Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.100.975.900.166 [Categoria DeCS]
Referências encontradas : 1431 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 144 ir para página                         

  1 / 1431 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27995378
[Au] Autor:Stanic Z
[Ad] Endereço:Faculty of Science, University of Kragujevac, Radoja Domanovica 12, P.O. Box 60, Kragujevac, 34000, Serbia. zorkas@kg.ac.rs.
[Ti] Título:Curcumin, a Compound from Natural Sources, a True Scientific Challenge - A Review.
[So] Source:Plant Foods Hum Nutr;72(1):1-12, 2017 Mar.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Curcumin, a plant-derived polyphenolic compound, naturally present in turmeric (Curcuma longa), has been the subject of intensive investigations on account of its various activities. The implementation of safe, beneficial and highly functional compounds from natural sources in human nutrition/prevention/therapy requires some modifications in order to achieve their multi-functionality, improve their bioavailability and delivery strategies, with the main aim to enhance their effectiveness. The low aqueous solubility of curcumin, its rapid metabolism and elimination from the body, and consequently, poor bioavailability, constitute major obstacles to its application. The main objectives of this review are related to reported strategies to overcome these limitations and, thereby, improve the solubility, stability and bioavailability of curcumin. The effectiveness of curcumin could be greatly improved by using nanoparticle-based carriers. The significance of the quality of a substance delivery system is reflected in the fact that carrying curcumin as a food additive/nutrition also means carrying the active biological product/drug. This review summarizes the state of the art, and highlights some examples and the most significant advances in the field of curcumin research.
[Mh] Termos MeSH primário: Curcuma/química
Curcumina/farmacocinética
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Curcumina/química
Aditivos Alimentares
Humanos
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Food Additives); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0590-1


  2 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28764078
[Au] Autor:Gad HA; Bouzabata A
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Abbassia, Cairo, Egypt. Electronic address: haidygad@pharma.asu.edu.eg.
[Ti] Título:Application of chemometrics in quality control of Turmeric (Curcuma longa) based on Ultra-violet, Fourier transform-infrared and H NMR spectroscopy.
[So] Source:Food Chem;237:857-864, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Turmeric (Curcuma longa L.) belongs to the family Zingiberaceae that is widely used as a spice in food preparations in addition to its biological activities. UV, FT-IR, H NMR in addition to HPLC were applied to construct a metabolic fingerprint for Turmeric in an attempt to assess its quality. 30 samples were analyzed, and then principal component analysis (PCA) and hierarchical clustering analysis (HCA) were utilized to assess the differences and similarities between collected samples. PCA score plot based on both HPLC and UV spectroscopy showed the same discriminatory pattern, where the samples were segregated into four main groups depending on their total curcuminoids content. The results revealed that UV could be utilized as a simple and rapid alternative for HPLC. However, FT-IR failed to discriminate between the same species. By applying H NMR, the metabolic variability between samples was more evident in the essential oils/fatty acid region.
[Mh] Termos MeSH primário: Curcuma
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Controle de Qualidade
Espectroscopia Infravermelho Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


  3 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28067055
[Au] Autor:Jena S; Ray A; Banerjee A; Sahoo A; Nasim N; Sahoo S; Kar B; Patnaik J; Panda PC; Nayak S
[Ad] Endereço:a Centre of Biotechnology , Siksha 'O' Anusandhan University , Bhubaneswar , India.
[Ti] Título:Chemical composition and antioxidant activity of essential oil from leaves and rhizomes of Curcuma angustifolia Roxb.
[So] Source:Nat Prod Res;31(18):2188-2191, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The essential oil extracted from rhizome and leaf of Curcuma angustifolia Roxb. (Zingiberaceae) was characterised by gas chromatography-mass spectrometry (GC-MS). The GC-MS analysis revealed the presence of 32 and 35 identified constituents, comprising 92.6% and 92% of total leaf and rhizome oil, respectively. Curzerenone (33.2%), 14-hydroxy-δ-cadinene (18.6%) and γ-eudesmol acetate (7.3%) were the main components in leaf oil. In rhizome oil, curzerenone (72.6%), camphor (3.3%) and germacrone (3.3%) were found to be the major constituents. Antioxidant capacities of oil were assessed by various methods, 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power ability (RPA). Based on the results, the leaf oil showed more antioxidant potential as compared to rhizome oil and reference standards (ascorbic acid and butylated hydroxytoluene (BHT)). Thus, the leaf essential oil of C. angustifolia can be used as an alternative source of natural antioxidant.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Curcuma/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Folhas de Planta/química
Rizoma/química
Sesquiterpenos/análise
Sesquiterpenos de Eudesmano/análise
Sesquiterpenos de Germacrano/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 0 (Sesquiterpenes, Germacrane); 0 (delta-cadinene); 0 (gamma-eudesmol); 6902-91-6 (germacrone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1278600


  4 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28255816
[Au] Autor:Gevú KV; Lima HRP; Kress J; Da Cunha M
[Ad] Endereço:Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, Parque Califórnia, Campos dos Goytacazes, RJ, 28013-602, Brazil.
[Ti] Título:Morphological analysis of vessel elements for systematic study of three Zingiberaceae tribes.
[So] Source:J Plant Res;130(3):527-538, 2017 May.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Zingiberaceae containing over 1,000 species that are divided into four subfamilies and six tribes. In recent decades, there has been an increase in the number of studies about vessel elements in families of monocotyledon. However, there are still few studies of Zingiberaceae tribes. This study aims to establish systematic significance of studying vessel elements in two subfamilies and three tribes of Zingiberaceae. The vegetative organs of 33 species processed were analysed by light and scanning electron microscopy and Principal Component Analysis was used to elucidate genera boundaries. Characteristics of vessel elements, such as the type of perforation plate, the number of bars and type of parietal thickening, are proved to be important for establishing the relationship among taxa. Scalariform perforation plate and the scalariform parietal thickening are frequent in Zingiberaceae and may be a plesiomorphic condition for this taxon. In the Principal Component Analysis, the most significant characters of the vessel elements were: simple perforation plates and partially pitted parietal thickening, found only in Alpinieae tribe, and 40 or more bars composing the plate in Elettariopsis curtisii, Renealmia chrysotricha, Zingiber spectabile, Z. officinale, Curcuma and Globba species. Vessel elements characters of 18 species of Alpinieae, Zingibereae and Globbeae were first described in this work.
[Mh] Termos MeSH primário: Filogenia
Feixe Vascular de Plantas/anatomia & histologia
Feixe Vascular de Plantas/citologia
Grupos Populacionais/classificação
Zingiberaceae/anatomia & histologia
Zingiberaceae/classificação
[Mh] Termos MeSH secundário: Angiospermas/anatomia & histologia
Angiospermas/classificação
Angiospermas/citologia
Curcuma
Humanos
Microscopia Eletrônica de Varredura
Extratos Vegetais
Folhas de Planta/anatomia & histologia
Raízes de Plantas/anatomia & histologia
Feixe Vascular de Plantas/classificação
Rizoma/anatomia & histologia
Especificidade da Espécie
Xilema
Zingiberaceae/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 856YO1Z64F (turmeric extract)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-017-0911-y


  5 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27966512
[Au] Autor:Makhija PP; Shigli K; Awinashe V
[Ad] Endereço:Department of Prosthodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
[Ti] Título:Evaluating the efficacy of denture cleansing materials in removal of tea and turmeric stains: An study.
[So] Source:Indian J Dent Res;27(5):528-534, 2016 Sep-Oct.
[Is] ISSN:1998-3603
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Extrinsic staining of acrylic resin dentures could be a major esthetic problem for denture wearers. Tea, coffee, cola, turmeric, and tobacco often cause extrinsic staining of dentures. AIM: To evaluate the efficacy of various denture cleansing materials in the removal of tea and turmeric stains and to compare the efficacy of those denture cleansers with each other in the removal of tea and turmeric stains. MATERIALS AND METHODS: Heat-cured acrylic resin specimens were stained using tea and turmeric solutions. The spectrophotometer was used to determine the reflectance values of the samples and to evaluate the efficacy of various denture cleansing materials in removal of tea and turmeric stains. Three denture cleansers, namely, sodium hypochlorite, Safe plus, and Clinsodent were used in the study. Water was used as a control. STATISTICAL ANALYSIS USED: ANOVA test and post hoc Tukey's test were used to determine the statistical difference between the groups. RESULT: A statistically significant difference was found (p ≤ 0.05) between the different denture cleansing materials used. Products containing sodium perborate along with trisodium phosphate had the highest stain removing capability. CONCLUSION: It was found that all the denture cleansing materials used in the study were effective in removing tea and turmeric stains. Products containing sodium perborate along with trisodium phosphate had a comparatively greater stain removal capability than products containing sodium perborate along with sodium bicarbonate followed by products containing sodium hypochlorite followed by water (control).
[Mh] Termos MeSH primário: Curcuma/efeitos adversos
Higienizadores de Dentadura/uso terapêutico
Chá/efeitos adversos
[Mh] Termos MeSH secundário: Resinas Acrílicas
Corantes
Dentaduras
Humanos
Técnicas In Vitro
Espectrofotometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Coloring Agents); 0 (Denture Cleansers); 0 (Tea)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.4103/0970-9290.195643


  6 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Rados, Pantelis Varvaki
Texto completo
[PMID]:28782139
[Au] Autor:de Campos PS; Matte BF; Diel LF; Jesus LH; Bernardi L; Alves AM; Rados PV; Lamers ML
[Ad] Endereço:Basic Research Center, Dentistry School, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Título:Low Doses of Curcuma longa Modulates Cell Migration and Cell-Cell Adhesion.
[So] Source:Phytother Res;31(9):1433-1440, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cell invasion and metastasis are involved in clinical failures in cancer treatment, and both events require the acquisition of a migratory behavior by tumor cells. Curcumin is a promising natural product with anti-proliferative activity, but its effects on cell migration are still unclear. We evaluated the effects of curcumin on the proliferation, apoptosis, migration, and cell-cell adhesion of keratinocyte, oral squamous cell carcinoma (OSCC), and fibroblast cell lines, as well as in a xenograft model of OSCC. Curcumin (2 µM) decreased cell proliferation in cell lines with mesenchymal characteristics, while cell death was detected only at 50 µM. We observed that highly migratory cells showed a decrease on migration speed and directionality when treated with 2 or 5 µM of curcumin (50% and 40%, respectively, p < 0.05). Using spheroids, we observed that curcumin dose dependently decreased cell-cell adhesion, especially on tumor-derived spheroids. Also, in a xenograft model with patient-derived OSCC cells, the administration of curcumin decreased tumor growth and aggressiveness when compared with untreated tumors, indicating the potential antitumor effect in oral cancer. These results suggest that lower doses of curcumin can influence several steps involved in tumorigenesis, including migration properties, suggesting a possible use in cancer therapy. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/quimioterapia
Adesão Celular/efeitos de drogas
Movimento Celular/efeitos de drogas
Curcuma/química
Curcumina/farmacologia
Neoplasias Bucais/quimioterapia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos de drogas
Carcinogênese
Carcinoma de Células Escamosas/patologia
Linhagem Celular
Proliferação de Células/efeitos de drogas
Humanos
Queratinócitos/efeitos de drogas
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Neoplasias Bucais/patologia
Células NIH 3T3
Esferoides Celulares/efeitos de drogas
Células Tumorais Cultivadas
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5872


  7 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28625730
[Au] Autor:Zhou CX; Zhang LS; Chen FF; Wu HS; Mo JX; Gan LS
[Ad] Endereço:College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
[Ti] Título:Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells.
[So] Source:Fitoterapia;121:141-145, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thirty four terpenoids, including two new cadinane-type sesquiterpenoids containing conjugated aromatic-ketone moieties, curcujinone A (1) and curcujinone B (2), were isolated from 95% ethanol extract of the root tubers of Curcuma wenyujin. Their structures were determined by spectroscopic methods, especially 2D NMR and HRMS techniques. The relative and absolute configurations of 1 and 2 were identified by quantum chemical DFT and TDDFT calculations of the C NMR chemical shifts, ECD spectra, and specific optical rotations. All compounds and extracts were evaluated for their anti-diabetic activities with a glucose consumption model on HepG2 Cells. The petroleum fraction CWP (10µg/mL) and compounds curcumenol (4), 7α,11α-epoxy-5ß-hydroxy-9-guaiaen-8-one (5), curdione (17), (1S, 4S, 5S 10S)-germacrone (18), zederone (20), a mixture of curcumanolide A (25) and curcumanolide B (26), gajutsulactone B (27), and wenyujinin C (30) showed promising activities with over 45% increasing of glucose consumption at 10µM.
[Mh] Termos MeSH primário: Curcuma/química
Glucose/metabolismo
Sesquiterpenos/química
Terpenos/química
[Mh] Termos MeSH secundário: Células Hep G2
Humanos
Estrutura Molecular
Tubérculos/química
Sesquiterpenos de Germacrano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); 0 (Terpenes); 0 (cadinane); 0 (curcumenol); 0 (curdione); 6902-91-6 (germacrone); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE


  8 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27507487
[Au] Autor:Nguyen TTH; Si J; Kang C; Chung B; Chung D; Kim D
[Ad] Endereço:The Institute of Food Industrialization, Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, South Korea. Electronic address: hara2910@snu.ac.kr.
[Ti] Título:Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides.
[So] Source:Food Chem;214:366-373, 2017 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. Curcuminoids solubilized in water showed 80% stability at pH from 6.0 to 10.0 after 1week of storage at 25°C. The particle sizes of curcuminoids prepared with Ste, RebA, and SG were 110.8, 95.7, and 32.7nm, respectively. The water soluble turmeric extracts prepared with Ste, RebA, and SG showed the 2,2-diphenyl-1-picrylhydrazyl radical scavenging (SC50) activities of 127.6, 105.4, and 109.8µg/ml, and the inhibition activities (IC50) against NS2B-NS3(pro) from dengue virus type IV of 14.1, 24.0 and 15.3µg/ml, respectively.
[Mh] Termos MeSH primário: Curcuma/química
Curcumina/análise
Diterpenos Caurânicos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Glucosídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0 (Plant Extracts); 0YON5MXJ9P (stevioside); 4741LYX6RT (steviol); 856YO1Z64F (turmeric extract); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


  9 / 1431 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28148897
[Au] Autor:Wu J; Feng Y; Han C; Huang W; Shen Z; Yang M; Chen W; Ye L
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
[Ti] Título:Germacrone derivatives: synthesis, biological activity, molecular docking studies and molecular dynamics simulations.
[So] Source:Oncotarget;8(9):15149-15158, 2017 Feb 28.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Germacrone is one of the major bioactive components in the Curcuma zedoaria oil product, which is extracted from Curcuma zedoaria Roscoe, known as zedoary. The present study designed some novel germacrone derivatives based on combination principles, synthesized these compounds, and investigated their inhibitions on Bel-7402, HepG2, A549 and HeLa cells. Meanwhile, the study evaluated inhibitions of these derivatives on c-Met kinase, which has been detected in a number of cancers. The results suggested that the majority of the compounds showed stronger inhibitory effect on cancers and c-Met kinase than germacrone. Furthermore, our docking experiments analyzed the results and explained the molecular mechanism. Molecular dynamics simulations were then applied to perform further evaluation of the binding stabilities between compounds and their receptors.
[Mh] Termos MeSH primário: Curcuma/química
Neoplasias/quimioterapia
Extratos Vegetais/farmacologia
Sesquiterpenos de Germacrano/química
Sesquiterpenos de Germacrano/farmacologia
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos/química
Antineoplásicos/farmacologia
Apoptose/efeitos de drogas
Proliferação de Células/efeitos de drogas
Células HeLa
Células Hep G2
Humanos
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
Neoplasias/metabolismo
Neoplasias/patologia
Proteínas Proto-Oncogênicas c-met/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); 0 (Sesquiterpenes, Germacrane); 6902-91-6 (germacrone); EC 2.7.10.1 (MET protein, human); EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14832


  10 / 1431 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28792522
[Au] Autor:Jaja-Chimedza A; Graf BL; Simmler C; Kim Y; Kuhn P; Pauli GF; Raskin I
[Ad] Endereço:Department of Plant Biology, Rutgers University, New Brunswick, New Jersey, United States of America.
[Ti] Título:Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract.
[So] Source:PLoS One;12(8):e0182658, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Moringa oleifera Lam. is a tropical plant, used for centuries as food and traditional medicine. The aim of this study was to develop, validate and biochemically characterize an isothiocyanate-enriched moringa seed extract (MSE), and to compare the anti-inflammatory effects of MSE-containing moringa isothiocyanate-1 (MIC-1) with a curcuminoid-enriched turmeric extract (CTE), and a material further enriched in its primary phytochemical, curcumin (curcumin-enriched material; CEM). MSE was prepared by incubating ground moringa seeds with water to allow myrosinase-catalyzed enzymatic formation of bioactive MIC-1, the predominant isothiocyanate in moringa seeds. Optimization of the extraction process yielded an extract of 38.9% MIC-1. Phytochemical analysis of MSE revealed the presence of acetylated isothiocyanates, phenolic glycosides unique to moringa, flavonoids, fats and fatty acids, proteins and carbohydrates. MSE showed a reduction in the carrageenan-induced rat paw edema (33% at 500 mg/kg MIC-1) comparable to aspirin (27% at 300 mg/kg), whereas CTE did not have any significant effect. In vitro, MIC-1 at 1 µM significantly reduced the production of nitric oxide (NO) and at 5 µM, the gene expression of LPS-inducible nitric oxide synthase (iNOS) and interleukins 1ß and 6 (IL-1ß and IL-6), whereas CEM did not show any significant activity at all concentrations tested. MIC-1 (10µM) was also more effective at upregulating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) target genes NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase pi 1 (GSTP1), and heme oxygenase 1 (HO1) than the CEM. Thus, in contrast to CTE and CEM, MSE and its major isothiocyanate MIC-1 displayed strong anti-inflammatory and antioxidant properties in vivo and in vitro, making them promising botanical leads for the mitigation of inflammatory-mediated chronic disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/farmacologia
Moringa oleifera/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sementes/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Carragenina
Linhagem Celular
Curcuma/química
Curcumina/química
Modelos Animais de Doenças
Avaliação Pré-Clínica de Medicamentos
Edema/quimioterapia
Edema/imunologia
Membro Posterior/efeitos de drogas
Membro Posterior/imunologia
Inflamação/quimioterapia
Inflamação/imunologia
Isotiocianatos/química
Macrófagos/efeitos de drogas
Macrófagos/metabolismo
Masculino
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Distribuição Aleatória
Ratos Sprague-Dawley
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Isothiocyanates); 0 (Phytochemicals); 0 (Plant Extracts); 3129-90-6 (isothiocyanic acid); 9000-07-1 (Carrageenan); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182658



página 1 de 144 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde