculino
Meia-Idade
Tipagem de Sequências Multilocus
Onygenales/classificação
Onygenales/genética
Análise de Sequência de DNA
Pele/microbiologia
Pele/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12583


  9 / 2145 MEDLINE  
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[PMID]:28213138
[Au] Autor:Ariaans M; Valladares MJ; Keuter M; Verweij P; van der Ven AJ; de Mast Q
[Ad] Endereço:Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
[Ti] Título:Fever and arthralgia after 'volcano boarding' in Nicaragua.
[So] Source:Travel Med Infect Dis;16:68-69, 2017 Mar - Apr.
[Is] ISSN:1873-0442
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Artralgia/microbiologia
Febre/microbiologia
Histoplasma
Histoplasmose
Recreação
[Mh] Termos MeSH secundário: Adulto
Antifúngicos/uso terapêutico
Diagnóstico Diferencial
Feminino
Histoplasmose/diagnóstico
Histoplasmose/tratamento farmacológico
Histoplasmose/etiologia
Histoplasmose/microbiologia
Seres Humanos
Itraconazol/uso terapêutico
Masculino
Nicarágua
Viagem
Erupções Vulcânicas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


  10 / 2145 MEDLINE  
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[PMID]:28176377
[Au] Autor:Dukik K; Muñoz JF; Jiang Y; Feng P; Sigler L; Stielow JB; Freeke J; Jamalian A; Gerrits van den Ende B; McEwen JG; Clay OK; Schwartz IS; Govender NP; Maphanga TG; Cuomo CA; Moreno LF; Kenyon C; Borman AM; de Hoog S
[Ad] Endereço:CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
[Ti] Título:Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales).
[So] Source:Mycoses;60(5):296-309, 2017 May.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.
[Mh] Termos MeSH primário: Micoses/microbiologia
Onygenales/classificação
Onygenales/genética
[Mh] Termos MeSH secundário: Blastomyces/genética
Chrysosporium/genética
Genoma Fúngico
Histoplasma/genética
Seres Humanos
Microscopia
Micélio/ultraestrutura
Micoses/epidemiologia
América do Norte/epidemiologia
Onygenales/patogenicidade
Onygenales/ultraestrutura
Fenótipo
Filogenia
Análise de Sequência de DNA
África do Sul/epidemiologia
Esporos Fúngicos/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12601



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