Base de dados : MEDLINE
Pesquisa : B01.650.940.800 [Categoria DeCS]
Referências encontradas : 87 [refinar]
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[PMID]:28254521
[Au] Autor:Ghosh S; Mukhopadhyay S; Sarkar M; Mandal A; Das V; Kumar A; Giri B
[Ad] Endereço:Department of Biotechnology, University of North Bengal, Darjeeling, 734 013, West Bengal, India. Electronic address: ghosshilpi@gmail.com.
[Ti] Título:Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation.
[So] Source:Chem Biol Interact;268:68-76, 2017 Apr 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The pentacyclic lupane-type (6-6-6-6-5 type) triterpenoid, Betulinic acid (BA) is a potent inhibitor of topoisomerases and is of immense interest as anticancer drugs. However, the compound being highly lipophilic, has limited in vivo uptake capacity. BA derivatives with halogen substituent at C-2 have improved membrane permeability and cytotoxicity against cancer cells. AIM: The halogenated triterpenoid, 2α-bromo-dihydrobetulonic acid (B1) was synthesized from betulinic acid (BA) isolated from Bischofia javanica. Aim of the study was to determine whether B1 could act as a more efficient inhibitor of Topo IIα activity and HeLa cell proliferation, in comparison to BA. RESULT: B1 displayed efficient inhibition of DNA relaxation activity of topoisomerase IIα and the inhibitory effect was markedly improved upon pre-incubation of the compound with enzyme. Topoisomerase IIα inhibition by B1 was relieved in presence of increasing concentrations of DNA suggesting the compound as a reversible catalytic inhibitor. Subsequent UV and fluorescence spectroscopy studies indicated that B1 interacts and intercalates with DNA at concentrations signicantly greater than that required for topoisomerase IIα inhibition. The compound showed cytotoxic activity against HeLa cells with significantly lower IC value (7.5 µM) as compared to that of BA (30 µM) and had very low damaging/cytotoxic effect on normal cells. Treatment of B1 impaired HeLa cell proliferation by inducing Go-G1 arrest through lowered expression of cyclin D1 and PCNA polypeptides, and enhanced expression of p21. B1 treatment also increased the accumulation of early and late apoptotic cells in a concentration dependent manner as indicated by annexin V-FITC/PI binding assay.
[Mh] Termos MeSH primário: Antígenos de Neoplasias/metabolismo
DNA Topoisomerases Tipo II/metabolismo
Proteínas de Ligação a DNA/metabolismo
Substâncias Intercalantes/farmacologia
Ácido Oleanólico/análogos & derivados
Inibidores da Topoisomerase II/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Ciclina D1/genética
Ciclina D1/metabolismo
Inibidor de Quinase Dependente de Ciclina p21/genética
Inibidor de Quinase Dependente de Ciclina p21/metabolismo
DNA/química
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Halogenação
Células HeLa
Seres Humanos
Substâncias Intercalantes/síntese química
Ácido Oleanólico/síntese química
Ácido Oleanólico/farmacologia
Antígeno Nuclear de Célula em Proliferação/genética
Antígeno Nuclear de Célula em Proliferação/metabolismo
Espectrometria de Fluorescência
Estreptófitas/química
Inibidores da Topoisomerase II/síntese química
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-bromo-dihydrobetulonic acid); 0 (Antigens, Neoplasm); 0 (CCND1 protein, human); 0 (Cyclin-Dependent Kinase Inhibitor p21); 0 (DNA-Binding Proteins); 0 (Intercalating Agents); 0 (Proliferating Cell Nuclear Antigen); 0 (Topoisomerase II Inhibitors); 0 (Triterpenes); 136601-57-5 (Cyclin D1); 4G6A18707N (betulinic acid); 6SMK8R7TGJ (Oleanolic Acid); 9007-49-2 (DNA); EC 5.99.1.3 (DNA Topoisomerases, Type II)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28116472
[Au] Autor:Jighly A; Al-Abdallat AM; Alnemer LM
[Ad] Endereço:Agriculture Victoria, Bioscience Research, AgriBio, Centre for AgriBiosciences, Bundoora, VIC, 3083, Australia. Abdulqader.jighly@ecodev.vic.gov.au.
[Ti] Título:The Role of Microsatellites in Streptophyta Gene Evolution.
[So] Source:J Mol Evol;84(2-3):144-148, 2017 Mar.
[Is] ISSN:1432-1432
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Microsatellites form hotspot regions for recombination. In this research, we investigated whether genic microsatellites can be responsible for generating new genes by enhancing crossover between gene containing microsatellites and other genomic regions. We tested our hypothesis on 33,531 UniGene entries containing microsatellites. Each sequence was divided into microsatellites upstream and downstream fragments, and each pair of sequences was compared to study the microsatellites effect. The candidate pairs of genes are supposed to share a high similar fragment in one side of the microsatellites, while the other fragments should be completely different. This in silico approach detected 448 valid pairs of sequences in which both of them showed semi-resemblance nature. The synteny analysis for the detected sequences against 55 plant genomes indicated low representation of them across plant kingdom. Our results will add a body of knowledge toward understanding the role of microsatellites in gene evolution.
[Mh] Termos MeSH primário: Repetições de Microssatélites/genética
Estreptófitas/genética
[Mh] Termos MeSH secundário: Evolução Molecular
Etiquetas de Sequências Expressas
Genes de Plantas/genética
Genoma de Planta/genética
Genômica/métodos
Sintenia/genética
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1007/s00239-016-9778-0


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[PMID]:28011994
[Au] Autor:Donner A; Glaser K; Borchhardt N; Karsten U
[Ad] Endereço:Institute of Biological Sciences, Applied Ecology and Phycology, University of Rostock, Albert-Einstein-Strasse 3, 18059, Rostock, Germany. antje.donner@uni-rostock.de.
[Ti] Título:Ecophysiological Response on Dehydration and Temperature in Terrestrial Klebsormidium (Streptophyta) Isolated from Biological Soil Crusts in Central European Grasslands and Forests.
[So] Source:Microb Ecol;73(4):850-864, 2017 May.
[Is] ISSN:1432-184X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The green algal genus Klebsormidium (Klebsormidiophyceae, Streptophyta) is a typical member of biological soil crusts (BSCs) worldwide. Ecophysiological studies focused so far on individual strains and thus gave only limited insight on the plasticity of this genus. In the present study, 21 Klebsormidium strains (K. dissectum, K. flaccidum, K. nitens, K. subtile) from temperate BSCs in Central European grassland and forest sites were investigated. Photosynthetic performance under desiccation and temperature stress was measured under identical controlled conditions. Photosynthesis decreased during desiccation within 335-505 min. After controlled rehydration, most isolates recovered, but with large variances between single strains and species. However, all K. dissectum strains had high recovery rates (>69%). All 21 Klebsormidium isolates exhibited the capability to grow under a wide temperature range. Except one strain, all others grew at 8.5 °C and four strains were even able to grow at 6.2 °C. Twenty out of 21 Klebsormidium isolates revealed an optimum growth temperature >17 °C, indicating psychrotrophic features. Growth rates at optimal temperatures varied between strains from 0.26 to 0.77 µ day . Integrating phylogeny and ecophysiological traits, we found no phylogenetic signal in the traits investigated. However, multivariate statistical analysis indicated an influence of the recovery rate and growth rate. The results demonstrate a high infraspecific and interspecific physiological plasticity, and thus wide ecophysiological ability to cope with strong environmental gradients. This might be the reason why members of the genus Klebsormidium successfully colonize terrestrial habitats worldwide.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Desidratação
Estreptófitas/classificação
Estreptófitas/fisiologia
Temperatura Ambiente
[Mh] Termos MeSH secundário: Biodiversidade
Clorofila
DNA Ribossômico/genética
Dessecação
Ecologia
Ecossistema
Florestas
Alemanha
Pradaria
Fotossíntese
Filogenia
Solo
Estreptófitas/genética
Estreptófitas/crescimento & desenvolvimento
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal); 0 (Soil); 1406-65-1 (Chlorophyll); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.1007/s00248-016-0917-3


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[PMID]:27902235
[Au] Autor:Zhao S; Liu C; Zheng W; Ma Z; Cao T; Zhao J; Yan K; Xiang W; Wang X
[Ad] Endereço:1​Key Laboratory of Agriculture Biological Functional Gene of Heilongjiang Provincial Education Committee, Northeast Agricultural University, No. 59 Mucai Street, Xiangfang District, Harbin 150030, PR China.
[Ti] Título:Micromonospora parathelypteridis sp. nov., an endophytic actinomycete with antifungal activity isolated from the root of Parathelypteris beddomei (Bak.) Ching.
[So] Source:Int J Syst Evol Microbiol;67(2):268-274, 2017 Feb.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel endophytic actinomycete with antifungal activity, designated strain NEAU-JXY5T, was isolated from the root of Parathelypteris beddomei (Bak.) Ching. Strain NEAU-JXY5T showed closest 16S rRNA gene sequence similarity to Micromonospora luteifusca GUI2T (99.31 %), and phylogenetically clustered with Micromonospora noduli GUI43T (99.24 %), 'Micromonospora lycii' NEAU-gq11 (99.19 %), 'Micromonospora zeae' NEAU-gq9 (99.12 %), Micromonospora saelicesensis Lupac 09T (98.97 %), Micromonospora vinacea GUI63T (98.96 %), 'Micromonospora jinlongensis' NEAU-GRX11 (98.91 %), Micromonospora profundi DS3010T (98.77 %), Micromonospora zamorensis CR38T (98.76 %), Micromonospora chokoriensis 2-19(6)T (98.71 %), Micromonospora lupini Lupac 14NT (98.69 %), Micromonospora ureilytica GUI23T (98.69 %), Micromonospora violae NEAU-zh8T (98.57 %) and Micromonospora taraxaci NEAU-P5T (98.37 %). Phylogenetic analysis based on gyrB gene sequences also indicated that the isolate clustered with the above strains except M. violae NEAU-zh8T. A combination of DNA-DNA hybridization results and some phenotypic characteristics indicated that the strain could be readily distinguished from these closest phylogenetic relatives. Therefore, it is concluded that strain NEAU-JXY5T represents a novel species of the genus Micromonospora, for which the name Micromonospora parathelypteridis sp. nov. is proposed. The type strain is NEAU-JXY5T (=CGMCC 4.7347T=DSM 103125T).
[Mh] Termos MeSH primário: Micromonospora/classificação
Filogenia
Raízes de Plantas/microbiologia
Estreptófitas/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácidos Graxos/química
Micromonospora/genética
Micromonospora/isolamento & purificação
Hibridização de Ácido Nucleico
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001614


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[PMID]:27707748
[Au] Autor:Zizková E; Kubes M; Dobrev PI; Pribyl P; Simura J; Zahajská L; Záveská Drábková L; Novák O; Motyka V
[Ad] Endereço:Laboratory of Hormonal Regulations in Plants, Institute of Experimental Botany CAS, Rozvojová 263, CZ-165 02 Prague 6, Czech Republic.
[Ti] Título:Control of cytokinin and auxin homeostasis in cyanobacteria and algae.
[So] Source:Ann Bot;119(1):151-166, 2017 Jan.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The metabolism of cytokinins (CKs) and auxins in vascular plants is relatively well understood, but data concerning their metabolic pathways in non-vascular plants are still rather rare. With the aim of filling this gap, 20 representatives of taxonomically major lineages of cyanobacteria and algae from Cyanophyceae, Xanthophyceae, Eustigmatophyceae, Porphyridiophyceae, Chlorophyceae, Ulvophyceae, Trebouxiophyceae, Zygnematophyceae and Klebsormidiophyceae were analysed for endogenous profiles of CKs and auxins and some of them were used for studies of the metabolic fate of exogenously applied radiolabelled CK, [ H]trans-zeatin (transZ) and auxin ([ H]indole-3-acetic acid (IAA)), and the dynamics of endogenous CK and auxin pools during algal growth and cell division. METHODS: Quantification of phytohormone levels was performed by high-performance or ultrahigh-performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-MS/MS, UHPLC-MS/MS). The dynamics of exogenously applied [ H]transZ and [ H]IAA in cell cultures were monitored by HPLC with on-line radioactivity detection. KEY RESULTS: The comprehensive screen of selected cyanobacteria and algae for endogenous CKs revealed a predominance of bioactive and phosphate CK forms while O- and N-glucosides evidently did not contribute greatly to the total CK pool. The abundance of cis-zeatin-type CKs and occurrence of CK 2-methylthio derivatives pointed to the tRNA pathway as a substantial source of CKs. The importance of the tRNA biosynthetic pathway was proved by the detection of tRNA-bound CKs during the course of Scenedesmus obliquus growth. Among auxins, free IAA and its oxidation catabolite 2-oxindole-3-acetic acid represented the prevailing endogenous forms. After treatment with [ H]IAA, IAA-aspartate and indole-3-acetyl-1-glucosyl ester were detected as major auxin metabolites. Moreover, different dynamics of endogenous CKs and auxin profiles during S. obliquus culture clearly demonstrated diverse roles of both phytohormones in algal growth and cell division. CONCLUSIONS: Our data suggest the existence and functioning of a complex network of metabolic pathways and activity control of CKs and auxins in cyanobacteria and algae that apparently differ from those in vascular plants.
[Mh] Termos MeSH primário: Clorófitas/metabolismo
Cianobactérias/metabolismo
Citocininas/metabolismo
Homeostase/fisiologia
Ácidos Indolacéticos/metabolismo
Reguladores de Crescimento de Planta/metabolismo
Estreptófitas/metabolismo
[Mh] Termos MeSH secundário: Clorófitas/química
Clorófitas/fisiologia
Cromatografia Líquida de Alta Pressão/métodos
Cianobactérias/química
Cianobactérias/fisiologia
Citocininas/análise
Ácidos Indolacéticos/análise
Filogenia
Reguladores de Crescimento de Planta/análise
Espectrometria de Massas por Ionização por Electrospray/métodos
Estreptófitas/química
Estreptófitas/fisiologia
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokinins); 0 (Indoleacetic Acids); 0 (Plant Growth Regulators)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw194


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[PMID]:27861610
[Au] Autor:Ziehe D; Dünschede B; Zenker M; Funke S; Nowaczyk MM; Schünemann D
[Ad] Endereço:Molecular Biology of Plant Organelles, Ruhr-University Bochum, 44780, Bochum, Germany.
[Ti] Título:The Chloroplast SRP Systems of Chaetosphaeridium globosum and Physcomitrella patens as Intermediates in the Evolution of SRP-Dependent Protein Transport in Higher Plants.
[So] Source:PLoS One;11(11):e0166818, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The bacterial signal recognition particle (SRP) mediates the cotranslational targeting of membrane proteins and is a high affinity complex consisting of a SRP54 protein subunit (Ffh) and an SRP RNA. The chloroplast SRP (cpSRP) pathway has adapted throughout evolution to enable the posttranslational targeting of the light harvesting chlorophyll a/b binding proteins (LHCPs) to the thylakoid membrane. In spermatophytes (seed plants), the cpSRP lacks the SRP RNA and is instead formed by a high affinity interaction of the conserved 54-kD subunit (cpSRP54) with the chloroplast-specific cpSRP43 protein. This heterodimeric cpSRP recognizes LHCP and delivers it to the thylakoid membrane. However, in contrast to spermatophytes, plastid SRP RNAs were identified within all streptophyte lineages and in all chlorophyte branches. Furthermore, it was shown that cpSRP43 does not interact with cpSRP54 in chlorophytes (e.g., Chlamydomonas reinhardtii). In this study, we biochemically characterized the cpSRP system of the charophyte Chaetosphaeridium globosum and the bryophyte Physcomitrella patens. Interaction studies demonstrate low affinity binding of cpSRP54 to cpSRP43 (Kd ~10 µM) in Chaetosphaeridium globosum and Physcomitrella patens as well as relatively low affinity binding of cpSRP54 to cpSRP RNA (Kd ~1 µM) in Physcomitrella patens. CpSRP54/cpSRP43 complex formation in charophytes is supported by the finding that specific alterations in the second chromodomain of cpSRP43, that are conserved within charophytes and absent in land plants, do not interfere with cpSRP54 binding. Furthermore, our data show that the elongated apical loop structure of the Physcomitrella patens cpSRP RNA contributes to the low binding affinity between cpSRP54 and the cpSRP RNA.
[Mh] Termos MeSH primário: Cloroplastos/metabolismo
Partícula de Reconhecimento de Sinal/metabolismo
Estreptófitas/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Complexos Multiproteicos/metabolismo
Conformação de Ácido Nucleico
Ligação Proteica
Transporte Proteico
RNA de Plantas/química
RNA de Plantas/genética
RNA de Plantas/metabolismo
Partícula de Reconhecimento de Sinal/química
Partícula de Reconhecimento de Sinal/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Multiprotein Complexes); 0 (RNA, Plant); 0 (Signal Recognition Particle)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0166818


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[PMID]:27861550
[Au] Autor:Luna CA; Loayza AP; Squeo FA
[Ad] Endereço:Universidad de La Serena, Departamento de Biología, La Serena, Chile.
[Ti] Título:Fruit Size Determines the Role of Three Scatter-Hoarding Rodents as Dispersers or Seed Predators of a Fleshy-Fruited Atacama Desert Shrub.
[So] Source:PLoS One;11(11):e0166824, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scatter-hoarding rodents can act as both predators and dispersers for many large-seeded plants because they cache seeds for future use, but occasionally forget them in sites with high survival and establishment probabilities. The most important fruit or seed trait influencing rodent foraging behavior is seed size; rodents prefer large seeds because they have higher nutritional content, but this preference can be counterbalanced by the higher costs of handling larger seeds. We designed a cafeteria experiment to assess whether fruit and seed size of Myrcianthes coquimbensis, an endangered desert shrub, influence the decision-making process during foraging by three species of scatter-hoarding rodents differing in body size: Abrothrix olivaceus, Phyllotis darwini and Octodon degus. We found that the size of fruits and seeds influenced foraging behavior in the three rodent species; the probability of a fruit being harvested and hoarded was higher for larger fruits than for smaller ones. Patterns of fruit size preference were not affected by rodent size; all species were able to hoard fruits within the entire range of sizes offered. Finally, fruit and seed size had no effect on the probability of seed predation, rodents typically ate only the fleshy pulp of the fruits offered and discarded whole, intact seeds. In conclusion, our results reveal that larger M. coquimbensis fruits have higher probabilities of being harvested, and ultimately of its seeds being hoarded and dispersed by scatter-hoarding rodents. As this plant has no other dispersers, rodents play an important role in its recruitment dynamics.
[Mh] Termos MeSH primário: Frutas
Comportamento Predatório
Roedores
Dispersão de Sementes
Sementes
Estreptófitas
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0166824


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[PMID]:27477927
[Au] Autor:Buschmann H; Zachgo S
[Ad] Endereço:Osnabrück University, Department of Biology and Chemistry, Barbarastrasse 11, 49076 Osnabrück, Germany. Electronic address: henrik.buschmann@biologie.uni-osnabrueck.de.
[Ti] Título:The Evolution of Cell Division: From Streptophyte Algae to Land Plants.
[So] Source:Trends Plant Sci;21(10):872-883, 2016 Oct.
[Is] ISSN:1878-4372
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mechanism of cell division has undergone significant alterations during the evolution from aquatic streptophyte algae to land plants. Two new structures evolved, the cytokinetic phragmoplast and the preprophase band (PPB) of microtubules, whereas the ancestral mechanism of cleavage and the centrosomes disappeared. We map cell biological data onto the recently emerged phylogenetic tree of streptophytes. The tree suggests that, after the establishment of the phragmoplast mechanism, several groups independently lost their centrosomes. Surprisingly, the phragmoplast shows reductions in the Zygnematophyceae (the sister to land plants), many of which returned to cleavage. The PPB by contrast evolved stepwise and, most likely, originated in the algae. The phragmoplast/PPB mechanism established in this way served as a basis for the 3D development of land plants.
[Mh] Termos MeSH primário: Evolução Biológica
Divisão Celular
Plantas/genética
Estreptófitas/fisiologia
[Mh] Termos MeSH secundário: Divisão Celular/fisiologia
Centrossomo/fisiologia
Filogenia
Fenômenos Fisiológicos Vegetais/genética
Prófase/fisiologia
Estreptófitas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


  9 / 87 MEDLINE  
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[PMID]:27347604
[Au] Autor:Wang Y; Cong J
[Ad] Endereço:Department of Mathematics, Shanghai University , Shanghai, China .
[Ti] Título:An Improved Model of Nonuniform Coleochaete Cell Division.
[So] Source:J Comput Biol;23(8):693-709, 2016 Aug.
[Is] ISSN:1557-8666
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell division is a key biological process in which cells divide forming new daughter cells. In the present study, we investigate continuously how a Coleochaete cell divides by introducing a modified differential equation model in parametric equation form. We discuss both the influence of "dead" cells and the effects of various end-points on the formation of the new cells' boundaries. We find that the boundary condition on the free end-point is different from that on the fixed end-point; the former has a direction perpendicular to the surface. It is also shown that the outer boundaries of new cells are arc-shaped. The numerical experiments and theoretical analyses for this model to construct the outer boundary are given.
[Mh] Termos MeSH primário: Simulação por Computador
Estreptófitas/citologia
[Mh] Termos MeSH secundário: Divisão Celular
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE
[do] DOI:10.1089/cmb.2016.0021


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[PMID]:27211326
[Au] Autor:Lopes CR; Falkowski GJ; Brustolin CF; Massini PF; Ferreira ÉC; Moreira NM; Aleixo DL; Kaneshima EN; de Araújo SM
[Ad] Endereço:Universidade Estadual de Maringá, Departamento de Ciências Básicas da Saúde/Parasitologia, Maringá, PR, Brazil. Electronic address: carinaedaniel@hotmail.com.
[Ti] Título:Highly diluted medication reduces tissue parasitism and inflammation in mice infected by Trypanosoma cruzi.
[So] Source:Homeopathy;105(2):186-93, 2016 May.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the effects of Kalium causticum, Conium maculatum, and Lycopodium clavatum 13cH in mice infected by Trypanosoma cruzi. MATERIALS AND METHODS: In a blind, controlled, randomized study, 102 male Swiss mice, 8 weeks old, were inoculated with 1400 trypomastigotes of the Y strain of T. cruzi and distributed into the following groups: CI (treated with 7% hydroalcoholic solution), Ca (treated with Kalium causticum 13cH), Co (treated with Conium maculatum 13cH), and Ly (treated with Lycopodium clavatum 13cH). The treatments were performed 48 h before and 48, 96, and 144 h after infection. The medication was repertorized and prepared in 13cH, according to Brazilian Homeopathic Pharmacopoeia. The following parameters were evaluated: infectivity, prepatent period, parasitemia peak, total parasitemia, tissue tropism, inflammatory infiltrate, and survival. Statistical analysis was conduced considering 5% of significance. RESULTS: The prepatent period was greater in the Ly group than in the CI group (p = 0.02). The number of trypomastigotes on the 8th day after infection was lower in the Ca group than in the CI group (p < 0.05). Total parasitemia was significantly lower in the Ca, Co, and Ly groups than in the CI group. On the 12th day after infection, the Ca, Co, and Ly groups had fewer nests and amastigotes/nest in the heart than the CI group (p < 0.05). Decreases in the number of nests and amastigotes in the intestine were observed in the Ly group compared with the CI group (p < 0.05). In the liver (day 12), Ly significantly prevented the formation of inflammatory foci compared with the other groups. In skeletal muscle, Co and Ly decreased the formation of inflammatory foci compared with CI (p < 0.05). Ly afforded greater animal survival compared with CI, Ca, and Co (p < 0.05). The animals in the Co group died prematurely compared with the CI group (p = 0.03). CONCLUSIONS: Ly with 13cH potency had significantly more benefits in the treatment of mice infected with T. cruzi, reducing the number of blood parasites, amastigote nests in tissue, and the number of amastigotes per nest and increasing animal survival.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Doença de Chagas/tratamento farmacológico
Homeopatia
Inflamação/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Estreptófitas
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/administração & dosagem
Antiprotozoários/farmacologia
Doença de Chagas/parasitologia
Conium
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Inflamação/patologia
Lycopodium
Masculino
Camundongos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Distribuição Aleatória
Trypanosoma cruzi/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE



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