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Pesquisa : B01.650.940.800.575.100.975.900.166 [Categoria DeCS]
Referências encontradas : 1416 [refinar]
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  1 / 1416 MEDLINE  
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Coy, Cláudio Saddy Rodrigues
Texto completo SciELO Brasil
[PMID]:28403342
[Au] Autor:Alves AJ; Pereira JA; Pansani AH; Magro DO; Coy CS; Martinez CA
[Ad] Endereço:Fellow Master degree, Postgraduate Program in Surgical Sciences, Universidade Estadual de Campinas (UNICAMP), Brazil. Intellectual and scientific content of the study; acquisition, analysis and interpretation of data.
[Ti] Título:Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with Curcuma longa (curcumin).
[So] Source:Acta Cir Bras;32(3):182-193, 2017 Mar.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Purpose:: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods:: Thirty-six rats were subjected to proximal right colostomy and distal mucous fistula. They were divided into two groups according to whether sacrifice was performed two or four weeks after the intervention. Each group was divided into three subgroups according to the enema applied daily: saline alone; curcumin at 50 mg/kg/day or curcumin at 200 mg/kg/day. Acid mucins were diagnosed using the Alcian blue technique. The mucin content was quantified by means of computer-assisted image analysis. The significance level of 5% was used throughout (p < 0.05). Results:: There were dose-related increases in the quantities of sulfomucins in the animals subjected to interventions with curcumin, both after two weeks (p < 0.00001) and after four weeks (p < 0.00001). There were increases in sialomucin quantity that were concentration-related (p < 0.00001) and time-related (p < 0.00001). Conclusion:: Curcumin enemas increase the quantity of acid mucins in the intestinal flow in the excluded colon, with dose and time dependency.
[Mh] Termos MeSH primário: Colo/química
Colo/efeitos de drogas
Mucosa Intestinal/química
Mucosa Intestinal/efeitos de drogas
Mucinas/análise
Extratos Vegetais/administração & dosagem
Sialomucinas/análise
[Mh] Termos MeSH secundário: Animais
Colite/quimioterapia
Colite/patologia
Colo/patologia
Colostomia
Curcuma
Enema/métodos
Fezes
Trânsito Gastrointestinal/efeitos de drogas
Processamento de Imagem Assistida por Computador
Mucosa Intestinal/patologia
Masculino
Mucinas/efeitos de drogas
Óleos Vegetais/administração & dosagem
Ratos Wistar
Valores de Referência
Reprodutibilidade dos Testes
Sialomucinas/efeitos de drogas
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mucins); 0 (Plant Extracts); 0 (Plant Oils); 0 (Sialomucins); 0 (sulfomucin); 856YO1Z64F (turmeric extract)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


  2 / 1416 MEDLINE  
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Coy, Cláudio Saddy Rodrigues
Texto completo SciELO Brasil
[PMID]:28225919
[Au] Autor:Martinez CA; Kadri CJ; Kanno DT; Alves AJ; Coy CS; Pereira JA
[Ad] Endereço:PhD, Associate Professor, Postgraduate Program in Health Sciences, Universidade São Francisco (USF), Bragança Paulista-SP, Brazil. Associate Professor, Department of Surgery, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil. Intellectual and scientific content of the study, manuscrip
[Ti] Título:Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa.
[So] Source:Acta Cir Bras;32(1):65-73, 2017 Jan.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Purpose: : To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: : Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, curcumin at 50 mg/kg/day or 200 mg/kg/day. Colitis was diagnosed by histological analysis. Claudin-3 and occludin were determined by immunohistochemistry. The tissue content of claudin-3 and occludin were quantified by computer-assisted image analysis. Mann-Whitney, Student t and ANOVA tests were used to analyze the results establishing the level of significance of 5% for both (p<0.05). Results: : Curcumin at both concentrations reduces the inflammation and preserves the tissue content of the proteins claudin-3 and occludin, which was related to the concentration used and to the time of the intervention. Conclusion: : The application of enemas with curcumin reduces inflammation and preserves the tissue content of the proteins claudin-3 and occludin in the colonic mucosa devoid from the fecal stream.
[Mh] Termos MeSH primário: Claudina-3/análise
Colo/química
Curcuma/química
Enema/métodos
Mucosa Intestinal/química
Ocludina/análise
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Colo/efeitos de drogas
Colo/patologia
Colostomia
Fezes
Imuno-Histoquímica
Mucosa Intestinal/efeitos de drogas
Mucosa Intestinal/patologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Claudin-3); 0 (Occludin); 0 (Plant Oils)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


  3 / 1416 MEDLINE  
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[PMID]:28104136
[Au] Autor:Nayeri A; Wu S; Adams E; Tanner C; Meshman J; Saini I; Reid W
[Ad] Endereço:Department of Medicine, University of California, Los Angeles, California. Electronic address: Anayeri@mednet.ucla.edu.
[Ti] Título:Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report.
[So] Source:Transplant Proc;49(1):198-200, 2017 Jan - Feb.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tacrolimus, also known as FK-506, is a potent immunosuppressant agent with a host of drug-drug and food-drug interactions. We present the first case of a probable food-drug interaction between the herb turmeric and tacrolimus leading to acute calcineurin inhibitor nephrotoxicity. A 56-year-old man with a history of orthotopic liver transplantation presented to the emergency department from the clinic with worsening edema in the setting of an elevated creatinine level of 4.2 mg/dL. Before the current presentation, the patient had been recently discharged on a previously tolerated low-dose regimen of tacrolimus with a whole-blood tacrolimus level within the desired range. Tacrolimus level on the day of re-hospitalization was elevated to 29.9 ng/mL in the absence of any changes to the patient's medication regimen. On further prompting, the patient identified recent high-dose intake of turmeric with his food. Tacrolimus was held from the patient's medication regimen, and he was discharged on hospital day 4 with objective evidence of improving renal function. Our report builds on the previous studies that described the effects of turmeric or its active ingredient on the pharmacokinetics of tacrolimus. The appropriate reconciliation of herbal agents such as turmeric can be worthwhile in patients with unexplained changes in tacrolimus levels.
[Mh] Termos MeSH primário: Inibidores de Calcineurina/efeitos adversos
Curcuma/efeitos adversos
Interações Alimento-Droga
Complicações Pós-Operatórias/induzido quimicamente
Tacrolimo/efeitos adversos
[Mh] Termos MeSH secundário: Doença Aguda
Creatinina/sangue
Edema/etiologia
Humanos
Transplante de Fígado
Masculino
Meia-Idade
Tacrolimo/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcineurin Inhibitors); AYI8EX34EU (Creatinine); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE


  4 / 1416 MEDLINE  
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[PMID]:28063511
[Au] Autor:Karuppagounder V; Arumugam S; Giridharan VV; Sreedhar R; Bose RJ; Vanama J; Palaniyandi SS; Konishi T; Watanabe K; Thandavarayan RA
[Ad] Endereço:Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
[Ti] Título:Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy.
[So] Source:Nutrition;34:47-54, 2017 Feb.
[Is] ISSN:1873-1244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diabetic cardiomyopathy (DCM) is described as impaired cardiac diastolic and systolic functions. Diabetes mellitus (DM), a related cardiovascular disease, has become one of the major causes of death in DM patients. Mortality in these diseases is 2 to 3 times higher than in non-DM patients with cardiovascular disease. The progression of DCM and the cellular and molecular perturbations associated with the pathogenesis are complex and multifactorial. Although considerable progress has been achieved, the molecular etiologies of DCM remain poorly understood. There is an expanding need for natural antidiabetic medicines that do not cause the side effects of modern drugs. Curcumin, a pleiotropic molecule, from Curcuma longa, is known to possess numerous impacts such as scavenging free radical, antioxidant, antitumor, and antiinflammatory activities. The reports from preclinical and clinical findings revealed that curcumin can reverse insulin resistance, hyperglycemia, obesity, and obesity-related metabolic diseases. The current review provides an updated overview of the possible molecular mechanism of DCM and multitarget approach of curcumin in alleviating DCM and diabetic complication. Additionally, we mentioned the approaches that are currently being implemented to improve the bioavailability of this promising natural product in diabetes therapeutics.
[Mh] Termos MeSH primário: Curcumina/farmacocinética
Cardiomiopatias Diabéticas/quimioterapia
Hipoglicemiantes/farmacocinética
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacocinética
Antioxidantes/administração & dosagem
Antioxidantes/farmacocinética
Curcuma/química
Curcumina/administração & dosagem
Curcumina/química
Modelos Animais de Doenças
Coração/efeitos de drogas
Coração/fisiologia
Humanos
Hipoglicemiantes/administração & dosagem
Estresse Oxidativo/efeitos de drogas
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Hypoglycemic Agents); 0 (Plant Extracts); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE


  5 / 1416 MEDLINE  
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[PMID]:28068085
[Au] Autor:Kim K; Kim JJ; Jung Y; Noh JY; Syed AS; Kim CY; Lee MY; Lim KM; Bae ON; Chung JH
[Ad] Endereço:College of Pharmacy, Seoul National University , Seoul 08826, Korea.
[Ti] Título:Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).
[So] Source:J Nat Prod;80(1):196-200, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 µM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.
[Mh] Termos MeSH primário: Canais de Cálcio Tipo L/efeitos de drogas
Curcuma/química
Curcumina/isolamento & purificação
Curcumina/farmacologia
Vasoconstrição/efeitos de drogas
[Mh] Termos MeSH secundário: Animais
Canais de Cálcio Tipo L/química
Canais de Cálcio Tipo L/metabolismo
Curcumina/química
Concentração Inibidora 50
Estrutura Molecular
Fosforilação
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Channels, L-Type); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00331


  6 / 1416 MEDLINE  
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[PMID]:28624450
[Au] Autor:Yu X; Xu M; Li N; Li Z; Li H; Shao S; Zou K; Zou L
[Ad] Endereço:Department of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
[Ti] Título:ß-elemene inhibits tumor-promoting effect of M2 macrophages in lung cancer.
[So] Source:Biochem Biophys Res Commun;490(2):514-520, 2017 Aug 19.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). ß-elemene has therapeutic effects against several cancers, however, it remains unknown whether ß-elemene could inhibit cancer by targeting TAMs. Herein, we examined the effect of ß-elemene on macrophages to elucidate a novel mechanism of ß-elemene in tumor therapy. We showed that the conditioned medium of M2 macrophages promoted lung cancer cells to migration, invasion and epithelial mesenchymal transition, which could be inhibited by ß-elemene. Moreover, ß-elemene regulated the polarization of macrophages from M2 to M1. ß-elemene also inhibited the proliferation, migration, invasion of lung cancer cells and enhanced its radiosensitivity. These results indicate ß-elemene suppresses lung cancer by regulating both macrophages and lung cancer cells, it is a promising drug for combination with chemotherapy or radiotherapy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Neoplasias Pulmonares/quimioterapia
Pulmão/efeitos de drogas
Macrófagos/efeitos de drogas
Invasividade Neoplásica/prevenção & controle
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Movimento Celular/efeitos de drogas
Polaridade Celular/efeitos de drogas
Curcuma/química
Transição Epitelial-Mesenquimal/efeitos de drogas
Humanos
Pulmão/patologia
Neoplasias Pulmonares/patologia
Macrófagos/patologia
Camundongos
Invasividade Neoplásica/patologia
Células RAW 264.7
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Sesquiterpenes); 0 (beta-elemene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE


  7 / 1416 MEDLINE  
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[PMID]:28420370
[Au] Autor:Ramkumar M; Rajasankar S; Gobi VV; Dhanalakshmi C; Manivasagam T; Justin Thenmozhi A; Essa MM; Kalandar A; Chidambaram R
[Ad] Endereço:Research Scholar, Bharath University, Selaiyur, Chennai, Tamil Nadu, 600073, India.
[Ti] Título:Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells.
[So] Source:BMC Complement Altern Med;17(1):217, 2017 Apr 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity. METHODS: SH-SY5Y neuroblastoma cells are divided into four experimental groups: untreated cells, cells incubated with rotenone (100 nM), cells treated with DMC (50 nM) + rotenone (100 nM) and DMC alone treated. 24 h after treatment with rotenone and 28 h after treatment with DMC, cell viability was assessed using the MTT assay, and levels of ROS and MMP, plus expression of apoptotic protein were analysed. RESULTS: Rotenone induced cell death in SH-SY5Y cells was significantly reduced by DMC pretreatment in a dose-dependent manner, indicating the potent neuroprotective effects of DMC. Rotenone treatment significantly increases the levels of ROS, loss of MMP, release of Cyt-c and expression of pro-apoptotic markers and decreases the expression of anti-apoptotic markers. CONCLUSIONS: Even though the results of the present study indicated that the DMC may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases like PD, further pre-clinical and clinical studies are required.
[Mh] Termos MeSH primário: Curcumina/análogos & derivados
Potencial da Membrana Mitocondrial/efeitos de drogas
Fármacos Neuroprotetores/farmacologia
Síndromes Neurotóxicas/metabolismo
Estresse Oxidativo/efeitos de drogas
Extratos Vegetais/farmacologia
Rotenona/toxicidade
[Mh] Termos MeSH secundário: Morte Celular
Linhagem Celular Tumoral
Sobrevivência Celular
Curcuma/química
Curcumina/farmacologia
Curcumina/uso terapêutico
Citocromos c/metabolismo
Neurônios Dopaminérgicos/efeitos de drogas
Humanos
Inseticidas/toxicidade
Fármacos Neuroprotetores/uso terapêutico
Síndromes Neurotóxicas/quimioterapia
Doença de Parkinson/quimioterapia
Doença de Parkinson/metabolismo
Fitoterapia
Extratos Vegetais/uso terapêutico
Espécies de Oxigênio Reativas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 03L9OT429T (Rotenone); 9007-43-6 (Cytochromes c); IT942ZTH98 (Curcumin); W2F8059T80 (demethoxycurcumin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1720-5


  8 / 1416 MEDLINE  
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[PMID]:27697575
[Au] Autor:Jin S; Song C; Jia S; Li S; Zhang Y; Chen C; Feng Y; Xu Y; Xiong C; Xiang Y; Jiang H
[Ad] Endereço:Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection; and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
[Ti] Título:An integrated strategy for establishment of curcuminoid profile in turmeric using two LC-MS/MS platforms.
[So] Source:J Pharm Biomed Anal;132:93-102, 2017 Jan 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Turmeric and curcuminoids are used as natural food coloring and functional food additives in various parts of the world. In this study, ninety-six curcuminoids were fully characterized using a targeted curcuminoid profile, which established by integrated use of two complementary LC-MS/MS platforms (liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF-MS/MS) and liquid chromatography-quadrupole linear ion trap mass spectrometry (LC-QTRAP-MS/MS)). The curcuminoid profile was represented in the form of a multiple reaction monitoring (MRM) mode based on LC-QTRAP-MS/MS analysis. It facilitated the qualitative and relative quantitative analysis of curcuminoids in a single injection. Meanwhile, the profile was successfully applied to the quality evaluation of raw materials of turmeric from different regions in China and Myanmar. The structural identification procedures of curcuminoids and the integrated strategy provide a suitable method to analyze targeted plant metabolites which occur in a high number but sharing either structural similarities or similar functional groups.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Curcuma/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: China
Análise de Alimentos/métodos
Mianmar
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  9 / 1416 MEDLINE  
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[PMID]:28415473
[Au] Autor:Amalraj A; Jude S; Varma K; Jacob J; Gopi S; Oluwafemi OS; Thomas S
[Ad] Endereço:R&D Centre, Aurea Biolabs (P) Ltd, Kolenchery, Cochin, 682 311, Kerala, India.
[Ti] Título:Preparation of a novel bioavailable curcuminoid formulation (Cureit™) using Polar-Nonpolar-Sandwich (PNS) technology and its characterization and applications.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:359-367, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Health benefits of curcuminoid are highly limited due to their poor aqueous solubility, very low systemic bioavailability, fast metabolic alterations and rapid elimination. In this study, a novel bioavailable curcuminoid formulation Cureit™ was prepared by using Polar-Nonpolar-Sandwich (PNS) technology with complete natural turmeric matrix (CNTM). The synthesized bioavailable curcuminoid formulation Cureit™ was characterizations by Nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infra-red (IR), current-voltage (I-V) study, Quadrupole Time-of-Flight Mass Spectrometry (Q-TOF), differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA). NMR study showed the presence of hydrogen bonding interactions with curcuminoids, polar and non-polar compounds in the PNS technology. SEM images indicated that Cureit™ was almost spherical and well dispersed with rough morphology, and separated with three layers of PNS formulation. The chemical profile of Cureit™ was analyzed by Q-TOF confirmed the presence of curcuminoids (curcumin, demethoxycurcumin and bismethoxycurcumin), lactones, sesquiterpenes and their derivatives derived from polar layer, aromatic turmerone, dihydroturmerone, turmeronol, curdione and bisacurone derived from non-polar layer. IR, XRD, DSC and TGA also confirmed the presence of curcuminoids with high stability in the PNS formulation. Various biological activities of Cureit™ were also discussed.
[Mh] Termos MeSH primário: Curcuma/química
Curcumina/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 856YO1Z64F (turmeric extract); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE


  10 / 1416 MEDLINE  
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[PMID]:28181675
[Au] Autor:van Die MD; Williams SG; Emery J; Bone KM; Taylor JM; Lusk E; Pirotta MV
[Ad] Endereço:Department of General Practice, University of Melbourne, Parkville, Victoria, Australia.
[Ti] Título:A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer.
[So] Source:Prostate;77(7):765-775, 2017 May.
[Is] ISSN:1097-0045
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Men with biochemical recurrence of prostate cancer following local therapies often use natural supplements in an attempt to delay metastases and/or avoid the need for more aggressive treatments with undesirable side-effects. While there is a growing body of research into phytotherapeutic agents in this cohort, with some promising results, as yet no definitive recommendations can be made. This pilot study was undertaken to assess the feasibility of a fully-powered study to examine the effects of this phytotherapeutic intervention (containing turmeric, resveratrol, green tea and broccoli sprouts) on PSA doubling time in men with biochemical recurrence with a moderate PSA rise rate. METHODS: A double blind, randomized, placebo-controlled parallel trial was conducted with 22 men with biochemically recurrent prostate cancer and a moderate rise rate (PSA doubling time of 4-15 months and no evidence of metastases from conventional imaging methods). Patients were randomized to either the active treatment arm or placebo for 12 weeks. The primary endpoints were feasibility of study recruitment and procedures, and measurement of proposed secondary endpoints (prostate symptoms, quality of life, anxiety, and depression as measured on the EORTC QLQ-C30 and PR-25, the IPSS and HADS). Data were collected to estimate PSA-log slopes and PSA-doubling times, using a mixed model, for both the pre-intervention and post-intervention periods. RESULTS: Adherence to study protocol was excellent, and the phytotherapeutic intervention was well-tolerated, with similar numbers of mild-to-moderate adverse events in the active and placebo arms. Both the intervention and data collection methods were acceptable to participants. No statistical difference between groups on clinical outcomes was expected in this pilot study. There was between-subject variation in the PSA post treatment, but on average the active treatment group experienced a non-significant increase in the log-slope of PSA (pre-treatment doubling time = 10.2 months, post-treatment doubling time = 5.5 months), and the placebo group experienced no change in the log-slope of PSA (pre-treatment doubling time = 10.8 months, post-treatment doubling time = 10.9 months). CONCLUSION: The findings suggest that a fully powered study of this combination is feasible in men with biochemically recurrent prostate cancer and a moderate PSA rise rate. Prostate 77:765-775, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Brassica
Curcuma
Recidiva Local de Neoplasia
Antígeno Prostático Específico/sangue
Neoplasias da Próstata
Qualidade de Vida
Estilbenos
Chá
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/efeitos adversos
Sintomas Comportamentais/diagnóstico
Sintomas Comportamentais/etiologia
Biomarcadores Tumorais/sangue
Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia/sangue
Recidiva Local de Neoplasia/psicologia
Prostatectomia/efeitos adversos
Neoplasias da Próstata/patologia
Neoplasias da Próstata/psicologia
Neoplasias da Próstata/terapia
Radioterapia/efeitos adversos
Estilbenos/administração & dosagem
Estilbenos/efeitos adversos
Avaliação de Sintomas/métodos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biomarkers, Tumor); 0 (Stilbenes); 0 (Tea); EC 3.4.21.77 (Prostate-Specific Antigen); Q369O8926L (resveratrol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1002/pros.23317



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