Base de dados : MEDLINE
Pesquisa : B01.650.700.585 [Categoria DeCS]
Referências encontradas : 17 [refinar]
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  1 / 17 MEDLINE  
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[PMID]:27627578
[Au] Autor:Sabry OM; Goeger DE; Valeriote FA; Gerwick WH
[Ad] Endereço:a College of Pharmacy , Oregon State University , Corvallis , OR , USA.
[Ti] Título:Cytotoxic halogenated monoterpenes from Plocamium cartilagineum.
[So] Source:Nat Prod Res;31(3):261-267, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC 4 µg/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC 1.3 µg/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined by spectroscopic methods (UV, IR, LRMS, HRMS, 1D NMR and 2D NMR). 1D and 2D NOE experiments were carried out on these compounds to confirm the geometry of the double bonds.
[Mh] Termos MeSH primário: Monoterpenos/farmacologia
Plocamium/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Neoplasias do Colo/tratamento farmacológico
Halogenação
Seres Humanos
Leucemia/tratamento farmacológico
Neoplasias Pulmonares/tratamento farmacológico
Espectroscopia de Ressonância Magnética
Camundongos
Estrutura Molecular
Monoterpenos/química
Monoterpenos/toxicidade
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Monoterpenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE


  2 / 17 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:25296201
[Au] Autor:Pereira RC; Vasconcelos MA
[Ad] Endereço:Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense - UFF, Niterói, RJ, Brazil.
[Ti] Título:Chemical defense in the red seaweed Plocamium brasiliense: spatial variability and differential action on herbivores.
[So] Source:Braz J Biol;74(3):545-52, 2014 Aug.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Species of Plocamium are known as prolific sources of halogenated secondary metabolites exhibiting few explored ecological roles. In this study the crude extracts from specimens of P. brasiliense collected in two distinct places, Enseada do Forno and Praia Rasa, Búzios, Estado do Rio de Janeiro, were evaluated as defense against the sea urchin Lytechinus variegatus and the crab Acanthonyx scutiformis. These specimens produce a similar amount of crude extract and also halogenated monoterpene compound-types, but individuals of P. brasiliense from Praia Rasa exhibit a major compound representing about 59% of the total chemicals. Natural concentrations of the crude extracts obtained from both specimens of P. brasiliense significantly inhibited the herbivory by the sea urchin L. variegatus, but had no significant effect on the feeding by A. scutiformis, a crab commonly associated to chemically defended host. Crude extract from P. brasiliense collected at Praia Rasa was more efficient as defense against L. variegatus than that crude extract from populations of this alga from Enseada do Forno, probably due to presence of a major secondary metabolite. These two studied population live under different environmental conditions, but they are only about 30 Km apart. However, it is impossible to affirm that environmental characteristics (abiotic or biotic) would be responsible for the difference of defensive potential found in the two populations of P. brasiliense studied here. Further genetic studies will be necessary to clarify this question and to explain why populations of a single species living in different but close locations can exhibit distinct chemicals.
[Mh] Termos MeSH primário: Braquiúros/fisiologia
Herbivoria/fisiologia
Plocamium/química
Ouriços-do-Mar/fisiologia
[Mh] Termos MeSH secundário: Animais
Braquiúros/classificação
Fenômenos Fisiológicos Vegetais/fisiologia
Ouriços-do-Mar/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1503
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141009
[St] Status:MEDLINE


  3 / 17 MEDLINE  
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[PMID]:25220828
[Au] Autor:Vogel CV; Pietraszkiewicz H; Sabry OM; Gerwick WH; Valeriote FA; Vanderwal CD
[Ad] Endereço:1102 Natural Sciences II, Department of Chemistry, University of California, Irvine, Irvine, CA 92697 (USA).
[Ti] Título:Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors.
[So] Source:Angew Chem Int Ed Engl;53(45):12205-9, 2014 Nov 03.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The family of polyhalogenated monoterpenes from Plocamium counts over a hundred known members. Using glyceraldehyde acetonide as a chiral-pool precursor, an enantioselective and divergent strategy was developed that provides a blueprint for the synthesis of many of the small yet complex acyclic members of this family. The broad applicability of this approach is demonstrated with the short, eight-step synthesis of four natural products and three analogues. These syntheses are the first of any members of the acyclic polyhalogenated Plocamium monoterpenes and permitted the evaluation of their selectivity against a range of tumor cell lines.
[Mh] Termos MeSH primário: Monoterpenos/síntese química
Neoplasias/tratamento farmacológico
Plocamium/química
[Mh] Termos MeSH secundário: Células HCT116
Seres Humanos
Monoterpenos/uso terapêutico
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoterpenes)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140916
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201407726


  4 / 17 MEDLINE  
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[PMID]:24797660
[Au] Autor:Motti CA; Thomas-Hall P; Hagiwara KA; Simmons CJ; Willis R; Wright AD
[Ad] Endereço:Australian Institute of Marine Science , PMB no. 3, Townsville MC, Townsville, 4810, Australia.
[Ti] Título:Accelerated identification of halogenated monoterpenes from Australian specimens of the red algae Plocamium hamatum and Plocamium costatum.
[So] Source:J Nat Prod;77(5):1193-200, 2014 May 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two species of red algae belonging to the genus Plocamium, P. hamatum from Moreton Bay, Queensland, and P. costatum, from Pandalowie Bay, South Australia, were investigated to assess their chemical variation and as potential sources of new halogenated monoterpenes. The hyphenated technique HPLC-UV-MS-SPE-NMR was used to assess the algal extracts and to determine its potential for accelerated identification of halogenated monoterpenes generally. A combination of the hyphenated and traditional chromatographic techniques resulted in the isolation and characterization of a total of 10 halogenated monoterpene metabolites, eight of which are reported for the first time. Their structures, including configurations, were determined through interpretation of their 1D and 2D NMR, mass spectrometric, infrared, and X-ray data. The two species of Plocamium produced different secondary metabolites and contained a significant number of new polyhalogenated monoterpenes. The investigation also showed the hyphenated technique HPLC-UV-MS-SPE-NMR to be useful for preliminary investigation of the chemical content of algal extracts.
[Mh] Termos MeSH primário: Hidrocarbonetos Bromados/isolamento & purificação
Hidrocarbonetos Clorados/isolamento & purificação
Monoterpenos/isolamento & purificação
Plocamium/química
[Mh] Termos MeSH secundário: Austrália
Hidrocarbonetos Bromados/química
Hidrocarbonetos Clorados/química
Estrutura Molecular
Monoterpenos/química
Ressonância Magnética Nuclear Biomolecular
Oceanos e Mares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Chlorinated); 0 (Monoterpenes)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140911
[Lr] Data última revisão:
140911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140507
[St] Status:MEDLINE
[do] DOI:10.1021/np500059h


  5 / 17 MEDLINE  
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[PMID]:23771046
[Au] Autor:Young RM; von Salm JL; Amsler MO; Lopez-Bautista J; Amsler CD; McClintock JB; Baker BJ
[Ad] Endereço:Department of Chemistry and Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL 33620, USA.
[Ti] Título:Site-specific variability in the chemical diversity of the Antarctic red alga Plocamium cartilagineum.
[So] Source:Mar Drugs;11(6):2126-39, 2013 Jun 14.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plocamium cartilagineum is a common red alga on the benthos of Antarctica and can be a dominant understory species along the western Antarctic Peninsula. Algae from this region have been studied chemically, and like "P. cartilagineum" from other worldwide locations where it is common, it is rich in halogenated monoterpenes, some of which have been implicated as feeding deterrents toward sympatric algal predators. Secondary metabolites are highly variable in this alga, both qualitatively and quantitatively, leading us to probe individual plants to track the possible link of variability to genetic or other factors. Using cox1 and rbcL gene sequencing, we find that the Antarctic alga divides into two closely related phylogroups, but not species, each of which is further divided into one of five chemogroups. The chemogroups themselves, defined on the basis of Bray-Curtis similarity profiling of GC/QqQ chromatographic analyses, are largely site specific within a 10 km² area. Thus, on the limited geographical range of this analysis, P. cartilagineum displays only modest genetic radiation, but its secondary metabolome was found to have experienced more extensive radiation. Such metabogenomic divergence demonstrated on the larger geographical scale of the Antarctic Peninsula, or perhaps even continent-wide, may contribute to the discovery of cryptic speciation.
[Mh] Termos MeSH primário: Metabolômica/métodos
Filogenia
Plocamium/química
[Mh] Termos MeSH secundário: Regiões Antárticas
Cromatografia Gasosa/métodos
Ciclo-Oxigenase 1/genética
Plocamium/genética
Plocamium/metabolismo
Ribulose-Bifosfato Carboxilase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 1.14.99.1 (Cyclooxygenase 1); EC 4.1.1.39 (RbcL protein, plastid); EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130618
[St] Status:MEDLINE
[do] DOI:10.3390/md11062126


  6 / 17 MEDLINE  
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[PMID]:23118723
[Au] Autor:Timmers MA; Dias DA; Urban S
[Ad] Endereço:School of Applied Sciences, Health Innovations Research Institute (HIRi), RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia. michael.timmers@rmit.edu.au
[Ti] Título:Application of HPLC-NMR in the identification of plocamenone and isoplocamenone from the marine red alga Plocamium angustum.
[So] Source:Mar Drugs;10(9):2089-102, 2012 Sep.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A combination of on-line HPLC-NMR and off-line chemical investigations has resulted in the identification of the previously reported polyhalogenated monoterpene plocamenone, together with the new structural analogue isoplocamenone from the crude extract of the marine alga Plocamium angustum. On-flow and stop-flow HPLC-NMR analyses (including the acquisition of WET 2D NMR spectra) rapidly assisted in the identification of the major component plocamenone and in the partial identification of its unstable double bond isomer isoplocamenone. Conventional off-line isolation and structural characterization techniques were employed to unequivocally confirm both structures, leading to a structural revision for plocamenone, as well as to obtain sufficient quantities for biological testing.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Espectroscopia de Ressonância Magnética/métodos
Monoterpenos/análise
Extratos Vegetais/análise
Plocamium/química
[Mh] Termos MeSH secundário: Monoterpenos/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Plant Extracts)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121103
[St] Status:MEDLINE
[do] DOI:10.3390/md10092089


  7 / 17 MEDLINE  
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[PMID]:22249429
[Au] Autor:de la Mare JA; Lawson JC; Chiwakata MT; Beukes DR; Edkins AL; Blatch GL
[Ad] Endereço:The Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P. O. Box 94, Grahamstown, 6140, South Africa.
[Ti] Título:Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro.
[So] Source:Invest New Drugs;30(6):2187-200, 2012 Dec.
[Is] ISSN:1573-0646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Red and brown algae have been shown to produce a variety of compounds with chemotherapeutic potential. A recent report described the isolation of a range of novel polyhalogenated monoterpene compounds from the red algae Plocamium corallorhiza and Plocamium cornutum collected off the coast of South Africa, together with the previously described tetraprenylquinone, sargaquinoic acid (SQA), from the brown algae Sargassum heterophyllum. In our study, the algal compounds were screened for anti-proliferative activity against metastatic MDA-MB-231 breast cancer cells revealing that a number of compounds displayed anti-cancer activity with IC(50) values in the micromolar range. A subset of the compounds was tested for differential toxicity in the MCF-7/MCF12A system and five of these, including sargaquinoic acid, were found to be at least three times more toxic to the breast cancer than the non-malignant cell line. SQA was further analysed in terms of its mechanism of cytotoxicity in MDA-MB-231 cells. The ability to initiate apoptosis was distinguished from the induction of an inflammatory necrotic response via flow cytometry with propidium iodide and Hoescht staining, confocal microscopy with Annexin V and propidium iodide staining as well as the PARP cleavage assay. We report that SQA induced apoptosis while a polyhalogenated monoterpene RU015 induced necrosis in metastatic breast cancer cells in vitro. Furthermore, we demonstrated that apoptosis induction by SQA occurs via caspase-3, -6, -8, -9 and -13 and was associated with down-regulation of Bcl-2. In addition, cell cycle analyses revealed that the compound causes G(1) arrest in MDA-MB-231 cells.
[Mh] Termos MeSH primário: Alcenos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Benzoquinonas/farmacologia
Monoterpenos/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/metabolismo
Caspases/metabolismo
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Feminino
Seres Humanos
Plocamium
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Sargassum
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkenes); 0 (Antineoplastic Agents, Phytogenic); 0 (Benzoquinones); 0 (Monoterpenes); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Reactive Oxygen Species); 0 (sargaquinoic acid); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120118
[St] Status:MEDLINE
[do] DOI:10.1007/s10637-011-9788-0


  8 / 17 MEDLINE  
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[PMID]:21495035
[Au] Autor:Gressler V; Fujii MT; Martins AP; Colepicolo P; Mancini-Filho J; Pinto E
[Ad] Endereço:Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
[Ti] Título:Biochemical composition of two red seaweed species grown on the Brazilian coast.
[So] Source:J Sci Food Agric;91(9):1687-92, 2011 Jul.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Algae species have been used as an important source of food because they are highly nutritive considering their vitamin, protein, mineral, fiber, essential fatty acid and carbohydrate contents. However, a large number of seaweeds have been poorly studied, especially Brazilian species. Two red macroalgae species from the Brazilian coast (Plocamium brasiliense and Ochtodes secundiramea) were assessed with respect to their total lipid, fatty acid, total nitrogen, protein, amino acid and total carbohydrate contents. RESULTS: The total lipid contents (dry weight) were 36.3 and 35.4 g kg(-1); fatty acid contents were 9.3 and 12.1 g kg(-1); total nitrogen contents were 37.4 and 24.9 g kg(-1); protein contents were 157.2 and 101.0 g kg(-1); amino acid contents were 127.5 and 91.4 g kg(-1); and total carbohydrate contents were 520.3 and 450.7 g kg(-1) for P. brasiliense and O. secundiramea, respectively. CONCLUSION: Considering these compositions, both algae species were determined to have sources of protein, essential amino acids and carbohydrates similar to the edible seaweeds Laminaria japonica and Palmaria palmata.
[Mh] Termos MeSH primário: Aminoácidos/análise
Lipídeos/análise
Nitrogênio/análise
Proteínas de Plantas/análise
Rodófitas/química
[Mh] Termos MeSH secundário: Animais
Brasil
Dieta
Meio Ambiente
Valor Nutritivo
Plocamium/química
Rodófitas/classificação
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acids); 0 (Lipids); 0 (Plant Proteins); N762921K75 (Nitrogen)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110416
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.4370


  9 / 17 MEDLINE  
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[PMID]:21392811
[Au] Autor:Antunes EM; Afolayan AF; Chiwakata MT; Fakee J; Knott MG; Whibley CE; Hendricks DT; Bolton JJ; Beukes DR
[Ad] Endereço:Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
[Ti] Título:Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum.
[So] Source:Phytochemistry;72(8):769-72, 2011 Jun.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R∗,4S∗,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) and (3R∗,4S∗)-3,4,6,7-tetrachloro-3,7-dimethyl-octen-1-ene (5) were isolated from the red macroalga Plocamium suhrii and their structures deduced from their spectroscopic data. The seven compounds from P. suhrii together with five related compounds from Plocamium cornutum have been evaluated for their cytotoxic effects on an esophageal cancer cell line (WHCO1). Compounds 1-6 showed greater cytotoxicity in this assay as compared to the known anticancer drug cisplatin.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Neoplasias Esofágicas/tratamento farmacológico
Hidrocarbonetos Halogenados/isolamento & purificação
Hidrocarbonetos Halogenados/farmacologia
Monoterpenos/isolamento & purificação
Monoterpenos/farmacologia
Plocamium/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cisplatino/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Hidrocarbonetos Halogenados/química
Estrutura Molecular
Monoterpenos/química
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Hydrocarbons, Halogenated); 0 (Monoterpenes); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110312
[St] Status:MEDLINE
[do] DOI:10.1016/j.phytochem.2011.02.003


  10 / 17 MEDLINE  
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[PMID]:20839610
[Au] Autor:Ferreira WJ; Amaro R; Cavalcanti DN; de Rezende CM; da Silva VA; Barbosa JE; Paixão IC; Teixeira VL
[Ad] Endereço:Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil.
[Ti] Título:Anti-herpetic activities of chemical components from the Brazilian red alga Plocamium brasiliense.
[So] Source:Nat Prod Commun;5(8):1167-70, 2010 Aug.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The CH2Cl2 crude extract and a fraction enriched with halogenated monoterpenes of the Brazilian red alga Plocamium brasiliense were evaluated for cytotoxicity and against the virus HSV-1. The extract showed low cytotoxicity compared with the fraction containing monoterpenes. The crude extract showed, in vitro, a high reduction of infectivity of the virus HSV-1.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Herpesvirus Humano 1/efeitos dos fármacos
Monoterpenos/farmacologia
Plocamium/química
[Mh] Termos MeSH secundário: Brasil
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Monoterpenes)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:100915
[Lr] Data última revisão:
100915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100916
[St] Status:MEDLINE



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