Base de dados : MEDLINE
Pesquisa : B01.300.930 [Categoria DeCS]
Referências encontradas : 16115 [refinar]
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  1 / 16115 MEDLINE  
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[PMID]:28946118
[Au] Autor:Rybczynska-Tkaczyk K; Swiecilo A; Szychowski KA; Kornillowicz-Kowalska T
[Ad] Endereço:Department of Environmental Microbiology, Laboratory of Mycology, The University of Life Sciences, Leszczynskiego Street 7, Lublin 20-069, Poland. Electronic address: kamila.rybczynska-tkaczyk@up.lublin.pl.
[Ti] Título:Comparative study of eco- and cytotoxicity during biotransformation of anthraquinone dye Alizarin Blue Black B in optimized cultures of microscopic fungi.
[So] Source:Ecotoxicol Environ Saf;147:776-787, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to select optimal conditions (C and N sources, initial pH and temperature) for biodecolorization of 0.03% anthraquinone dye Alizarin Blue Black B (ABBB) by microscopic fungi: Haematonectria haematococca BwIII43, K37 and Trichoderma harzianum BsIII33. The phenolic compounds, phytotoxicity (Lepidium sativum L.), biotoxicity (Microtox), cytotoxicity and yeast viability assay were performed to determine the extent of ABBB detoxification. Biodecolorization and detoxification of 0.03% ABBB in H. haematococca BwIII43 and T. harzianum BsIII33 cultures was correlated with extracellular oxidoreductases activity. In turn, secondary products, toxic to human fibroblasts and respiring sod1 Saccharomyces cerevisiae cells, were formed in H. haematococca K37 strain cultures, despite efficient decolorization.
[Mh] Termos MeSH primário: Antraquinonas/toxicidade
Corantes/toxicidade
Poluentes Químicos da Água/toxicidade
Purificação da Água/métodos
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Antraquinonas/análise
Biodegradação Ambiental
Biotransformação
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Corantes/análise
Seres Humanos
Lepidium sativum/efeitos dos fármacos
Oxirredução
Testes de Toxicidade/métodos
Poluentes Químicos da Água/análise
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Coloring Agents); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  2 / 16115 MEDLINE  
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[PMID]:29367589
[Au] Autor:Ho WC; Zhang J
[Ad] Endereço:Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
[Ti] Título:Evolutionary adaptations to new environments generally reverse plastic phenotypic changes.
[So] Source:Nat Commun;9(1):350, 2018 01 24.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organismal adaptation to a new environment may start with plastic phenotypic changes followed by genetic changes, but whether the plastic changes are stepping stones to genetic adaptation is debated. Here we address this question by investigating gene expression and metabolic flux changes in the two-phase adaptation process using transcriptomic data from multiple experimental evolution studies and computational metabolic network analysis, respectively. We discover that genetic changes more frequently reverse than reinforce plastic phenotypic changes in virtually every adaptation. Metabolic network analysis reveals that, even in the presence of plasticity, organismal fitness drops after environmental shifts, but largely recovers through subsequent evolution. Such fitness trajectories explain why plastic phenotypic changes are genetically compensated rather than strengthened. In conclusion, although phenotypic plasticity may serve as an emergency response to a new environment that is necessary for survival, it does not generally facilitate genetic adaptation by bringing the organismal phenotype closer to the new optimum.
[Mh] Termos MeSH primário: Adaptação Biológica
Meio Ambiente
Redes e Vias Metabólicas/genética
[Mh] Termos MeSH secundário: Animais
Escherichia coli/genética
Escherichia coli/metabolismo
Escherichia coli/fisiologia
Perfilação da Expressão Gênica
Fenótipo
Poecilia/genética
Poecilia/metabolismo
Poecilia/fisiologia
Transcriptoma
Leveduras/genética
Leveduras/metabolismo
Leveduras/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02724-5


  3 / 16115 MEDLINE  
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[PMID]:29422098
[Au] Autor:Huyben D; Boqvist S; Passoth V; Renström L; Allard Bengtsson U; Andréoletti O; Kiessling A; Lundh T; Vågsholm I
[Ad] Endereço:Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden. david.huyben@slu.se.
[Ti] Título:Screening of intact yeasts and cell extracts to reduce Scrapie prions during biotransformation of food waste.
[So] Source:Acta Vet Scand;60(1):9, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Yeasts can be used to convert organic food wastes to protein-rich animal feed in order to recapture nutrients. However, the reuse of animal-derived waste poses a risk for the transmission of infectious prions that can cause neurodegeneration and fatality in humans and animals. The aim of this study was to investigate the ability of yeasts to reduce prion activity during the biotransformation of waste substrates-thereby becoming a biosafety hurdle in such a circular food system. During pre-screening, 30 yeast isolates were spiked with Classical Scrapie prions and incubated for 72 h in casein substrate, as a waste substitute. Based on reduced Scrapie seeding activity, waste biotransformation and protease activities, intact cells and cell extracts of 10 yeasts were further tested. Prion analysis showed that five yeast species reduced Scrapie seeding activity by approximately 1 log10 or 90%. Cryptococcus laurentii showed the most potential to reduce prion activity since both intact and extracted cells reduced Scrapie by 1 log10 and achieved the highest protease activity. These results show that select forms of yeast can act as a prion hurdle during the biotransformation of waste. However, the limited ability of yeasts to reduce prion activity warrants caution as a sole barrier to transmission as higher log reductions are needed before using waste-cultured yeast in circular food systems.
[Mh] Termos MeSH primário: Biotransformação
Príons/metabolismo
Scrapie/prevenção & controle
Gerenciamento de Resíduos/métodos
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Animais
Extratos Celulares/análise
Alimentos
Parasitologia de Alimentos/normas
Parasitologia de Alimentos/tendências
Peptídeo Hidrolases/metabolismo
Gerenciamento de Resíduos/normas
Leveduras/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Extracts); 0 (Prions); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0363-y


  4 / 16115 MEDLINE  
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[PMID]:29401883
[Au] Autor:Anastasiadi G; Leonard M; Paterson L; Macpherson WN
[Ti] Título:Fabrication and characterization of machined multi-core fiber tweezers for single cell manipulation.
[So] Source:Opt Express;26(3):3557-3567, 2018 Feb 05.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Optical tweezing is a non-invasive technique that can enable a variety of single cell experiments; however, it tends to be based on a high numerical aperture (NA) microscope objective to both deliver the tweezing laser light and image the sample. This introduces restrictions in system flexibility when both trapping and imaging. Here, we demonstrate a novel, high NA tweezing system based on micro-machined multicore optical fibers. Using the machined, multicore fiber tweezer, cells are optically manipulated under a variety of microscopes, without requiring a high NA objective lens. The maximum NA of the fiber-based tweezer demonstrated is 1.039. A stable trap with a maximum total power 30 mW has been characterized to exert a maximum optical force of 26.4 pN, on a trapped, 7 µm diameter yeast cell. Single cells are held 15-35 µm from the fiber end and can be manipulated in the x, y and z directions throughout the sample. In this way, single cells are controllably trapped under a Raman microscope to categorize the yeast cells as live or dead, demonstrating trapping by the machined multicore fiber-based tweezer decoupled from the imaging or excitation objective lens.
[Mh] Termos MeSH primário: Fibras Ópticas
Pinças Ópticas
Manejo de Espécimes/métodos
Leveduras/citologia
[Mh] Termos MeSH secundário: Imagem Tridimensional/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1364/OE.26.003557


  5 / 16115 MEDLINE  
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[PMID]:29287094
[Au] Autor:Chudejova K; Bohac M; Skalova A; Rotova V; Papagiannitsis CC; Hanzlickova J; Bergerova T; Hrabák J
[Ad] Endereço:Biomedical Center and Department of Microbiology, Faculty of Medicine and University Hospital in Pilsen, Charles University, Plzen, Czech Republic.
[Ti] Título:Validation of a novel automatic deposition of bacteria and yeasts on MALDI target for MALDI-TOF MS-based identification using MALDI Colonyst robot.
[So] Source:PLoS One;12(12):e0190038, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) -based identification of bacteria and fungi significantly changed the diagnostic process in clinical microbiology. We describe here a novel technique for bacterial and yeast deposition on MALDI target using an automated workflow resulting in an increase of the microbes' score of MALDI identification. We also provide a comparison of four different sample preparation methods. In the first step of the study, 100 Gram-negative bacteria, 100 Gram-positive bacteria, 20 anaerobic bacteria and 20 yeasts were spotted on the MALDI target using manual deposition, semi-extraction, wet deposition onto 70% formic acid and by automatic deposition using MALDI Colonyst. The lowest scores were obtained by manual toothpick spotting which significantly differ from other methods. Identification score of semi-extraction, wet deposition and automatic wet deposition did not significantly differ using calculated relative standard deviation (RSD). Nevertheless, the best results with low error rate have been observed using MALDI Colonyst robot. The second step of validation included processing of 542 clinical isolates in routine microbiological laboratory by a toothpick direct spotting, on-plate formic acid extraction (for yeasts) and automatic deposition using MALDI Colonyst. Validation in routine laboratory process showed significantly higher identification scores obtained using automated process compared with standard manual deposition in all tested microbial groups (Gram-positive, Gram-negative, anaerobes, and yeasts). As shown by our data, automatic colony deposition on MALDI target results in an increase of MALDI-TOF MS identification scores and reproducibility.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Robótica
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
Leveduras/isolamento & purificação
[Mh] Termos MeSH secundário: Automação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190038


  6 / 16115 MEDLINE  
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[PMID]:29244496
[Au] Autor:Noestheden M; Dennis EG; Zandberg WF
[Ad] Endereço:University of British Columbia Okanagan , Kelowna, British Columbia V1V 1V7, Canada.
[Ti] Título:Quantitating Volatile Phenols in Cabernet Franc Berries and Wine after On-Vine Exposure to Smoke from a Simulated Forest Fire.
[So] Source:J Agric Food Chem;66(3):695-703, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Smoke-taint is a wine defect linked to organoleptic volatile phenols (VPs) in Vitis vinifera L. berries that have been exposed to smoke from wildland fires. Herein, the levels of smoke-taint-associated VPs are reported in Cabernet Franc berries from veraison to commercial maturity and in wine after primary fermentation following on-vine exposure to simulated wildland fire smoke. VPs increased after smoke exposure were rapidly stored as acid-labile conjugates, and the levels of both free VPs and conjugated forms remained constant through ripening to commercial maturity. An increase in total VPs after primary fermentation suggested the existence of VP-conjugates other than the acid-labile VP-glycosides already reported. This conclusion was supported with base hydrolysis on the same samples. Relative to published results, the data suggested a multifactorial regional identity for smoke-taint and they inform efforts to produce a predictive model for perceptible smoke-taint in wine based on the chemical composition of smoke-exposed berries.
[Mh] Termos MeSH primário: Frutas/química
Fenóis/química
Fumaça/análise
Vitis/química
Vinho/análise
[Mh] Termos MeSH secundário: Fermentação
Frutas/microbiologia
Vitis/crescimento & desenvolvimento
Vitis/microbiologia
Volatilização
Incêndios Florestais
Vinho/microbiologia
Leveduras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04946


  7 / 16115 MEDLINE  
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[PMID]:29232952
[Au] Autor:Du H; Song Z; Xu Y
[Ad] Endereço:The Key Laboratory of Industrial Biotechnology of the Ministry of Education, State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University , 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China.
[Ti] Título:Ethyl Carbamate Formation Regulated by Lactic Acid Bacteria and Nonconventional Yeasts in Solid-State Fermentation of Chinese Moutai-Flavor Liquor.
[So] Source:J Agric Food Chem;66(1):387-392, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to identify specific microorganisms related to the formation of precursors of EC (ethyl carbamate) in the solid-state fermentation of Chinese Moutai-flavor liquor. The EC content was significantly correlated with the urea content during the fermentation process (R = 0.772, P < 0.01). Differences in urea production and degradation were found at both species and functional gene levels by metatranscriptomic sequencing and culture-dependent analysis. Lactobacillus spp. could competitively degrade arginine through the arginine deiminase pathway with yeasts, and most Lactobacillus species were capable of degrading urea. Some dominant nonconventional yeasts, such as Pichia, Schizosaccharomyces, and Zygosaccharomyces species, were shown to produce low amounts of urea relative to Saccharomyces cerevisiae. Moreover, unusual urea degradation pathways (urea carboxylase, allophanate hydrolase, and ATP-independent urease) were identified. Our results indicate that EC precursor levels in the solid-state fermentation can be controlled using lactic acid bacteria and nonconventional yeasts.
[Mh] Termos MeSH primário: Lactobacillus/metabolismo
Uretana/metabolismo
Vinho/análise
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Etanol/análise
Etanol/metabolismo
Fermentação
Aromatizantes/análise
Aromatizantes/metabolismo
Seres Humanos
Paladar
Uretana/análise
Vinho/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavoring Agents); 3IN71E75Z5 (Urethane); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05034


  8 / 16115 MEDLINE  
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[PMID]:28470627
[Au] Autor:Zhu H; Liu D; Wang Y; Ren D; Zheng L; Chen L; Ma A
[Ad] Endereço:College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
[Ti] Título:Use of the yeast-like cells of Tremella fuciformis as a cell factory to produce a Pleurotus ostreatus hydrophobin.
[So] Source:Biotechnol Lett;39(8):1167-1173, 2017 Aug.
[Is] ISSN:1573-6776
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To obtain hydrophobin, a Class I hydrophobin gene, Po.hyd from Pleurotus ostreatus, was transformed into the yeast-like cells of Tremella fuciformis using Agrobacterium tumefaciens. RESULTS: The hydrophobin Po.HYD from P. ostreatus was heterogeneously expressed by the yeast-like cells of T. fuciformis. Plasmids harboring the Po.hyd gene driven by endogenous glyceraldehyde-3-phosphate dehydrogenase promoter were transformed by A. tumefaciens. The integration and expression of the rPo.HYD in the T. fuciformis cells were confirmed by PCR, Southern blot, fluorescence microscopy and quantitative real-time PCR. SDS-PAGE demonstrated that the rPo.HYD was extracted with the expected MW of 14 kDa. The yield of purified rPo.HYD was 0.58 mg/g dry wt. The protein, with its ability to stabilize oil droplets, exhibited a better emulsifying activity than the typical food emulsifiers Tween 20 and sodium caseinate. CONCLUSION: Tremella fuciformis can be used as a cell factory to produce hydrophobin on a large scale for the food industry.
[Mh] Termos MeSH primário: Agaricales/genética
Basidiomycota
Proteínas Fúngicas/genética
Proteínas Recombinantes/genética
[Mh] Termos MeSH secundário: Agrobacterium/genética
Basidiomycota/citologia
Basidiomycota/genética
Basidiomycota/metabolismo
Emulsificantes
Proteínas Fúngicas/metabolismo
Proteínas Recombinantes/metabolismo
Leveduras
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Fungal Proteins); 0 (Recombinant Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-017-2343-0


  9 / 16115 MEDLINE  
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[PMID]:29183788
[Au] Autor:Kelly RL; Le D; Zhao J; Wittrup KD
[Ad] Endereço:Department of Biological, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, 02142, MA, USA.
[Ti] Título:Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.
[So] Source:J Mol Biol;430(1):119-130, 2018 Jan 05.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, or nonspecificity. We used a high-throughput nonspecificity assay to isolate panels of nonspecific antibodies from two synthetic single-chain variable fragment libraries expressed on the surface of yeast, identifying both individual amino acids and motifs within the complementarity-determining regions which contribute to the phenotype. We find enrichment of glycine, valine, and arginine as both individual amino acids and as a part of motifs, and additionally enrichment of motifs containing tryptophan. Insertion of any of these motifs into the complementarity-determining region H3 of a "clean" antibody increased its nonspecificity, with greatest increases in antibodies containing Trp or Val motifs. We next applied these rules to the creation of a synthetic diversity library based on natural frameworks with significantly decreased incorporation of such motifs and demonstrated its ability to isolate binders to a wide panel of antigens. This work both provides a greater understanding of the drivers of nonspecificity and provides design rules to increase efficiency in the isolation of antibodies with drug-like properties.
[Mh] Termos MeSH primário: Motivos de Aminoácidos/genética
Anticorpos de Cadeia Única/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Aminoácidos/genética
Animais
Afinidade de Anticorpos/genética
Linhagem Celular
Regiões Determinantes de Complementaridade/genética
Células HEK293
Seres Humanos
Biblioteca de Peptídeos
Células Sf9
Triptofano/genética
Leveduras/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Complementarity Determining Regions); 0 (Peptide Library); 0 (Single-Chain Antibodies); 8DUH1N11BX (Tryptophan)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  10 / 16115 MEDLINE  
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[PMID]:27779268
[Au] Autor:Hazra S; Meyrelles R; Charmier AJ; Rijo P; Guedes da Silva MF; Pombeiro AJ
[Ad] Endereço:Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal. h.susanta@gmail.com fatima.guedes@tecnico.ulisboa.pt pombeiro@tecnico.ulisboa.pt.
[Ti] Título:N-HO and N-HCl supported 1D chains of heterobimetallic Cu /Ni -Sn cocrystals.
[So] Source:Dalton Trans;45(44):17929-17938, 2016 Nov 28.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Schiff base H L [N,N'-ethylenebis(3-methoxysalicylaldimine)] or H L [N,N'-ethylenebis(3-ethoxysalicylaldimine)] was reacted with MCl ·xH O and SnCl ·5H O to afford the supramolecular heterobimetallic systems (H ED) ·2[ML]·[SnCl ] [M = Cu, L = L (1), L = L (2); M = Ni, L = L (3), L = L (4); ED = 1,2-ethylenediamine], whose structures were established by single crystal X-ray analyses. Each structure includes different entities, viz. a mononuclear [CuL]/[NiL] neutral complex (coformer), a hexachlorostannate dianion [SnCl ] , a 1,2-ethylenediammonium dication (H ED ) and, only in 2 and 4, a methanol molecule. Based on the work of Grothe et al. (Cryst. Growth Des., 2016, 16, 3237-3243), compounds 1 and 3 are cocrystal salts, 2 and 4 are cocrystal salt solvates. The ionic pairs (H ED) ·[SnCl ] in 1-4 are encapsulated by the Cu- or Ni-complexes, and stabilized by N-HO and one N-HCl bond interactions leading to infinite 1D chains. The antimicrobial studies of 1-4 against yeasts (C. albicans and S. cerevisiae) and Gram-positive (S. aureus and E. faecalis) and -negative bacteria (P. aeruginosa and E. coli) indicate that the Ni Sn systems (3 and 4) are more active than the analogous Cu Sn ones (1 and 2).
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Complexos de Coordenação/química
Cobre/química
Níquel/química
Bases de Schiff/química
Estanho/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Candidíase/tratamento farmacológico
Complexos de Coordenação/farmacologia
Cobre/farmacologia
Cristalização
Cristalografia por Raios X
Seres Humanos
Modelos Moleculares
Níquel/farmacologia
Bases de Schiff/farmacologia
Estanho/farmacologia
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Coordination Complexes); 0 (Schiff Bases); 7440-31-5 (Tin); 789U1901C5 (Copper); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde