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Pesquisa : B01.650.940.800.575.100.975.900.166 [Categoria DeCS]
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[PMID]:28143589
[Au] Autor:Lee GH; Lee HY; Choi MK; Chung HW; Kim SW; Chae HJ
[Ad] Endereço:Department of Pharmacology and New Drug Development Institute, Chonbuk National University Medical School, Jeonju, Chonbuk, 561-180, Republic of Korea.
[Ti] Título:Protective effect of Curcuma longa L. extract on CCl -induced acute hepatic stress.
[So] Source:BMC Res Notes;10(1):77, 2017 Feb 01.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Curcuma longa L. (CLL) rhizome has long been used to treat patients with hepatic dysfunction. CLL is a member of the ginger family of spices that are widely used in China, India, and Japan, and is a common spice, coloring, flavoring, and traditional medicine. This study was performed to evaluate the hepatoprotective activity of CLL extract and its active component curcumin in an acute carbon tetrachloride (CCl )-induced liver stress model. METHODS: Acute hepatic stress was induced by a single intraperitoneal injection of CCl (0.1 ml/kg body weight) in rats. CLL extract was administered once a day for 3 days at three dose levels (100, 200, and 300 mg/kg/day) and curcumin was administered once a day at the 200 mg/kg/day. We performed alanine transaminase (ALT) and aspartate transaminase (AST). activity analysis and also measured total lipid, triglyceride, and cholesterol levels, and lipid peroxidation. RESULTS: At 100 g CLL, the curcuminoid components curcumin (901.63 ± 5.37 mg/100 g), bis-demethoxycurcumin (108.28 ± 2.89 mg/100 g), and demethoxycurcumin (234.85 ± 1.85 mg/100 g) were quantified through high liquid chromatography analysis. In CCl -treated rats, serum AST and ALT levels increased 2.1- and 1.2-fold compared with the control. AST but not ALT elevation induced by CCl was significantly alleviated in CLL- and curcumin-treated rats. Peroxidation of membrane lipids in the liver was significantly prevented by CLL (100, 200, and 300 mg/kg/day) on tissue lipid peroxidation assay and immunostaining with anti-4HNE antibody. We found that CLL extract and curcumin exhibited significant protection against liver injury by improving hepatic superoxide dismutase (p < 0.05) and glutathione peroxidase activity, and glutathione content in the CCl -treated group (p < 0.05), leading to a reduced lipid peroxidase level. CONCLUSION: Our data suggested that CLL extract and curcumin protect the liver from acute CCl -induced injury in a rodent model by suppressing hepatic oxidative stress. Therefore, CLL extract and curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Curcuma/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Alanina Transaminase/metabolismo
Animais
Anti-Inflamatórios não Esteroides/farmacologia
Aspartato Aminotransferases/sangue
Aspartato Aminotransferases/metabolismo
Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Colesterol/análise
Cromatografia Líquida de Alta Pressão
Curcumina/farmacologia
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos de drogas
Lipídeos/análise
Lipídeos/sangue
Fígado/efeitos de drogas
Fígado/metabolismo
Fígado/patologia
Masculino
Estresse Oxidativo/efeitos de drogas
Fitoterapia
Ratos Sprague-Dawley
Rizoma/química
Superóxido Dismutase/metabolismo
Triglicerídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lipids); 0 (Plant Extracts); 0 (Protective Agents); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol); CL2T97X0V0 (Carbon Tetrachloride); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170216
[Lr] Data última revisão:
170216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2409-z


  2 / 1313 MEDLINE  
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[PMID]:27507487
[Au] Autor:Nguyen TT; Si J; Kang C; Chung B; Chung D; Kim D
[Ad] Endereço:The Institute of Food Industrialization, Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, South Korea. Electronic address: hara2910@snu.ac.kr.
[Ti] Título:Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides.
[So] Source:Food Chem;214:366-73, 2017 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. Curcuminoids solubilized in water showed 80% stability at pH from 6.0 to 10.0 after 1week of storage at 25°C. The particle sizes of curcuminoids prepared with Ste, RebA, and SG were 110.8, 95.7, and 32.7nm, respectively. The water soluble turmeric extracts prepared with Ste, RebA, and SG showed the 2,2-diphenyl-1-picrylhydrazyl radical scavenging (SC50) activities of 127.6, 105.4, and 109.8µg/ml, and the inhibition activities (IC50) against NS2B-NS3(pro) from dengue virus type IV of 14.1, 24.0 and 15.3µg/ml, respectively.
[Mh] Termos MeSH primário: Curcuma/química
Curcumina/análise
Diterpenos Caurânicos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Glucosídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0 (Plant Extracts); 0YON5MXJ9P (stevioside); 4741LYX6RT (steviol); 856YO1Z64F (turmeric extract); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


  3 / 1313 MEDLINE  
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[PMID]:27855875
[Au] Autor:Hu Y; Zhang J; Kong W; Zhao G; Yang M
[Ad] Endereço:School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, PR China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical
[Ti] Título:Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus.
[So] Source:Food Chem;220:1-8, 2017 Apr 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The antifungal activity and potential mechanisms in vitro as well as anti-aflatoxigenic efficiency in vivo of natural essential oil (EO) derived from turmeric (Curcuma longa L.) against Aspergillus flavus was intensively investigated. Based on the previous chemical characterization of turmeric EO by gas chromatography-mass spectrometry, the substantially antifungal activities of turmeric EO on the mycelial growth, spore germination and aflatoxin production were observed in a dose-dependent manner. Furthermore, these antifungal effects were related to the disruption of fungal cell endomembrane system including the plasma membrane and mitochondria, specifically i.e. the inhibition of ergosterol synthesis, mitochondrial ATPase, malate dehydrogenase, and succinate dehydrogenase activities. Moreover, the down-regulation profiles of turmeric EO on the relative expression of mycotoxin genes in aflatoxin biosynthetic pathway revealed its anti-aflatoxigenic mechanism. Finally, the suppression effect of fungal contamination in maize indicated that turmeric EO has potential as an eco-friendly antifungal agent.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus flavus/efeitos de drogas
Curcuma
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aflatoxinas/biossíntese
Regulação para Baixo/efeitos de drogas
Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Antifungal Agents); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161231
[Lr] Data última revisão:
161231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


  4 / 1313 MEDLINE  
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[PMID]:27491236
[Au] Autor:Wang SL; Xie T; Zeng ZW; Pang XQ; Liu N; Yang YJ; Zhao H; Zhang DF
[Ti] Título:[Study on the Fingerprint of Kingkong Zedoary Turmeric Oil].
[So] Source:Zhongguo Zhong Xi Yi Jie He Za Zhi;36(6):744-8, 2016 Jun.
[Is] ISSN:1003-5370
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the fingerprint of Zedoary Turmeric Oil (ZTO) as the bulk drug of Kingkong Elemene for making it safe, effective, stable, and controllable. METHODS: Fingerprints were detected by gas chromatography. ß-elemene peak was regarded as reference peak (S). The relative peak area of each common peak and the relative retention time were calculated. With a total of modes for reference, the fingerprints of 10 batches of Kingkong ZTO were detected, and their similarity was calculated by traditional Chinese medicine (TCM) fingerprint similarity calculation software. RESULTS: The determination method was stable and reliable. Totally 19 common characteristic peaks of Kingkong ZTO was found. The fingerprint similarity of these batches of Kingkong ZTO were not lower than 0.96. CONCLUSIONS: Gas chromatography for detecting the fingerprint of Kingkong ZTO was reliable and repeatable. The established fingerprint of Kingkong ZTO could guarantee the quality stability and safety of different product batches.
[Mh] Termos MeSH primário: Curcuma/química
Óleos Vegetais/química
Sesquiterpenos/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Medicamentos de Ervas Chinesas/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (beta-elemene)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE


  5 / 1313 MEDLINE  
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[PMID]:27393429
[Au] Autor:Hayat S; Sabri AN
[Ad] Endereço:Department of Microbiology and Molecular Genetics, Universityof the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan.
[Ti] Título:Screening for antibiofilm and antioxidant potential of turmeric (Curcuma longa) extracts.
[So] Source:Pak J Pharm Sci;29(4):1163-70, 2016 Jul.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The antibiofilm and antioxidant activities associated with turmeric were the main focus of the study. Antibacterial activity was explored against bacteria isolated from dental plaques and dental unit water lines exhibiting resistance against antibiotics and biocides respectively. This study provides a comparison of the natural plant extract against synthetic mouthwash, chemicals and commonly prescribed antibiotics. Methanol extract was more effective as compared to other extracts. Minimum inhibitory concentrations (MIC) ranged from 2.5-10mg/ml. Time based killing kinetic assay showed a significant reduction of bacterial load with increasing concentration of turmeric. Micro titer plate assay indicated significant inhibition of biofilm formation in cells treated with turmeric extract. Phytochemical screening of plant extracts showed the presence of vital secondary metabolites. Flavonoid content and total phenolic content varied among extracts, phenolic content for methanolic extract was 61.669 mg GAE/ gm dry extract and flavonoid content was 3.119mg quercitin/gm dry extract. The values of ferric reducing power were in the range of 5.55- 15.55 mmol of FeSO4 equivalent/ liter of the extract. Antioxidant activities and total phenolic content of the turmeric extracts had significant positive correlation. On the basis of these results turmeric may confidently be recommended as natural antibiofilm and antioxidant agent.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Biofilmes/efeitos de drogas
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Curcuma
Flavonoides/análise
Extratos Vegetais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 856YO1Z64F (turmeric extract)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE


  6 / 1313 MEDLINE  
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[PMID]:27211357
[Au] Autor:Korossy A; Blázovics A
[Ad] Endereço:Farmakognóziai Intézet, Semmelweis Egyetem, Gyógyszerésztudományi Kar Budapest.
[Ti] Título:[Ajurveda in modern medical science].
[Ti] Título:Ájurvéda a modern orvostudományban..
[So] Source:Orv Hetil;157(22):873-6, 2016 May 29.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Mh] Termos MeSH primário: Educação Médica/história
Órgãos Governamentais
Saúde Holística
Medicina Ayurvédica
Fitoterapia
Plantas Medicinais
[Mh] Termos MeSH secundário: Curcuma
Curcumina/uso terapêutico
Contaminação de Medicamentos
Europa (Continente)/etnologia
Órgãos Governamentais/organização & administração
História do Século XVIII
História do Século XIX
História Antiga
Saúde Holística/educação
Saúde Holística/tendências
Humanos
Hungria
Índia
Intoxicação por Chumbo/etiologia
Medicina Ayurvédica/história
Farmacopeias como Assunto
Extratos Vegetais/uso terapêutico
Estados Unidos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160523
[Lr] Data última revisão:
160523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1556/650.2016.HO2545


  7 / 1313 MEDLINE  
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[PMID]:27087084
[Au] Autor:Hassan W; Gul S; Rehman S; Kanwal F; Afridi MS; Fazal H; Shah Z; Rahman A; da Rocha JB
[Ad] Endereço:Institute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan / Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP, RS, Brazil.
[Ti] Título:Gas chromatography coupled with mass spectrometric characterization of Curcuma longa: Protection against pathogenic microbes and lipid peroxidation in rat's tissue homogenate.
[So] Source:Pak J Pharm Sci;29(2):615-21, 2016 Mar.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the mineral content and antimicrobial activity of Curcuma Longa extracts and its essential oil. We also determined the lipid peroxidation inhibition activity of the ethanolic extract against sodium nitroprusside (SNP) induced thiobarbituric acid reactive species (TBARS) formation in rat's brain, kidney and liver homogenates. Major constituents of essential oil identified by gas chromatography and mass spectrometry (GCMS) were beta-sesquiphellandrene (38.69%), alpha-curcumene (18.44%) and p-mentha-1,4 (8)-diene (16.29%). Atomic absorption spectroscopy (AAS) was used for the quantitative estimation of Calcium (Ca), Magnesium (Mg), Iron (Fe), Copper (Cu), Zinc (Zn), Chromium (Cr), Nickel (Ni) and Manganese (Mn). The extract showed highest Mg (49.4 mg/l) concentration followed by Ca (35.42 mg/l) and Fe (1.27 mg/l). Our data revealed that the ethanolic extract of Curcuma Longa at 1-10 mg/kg significantly inhibited TBARS production in all tested homogenates. Crude extracts and essential oil were tested against three gram positive bacteria i.e. Bacillus subtilis, Bacillus atrophoeus, Staphylococcus aureus, six gram negative bacteria i.e. Escherichia coli, Klebsiella pneumonias, Salmonella typhi, Pseudomonas aeruginosa, Erwinia carotovora, Agrobacterium tumefaciens and one fungal strain namely Candida albicans by disc diffusion assay. Essential oil showed highest anti-microbial activity as compared to the crude extracts. The present study confirms the significant antimicrobial and antioxidant potential of the studied plant, which can be considered as a diet supplement for a variety of oxidative stress induced or infectious diseases.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Curcuma/química
Cromatografia Gasosa-Espectrometria de Massas
Peroxidação de Lipídeos/efeitos de drogas
Óleos Voláteis/farmacologia
Estresse Oxidativo/efeitos de drogas
Extratos Vegetais/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/isolamento & purificação
Antioxidantes/isolamento & purificação
Bactérias/efeitos de drogas
Bactérias/crescimento & desenvolvimento
Encéfalo/efeitos de drogas
Encéfalo/metabolismo
Candida albicans/efeitos de drogas
Candida albicans/crescimento & desenvolvimento
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Relação Dose-Resposta a Droga
Etanol/química
Rim/efeitos de drogas
Rim/metabolismo
Fígado/efeitos de drogas
Fígado/metabolismo
Malondialdeído/metabolismo
Nitroprussiato/farmacologia
Óleos Voláteis/isolamento & purificação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Plantas Medicinais
Solventes/química
Espectrofotometria Atômica
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils); 0 (Solvents); 0 (Thiobarbituric Acid Reactive Substances); 169D1260KM (Nitroprusside); 3K9958V90M (Ethanol); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160418
[Lr] Data última revisão:
160418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE


  8 / 1313 MEDLINE  
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[PMID]:27036211
[Au] Autor:Tong S; Lu M; Chu C; Yan J; Huang J; Ying Y
[Ad] Endereço:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address: sqtong@zjut.edu.cn.
[Ti] Título:Selective isolation of components from natural volatile oil by countercurrent chromatography with cyclodextrins as selective reagent.
[So] Source:J Chromatogr A;1444:99-105, 2016 Apr 29.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Selective separation of chemical components from seven kinds of volatile oil by countercurrent chromatography with three types of cyclodextrins as selective reagent was investigated in this work. Preparative separation of chemical components from volatile oil is generally quite challenging due to their extremely complexity of the composition. A biphasic solvent system n-hexane-0.10 mol L(-1) cyclodextrin (1:1, v/v) was selected for separation of components from volatile oil and three types of cyclodextrins were investigated, including ß-cyclodexrin, methyl-ß-cyclodexrin and hydroxypropyl-ß-cyclodexrin. All kinds of volatile oils are from seven kinds of traditional Chinese herb. Results showed that some chemical components could be well separated with high purity from each kind of volatile oil using different type of cyclodextrin as selective reagent. For example, germacrone and curcumenone could be selectively separated from volatile oil of Curcumae Rhizoma with methyl-ß-cyclodexrin and hydroxypropyl-ß-cyclodexrin as selector respectively, and other five components were selectively separated from volatile oil of Chuanxiong Rhizoma, Myristicae Semen, Aucklandiae Radix and Angelicae Sinensis Radix by countercurrent chromatography with different cyclodexrin as selective reagent. Separation mechanism for separation of components from volatile oil by countercurrent chromatography with cyclodextrin as selective reagent was proposed. Peak resolution of the present separation method could be greatly influenced by the chemical compositions of volatile oil.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Distribuição Contracorrente
Ciclodextrinas/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Curcuma/química
Hexanos/química
Rizoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclodextrins); 0 (Hexanes); 0 (Oils, Volatile); 2DDG612ED8 (n-hexane)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160411
[Lr] Data última revisão:
160411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160411
[St] Status:MEDLINE


  9 / 1313 MEDLINE  
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[PMID]:26984113
[Au] Autor:Ford CT; Richardson S; McArdle F; Lotito SB; Crozier A; McArdle A; Jackson MJ
[Ad] Endereço:1Department of Musculoskeletal Biology,Institute of Ageing and Chronic Disease,University of Liverpool,Liverpool L7 8TX,UK.
[Ti] Título:Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes.
[So] Source:Br J Nutr;115(10):1699-710, 2016 May 28.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diets rich in fruits and vegetables (FV), which contain (poly)phenols, protect against age-related inflammation and chronic diseases. T-lymphocytes contribute to systemic cytokine production and are modulated by FV intake. Little is known about the relative potency of different (poly)phenols in modulating cytokine release by lymphocytes. We compared thirty-one (poly)phenols and six (poly)phenol mixtures for effects on pro-inflammatory cytokine release by Jurkat T-lymphocytes. Test compounds were incubated with Jurkat cells for 48 h at 1 and 30 µm, with or without phorbol ester treatment at 24 h to induce cytokine release. Three test compounds that reduced cytokine release were further incubated with primary lymphocytes at 0·2 and 1 µm for 24 h, with lipopolysaccharide added at 5 h. Cytokine release was measured, and generation of H2O2 by test compounds was determined to assess any potential correlations with cytokine release. A number of (poly)phenols significantly altered cytokine release from Jurkat cells (P<0·05), but H2O2 generation did not correlate with cytokine release. Resveratrol, isorhamnetin, curcumin, vanillic acid and specific (poly)phenol mixtures reduced pro-inflammatory cytokine release from T-lymphocytes, and there was evidence for interaction between (poly)phenols to further modulate cytokine release. The release of interferon-γ induced protein 10 by primary lymphocytes was significantly reduced following treatment with 1 µm isorhamnetin (P<0·05). These results suggest that (poly)phenols derived from onions, turmeric, red grapes, green tea and açai berries may help reduce the release of pro-inflammatory mediators in people at risk of chronic inflammation.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Linfócitos/efeitos de drogas
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos de drogas
Doença Crônica
Curcuma/química
Curcumina/farmacologia
Euterpe/química
Feminino
Humanos
Peróxido de Hidrogênio/metabolismo
Inflamação/quimioterapia
Células Jurkat
Lipopolissacarídeos/metabolismo
Linfócitos/metabolismo
Meia-Idade
Cebolas/química
Quercetina/análogos & derivados
Quercetina/farmacologia
Estilbenos/farmacologia
Chá/química
Ácido Vanílico/farmacologia
Vitis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Lipopolysaccharides); 0 (Polyphenols); 0 (Stilbenes); 0 (Tea); 07X3IB4R4Z (3-methylquercetin); 9IKM0I5T1E (Quercetin); BBX060AN9V (Hydrogen Peroxide); GM8Q3JM2Y8 (Vanillic Acid); IT942ZTH98 (Curcumin); Q369O8926L (resveratrol)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114516000805


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[PMID]:26927041
[Au] Autor:Pulido-Moran M; Moreno-Fernandez J; Ramirez-Tortosa C; Ramirez-Tortosa M
[Ad] Endereço:Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Campus Universitario de Cartuja, Universidad de Granada, 18071 Granada, Spain. mpulido@ugr.es.
[Ti] Título:Curcumin and Health.
[So] Source:Molecules;21(3):264, 2016 Feb 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides a brief review about the origin, bioavailability and new research on curcumin and synthetized derivatives. It examines the beneficial effects on health, delving into aspects such as cancer, cardiovascular effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, and neurological, liver and respiratory disorders. Thanks to all these activities, curcumin is positioned as an interesting nutraceutical. This is the reason why it has been subjected to several modifications in its structure and administration form that have permitted an increase in bioavailability and effectiveness against different diseases, decreasing the mortality and morbidity associated to these pathologies.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/uso terapêutico
Cardiotônicos/uso terapêutico
Curcuma/química
Curcumina/uso terapêutico
Fármacos Neuroprotetores/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/síntese química
Anti-Inflamatórios/isolamento & purificação
Antineoplásicos Fitogênicos/síntese química
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/síntese química
Antioxidantes/isolamento & purificação
Disponibilidade Biológica
Cardiotônicos/síntese química
Cardiotônicos/isolamento & purificação
Doenças Cardiovasculares/quimioterapia
Curcumina/síntese química
Curcumina/isolamento & purificação
Humanos
Inflamação
Neoplasias/quimioterapia
Doenças Neurodegenerativas/quimioterapia
Fármacos Neuroprotetores/síntese química
Fármacos Neuroprotetores/isolamento & purificação
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Cardiotonic Agents); 0 (Neuroprotective Agents); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161112
[Lr] Data última revisão:
161112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE



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