Base de dados : MEDLINE
Pesquisa : B01.300.381.640 [Categoria DeCS]
Referências encontradas : 639 [refinar]
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[PMID]:28749671
[Au] Autor:Xu L; Wu P; Xue J; Molnar I; Wei X
[Ad] Endereço:Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
[Ti] Título:Antifungal and Cytotoxic ß-Resorcylic Acid Lactones from a Paecilomyces Species.
[So] Source:J Nat Prod;80(8):2215-2223, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eight new ß-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.
[Mh] Termos MeSH primário: Éteres de Hidroxibenzoatos/isolamento & purificação
Éteres de Hidroxibenzoatos/farmacologia
Hidroxibenzoatos/isolamento & purificação
Hidroxibenzoatos/farmacologia
Lactonas/isolamento & purificação
Lactonas/farmacologia
Macrolídeos/farmacologia
Paecilomyces/química
Phytophthora/química
Zearalenona/análogos & derivados
[Mh] Termos MeSH secundário: Antifúngicos
Células HeLa
Seres Humanos
Éteres de Hidroxibenzoatos/química
Hidroxibenzoatos/química
Lactonas/química
Macrolídeos/química
Estrutura Molecular
Difração de Raios X
Zearalenona/química
Zearalenona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Hydroxybenzoate Ethers); 0 (Hydroxybenzoates); 0 (Lactones); 0 (Macrolides); 0 (hypothemycin); 0 (paecilomycin-N); 0 (paecilomycin-O); 0 (paecilomycin-P); 5W827M159J (Zearalenone); I60EH8GECX (monorden); LU39SC9JYL (beta-resorcylic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00066


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[PMID]:28562046
[Au] Autor:Zheng Y; Zhang J; Wei L; Shi M; Wang J; Huang J
[Ad] Endereço:Engineering Research Center of Industrial Microbiology, College of Life Sciences, Fujian Normal University , Fuzhou 350117, People's Republic of China.
[Ti] Título:Gunnilactams A-C, Macrocyclic Tetralactams from the Mycelial Culture of the Entomogenous Fungus Paecilomyces gunnii.
[So] Source:J Nat Prod;80(6):1935-1938, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three novel macrocyclic tetralactams, gunnilactam A (1), gunnilactam B (2), and gunnilactam C (3), were isolated from the submerged fermentation broth of Paecilomyces gunnii, an entomogenous fungus identified as the anamorph of Cordyceps gunnii. Their structures were determined using NMR data, HREIMS, and single-crystal X-ray crystallography. Gunnilactam A exhibited selective cytotoxic activity against human prostate cancer C42B cells with an IC value of 5.4 µM.
[Mh] Termos MeSH primário: Lactamas Macrocíclicas/isolamento & purificação
Paecilomyces/química
[Mh] Termos MeSH secundário: Cordyceps/química
Cristalografia por Raios X
Seres Humanos
Lactamas
Lactamas Macrocíclicas/química
Compostos Macrocíclicos
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactams); 0 (Lactams, Macrocyclic); 0 (Macrocyclic Compounds); 0 (gunnilactam A); 0 (gunnilactam B); 0 (gunnilactam C); 0 (tetralactam macrocycle)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00060


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[PMID]:28347903
[Au] Autor:Xu X; Xia L; Chen W; Huang Q
[Ad] Endereço:State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China.
[Ti] Título:Detoxification of hexavalent chromate by growing Paecilomyces lilacinus XLA.
[So] Source:Environ Pollut;225:47-54, 2017 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the study, the capability of Paecilomyces lilacinus XLA (CCTCC: M2012135) to reduce Cr and its main antagonistic mechanisms to Cr were experimentally evaluated. Activated growing fungus XLA efficiently reduced over 90% Cr in the media with Cr concentration below 100 mg L at pH 6 after 14 days. After 1-day exposure to 100 mg L Cr , nearly 50% of Cr was reduced. Moreover, SO stimulated Cr reduction, whereas other interferential ions inhibited Cr reduction. The interaction mechanisms between XLA and Cr mainly involve biotransformation, biosorption, and bioaccumulation, as detected by electron microscopy and chemical methods. The lower concentrations of Cr (5 and 50 mg L ) stimulated the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) level in XLA, respectively, but the higher concentration of Cr (150 mg L ) decreased the enzymatic activities and GSH concentration. The results implied that SOD, CAT and GSH were defensive guards to the oxidant stress produced by Cr . All these extracellular/intracellular defense systems endowed XLA with the ability to resist and detoxify Cr by transforming its valent species. The fungus XLA could efficiently reduce Cr under different environmental conditions (pH, interferential ions, and concentration). Moreover, XLA could endure the high concentration of Cr probably due to its high biotransformation capability of Cr and intracellular antioxidant systems for the detoxification of ROS generated by external Cr . All these results suggested that the fungus XLA can be applied to remediation of Cr -contaminated environments.
[Mh] Termos MeSH primário: Biotransformação
Cromatos/metabolismo
Substâncias Perigosas/metabolismo
Paecilomyces/metabolismo
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Catalase/metabolismo
Cromatos/toxicidade
Glutationa/metabolismo
Substâncias Perigosas/toxicidade
Inativação Metabólica
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chromates); 0 (Hazardous Substances); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


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[PMID]:28322145
[Au] Autor:Jiang L; Li Y; Wang WJ; Imoulan A; Yao YJ
[Ad] Endereço:State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
[Ti] Título:Total Phenolic Content and Antioxidant Activity of Mycelial Extracts from the Medicinal Fungus Paecilomyces hepiali (Ascomycetes).
[So] Source:Int J Med Mushrooms;19(1):35-44, 2017.
[Is] ISSN:1940-4344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paecilomyces hepialid, a fungus originating in the Tibetan Plateau, has been used as a substitute for Ophiocordyceps sinensis because the primary chemical compounds and pharmacological effects of P. hepialid are similar to those of O. sinensis. P. hepialid has been developed into a dietary supplement and pharmaceutical products. The antioxidant activity of extracts using 2 solvents (water and ethanol) from mycelia obtained from 2 cultivation modes (solid-state and submerged cultivation) were evaluated in this study. Four strains of P. hepialid obtained from Qinghai, Sichuan, and Yunnan Provinces were included; the total phenolic content and in vitro antioxidant activity of mycelial extracts were compared. The total phenolic content and antioxidant activity of strains were found to be affected by the cultivation mode and extraction solvent. The ethanol extracts of solid-state cultivation of strain 2138, obtained from Sichuan Province, exhibited the highest antioxidant activity. The results showed that different strains might require different cultivation modes and extraction solvents for better antioxidant activity. However, solid-state cultivation and ethanol extraction are generally recommended based on the analyses conducted. Strain 2138 may be a good candidate for the purpose of producing functional foods. The results suggest that strain selection is important when P. hepialid is used to manufacture pharmaceutical products.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Misturas Complexas/farmacologia
Micélio/química
Paecilomyces/química
Fenóis/análise
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
China
Misturas Complexas/isolamento & purificação
Paecilomyces/crescimento & desenvolvimento
Fenóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Complex Mixtures); 0 (Phenols)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1615/IntJMedMushrooms.v19.i1.40


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Azevedo, Joäo Lucio
Texto completo
[PMID]:28144871
[Au] Autor:Bulla LM; Polonio JC; Portela-Castro AL; Kava V; Azevedo JL; Pamphile JA
[Ad] Endereço:Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Parana, CEP 87020-900, Brazil.
[Ti] Título:Activity of the endophytic fungi Phlebia sp. and Paecilomyces formosus in decolourisation and the reduction of reactive dyes' cytotoxicity in fish erythrocytes.
[So] Source:Environ Monit Assess;189(2):88, 2017 Feb.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The current study investigates the potential for discolouration and degradation of Reactive Blue 19 and Reactive Black 5 textile dyes by endophytic fungi Phlebia sp. and Paecilomyces formosus as well as the potential cytotoxicity of products or by-products generated by the treatments in fish erythrocytes. It was observed at 30 days that both endophytes showed biodegradation activity with 0.1 g mL of dyes. P. formosus showed highest extracellular and intracellular protein content levels after the 15th day, and Phlebia sp. stands out for production of extracellular laccase, indicating that this enzyme may be associated with the decolouration capacity. The dyes showed toxic effects in fishes at 0.01 g mL concentration, resulting in the appearance of micronuclei in erythrocyte cells. When degraded dyes treated by endophytes were tested, the frequency of micronuclei reduced approximately 20%, indicating the effectiveness of these endophytic in the treatment of textile dyes with less environmental impact, thus indicating a potential for application of these fungi in bioremediation process.
[Mh] Termos MeSH primário: Basidiomycota/metabolismo
Biodegradação Ambiental
Corantes/metabolismo
Monitoramento Ambiental
Paecilomyces/metabolismo
[Mh] Termos MeSH secundário: Animais
Antraquinonas/efeitos adversos
Antraquinonas/metabolismo
Corantes/efeitos adversos
Endófitos/metabolismo
Eritrócitos/efeitos dos fármacos
Peixes
Proteínas Fúngicas/metabolismo
Lacase/metabolismo
Testes para Micronúcleos/veterinária
Naftalenossulfonatos/efeitos adversos
Naftalenossulfonatos/metabolismo
Indústria Têxtil
Eliminação de Resíduos Líquidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Coloring Agents); 0 (Fungal Proteins); 0 (Naphthalenesulfonates); EC 1.10.3.2 (Laccase); L51IMM9UP9 (Remazol Brilliant Blue R); O0HDY58362 (Remazol black B)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5790-0


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[PMID]:27956553
[Au] Autor:Qin Z; Yang S; Zhao L; You X; Yan Q; Jiang Z
[Ad] Endereço:From the Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering and.
[Ti] Título:Catalytic Mechanism of a Novel Glycoside Hydrolase Family 16 "Elongating" ß-Transglycosylase.
[So] Source:J Biol Chem;292(5):1666-1678, 2017 Feb 03.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carbohydrates are complex macromolecules in biological metabolism. Enzymatic synthesis of carbohydrates is recognized as a powerful tool to overcome the problems associated with large scale synthesis of carbohydrates. Novel enzymes with significant transglycosylation ability are still in great demand in glycobiology studies. Here we report a novel glycoside hydrolase family 16 "elongating" ß-transglycosylase from Paecilomyces thermophila (PtBgt16A), which efficiently catalyzes the synthesis of higher polymeric oligosaccharides using ß-1,3/1,4-oligosaccharides as donor/acceptor substrates. Further structural information reveals that PtBgt16A has a binding pocket around the -1 subsite. The catalytic mechanism of PtBgt16A is partly similar to an exo-glycoside hydrolase, which cleaves the substrate from the non-reducing end one by one. However, PtBgt16A releases the reducing end product and uses the remainder glucosyl as a transglycosylation donor. This catalytic mechanism has similarity with the catalytic mode of amylosucrase, which catalyzes the transglycosylation products gradually extend by one glucose unit. PtBgt16A thus has the potential to be a tool enzyme for the enzymatic synthesis of new ß-oligosaccharides and glycoconjugates.
[Mh] Termos MeSH primário: Polissacarídeos Fúngicos/biossíntese
Proteínas Fúngicas/metabolismo
Glicosídeo Hidrolases/metabolismo
Complexos Multienzimáticos/metabolismo
Oligossacarídeos/biossíntese
Paecilomyces/enzimologia
Transferases/metabolismo
[Mh] Termos MeSH secundário: Catálise
Polissacarídeos Fúngicos/genética
Proteínas Fúngicas/genética
Glicosídeo Hidrolases/genética
Complexos Multienzimáticos/genética
Oligossacarídeos/genética
Paecilomyces/genética
Transferases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Polysaccharides); 0 (Fungal Proteins); 0 (Multienzyme Complexes); 0 (Oligosaccharides); 0 (transglycosidase enzyme system); EC 2.- (Transferases); EC 3.2.1.- (Glycoside Hydrolases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.762419


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[PMID]:27055483
[Au] Autor:Brunner-Mendoza C; Navarro-Barranco H; León-Mancilla B; Pérez-Torres A; Toriello C
[Ad] Endereço:a Departamento de Microbiología y Parasitología , Facultad de Medicina.
[Ti] Título:Biosafety of an entomopathogenic fungus Isaria fumosorosea in an acute dermal test in rabbits.
[So] Source:Cutan Ocul Toxicol;36(1):12-18, 2017 Mar.
[Is] ISSN:1556-9535
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Isaria fumosorosea (formerly Paecilomyces fumosoroseus) is an entomopathogenic fungus that has been proposed as a low risk environmental alternative to the use of chemical insecticides to control agricultural pests and disease vectors. Although there are some mycoinsecticides already being marketed in many countries, not all their biosafety protocols have been published. The acute dermal toxicity test in an animal model is one in a series of biosafety protocols that must be developed, in order to provide information on health hazards, while taking into consideration the periods that the workers are in direct contact with the microbial agent when applied for the control of pests. For this test, we used I. fumosorosea monospore culture EH-506/3, isolated in Mexico from the Bemisia tabaci whitefly, applying a dose of 2 g/kg of animal body weight, on the shaved skin of 16 New Zealand rabbits, with an exposure time of 24 h. Clinical observations were conducted to evaluate the presence of erythema, edema and other alterations in the skin, as well as the behavior and health of the animals, for a period of 14 days. None of the rabbits showed clinical signs of any disease and their body weight corresponded to the expected weight for a healthy rabbit. The test showed no inflammatory reactions in the skin, supporting the safety of a single dose of this fungus in dermal exposure. Therefore, these data support the safety of I. fumosorosea EH-506/3 when applied to the skin.
[Mh] Termos MeSH primário: Agentes de Controle Biológico/toxicidade
Hypocreales
Paecilomyces
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Coelhos
Pele/anatomia & histologia
Testes Cutâneos
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE
[do] DOI:10.3109/15569527.2016.1156122


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[PMID]:28154672
[Au] Autor:Toker E; Ziyade N; Atici S; Eda KK; Türel Ö; Toprak D; Oray M; Cerikcioglu N; Soysal A; Bakir M
[Ad] Endereço:Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology, Pendik, Istanbul, Turkey.
[Ti] Título:Postoperative keratitis due to : a rare pediatric case.
[So] Source:Pan Afr Med J;24:317, 2016.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Fungal infections like have emerged in childhood recently. The diagnosis and treatment of is difficult and the outcome is usually poor. Corneal culture should be performed on fungal media such as Sabouraud glucose neopeptone agar (SDA) as soon as possible for diagnosis. We report a rare case of in an immunocompetent child, which was unresponsive to amphotericin B. The case was managed by a multidisciplinary approach involving the departments of ophthalmology, microbiology and pediatric infectious diseases. We want to draw attention once again that fungal keratitis caused by unusual agents are increasing. Physicians should consider fungal causes of keratitis, in patients with some predisposing factors like ocular surgery and prolonged use of topical corticosteroids.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Infecções Oculares Fúngicas/diagnóstico
Ceratite/diagnóstico
Paecilomyces/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Anfotericina B/uso terapêutico
Córnea/microbiologia
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Seres Humanos
Ceratite/tratamento farmacológico
Ceratite/microbiologia
Masculino
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 7XU7A7DROE (Amphotericin B)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2016.24.317.9772


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[PMID]:27980367
[Au] Autor:Kim JH; Ahn M; Cho NC; You IC
[Ad] Endereço:Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea.
[Ti] Título:Recurrent Keratitis in a Patient with Jones Tube after Conjunctivodacryocystorhinostomy.
[So] Source:Korean J Ophthalmol;30(6):479-480, 2016 Dec.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Mh] Termos MeSH primário: Túnica Conjuntiva/cirurgia
Dacriocistorinostomia/efeitos adversos
Infecções Oculares Fúngicas/etiologia
Ceratite/etiologia
Obstrução dos Ductos Lacrimais/diagnóstico
Paecilomyces/isolamento & purificação
Infecção da Ferida Cirúrgica/etiologia
[Mh] Termos MeSH secundário: Idoso
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/microbiologia
Feminino
Seres Humanos
Ceratite/diagnóstico
Ceratite/microbiologia
Recidiva
Infecção da Ferida Cirúrgica/diagnóstico
Infecção da Ferida Cirúrgica/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27910757
[Au] Autor:Mal'ucka LU; Harvanova J; Pavlik M; Rajtar M; Jarosciak L
[Ad] Endereço:Department of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, University of Veterinary Medicine and Pharmacy in Kosice, Kosice, Slovak Republic.
[Ti] Título:Free-Radical Scavenging Activities of Cultured Mycelia of Paecilomyces hepiali (Ascomycetes) Extracts and Structural Characterization of Bioactive Components by Nuclear Magnetic Resonance Spectroscopy.
[So] Source:Int J Med Mushrooms;18(10):895-903, 2016.
[Is] ISSN:1940-4344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Current research is focused on testing the cultivation of Paecilomyces hepiali mycelia on various plant substrates and producing fungus or mycelial biomass with qualitatively interesting substances. P. hepiali mycelia was cultivated using solid-state fermentation of different substrates. Mycelial biomass was then analyzed, and antioxidant activity was evaluated using the DPPH radical scavenging method for different ethanolic extracts based on a millet substrate (extract 1) or a chickpea substrate (extract 2). Extract 1 corresponds to a half-maximal DPPH radical inhibitory concentration of 1.73 mg/mL; the inhibitory concentration of ethanol extract 2 was almost 4.5 times higher at 7.92 mg/mL. Extracts 1 and 2 were separated into fractions by column chromatography and the chemical structures were determined for the substances that formed the most effective fraction of sample 1. The chemical structures of all compounds in the most active fraction of sample 1 were analyzed by 1H, 13C, distortionless enhancement by polarization transfer, correlation spectroscopy, heteronuclear single-quantum correlation spectroscopy, and heteronuclear multiple-bond correlation spectra.
[Mh] Termos MeSH primário: Antioxidantes/química
Misturas Complexas/química
Depuradores de Radicais Livres/química
Espectroscopia de Ressonância Magnética/métodos
Paecilomyces/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Misturas Complexas/isolamento & purificação
Etanol
Fermentação
Depuradores de Radicais Livres/isolamento & purificação
Micélio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Complex Mixtures); 0 (Free Radical Scavengers); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE



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