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Pesquisa : B01.650.940.800.575.100.350 [Categoria DeCS]
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[PMID]:28846740
[Au] Autor:Ribeiro PPC; Silva DMLE; Assis CF; Correia RTP; Damasceno KSFDSC
[Ad] Endereço:Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil.
[Ti] Título:Bioactive properties of faveleira (Cnidoscolus quercifolius) seeds, oil and press cake obtained during oilseed processing.
[So] Source:PLoS One;12(8):e0183935, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To the best of our knowledge, this is the first report in the literature concerning the bioactive properties of faveleira products. This work focuses on the physicochemical evaluation of faveleira oil, as well as it investigates the bioactive properties of faveleira seeds, faveleira oil and the press cake obtained during the oilseed processing. The seeds were cold pressed and the following tests were performed: physicochemical characteristics (acidity, peroxide values, moisture and volatile matter, density and viscosity) and fatty acid profile of faveleira oil; total phenolic and flavonoid content of faveleira seed and press cake; antibacterial activity of seed, oil and press cake; and antioxidant activity (DPPH radical scavenging activity, reducing power assay, total antioxidant capacity, superoxide radical scavenging assay and oxygen radical absorbance capacity) of seed, oil and press cake. Our work demonstrated that the faveleira seed oil has low acidity (0.78 ± 0.03% oleic acid) and peroxide value (1.13 ± 0.12 mEq/1000g), associated with the relevant concentration of linoleic acid (53.56%). It was observed that important phenolics (398.89 ± 6.34 mg EAG/100 g), especially flavonoids (29.81 ± 0.71 mg RE/g) remain in the press cake, which indicates that the by-product of the faveleira oilseed production constitutes a rich residual source of bioactive compounds. No bacterial growth inhibition was detected, but all samples including faveleira seeds, press cake, oil and its fractions have potent antioxidant activities, mainly the press cake, with oxygen radical absorbance capacity of 28.39 ± 4.36 µM TE/g. Our results also show that faveleira oil has potential to be used as edible oil and the press cake should be used to contain the most antioxidants from seed.
[Mh] Termos MeSH primário: Euphorbiaceae/metabolismo
Óleos Vegetais/metabolismo
Sementes/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Euphorbiaceae/embriologia
Ácidos Graxos/metabolismo
Flavonoides/metabolismo
Fenóis/metabolismo
Extratos Vegetais/metabolismo
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Fatty Acids); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170828
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183935


  2 / 956 MEDLINE  
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[PMID]:28791544
[Au] Autor:Kyallo M; Ateka EM; Sseruwagi P; Ascencio-Ibáñez JT; Ssemakula MO; Skilton R; Ndunguru J
[Ad] Endereço:Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub, P.O. Box 30709-00100, Nairobi, Kenya. m.kyalo@cgiar.org.
[Ti] Título:Infectivity of Deinbollia mosaic virus, a novel weed-infecting begomovirus in East Africa.
[So] Source:Arch Virol;162(11):3439-3445, 2017 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Weed-infecting begomoviruses play an important role in the epidemiology of crop diseases because they can potentially infect crops and contribute to the genetic diversity of crop-infecting begomoviruses. Despite the important epidemiological role that weed-infecting begomoviruses play, they remain insufficiently studied in Africa. Recently, we identified Deinbollia mosaic virus (DMV), a distinct begomovirus found naturally infecting the weed host Deinbollia borbonica (Sapindaceae) in Kenya and Tanzania. In this study, we investigated the capacity of DMV to infect a restricted host range of Solanaceae and Euphorbiaceae species. Biolistic inoculation of Nicotiana benthamiana with concatemeric DNAs resulted in systemic infection associated with yellow mosaic symptoms, while DNA partial dimers caused asymptomatic systemic infection. DMV was not infectious to cassava (Manihot esculenta Crantz), suggesting host resistance to the virus. Here, we demonstrate the first experimental infectivity analysis of DMV in N. benthamiana and cassava.
[Mh] Termos MeSH primário: Begomovirus/fisiologia
Euphorbiaceae/virologia
Doenças das Plantas/virologia
Plantas Daninhas/virologia
Solanaceae/virologia
[Mh] Termos MeSH secundário: África Oriental
Folhas de Planta/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3495-x


  3 / 956 MEDLINE  
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[PMID]:28910307
[Au] Autor:Vasek J; Hlásná Cepková P; Viehmannová I; Ocelák M; Cachique Huansi D; Vejl P
[Ad] Endereço:Department of Genetics and Breeding, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká, Prague, Czech Republic.
[Ti] Título:Dealing with AFLP genotyping errors to reveal genetic structure in Plukenetia volubilis (Euphorbiaceae) in the Peruvian Amazon.
[So] Source:PLoS One;12(9):e0184259, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An analysis of the population structure and genetic diversity for any organism often depends on one or more molecular marker techniques. Nonetheless, these techniques are not absolutely reliable because of various sources of errors arising during the genotyping process. Thus, a complex analysis of genotyping error was carried out with the AFLP method in 169 samples of the oil seed plant Plukenetia volubilis L. from small isolated subpopulations in the Peruvian Amazon. Samples were collected in nine localities from the region of San Martin. Analysis was done in eight datasets with a genotyping error from 0 to 5%. Using eleven primer combinations, 102 to 275 markers were obtained according to the dataset. It was found that it is only possible to obtain the most reliable and robust results through a multiple-level filtering process. Genotyping error and software set up influence both the estimation of population structure and genetic diversity, where in our case population number (K) varied between 2-9 depending on the dataset and statistical method used. Surprisingly, discrepancies in K number were caused more by statistical approaches than by genotyping errors themselves. However, for estimation of genetic diversity, the degree of genotyping error was critical because descriptive parameters (He, FST, PLP 5%) varied substantially (by at least 25%). Due to low gene flow, P. volubilis mostly consists of small isolated subpopulations (ΦPT = 0.252-0.323) with some degree of admixture given by socio-economic connectivity among the sites; a direct link between the genetic and geographic distances was not confirmed. The study illustrates the successful application of AFLP to infer genetic structure in non-model plants.
[Mh] Termos MeSH primário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Euphorbiaceae/genética
Técnicas de Genotipagem
[Mh] Termos MeSH secundário: Peru
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184259


  4 / 956 MEDLINE  
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[PMID]:28803995
[Au] Autor:Saetang P; Rukachaisirikul V; Phongpaichit S; Preedanon S; Sakayaroj J; Borwornpinyo S; Seemakhan S; Muanprasat C
[Ad] Endereço:Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
[Ti] Título:Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf.
[So] Source:Phytochemistry;143:115-123, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 µg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 µg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Depsídeos/isolamento & purificação
Euphorbiaceae/química
Hevea/química
Lactonas/isolamento & purificação
Pironas/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antifúngicos/química
Antifúngicos/farmacologia
Cercopithecus aethiops
Cryptococcus neoformans/efeitos de drogas
Depsídeos/química
Depsídeos/farmacologia
Lactonas/química
Lactonas/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos de drogas
Testes de Sensibilidade Microbiana
Estrutura Molecular
Folhas de Planta/química
Pironas/química
Pironas/farmacologia
Staphylococcus aureus/efeitos de drogas
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Depsides); 0 (Lactones); 0 (Pyrones); 3580-77-6 (depsidone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


  5 / 956 MEDLINE  
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[PMID]:28490010
[Au] Autor:Banerjee K; Das S; Choudhury P; Ghosh S; Baral R; Choudhuri SK
[Ad] Endereço:Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata, India.
[Ti] Título:A Novel Approach of Synthesizing and Evaluating the Anticancer Potential of Silver Oxide Nanoparticles in vitro.
[So] Source:Chemotherapy;62(5):279-289, 2017.
[Is] ISSN:1421-9794
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the anticancer potential of biocompatible AgONPs in vitro. METHODS: A new approach of utilizing the leaf extract of Excoecaria agallocha was used to synthesize AgONPs. This was then characterized by ultraviolet-visible spectrophotometry, nanoparticle-tracking analysis, and ζ-potential analysis. Cytotoxicity and apoptotic potential were evaluated with an MTT assay and an annexin V-binding assay against the murine melanoma (B16F10), murine colon cancer (CT26), murine lung adenocarcinoma (3LL), and murine Ehrlich ascites carcinoma (EAC) cell lines. Cellular localization of AgONPs was evaluated on fluorescence microscopy. RESULTS: UV peaks at 270 and 330 nm indicated the formation of nanoparticles (NPs) and the NP-tracking analyzer revealed them to have a size of 228 nm. AgONPs exerted initial cytotoxicity, specifically against all the experimental malignant cells by sparing the normal cell lines. Moreover, AgONPs exert apoptosis equally on all the malignant cells in vitro and ex vivo. This cytotoxicity possibly occurs via the nuclear translocation of AgONPs as analyzed in B16F10 cells. CONCLUSIONS: AgONPs utilizing natural sources would be a new medicinal approach against a broad spectrum of malignancy.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos de drogas
Nanopartículas Metálicas/química
Óxidos/química
Extratos Vegetais/farmacologia
Compostos de Prata/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antineoplásicos/química
Linhagem Celular Tumoral
Núcleo Celular/metabolismo
Proliferação de Células/efeitos de drogas
Euphorbiaceae/química
Euphorbiaceae/metabolismo
Química Verde
Humanos
Camundongos
Microscopia Confocal
Tamanho da Partícula
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Oxides); 0 (Plant Extracts); 0 (Silver Compounds); 897WUN6G6T (disilver oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1159/000453446


  6 / 956 MEDLINE  
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[PMID]:28676114
[Au] Autor:Djimeli MN; Fodouop SPC; Njateng GSS; Fokunang C; Tala DS; Kengni F; Gatsing D
[Ad] Endereço:Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae).
[So] Source:BMC Complement Altern Med;17(1):349, 2017 Jul 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A. cordifolia is a plant widely used in Africa to solve many health problems. In Cameroon, it is used in the treatment of urogenital infections. As a continuation of our search for pharmacologically active agents from natural sources, the antimicrobial activity of A. cordifolia leaf extracts against E. coli and the toxicity of this extract were investigated. METHODS: The antibacterial activity of the aqueous extract from leaves of Alchornea cordifolia was carried out in vitro on Escherichia coli, as well as in vivo on E. coli-infected rat model. Phytochemical screening was performed using standard methods. The acute toxicity was investigated in mice, while at the end of treatment of infected rats, some biochemical, hematological and histological markers of toxicity were evaluated. RESULTS: The extract exhibited a bacteriostatic activity with MIC value of 1500 µg/ml. Phytochemical screening revealed the presence of phenols, tannins, triterpens, flavonoids, alkaloids, anthraquinones, anthocyanins, saponins and coumarins in the extract. The acute toxicity study showed LD values of 8.6 g/kg and 3.8 g/kg in male and female mice respectively. In vivo, the oral administration of the extract showed a dose-dependent decrease of the bacterial load as the extract at 232, 112 and 58 g/kg were able to eradicate the infection after 9, 11 and 13 days of treatment. The infected rats showed a significant (p < 0.05) increase in the level of serum creatinine, ALAT, white blood cells, and a significant (p < 0.05) decrease in the level of food and water intake, the relative weight of lungs, heart and spleen. In the treated rats, a significant (p < 0.05) increase in food and water intake and ALAT was observed at the doses of 116 and 232 mg/kg. A decrease in the red blood cells count and serum protein levels was also observed. These observations corroborate liver damages as revealed by the histopathological examination of the cross sections of this organ. CONCLUSION: The results of this assay thus showed that the extract of A. cordifolia is bacteriostatic, therapeutic at 58 g/kg bw and may be considered as slightly and almost non-toxic on females and males mice respectively.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Euphorbiaceae/química
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/isolamento & purificação
Antibacterianos/toxicidade
Escherichia coli/efeitos de drogas
Escherichia coli/crescimento & desenvolvimento
Infecções por Escherichia coli/quimioterapia
Infecções por Escherichia coli/microbiologia
Feminino
Humanos
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Folhas de Planta/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1854-5


  7 / 956 MEDLINE  
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[PMID]:28503066
[Au] Autor:Zhang K; Zhang Y; Li Z; Li N; Feng N
[Ad] Endereço:Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
[Ti] Título:Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo.
[So] Source:Int J Nanomedicine;12:3521-3532, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.
[Mh] Termos MeSH primário: Portadores de Fármacos/administração & dosagem
Portadores de Fármacos/química
Óleos Voláteis/administração & dosagem
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Tópica
Animais
Colesterol/química
Portadores de Fármacos/farmacocinética
Sistemas de Liberação de Medicamentos/métodos
Euphorbiaceae/química
Glucosídeos/administração & dosagem
Glucosídeos/química
Glucosídeos/farmacocinética
Glicerol/química
Cobaias
Lipossomos/química
Masculino
Camundongos
Monoterpenos/administração & dosagem
Monoterpenos/química
Monoterpenos/farmacocinética
Óleos Voláteis/química
Óleos Voláteis/farmacocinética
Permeabilidade
Ratos Sprague-Dawley
Absorção Cutânea/efeitos de drogas
Membrana Sinovial/efeitos de drogas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Glucosides); 0 (Liposomes); 0 (Monoterpenes); 0 (Oils, Volatile); 21AIQ4EV64 (peoniflorin); 97C5T2UQ7J (Cholesterol); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S135749


  8 / 956 MEDLINE  
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[PMID]:28480421
[Au] Autor:Reddy BS; Rao NR; Vijeepallam K; Pandy V
[Ad] Endereço:Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522034, Andra Pradesh, India.
[Ti] Título:PHYTOCHEMICAL, PHARMACOLOGICAL AND BIOLOGICAL PROFILES OF TRAGIA SPECIES (FAMILY: EUPHORBIACEAE).
[So] Source:Afr J Tradit Complement Altern Med;14(3):105-112, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tragia belongs to the family Euphorbiaceae which contains about 152 species. Interestingly, most of the earlier investigations have been done using only five Tragia species, namely, , , , , and . The objective of the present review is to compile the phytochemical, pharmacological and biological studies of the selected five Tragia species reported in the literature. METHODS: The reported data/information was retrieved mainly from the online databases of PubMed (MEDLINE), EMBASE and Botanical Survey of India. RESULTS: The present review elaborated the phytochemical, pharmacological and biological properties of the selected five Tragia species obtained from recent literature. CONCLUSION: This review provides a basis for future investigation of Tragia species and, especially for those species that have not been explored for biological and pharmacological activities.
[Mh] Termos MeSH primário: Euphorbiaceae/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Compostos Fitoquímicos/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.11


  9 / 956 MEDLINE  
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[PMID]:28187612
[Au] Autor:Liao JR; Ho CC; Ko CC
[Ad] Endereço:Department of Entomology, National Taiwan University, Taipei City 10617, Taiwan. user@example.com.
[Ti] Título:Species of the genus Euseius Wainstein (Acari: Phytoseiidae: Amblyseiinae) from Taiwan.
[So] Source:Zootaxa;4226(2):zootaxa.4226.2.3, 2017 Jan 26.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The six mite species of the genus Euseius Wainstein from Taiwan are reviewed, including E. ovalis (Evans), E. daluensis sp. nov., E. macaranga sp. nov., E. paraovalis sp. nov., and two species recorded for the first time in Taiwan, E. aizawai (Ehara & Bhandhufalck) and E. circellatus (Wu & Li). Measurements of these species and an identification key for adult females of the six Euseius species from Taiwan are provided.
[Mh] Termos MeSH primário: Ácaros e Carrapatos
[Mh] Termos MeSH secundário: Animais
Euphorbiaceae
Feminino
Ácaros
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4226.2.3


  10 / 956 MEDLINE  
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[PMID]:28340621
[Au] Autor:Fankam AG; Kuiate JR; Kuete V
[Ad] Endereço:Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria.
[So] Source:BMC Complement Altern Med;17(1):168, 2017 Mar 24.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the extracts of the leaves (RHL) and bark (RHB) of R. heudelotii for their antibacterial and antibiotic resistance modulating activities against 29 Gram-negative bacteria, including multidrug-resistant (MDR) phenotypes. METHODS: The broth micro-dilution assay was used to evaluate the antibacterial activity, and the antibiotic resistance modulating effects of the plant extracts. RESULTS: RHL displayed the most important spectrum of activity with minimal inhibitory concentrations (MICs) values ranging from 256 to 1024 µg/mL against 75.86% of the 29 tested bacteria strains while RHB was not active. RHL also showed killing effects with minimal bactericidal concentrations (MBCs) ranging from 256 to 1024 µg/mL. The activities of tetracycline and kanamycin associated with RHL were improved on 88.89% and 77.78% of the tested MDR bacteria, at MIC/2 at MIC/4 respectively, with 2 to 16-folds decreasing of MIC. This suggests the antibiotic resistance modulating effects of these antibiotics. CONCLUSION: The present study provides data indicating a possible use of the leaves extract of Recinodindron heudelotii alone or in association with common antibiotics in the fight against bacterial infections including those involving MDR bacteria.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Euphorbiaceae/química
Bactérias Gram-Negativas/efeitos de drogas
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Farmacorresistência Bacteriana Múltipla
Bactérias Gram-Negativas/fisiologia
Humanos
Canamicina/farmacologia
Testes de Sensibilidade Microbiana
Casca de Planta/química
Folhas de Planta/química
Tetraciclina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 59-01-8 (Kanamycin); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1687-2



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