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[PMID]:26976085
[Au] Autor:Perkins K; Sahy W; Beckett RD
[Ad] Endereço:Manchester University College of Pharmacy, Natural, and Health Sciences, Fort Wayne, IN, USA.
[Ti] Título:Efficacy of Curcuma for Treatment of Osteoarthritis.
[So] Source:J Evid Based Complementary Altern Med;22(1):156-165, 2017 Jan.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this review is to identify, summarize, and evaluate clinical trials to determine the efficacy of curcuma in the treatment of osteoarthritis. A literature search for interventional studies assessing efficacy of curcuma was performed, resulting in 8 clinical trials. Studies have investigated the effect of curcuma on pain, stiffness, and functionality in patients with knee osteoarthritis. Curcuma-containing products consistently demonstrated statistically significant improvement in osteoarthritis-related endpoints compared with placebo, with one exception. When compared with active control, curcuma-containing products were similar to nonsteroidal anti-inflammatory drugs, and potentially to glucosamine. While statistical significant differences in outcomes were reported in a majority of studies, the small magnitude of effect and presence of major study limitations hinder application of these results. Further rigorous studies are needed prior to recommending curcuma as an effective alternative therapy for knee osteoarthritis.
[Mh] Termos MeSH primário: Curcuma
Osteoartrite/quimioterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Suplementos Nutricionais
Humanos
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE


  2 / 1378 MEDLINE  
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[PMID]:28274852
[Au] Autor:Jiang S; Han J; Li T; Xin Z; Ma Z; Di W; Hu W; Gong B; Di S; Wang D; Yang Y
[Ad] Endereço:Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
[Ti] Título:Curcumin as a potential protective compound against cardiac diseases.
[So] Source:Pharmacol Res;119:373-383, 2017 May.
[Is] ISSN:1096-1186
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Curcumin, which was first used 3000 years ago as an anti-inflammatory agent, is a well-known bioactive compound derived from the active ingredient of turmeric (Curcuma longa). Previous research has demonstrated that curcumin has immense therapeutic potential in a variety of diseases via anti-oxidative, anti-apoptotic, and anti-inflammatory pathways. Cardiac diseases are the leading cause of mortality worldwide and cause considerable harm to human beings. Numerous studies have suggested that curcumin exerts a protective role in the human body whereas its actions in cardiac diseases remain elusive and poorly understood. On the basis of the current evidence, we first give a brief introduction of cardiac diseases and curcumin, especially regarding the effects of curcumin in embryonic heart development. Secondly, we analyze the basic roles of curcumin in pathways that are dysregulated in cardiac diseases, including oxidative stress, apoptosis, and inflammation. Thirdly, actions of curcumin in different cardiac diseases will be discussed, as will relevant clinical trials. Eventually, we would like to discuss the existing controversial opinions and provide a detailed analysis followed by the remaining obstacles, advancement, and further prospects of the clinical application of curcumin. The information compiled here may serve as a comprehensive reference of the protective effects of curcumin in the heart, which is significant to the further research and design of curcumin analogs as therapeutic options for cardiac diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Cardiotônicos/uso terapêutico
Curcumina/uso terapêutico
Cardiopatias/quimioterapia
Coração/efeitos de drogas
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Cardiotônicos/química
Cardiotônicos/farmacologia
Curcuma/química
Curcumina/química
Curcumina/farmacologia
Coração/embriologia
Cardiopatias/imunologia
Cardiopatias/metabolismo
Cardiopatias/patologia
Humanos
Inflamação/quimioterapia
Inflamação/imunologia
Inflamação/metabolismo
Inflamação/patologia
Miocárdio/imunologia
Miocárdio/metabolismo
Miocárdio/patologia
Estresse Oxidativo/efeitos de drogas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cardiotonic Agents); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


  3 / 1378 MEDLINE  
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[PMID]:28401758
[Au] Autor:Burapan S; Kim M; Han J
[Ad] Endereço:Metalloenzyme Research Group and Department of Integrative Plant Science, Chung-Ang University , Anseong 17546, Korea.
[Ti] Título:Curcuminoid Demethylation as an Alternative Metabolism by Human Intestinal Microbiota.
[So] Source:J Agric Food Chem;65(16):3305-3310, 2017 Apr 26.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Curcumin and other curcuminoids from Curcuma longa are important bioactive compounds exhibiting various pharmacological activities. In addition to the known reductive metabolism of curcuminoids, an alternative biotransformation of curcuminoids by human gut microbiota is reported herein. A curcuminoid mixture, composed of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3), was metabolized by the human intestinal bacterium Blautia sp. MRG-PMF1. 1 and 2 were converted to new metabolites by the methyl aryl ether cleavage reaction. Two metabolites, demethylcurcumin (4) and bisdemethylcurcumin (5), were sequentially produced from 1, and demethyldemethoxycurcumin (6) was produced from 2. Until now, sequential reduction of the heptadienone backbone of curcuminoids was the only known metabolism to occur in the human intestine. In this study, a new intestinal metabolism of curcuminoids was discovered. Demethylation of curcuminoids produced three new colonic metabolites that were already known as promising synthetic curcumin analogues. The results could explain the observed beneficial effects of turmeric.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Curcuma/metabolismo
Curcumina/metabolismo
Microbioma Gastrointestinal
Intestinos/metabolismo
Intestinos/microbiologia
Extratos Vegetais/metabolismo
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/isolamento & purificação
Curcumina/análogos & derivados
Curcumina/química
Humanos
Metilação
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); IT942ZTH98 (Curcumin); W2F8059T80 (demethoxycurcumin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00943


  4 / 1378 MEDLINE  
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[PMID]:28412809
[Au] Autor:Thongon N; Boonmuen N; Suksen K; Wichit P; Chairoungdua A; Tuchinda P; Suksamrarn A; Winuthayanon W; Piyachaturawat P
[Ad] Endereço:Department of Physiology, Faculty of Science, Mahidol University , Bangkok 10400, Thailand.
[Ti] Título:Selective Estrogen Receptor Modulator (SERM)-like Activities of Diarylheptanoid, a Phytoestrogen from Curcuma comosa, in Breast Cancer Cells, Pre-osteoblast Cells, and Rat Uterine Tissues.
[So] Source:J Agric Food Chem;65(17):3490-3496, 2017 May 03.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diarylheptanoids from Curcuma comosa, of the Zingiberaceae family, exhibit diverse estrogenic activities. In this study we investigated the estrogenic activity of a major hydroxyl diarylheptanoid, 7-(3,4 -dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 092) isolated from C. comosa. The compound elicited different transcriptional activities of estrogen agonist at low concentrations (0.1-1 µM) and antagonist at high concentrations (10-50 µM) using luciferase reporter gene assay in HEK-293T cells. In human breast cancer (MCF-7) cells, compound 092 showed an anti-estrogenic activity by down-regulating ERα-signaling and suppressing estrogen-responsive genes, whereas it attenuated the uterotrophic effect of estrogen in immature ovariectomized rats. Of note, compound 092 promoted mouse pre-osteoblastic (MC3T3-E1) cell differentiation and the related bone markers, indicating its positive osteogenic effect. Our findings highlight a new, nonsteroidal, estrogen agonist/antagonist of catechol diarylheptanoid from C. comosa, which is scientific evidence supporting its potential as a dietary supplement to prevent bone loss with low risk of breast and uterine cancers in postmenopausal women.
[Mh] Termos MeSH primário: Neoplasias da Mama/quimioterapia
Curcuma/química
Diarileptanoides/administração & dosagem
Receptor alfa de Estrogênio/metabolismo
Osteoblastos/efeitos de drogas
Fitoestrógenos/administração & dosagem
Extratos Vegetais/administração & dosagem
Moduladores Seletivos de Receptor Estrogênico/administração & dosagem
[Mh] Termos MeSH secundário: Células 3T3
Animais
Neoplasias da Mama/genética
Neoplasias da Mama/metabolismo
Neoplasias da Mama/fisiopatologia
Diferenciação Celular/efeitos de drogas
Proliferação de Células/efeitos de drogas
Receptor alfa de Estrogênio/genética
Feminino
Humanos
Camundongos
Osteoblastos/citologia
Osteoblastos/metabolismo
Ratos
Ratos Wistar
Útero/citologia
Útero/efeitos de drogas
Útero/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diarylheptanoids); 0 (Estrogen Receptor alpha); 0 (Phytoestrogens); 0 (Plant Extracts); 0 (Selective Estrogen Receptor Modulators)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00769


  5 / 1378 MEDLINE  
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[PMID]:28155996
[Au] Autor:Park SI; Lee EH; Kim SR; Jang YP
[Ad] Endereço:Department of Life and Nanopharmaceutical Sciences, Graduated School, Kyung Hee University, Seoul, Korea.
[Ti] Título:Anti-apoptotic effects of Curcuma longa L. extract and its curcuminoids against blue light-induced cytotoxicity in A2E-laden human retinal pigment epithelial cells.
[So] Source:J Pharm Pharmacol;69(3):334-340, 2017 Mar.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of the study was to investigate the protective effect of the Curcuma longa L. extract (CLE) and its curcuminoids against blue light-induced cytotoxicity in human retinal pigment epithelial (RPE) cells laded with A2E. A2E has been concerned in age-related macular degeneration (AMD). METHODS: To perform this study, A2E-accumulated ARPE-19 cells were exposed to blue light to induce cytotoxicity. The cytotoxicity and apoptotic gene expression levels were evaluated using a lactate dehydrogenase (LDH) assay and real-time PCR analysis, respectively. KEY FINDINGS: Curcuma longa L. extract was found to exert a protective effect in a dose-dependent manner. At a concentration of 15 µm, curcumin, demethoxycurcumin and bisdemethoxycurcumin exerted significant protective effects against blue light-induced cytotoxicity. Treatment with CLE and curcuminoids meaningfully reduced the mRNA levels of c-Abl and p53, which was known to be augmented in apoptotic RPE cells. Demethoxycurcumin and bisdemethoxycurcumin were found to inhibit p38 expression, which is increased in blue light-irradiated A2E-accumulated RPE cells. CONCLUSIONS: Curcuma longa L. extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis in the RPE cells. Our results suggest that curcuminoids may show potential in the treatment of AMD.
[Mh] Termos MeSH primário: Apoptose/efeitos de drogas
Curcuma/química
Células Epiteliais/efeitos de drogas
Extratos Vegetais/farmacologia
Epitélio Pigmentado da Retina/efeitos de drogas
[Mh] Termos MeSH secundário: Morte Celular/efeitos de drogas
Linhagem Celular
Sobrevivência Celular/efeitos de drogas
Células Epiteliais/metabolismo
Humanos
Luz
Degeneração Macular/quimioterapia
Extratos Vegetais/química
RNA Mensageiro/metabolismo
Epitélio Pigmentado da Retina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (RNA, Messenger)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12691


  6 / 1378 MEDLINE  
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[PMID]:28277992
[Au] Autor:Masood R; Hussain T; Umar M; Azeemullah; Areeb T; Riaz S
[Ad] Endereço:Director, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
[Ti] Título:In situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections.
[So] Source:J Wound Care;26(3):115-120, 2017 Mar 02.
[Is] ISSN:0969-0700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process. METHOD: Hydrolysed chitosan, turmeric powder and clove oil were used in different proportions to formulate antimicrobial coating for the polyethylene terephthalate (PET) and polyamide (Nylon 6) threads. The threads were coated using a lab-scale yarn sizing machine. Tensile, and knot strength of the coated sutures were measured. As was the antimicrobial action of Staphylococcus aureus strain ATCC29213. RESULTS: The results show that coatings have slightly improved the tensile and knot strength properties of these sutures. The coated sutures also have satisfactory microbial inhibition against Staphylococcus aureus. CONCLUSION: The coating slightly improved the tensile strength of the sutures. However, the knot is the weakest part of the suture strand. All the formulations of the coating have shown satisfactory antimicrobial activity against Gram-positive Staphylococcus aureus bacteria. We conclude that application of natural coatings on non-absorbable sutures can be useful to reduce the incisions and wound site infections.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/farmacologia
Aderência Bacteriana/efeitos de drogas
Quitosana
Curcuma
Óleos Voláteis
Infecção da Ferida Operatória/prevenção & controle
[Mh] Termos MeSH secundário: Materiais Revestidos Biocompatíveis
Humanos
Hidrólise
Suturas
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Coated Materials, Biocompatible); 0 (Oils, Volatile); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.12968/jowc.2017.26.3.115


  7 / 1378 MEDLINE  
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[PMID]:28221973
[Au] Autor:Han D; Lee HT; Lee JB; Kim Y; Lee SJ; Yoon JW
[Ad] Endereço:College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
[Ti] Título:A Bioprocessed Polysaccharide from Lentinus edodes Mycelia Cultures with Turmeric Protects Chicks from a Lethal Challenge of Salmonella Gallinarum.
[So] Source:J Food Prot;80(2):245-250, 2017 Feb.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our previous studies demonstrated that a bioprocessed polysaccharide (BPP) isolated from Lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against Salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from Salmonella Typhimurium infection through upregulated T-helper 1 immunity. Here, we report that a BPP from L. edodes mushroom mycelia liquid cultures supplemented with turmeric (referred to as BPP-turmeric) alters chicken macrophage responses against avian-adapted Salmonella Gallinarum and protects chicks against a lethal challenge from Salmonella Gallinarum. In vitro analyses revealed that the water extract of BPP-turmeric (i) changed the protein expression or secretion profile of Salmonella Gallinarum, although it was not bactericidal, (ii) reduced the phagocytic activity of the chicken-derived macrophage cell line HD-11 when infected with Salmonella Gallinarum, and (iii) significantly activated the transcription expression of interleukin (IL)-1ß, IL-10, tumor necrosis factor α, and inducible nitric oxide synthase in response to various Salmonella infections, whereas it repressed that of IL-4, IL-6, interferon-ß, and interferon-γ. We also found that BPP-turmeric (0.1 g/kg of feed) as a feed additive provided significant protection to 1-day-old chicks infected with a lethal dose of Salmonella Gallinarum. Collectively, these results imply that BPP-turmeric contains biologically active component(s) that protect chicks against Salmonella Gallinarum infection, possibly by regulating macrophage immune responses. Further studies are needed to evaluate the potential efficacy of BPP-turmeric as a livestock feed additive for the preharvest control of fowl typhoid or foodborne salmonellosis.
[Mh] Termos MeSH primário: Curcuma
Cogumelos Shiitake
[Mh] Termos MeSH secundário: Animais
Galinhas
Camundongos
Polissacarídeos
Doenças das Aves Domésticas
Salmonella/imunologia
Salmonelose Animal/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polysaccharides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-306


  8 / 1378 MEDLINE  
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[PMID]:28314475
[Au] Autor:Chen Z; Sun D; Bi X; Zeng X; Luo W; Cai D; Zeng Q; Xu A
[Ad] Endereço:Guangdong Province Engineering Technology Research Institute of T.C.M., 60 Hengfu rd., Guangzhou, 510095, China; Affiliated Guangdong second TCM hospital, Guangzhou University of Chinese Medicine, 60 Hengfu rd., Guangzhou, 510095, China; Guangdong Provincial Key Laboratory of Research and Developmen
[Ti] Título:Pharmacokinetic based study on "lagged stimulation" of Curcumae Longae Rhizoma - Piper nigrum couplet in their main active components' metabolism using UPLC-MS-MS.
[So] Source:Phytomedicine;27:15-22, 2017 Apr 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions. Therefore, order of administration should be adjusted according to pharmacokinetic parameters of the ingredients, which the ones act as supplement can first be taken, and main therapeutic components followed when the former reached its peak. METHOD: the extract of Piper nigrum (containing at least 95% piperine) was taken by rats 6h before taking Curcumae Longae Rhizoma extract (containing at least 95% curcumin). Then, a UPLC-MS-MS method was developed to determine their content in plasma simultaneously. Determination was carried out by on a C18 column within 5min by isocratic elution using 0.2% formic acid and acetonitrile (50:50, v/v). Tandem mass detection was conducted by selective reaction monitoring (SRM) via electrospray ionization (ESI) source in positive mode. Samples were pre-treated by liquid-liquid extraction (LLE), and verapamil was used as internal standard (IS). RESULTS: For both curcumin and piperine, the proposed method had good linearity (r =0.999) within the concentration range of 1-1000ng/ml, with good recovery, precision and stability. The lower limit of quantification (LLOQ) was 1ng/ml. As pharmacokinetic data indicated, Maximum concentration (C ) of curcumin increased significantly to 394.06; the time reach maximum concentration (T ) and elimination half-life (T ) were 0.5 and 0.67h, respectively; CONCLUSION: The results provide a good strategy for the investigation of TCM formula especially the couplets, as well as a fast, selective and sensitive UPLC-MS-MS method determining active components in-vivo. Furthermore, the finding of "lagged stimulation" suggested that the use of complex formula should take pharmacokinetics into much more careful consideration.
[Mh] Termos MeSH primário: Curcuma/metabolismo
Curcumina/farmacocinética
Inibidores das Enzimas do Citocromo P-450/farmacocinética
Piper nigrum/metabolismo
Piperidinas/farmacocinética
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Curcuma/química
Medicamentos de Ervas Chinesas/farmacocinética
Masculino
Piper nigrum/química
Ratos
Ratos Sprague-Dawley
Rizoma/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Drugs, Chinese Herbal); 0 (Piperidines); 0 (Plant Extracts); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  9 / 1378 MEDLINE  
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[PMID]:28196290
[Au] Autor:Cai Y; Lu D; Zou Y; Zhou C; Liu H; Tu C; Li F; Liu L; Zhang S
[Ad] Endereço:Dept. of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan Univ., 180 Fenglin Rd., Xuhui District, Shanghai, P.R. China.
[Ti] Título:Curcumin Protects Against Intestinal Origin Endotoxemia in Rat Liver Cirrhosis by Targeting PCSK9.
[So] Source:J Food Sci;82(3):772-780, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intestinal origin endotoxemia always occurs in severe liver injury. The aim of the current study was to test antiendotoxemia effect of curcumin on tetrachloride (CCl )-induced liver cirrhosis rats, and to elucidate the underlying molecular mechanism. Rat cirrhosis models were constructed with CCl subcutaneous injections with curcumin (200 mg/kg/d) administered via gavages for 12 wk until the rats were sacrificed. We found that the administration of curcumin improved the physiological condition pertaining to activity index and temperature, and ameliorated the liver injury in CCl -induced cirrhosis rats. Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-α, IL-1ß, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue. Furthermore, curcumin treatment decreased lipopolysaccharide (LPS) levels in peripheral vein, but not in portal vein. As low-density lipoprotein receptor (LDLR) is the important receptor on the surface of hepatocyte during LPS detoxification process, we used qRT-PCR, western blot, and immunohistochemistry (IHC), finding that curcumin significantly increased LDLR protein levels, but not gene levels in the liver tissues. We also tested proprotein convertase subtilisin/kexin type 9 (PCSK9), one negative regulator of LDLR, by qRT-PCR, western blot, and IHC. The results showed that PCSK9 significantly decreased both gene and protein levels in the rat liver tissues of curcumin treatment. Thus, we concluded that curcumin could function to protect against intestinal origin endotoxemia by inhibiting PCSK9 to promote LDLR expression, thereby enhancing LPS detoxification as one pathogen lipid through LDLR in the liver.
[Mh] Termos MeSH primário: Curcumina/farmacologia
Endotoxemia
Intestinos/efeitos de drogas
Cirrose Hepática/complicações
Fígado/efeitos de drogas
Extratos Vegetais/farmacologia
Pró-Proteína Convertase 9/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Tetracloreto de Carbono
Doença Hepática Induzida por Substâncias e Drogas/complicações
Doença Hepática Induzida por Substâncias e Drogas/patologia
Quimiocina CXCL1/sangue
Curcuma/química
Curcumina/uso terapêutico
Citocinas/sangue
Endotoxemia/etiologia
Endotoxemia/prevenção & controle
Humanos
Intestinos/patologia
Lipopolissacarídeos/metabolismo
Lipoproteínas LDL/metabolismo
Fígado/metabolismo
Cirrose Hepática/induzido quimicamente
Cirrose Hepática/quimioterapia
Cirrose Hepática/metabolismo
Masculino
Fitoterapia
Extratos Vegetais/uso terapêutico
Ratos
Receptores de LDL/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Chemokine CXCL1); 0 (Cxcl1 protein, rat); 0 (Cytokines); 0 (Lipopolysaccharides); 0 (Lipoproteins, LDL); 0 (Plant Extracts); 0 (Receptors, LDL); CL2T97X0V0 (Carbon Tetrachloride); EC 3.4.21.- (Proprotein Convertase 9); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13647


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[PMID]:28192240
[Au] Autor:Ganjali S; Blesso CN; Banach M; Pirro M; Majeed M; Sahebkar A
[Ad] Endereço:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ti] Título:Effects of curcumin on HDL functionality.
[So] Source:Pharmacol Res;119:208-218, 2017 May.
[Is] ISSN:1096-1186
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Antioxidantes/farmacologia
Curcumina/farmacologia
Lipoproteínas HDL/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/uso terapêutico
Antioxidantes/química
Antioxidantes/uso terapêutico
Aterosclerose/quimioterapia
Aterosclerose/metabolismo
Curcuma/química
Curcumina/química
Curcumina/uso terapêutico
Dislipidemias/quimioterapia
Dislipidemias/metabolismo
Humanos
Lipoproteínas HDL/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Lipoproteins, HDL); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE



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