Base de dados : MEDLINE
Pesquisa : B01.650.660 [Categoria DeCS]
Referências encontradas : 16256 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1626 ir para página                         

  1 / 16256 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29281648
[Au] Autor:Handeland K; Vikøren T; Josefsen TD; Madslien K; Valdecanas B; Uhlig S
[Ad] Endereço:Norwegian Veterinary Institute, Oslo, Norway.
[Ti] Título:Yew (Taxus) intoxication in free-ranging cervids.
[So] Source:PLoS One;12(12):e0188961, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wild ruminants, including deer species (cervids) have incorrectly been regarded as refractory to yew (Taxus) intoxication. This assumption has been based upon anecdotal observations of individual deer browsing on yew over time without apparent adverse effect. A single case of yew intoxication was reported in a free-ranging Norwegian moose (Alces alces) in 2008. The current report describes five additional cases of yew toxicosis in moose, seven in roe deer (Capreolus capreolus) and two in reindeer (Rangifer tarandus tarandus), all in Norway. The animals were found dead during the winter, close to or within gardens containing yew plants showing signs of browsing. Gross findings included lung congestion and edema, thoracic and pericardial effusion, bilateral heart dilatation, epi- and endocardial hemorrhage, and enlarged (congested) spleen. Yew plant remnants were detected in the rumen of all animals with the exception of a single moose. Histology revealed multifocal acute myocardial degeneration and necrosis with hemorrhage in roe deer, but not in the two other species. A qualitative high performance liquid chromatography-ion trap mass spectrometry analysis was used to tentatively identify five major Taxus alkaloids (taxines) in crude yew extracts and in heart and liver samples from the moose cases. All five major taxines were detected with good signal/noise ratio in tissue samples from the four moose with visible ruminal yew content, whereas lower levels of taxines were detected in the moose without visible ruminal yew content. Possible differences in interspecies tolerance to taxines and role of individual protective adaptation are discussed.
[Mh] Termos MeSH primário: Cervos/fisiologia
Plantas Tóxicas
Taxus
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Animais
Animais Selvagens
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Noruega
Especificidade da Espécie
Taxus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188961


  2 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28300580
[Au] Autor:Mebs D; Wunder C; Pogoda W; Toennes SW
[Ad] Endereço:Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D-60956 Frankfurt, Germany. Electronic address: mebs@em.uni-frankfurt.de.
[Ti] Título:Feeding on toxic prey. The praying mantis (Mantodea) as predator of poisonous butterfly and moth (Lepidoptera) caterpillars.
[So] Source:Toxicon;131:16-19, 2017 Jun 01.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Caterpillars of the monarch butterfly, Danaus plexippus, feed on milkweed plants, Asclepias spp. (Apocynaceae), and sequester their toxic cardenolides aimed at deterring predators. Nevertheless, Chinese praying mantids, Tenodera sinensis, consume these caterpillars after removing the midgut ("gutting") including its plant content. In the present study, monarch caterpillars raised on A. curassavica, and those of the death's-head hawkmoth, Acherontia atropos, raised on Atropa belladonna containing atropine, were fed to mantids, Hierodula membranacea, which removed the gut of both species discarding about 59% of cardenolides and more than 90% of atropine, respectively. The ingestion of these compounds produced no apparent ill effects in the mantids and both were excreted with faeces. On the other hand, when mantids were fed with larvae of two moth species, Amata mogadorensis and Brahmaea certia, raised on non-poisonous host plants, the mantids showed the same gutting behaviour, thereby discarding indigestible plant material. As polar compounds, e.g. cardenolides and atropine, are not absorbed from the mantids midgut and do not pass the gut membrane, this enables the mantids to feed on toxic prey.
[Mh] Termos MeSH primário: Borboletas
Mantódeos/fisiologia
Mariposas
Comportamento Predatório
[Mh] Termos MeSH secundário: Animais
Asclepias/química
Cardenolídeos/química
Fezes/química
Intestinos
Larva
Plantas Tóxicas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardenolides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  3 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Barros, Cláudio S L
Texto completo
[PMID]:28300579
[Au] Autor:Leal PV; Pupin RC; Lima SC; Melo GK; Araújo MA; Gomes DC; Barros CS; Lemos RA
[Ad] Endereço:Programa de pós graduação em Ciência Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal do Mato Grosso do Sul, Av. Senador Felinto Muller, 2443, Campo Grande, MS, 79070-900, Brazil. Electronic address: paulavleal@hotmail.com.
[Ti] Título:Ingestion of the pods of Enterolobium contortisiliquum causes hepatogenous photosensitization in cattle.
[So] Source:Toxicon;131:6-10, 2017 Jun 01.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enterolobium contortisiliquum (Leg. Mimosoidae) is reported as a poisonous plant related to photosensitization and photodermatitis, digestive disturbs and abortion. To date, the clinical and pathological features of photosensitization has not been reproduced or only reproduced associated with very mild presentations. The objective of this study was to reproduce in cattle the clinicopathological features of photosensitization associated with the ingestion of the pods of E. contortisiliquum. The pods were harvested from a property with a history of an ongoing outbreak of photosensitization and abortion in cattle. Six 24-month-old steers were cannulated and used in the experiment, two of them served as negative controls. E. contortisiliquum pods were administered to four steers through ruminal cannula. In the first phase of the experiment, daily doses of 30 g/kg/body weight (bw) and 20 g/kg/bw were administered to Bovines 1 and 2 respectively, for three consecutive days. In the second phase, starting four days after the last daily feeding of the pods, these two bovines were challenged with the same doses of the pods for three consecutive days and another two steers (Bovines 3 and 4) were fed 15 g/kg/bw each for three consecutive days. In the two phases, the steers developed signs compatible with ruminal acidosis which were more severe during the second phase. Three and five days after the administration of the pods, two steers presented photodermatitis characterized by hyperemia and edema on the skin of the dorsum of the neck, of the shaved skin around the cannula, of muzzle and ear. Lesions evolved to dermal necrosis with sloughing and subsequent scar retraction and dermal thickening. Ulceration of mucosae exposed to sunlight was also observed. All the steers which received the pods had significant elevations in the serum activities of gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST). The levels of GGT and AST remained elevated for up to 12 days after the administration of the pods was discontinued. Histopathological hepatic changes detected by liver biopsies were hepatocellular swelling and randomly scattered individual hepatocellular necrosis. The current study presents solid experimental evidence that the ingestion of E. contortisiliquum definitely induces the classical lesions of hepatogenous photosensitization in cattle.
[Mh] Termos MeSH primário: Doenças dos Bovinos/induzido quimicamente
Fabaceae/toxicidade
Fígado/patologia
Transtornos de Fotossensibilidade/veterinária
Plantas Tóxicas/toxicidade
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Aspartato Aminotransferases/sangue
Bovinos
Ingestão de Alimentos
Masculino
Transtornos de Fotossensibilidade/induzido quimicamente
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  4 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28291394
[Au] Autor:Clarke C; Burney D
[Ad] Endereço:From the Veterinary Emergency & Referral Group South, Brooklyn, New York (C.C.); Veterinary Specialists of North Texas, Dallas, Texas (D.B.); and Gulf Coast Veterinary Specialists, Houston, Texas (D.B.).
[Ti] Título:Cycad Palm Toxicosis in 14 Dogs from Texas.
[So] Source:J Am Anim Hosp Assoc;53(3):159-166, 2017 May/Jun.
[Is] ISSN:0587-2871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study is to report clinical information, diagnostic findings, and treatment modalities; assess variables that may help distinguish survivors from nonsurvivors; and review the outcome of cycad palm toxicosis in dogs. Fourteen client-owned dogs with confirmed cycad palm ingestion were identified by reviewing the medical record database at Gulf Coast Veterinary Specialists. Information on signalment, time of ingestion to presentation, clinical signs, physical examination findings, initial and peak/nadir laboratory abnormalities, radiographic and ultrasonographic findings, treatment modalities, liver histopathology, and clinical outcome was retrieved. Of the 14 dogs, nine (64%) died as a direct result of cycad palm intoxication, and three survivors had persistently elevated liver enzymes, signifying residual liver damage. Despite decontamination, patients continued to display evidence of illness, indicating rapid absorption of toxins. When evaluating initial and peak/nadir laboratory values, nadir serum albumin levels and nadir platelet counts were significantly lower in nonsurvivors compared to survivors (1.25 g/dL [0.4-2.1 g/dL] versus 2.6 g/dL [1.7-3.4 g/dL] and 21 × 10 [0-64 × 10 ] versus 62 × 10 [6-144 × 10 ], respectively). In this cohort of dogs, the case fatality rate was higher than previously reported. Nadir serum albumin levels and nadir platelet counts may help distinguish potential survivors from nonsurvivors.
[Mh] Termos MeSH primário: Cycas/toxicidade
Doenças do Cão/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Antibacterianos/uso terapêutico
Transfusão de Sangue/veterinária
Cardiotônicos/uso terapêutico
Doenças do Cão/tratamento farmacológico
Doenças do Cão/epidemiologia
Doenças do Cão/mortalidade
Cães
Dopamina/uso terapêutico
Feminino
Fármacos Gastrointestinais/uso terapêutico
Soluções Isotônicas/administração & dosagem
Masculino
Plantas Tóxicas
Estudos Retrospectivos
Análise de Sobrevida
Texas/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cardiotonic Agents); 0 (Gastrointestinal Agents); 0 (Isotonic Solutions); 0 (crystalloid solutions); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-6517


  5 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Rosalen, Pedro Luiz
Texto completo
[PMID]:28259673
[Au] Autor:Sardi JC; Freires IA; Lazarini JG; Infante J; de Alencar SM; Rosalen PL
[Ad] Endereço:Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
[Ti] Título:Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp.
[So] Source:Microb Pathog;105:280-287, 2017 Apr.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Brazilian endemic fruit species have aroused attention due to their highly valuable, yet unexplored, agro-industrial, food and therapeutic potential. Herein, we describe the antifungal activity of four Eugenia spp. against Candida albicans biofilms, and further demonstrate insights into their potential mode(s) of action and toxicity in vitro and in vivo. Extracts from different parts (seeds, pulps, leaves) of E. leitonii (EL), E. brasiliensis (EB), E. myrcianthes (EM) and E. involucrata (EI) were obtained (S23°23',W45°39') and chemically characterized by GC/MS. The active extracts were tested against C. albicans biofilm viability and architecture, as well as mode of action, and toxicology using RAW 264.7 macrophages and Galleria mellonella larvae. The MIC values ranged from 15.62 to >2000 µg/mL. The most active extracts were EL (seed, 15.62 µg/mL) and EB (leaf and seeds, 31.25 and 15.62 µg/mL, respectively). Treatment with these extracts at 10xMIC reduced biofilm viability by 54-55% (P < 0.0001) as compared to 42% by nystatin. At 10xMIC, all extracts caused damages to biofilm architecture and integrity, and fewer hyphae remained attached to treated biofilms. None of them was found to interfere with cell wall biosynthesis or complexation with ergosterol. The extracts had low toxicity against macrophages in vitro (P > 0.05) and G. mellonella larvae, with mean in vivo LD of 1500 mg/kg (EL, seeds); 2500 mg/kg (EB, seeds); and 1250 mg/kg (EB, leaf). The phenolic compounds epicatechin and gallic acid were the major constituents in the extracts. Our findings may open avenues for the application of these yet unexplored native fruits in the food and pharmaceutical industry.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Eugenia/química
Frutas/química
Extratos Vegetais/farmacologia
Extratos Vegetais/toxicidade
Plantas Tóxicas/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Antifúngicos/farmacologia
Brasil
Candida albicans/efeitos dos fármacos
Parede Celular/metabolismo
Ergosterol/metabolismo
Ácido Gálico/química
Camundongos
Testes de Sensibilidade Microbiana
Nistatina/farmacologia
Fenóis/química
Extratos Vegetais/química
Folhas de Planta/química
Plantas Medicinais/química
Células RAW 264.7
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Phenols); 0 (Plant Extracts); 1400-61-9 (Nystatin); 632XD903SP (Gallic Acid); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


  6 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28153491
[Au] Autor:Welch KD; Stonecipher CA; Green BT; Gardner DR; Cook D; Pfister JA
[Ad] Endereço:USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, USA. Electronic address: Kevin.Welch@ars.usda.gov.
[Ti] Título:Administering multiple doses of a non N-(methylsuccinimido) anthranoyllycoctonine (MSAL)-containing tall larkspur (Delphinium occidentale) to cattle.
[So] Source:Toxicon;128:46-49, 2017 Mar 15.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Larkspurs (Delphinium spp.) are a serious toxic plant problem for cattle in western North America. There are two chemotypes of D. occidentale, a more toxic and a less toxic chemotype. The objective of this study was to evaluate the acute toxicity of the less toxic chemotype when administered in multiple doses to cattle. These results suggest that cattle could consume enough of the less toxic chemotype to be poisoned in a range setting.
[Mh] Termos MeSH primário: Ração Animal
Delphinium/toxicidade
Diterpenos/administração & dosagem
Diterpenos/toxicidade
Plantas Tóxicas/toxicidade
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/induzido quimicamente
Delphinium/classificação
Relação Dose-Resposta a Droga
Dose Letal Mediana
América do Norte
Plantas Tóxicas/química
Plantas Tóxicas/classificação
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (deltaline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  7 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28125883
[Au] Autor:Fu PP; Xia Q; He X; Barel S; Edery N; Beland FA; Shimshoni JA
[Ad] Endereço:National Center for Toxicological Research , Jefferson, Arkansas 72079, United States.
[Ti] Título:Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum.
[So] Source:Chem Res Toxicol;30(3):851-858, 2017 Mar 20.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pyrrolizidine alkaloids are among the most common poisonous plants affecting livestock, wildlife, and humans. Exposure of humans and livestock to toxic pyrrolizidine alkaloids through the intake of contaminated food and feed may result in poisoning, leading to devastating epidemics. During February 2014, 73 mixed breed female beef cows from the Galilee region of Israel were accidently fed pyrrolizidine alkaloid contaminated hay for 42 days, resulting in the sudden death of 24 cows over a period of 63 days. The remaining cows were slaughtered 2.5 months after the last ingestion of the contaminated hay. In this study, we report the histopathological analysis of the livers from five of the slaughtered cows and quantitation of pyrrolizidine alkaloid-derived DNA adducts from their livers and three livers of control cows fed with feed free of weeds producing pyrrolizidine alkaloids. Histopathological examination revealed that the five cows suffered from varying degrees of bile duct proliferation, fibrosis, and megalocytosis. Selected reaction monitoring HPLC-ES-MS/MS analysis indicated that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts were formed in all five livers. The livers from the three control cows did not have any liver damage nor any indication of DHP-DNA adduct formed. These results confirm that the toxicity observed in these cattle was caused by pyrrolizidine alkaloid poisoning and that pyrrolizidine alkaloid-derived DNA adducts could still be detected and quantified in the livers of the chronically poisoned cows 2.5 months after their last exposure to the contaminated feed, suggesting that DHP-derived DNA adducts can serve as biomarkers for pyrrolizidine alkaloid exposure and poisoning.
[Mh] Termos MeSH primário: Adutos de DNA/química
Heliotropium/fisiologia
Fígado/química
Plantas Tóxicas/toxicidade
Alcaloides de Pirrolizidina/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida
Fígado/patologia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Pyrrolizidine Alkaloids)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.6b00456


  8 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28093222
[Au] Autor:Micheloud JF; Marin R; Colque-Caro LA; Martínez OG; Gardner D; Gimeno EJ
[Ad] Endereço:Grupo de Trabajo de Patología, Epidemiología e Investigación Diagnóstica, Área de Sanidad Animal-IIACS/INTA, Salta, Argentina; Facultad de Ciencias Veterinarias y Agrarias-UCASAL, Salta, Argentina. Electronic address: micheloud.juan@inta.gob.ar.
[Ti] Título:Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina.
[So] Source:Toxicon;128:1-4, 2017 Mar 15.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins. Finally, toxic levels of swansonine were identified in the plant. The present investigation allowed to recognize S. rodrigoi Monteiro poisoning as a plant induced α-mannosidosis.
[Mh] Termos MeSH primário: Doenças das Cabras/diagnóstico
Malvaceae/química
Intoxicação por Plantas/veterinária
Swainsonina/toxicidade
alfa-Manosidose/veterinária
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Argentina
Ataxia/diagnóstico
Ataxia/etiologia
Ataxia/veterinária
Sistema Nervoso Central/fisiopatologia
Dieta/veterinária
Doenças das Cabras/etiologia
Cabras
Lectinas de Plantas/análise
Intoxicação por Plantas/diagnóstico
Intoxicação por Plantas/etiologia
Plantas Tóxicas/química
alfa-Manosidose/diagnóstico
alfa-Manosidose/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Lectins); 0 (lentil lectin); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


  9 / 16256 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27796590
[Au] Autor:Mezzasalma V; Ganopoulos I; Galimberti A; Cornara L; Ferri E; Labra M
[Ad] Endereço:ZooPlantLab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.za Della Scienza 2, 20126, Milan, Italy.
[Ti] Título:Poisonous or non-poisonous plants? DNA-based tools and applications for accurate identification.
[So] Source:Int J Legal Med;131(1):1-19, 2017 Jan.
[Is] ISSN:1437-1596
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Plant exposures are among the most frequently reported cases to poison control centres worldwide. This is a growing condition due to recent societal trends oriented towards the consumption of wild plants as food, cosmetics, or medicine. At least three general causes of plant poisoning can be identified: plant misidentification, introduction of new plant-based supplements and medicines with no controls about their safety, and the lack of regulation for the trading of herbal and phytochemical products. Moreover, an efficient screening for the occurrence of plants poisonous to humans is also desirable at the different stages of the food supply chain: from the raw material to the final transformed product. A rapid diagnosis of intoxication cases is necessary in order to provide the most reliable treatment. However, a precise taxonomic characterization of the ingested species is often challenging. In this review, we provide an overview of the emerging DNA-based tools and technologies to address the issue of poisonous plant identification. Specifically, classic DNA barcoding and its applications using High Resolution Melting (Bar-HRM) ensure high universality and rapid response respectively, whereas High Throughput Sequencing techniques (HTS) provide a complete characterization of plant residues in complex matrices. The pros and cons of each approach have been evaluated with the final aim of proposing a general user's guide to molecular identification directed to different stakeholder categories interested in the diagnostics of poisonous plants.
[Mh] Termos MeSH primário: Plantas Tóxicas/genética
[Mh] Termos MeSH secundário: Código de Barras de DNA Taxonômico
DNA de Plantas/genética
Toxicologia Forense
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1007/s00414-016-1460-y


  10 / 16256 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27754343
[Au] Autor:Wang YY; Tian JM; Zhang CC; Luo B; Gao JM
[Ad] Endereço:Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China. 15829461284@163.com.
[Ti] Título:Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity.
[So] Source:Molecules;21(10), 2016 Oct 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two picrotoxane sesquiterpene lactone glycosides, nepalactones A ( ) and B ( ), and one new coumarin, nepalarin ( ), were isolated from the root barks of the poisonous plant . Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds - and five semisynthetic congeners ( - ) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative and nepalarin ( ) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
[Mh] Termos MeSH primário: Cumarínicos/farmacologia
Glicosídeos/farmacologia
Magnoliopsida/química
Neuritos/efeitos dos fármacos
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Cumarínicos/química
Cumarínicos/isolamento & purificação
Sinergismo Farmacológico
Glicosídeos/química
Glicosídeos/isolamento & purificação
Estrutura Molecular
Fator de Crescimento Neural/farmacologia
Neuritos/metabolismo
Células PC12
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Plantas Tóxicas/química
Ratos
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Glycosides); 0 (Plant Extracts); 0 (Sesquiterpenes); 9061-61-4 (Nerve Growth Factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE



página 1 de 1626 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde