Base de dados : MEDLINE
Pesquisa : B01.300.381.706 [Categoria DeCS]
Referências encontradas : 284 [refinar]
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  1 / 284 MEDLINE  
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[PMID]:28101893
[Au] Autor:Moussa TA; Gerrits van den Ende BH; Al Zahrani HS; Kadasa NM; de Hoog SG; Dolatabadi S
[Ad] Endereço:Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
[Ti] Título:The genus Anthopsis and its phylogenetic position in Chaetothyriales.
[So] Source:Mycoses;60(4):254-259, 2017 Apr.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The genus Anthopsis was introduced for a black fungus with peculiar, inverted phialides and triangular conidia. The genus accommodates, in addition to the type species Anthopsis deltoidea, which once was reported as a cause of human phaeohyphomycosis, two further taxa: A. catenata and A. microspora. Current taxonomy is mainly based on microscopic structures of phialides. To assess the phylogenetic position of the genus, sequences of the internal transcribed spacer region and partial LSU rDNA were obtained for Anthopsis spp. and compared with sequences from public databases. Phylogenetic analyses based on both loci were used to assess the evolutionary relationships of Anthopsis spp. at the family and ordinal levels. Anthopsis s.str. was found to cluster in Chaetothyriales, while A. catenata proved to be of helotialean affinity. Thermotolerance and morphology of each species were recorded.
[Mh] Termos MeSH primário: Ascomicetos/classificação
Ascomicetos/genética
[Mh] Termos MeSH secundário: Ascomicetos/fisiologia
Ascomicetos/ultraestrutura
DNA Fúngico
DNA Ribossômico
DNA Espaçador Ribossômico
Seres Humanos
Phialophora/genética
Filogenia
Alinhamento de Sequência
Análise de Sequência de DNA
Esporos Fúngicos/ultraestrutura
Termotolerância
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (DNA, Ribosomal); 0 (DNA, Ribosomal Spacer)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12591


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[PMID]:27534128
[Au] Autor:He JW; Wang CX; Yang L; Chen GD; Hu D; Guo LD; Yao XS; Gao H
[Ti] Título:A Pair of New Polyketide Enantiomers from Three Endolichenic Fungal Strains Nigrospora sphaerica, Alternaria alternata, and Phialophora sp.
[So] Source:Nat Prod Commun;11(6):829-31, 2016 Jun.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A pair of new enantiomeric polyketides, (-)- and (+)-nigrosporaol A (1a and 1b), along with one related known compound, (+)-alternarienoic acid (2), were isolated from three endolichenic fungal strains, Nigrospora sphaerica (No.83-1-1-2), Alternaria alternata (No.58-8-4-1), and Phialophora sp.(No.96-1-8-1). Their structures, including the absolute configurations, were elucidated on the basis of spectroscopic methods, X-ray diffraction analysis, and the modified Mosher's method.
[Mh] Termos MeSH primário: Alternaria/química
Ascomicetos/química
Phialophora/química
Policetídeos/química
[Mh] Termos MeSH secundário: Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polyketides)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160818
[Lr] Data última revisão:
160818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


  3 / 284 MEDLINE  
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[PMID]:27421992
[Au] Autor:Wu W; Zhang R; Wang X; Song Y; Liu Z; Han W; Li R
[Ad] Endereço:Department of Dermatology, Peking University First Hospital, Beijing, China.
[Ti] Título:Impairment of Immune Response against Dematiaceous Fungi in Card9 Knockout Mice.
[So] Source:Mycopathologia;181(9-10):631-42, 2016 Oct.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dematiaceous fungi are a large group of pathogens that can cause a wide range of diseases in both immunocompetent and immunocompromised hosts. Based on our previous finding of caspase recruitment domain-containing protein 9 (CARD9) mutations in patients with subcutaneous phaeohyphomycosis caused by Phialophora verrucosa (P. verrucosa), we further investigated the exact role of CARD9 in the pathogenesis of phaeohyphomycosis using Card9 knockout (Card9 KO) mice. We showed that Card9 KO mice are profoundly susceptible to P. verrucosa infection compared with wild-type mice, reflected by significantly more severe footpad swelling, higher fungal burden, lower survival, and systemic dissemination. The inability of Card9 KO mice to control P. verrucosa infection was associated with lack of Th17 differentiation and reduction of tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6, and IL-17A levels in footpad homogenates. In vitro experiments showed a defect of fungal conidia killing and pro-inflammatory cytokine production in Card9 KO bone marrow-derived macrophages and dendritic cells. Furthermore, ex vivo coculture and in vitro T cell differentiation assay demonstrated that Card9 signaling pathway acts indispensably on differentiation of Th17 cells. In conclusion, our findings suggest that CARD9 mediate the innate immune and Th17-mediated adaptive immune responses against dematiaceous fungal infections at the early stage of infection.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Sinalização CARD/deficiência
Suscetibilidade a Doenças
Feoifomicose/imunologia
Feoifomicose/patologia
Phialophora/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Contagem de Colônia Microbiana
Citocinas/análise
Modelos Animais de Doenças
Macrófagos/imunologia
Macrófagos/microbiologia
Camundongos Knockout
Feoifomicose/microbiologia
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CARD Signaling Adaptor Proteins); 0 (Card9 protein, mouse); 0 (Cytokines)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-016-0029-0


  4 / 284 MEDLINE  
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[PMID]:26066414
[Au] Autor:Takeuchi A; Anzawa K; Mochizuki T; Takehara K; Hamaguchi Y
[Ad] Endereço:Department of Dermatology, Faculty of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan, Department of Dermatology, Nanto Municipal Hospital, Toyama, Japan.
[Ti] Título:Chromoblastomycosis caused by Phialophora verrucosa on the hand.
[So] Source:Eur J Dermatol;25(3):274-5, 2015 May-Jun.
[Is] ISSN:1952-4013
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Cromoblastomicose/microbiologia
Dermatoses da Mão/microbiologia
Phialophora
[Mh] Termos MeSH secundário: Idoso
Antifúngicos/uso terapêutico
Cromoblastomicose/tratamento farmacológico
Dermatoses da Mão/tratamento farmacológico
Seres Humanos
Itraconazol/uso terapêutico
Masculino
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antifungal Agents); 304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150928
[Lr] Data última revisão:
150928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150613
[St] Status:MEDLINE
[do] DOI:10.1684/ejd.2015.2581


  5 / 284 MEDLINE  
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[PMID]:25790941
[Au] Autor:Liang P; Wang X; Wang R; Wan Z; Han W; Li R
[Ad] Endereço:Department of Dermatology, Peking University First Hospital, Beijing, China.
[Ti] Título:CARD9 deficiencies linked to impaired neutrophil functions against Phialophora verrucosa.
[So] Source:Mycopathologia;179(5-6):347-57, 2015 Jun.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule that is critical for NF-κB activation and forms a complex with B cell lymphoma 10 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 that mediates C-type lectin receptors (CLRs)-triggered intracellular signaling during antifungal immunity. However, the role of CARD9 in the host defense against Phialophora verrucosa (P. verrucosa) infection remains to be elucidated. In the present study, we investigated the functions of polymorphonuclear neutrophils (PMNs) from patients with CARD9 deficiencies against P. verrucosa. By isolating PMNs from patients and healthy blood donors and subsequently challenging the cells with P. verrucosa, we demonstrated that, compared with healthy donors, CARD9-deficient PMNs exhibited defects in P. verrucosa killing and pro-inflammatory cytokine productions, which can be rescued in the presence of serum; however, the CARD9-deficient PMNs exhibited normal reactive oxygen species generation and phagocytotic ability. In conclusion, our results indicate that CARD9 is indispensable for P. verrucosa killing by PMNs, and serum opsonization acts as a CARD9-independent way, which could be a promising immunotherapy in the future.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Sinalização CARD/deficiência
Micoses/genética
Micoses/imunologia
Neutrófilos/imunologia
Phialophora/isolamento & purificação
[Mh] Termos MeSH secundário: Citocinas/secreção
Seres Humanos
Viabilidade Microbiana
Micoses/microbiologia
Óxido Nítrico/metabolismo
Fagocitose
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CARD Signaling Adaptor Proteins); 0 (CARD9 protein, human); 0 (Cytokines); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150321
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-015-9877-2


  6 / 284 MEDLINE  
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[PMID]:25789353
[Au] Autor:Rodriguez B; Karnes J
[Ad] Endereço:Maine-Dartmouth Family Medicine Residency, Augusta, ME, USA.
[Ti] Título:Plaques on dorsal hands & arms.
[So] Source:J Fam Pract;64(3):E11-3, 2015 Mar.
[Is] ISSN:1533-7294
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This patient's slow-growing lesions hadn't responded to topical steroids or antifungals. Careful consideration of her work environment led us to a curious diagnosis.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Cromoblastomicose
Crioterapia/métodos
Mãos
Phialophora/isolamento & purificação
Procedimentos Cirúrgicos Operatórios/métodos
[Mh] Termos MeSH secundário: Cromoblastomicose/diagnóstico
Cromoblastomicose/etiologia
Cromoblastomicose/fisiopatologia
Cromoblastomicose/terapia
Terapia Combinada/métodos
Diagnóstico Diferencial
Feminino
Mãos/microbiologia
Mãos/patologia
Seres Humanos
Meia-Idade
Recidiva
Pele/microbiologia
Pele/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:150319
[Lr] Data última revisão:
150319
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150320
[St] Status:MEDLINE


  7 / 284 MEDLINE  
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Rozental, Sonia
Alviano, Celuta Sales
Texto completo
[PMID]:25502596
[Au] Autor:Granato MQ; Massapust Pde A; Rozental S; Alviano CS; dos Santos AL; Kneipp LF
[Ad] Endereço:Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
[Ti] Título:1,10-phenanthroline inhibits the metallopeptidase secreted by Phialophora verrucosa and modulates its growth, morphology and differentiation.
[So] Source:Mycopathologia;179(3-4):231-42, 2015 Apr.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phialophora verrucosa is one of the etiologic agents of chromoblastomycosis, a fungal infection that affects cutaneous and subcutaneous tissues. This disease is chronic, recurrent and difficult to treat. Several studies have shown that secreted peptidases by fungi are associated with important pathophysiological processes. Herein, we have identified and partially characterized the peptidase activity secreted by P. verrucosa conidial cells. Using human serum albumin as substrate, the best hydrolysis profile was detected at extreme acidic pH (3.0) and at 37 °C. The enzymatic activity was completely blocked by classical metallopeptidase inhibitors/chelating agents as 1,10-phenanthroline and EGTA. Zinc ions stimulated the metallo-type peptidase activity in a dose-dependent manner. Several proteinaceous substrates were cleaved, in different extension, by the P. verrucosa metallopeptidase activity, including immunoglobulin G, fibrinogen, collagen types I and IV, fibronectin, laminin and keratin; however, mucin and hemoglobin were not susceptible to proteolysis. As metallopeptidases participate in different cellular metabolic pathways in fungal cells, we also tested the influence of 1,10-phenanthroline and EGTA on P. verrucosa development. Contrarily to EGTA, 1,10-phenanthroline inhibited the fungal viability (MIC 0.8 µg/ml), showing fungistatic effect, and induced profound morphological alterations as visualized by transmission electron microscopy. In addition, 1,10-phenanthroline arrested the filamentation process in P. verrucosa. Our results corroborate the supposition that metallopeptidase inhibitors/chelating agents have potential to control crucial biological events in fungal agents of chromoblastomycosis.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Proteínas Fúngicas/metabolismo
Metaloproteases/metabolismo
Fenantrolinas/farmacologia
Phialophora/efeitos dos fármacos
Phialophora/enzimologia
Esporos Fúngicos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Seres Humanos
Micoses/microbiologia
Phialophora/crescimento & desenvolvimento
Sistemas de Translocação de Proteínas/metabolismo
Transporte Proteico
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fungal Proteins); 0 (Phenanthrolines); 0 (Protein Translocation Systems); EC 3.4.- (Metalloproteases); W4X6ZO7939 (1,10-phenanthroline)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-014-9832-7


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[PMID]:25026626
[Au] Autor:Blake M; Embil JM; Trepman E; Adam H; Myers R; Mutcher P
[Ad] Endereço:Infection Prevention and Control Unit, Health Sciences Centre, Winnipeg, Manitoba, Canada.
[Ti] Título:Pseudo-outbreak of Phaeoacremonium parasiticum from a hospital ice dispenser.
[So] Source:Infect Control Hosp Epidemiol;35(8):1063-5, 2014 Aug.
[Is] ISSN:1559-6834
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 31 patients, Phaeoacremonium parasiticum was recovered from bronchoscopy specimens (biopsies and aspirates). The pseudo-outbreak was caused by contaminated ice used to control hemorrhage during bronchoscopy and was associated with deficiencies in equipment cleaning. The bronchoscopy technique was modified, the ice dispenser was disinfected, bronchoscope reprocessing was improved, and there were no recurrences.
[Mh] Termos MeSH primário: Broncoscópios/microbiologia
Infecção Hospitalar/etiologia
Contaminação de Equipamentos
Gelo/efeitos adversos
Micoses/etiologia
Phialophora
[Mh] Termos MeSH secundário: Broncoscópios/efeitos adversos
Broncoscopia/efeitos adversos
Infecção Hospitalar/epidemiologia
Surtos de Doenças
Seres Humanos
Micoses/epidemiologia
Micoses/microbiologia
Refrigeração/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ice)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140716
[Lr] Data última revisão:
140716
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:140716
[St] Status:MEDLINE
[do] DOI:10.1086/677150


  9 / 284 MEDLINE  
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PubMed Central Texto completo
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[PMID]:24982078
[Au] Autor:Li Y; Wan Z; Li R
[Ad] Endereço:Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
[Ti] Título:In vitro activities of nine antifungal drugs and their combinations against Phialophora verrucosa.
[So] Source:Antimicrob Agents Chemother;58(9):5609-12, 2014 Sep.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (µg/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Phialophora/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cromoblastomicose/tratamento farmacológico
Combinação de Medicamentos
Testes de Sensibilidade Microbiana
Phialophora/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Drug Combinations)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150301
[Lr] Data última revisão:
150301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140702
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.02875-14


  10 / 284 MEDLINE  
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[PMID]:24879418
[Au] Autor:Impullitti AE; Malvick DK
[Ad] Endereço:Department of Plant Pathology, University of Minnesota, St. Paul, Minnesota, United States of America.
[Ti] Título:Anatomical response and infection of soybean during latent and pathogenic infection by type A and B of Phialophora gregata.
[So] Source:PLoS One;9(5):e98311, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growth and anatomical responses of plants during latent and pathogenic infection by fungal pathogens are not well understood. The interactions between soybean (Glycine max) and two types of the pathogen Phialophora gregata were investigated to determine how plants respond during latent and pathogenic infection. Stems of soybean cultivars with different or no genes for resistance to infection by P. gregata were inoculated with wildtype or GFP and RFP-labeled strains of types A or B of P. gregata. Plants were sectioned during latent and pathogenic infection, examined with transmitted light or fluorescent microscopy, and quantitative differences in vessels and qualitative differences in infection were assessed using captured images. During latent infection, the number of vessels was similar in resistant and susceptible plants infected with type A or B compared to the control, and fungal infection was rarely observed in vessels. During pathogenic infection, the resistant cultivars had 20 to 25% more vessels than the uninfected plants, and fungal hyphae were readily observed in the vessels. Furthermore, during the pathogenic phase in a resistant cultivar, P. gregata type A-GFP was limited to outside of the primary xylem, while P. gregata type B-RFP was observed in the primary xylem. The opposite occurred with the susceptible cultivar, where PgA-GFP was observed in the primary xylem and PgB-RFP was limited to the interfascicular region. In summary, soybean cultivars with resistance to BSR produced more vessels and can restrict or exclude P. gregata from the vascular system compared to susceptible cultivars. Structural resistance mechanisms potentially compensate for loss of vessel function and disrupted water movement.
[Mh] Termos MeSH primário: Phialophora/fisiologia
Doenças das Plantas/microbiologia
Feijão de Soja/anatomia & histologia
Feijão de Soja/microbiologia
[Mh] Termos MeSH secundário: Resistência à Doença
Suscetibilidade a Doenças
Feijão de Soja/citologia
Feijão de Soja/imunologia
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140601
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0098311



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