Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.156.100.833.250 [Categoria DeCS]
Referências encontradas : 63 [refinar]
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  1 / 63 MEDLINE  
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[PMID]:28633536
[Au] Autor:Ahmed A; Li W; Zhang JS; Sam PH; Zou YH; Tang GH; Yin S
[Ad] Endereço:a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
[Ti] Título:A new bisabolane sesquiterpenoid and a new abietane diterpenoid from Cephalotaxus sinensis.
[So] Source:Nat Prod Res;32(2):175-181, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of Cephalotaxus sinensis has led to the isolation of a new bisabolane sesquiterpenoid (1), a new abietane diterpenoid (2), and 13 known compounds (3-15). Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, and NMR).
[Mh] Termos MeSH primário: Cephalotaxus/química
Diterpenos Abietanos/isolamento & purificação
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Diterpenos Abietanos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Sesquiterpenos/química
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Abietane); 0 (Phytochemicals); 0 (Sesquiterpenes)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1343323


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[PMID]:28771599
[Au] Autor:Park G; Kim SY; Song YJ
[Ad] Endereço:Department of Life Science, Gachon University, Seongnam-Si, Kyeonggi-Do, Korea.
[Ti] Título:Ester alkaloids from Cephalotaxus interfere with the 2'3'-cGAMP-induced type I interferon pathway in vitro.
[So] Source:PLoS One;12(8):e0182701, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dysregulated activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway by self-DNA contributes to interferonopathy and promotes autoimmune diseases. To identify potential suppressors of STING-induced type I interferon (IFN) induction, ethanol extracts of medicinal plants were screened for inhibitory activity against IFN-ß promoter activation. Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING-induced, but not TBK1- or IRF3-induced, IFN-ß promoter activity. The compounds exerting inhibitory activity specifically against STING-mediated IFN-ß promoter activation were identified as ester alkaloids isolated from the genus, Cephalotaxus, homoharringtonine and harringtonine. Furthermore, these two compounds inhibited 2'3'-cGAMP-induced IFN-stimulated gene expression and interaction between STING and TBK1. These suppressive effects were not observed with cephalotaxine devoid of the ester side-chain. Our data support the potential utility of homoharringtonine and harringtonine to treat STING-associated interferonopathy and autoimmune diseases.
[Mh] Termos MeSH primário: Cephalotaxus/química
Harringtoninas/farmacologia
Interferon beta/genética
Proteínas de Membrana/metabolismo
Nucleotidiltransferases/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular
Etanol/química
Etanol/farmacologia
Células HEK293
Harringtoninas/química
Seres Humanos
Técnicas In Vitro
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Regiões Promotoras Genéticas/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Harringtonines); 0 (MPYS protein, human); 0 (Membrane Proteins); 0 (Plant Extracts); 3K9958V90M (Ethanol); 62624-24-2 (harringtonine); 6FG8041S5B (homoharringtonine); 77238-31-4 (Interferon-beta); EC 2.7.7.- (MB21D1 protein, human); EC 2.7.7.- (Nucleotidyltransferases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182701


  3 / 63 MEDLINE  
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[PMID]:28237091
[Au] Autor:Sakamoto S; Yusakul G; Nuntawong P; Kitisripanya T; Putalun W; Miyamoto T; Tanaka H; Morimoto S
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: s.sakamoto@phar.kyushu-u.ac.jp.
[Ti] Título:Development of an indirect competitive immunochromatographic strip test for rapid detection and determination of anticancer drug, harringtonine.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1048:150-154, 2017 Mar 24.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Harringtonine (HT) is a natural compound, which is mainly produced by the genus Cephalotaxus, and has been clinically utilized in China for the treatment of acute leukemia and lymphoma. However, the amounts of HT in the Cephalotaxus species are very small; therefore, plant tissue cultures have been focused upon to enhance HT production. Qualitative/quantitative methods for HT detection are required to screen superior cell lines. We developed a one-step indirect competitive immunochromatographic assay (ICA) using colloidal gold nanoparticles conjugated with highly specific monoclonal antibodies against HT (MAb 1D2) for simple, rapid, and sensitive detection of HT in plant samples. This ICA can be completed in 15min after dipping the strip into analytes with a limit of detection of ∼313ng/mL. In developed ICA, fiber pad which is usually used for conventional ICA, was not used to shorten the time for preparing chromatographic strip, resulting in a decrease in the volume of valuable analytes (20µL). Considering simplicity, rapidity, and sensitivity of the developed ICA, this study could be applied to a fieldwork study for finding new natural resources containing HT.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/análise
Cephalotaxus/química
Harringtoninas/análise
Imunocromatografia/métodos
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/química
Desenho de Equipamento
Coloide de Ouro/química
Imunocromatografia/instrumentação
Nanopartículas Metálicas/química
Fitas Reagentes/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antineoplastic Agents, Phytogenic); 0 (Gold Colloid); 0 (Harringtonines); 0 (Reagent Strips); 62624-24-2 (harringtonine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28139925
[Au] Autor:Zhao JX; Fan YY; Xu JB; Gan LS; Xu CH; Ding J; Yue JM
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
[Ti] Título:Diterpenoids and Lignans from Cephalotaxus fortunei.
[So] Source:J Nat Prod;80(2):356-362, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 and 4 are the first examples of 17-nor-cephalotane-type diterpenoids that are likely the biosynthesis precursors of the co-occurring troponoids (e.g., 1, 2, and 9). Compound 1 exhibited cytotoxic activities against HL-60 and A-549 cells with IC values of 0.77 ± 0.05 and 1.129 ± 0.057 µM, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Cephalotaxus/química
Diterpenos/isolamento & purificação
Lignanas/isolamento & purificação
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Diterpenos/química
Diterpenos/farmacologia
Doxorrubicina/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Células HL-60
Seres Humanos
Concentração Inibidora 50
Lignanas/química
Lignanas/farmacologia
Estrutura Molecular
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (Lignans); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00802


  5 / 63 MEDLINE  
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[PMID]:27323030
[Au] Autor:Liu YH; Hu XP; Li W; Cao XY; Yang HR; Lin ST; Xu CB; Liu SX; Li CF
[Ad] Endereço:College of Food Science and Technology, Hainan University, Haikou, Hainan, China.
[Ti] Título:Antimicrobial and antitumor activity and diversity of endophytic fungi from traditional Chinese medicinal plant Cephalotaxus hainanensis Li.
[So] Source:Genet Mol Res;15(2), 2016 May 13.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Endophytes from Cephalotaxus hainanensis Li, an important source of anti-leukemia drugs, have not been widely explored. In this study, 265 endophytic fungal isolates from C. hainanensis Li were screened for antimicrobial activities against tilapia, banana, rice, and rape and for antitumor activities against human leukemia cell lines (K562, NB4, and HL-60). Diversity was also analyzed. The results showed that 17.7% of the endophytic fungi had antimicrobial activities against at least three different test microbes, and activity against Fusarium oxysporum RKY102 was the highest at 15.8%. Cytotoxicity against at least one tumor cell line tested was observed in 18.5% of the endophytic fungi; with the highest value of 10.6% against K562. The endophytic fungal strains also showed relatively high activities against K562, NB4, and HL-60 while relatively fewer strains were cytotoxic against the human hepatic Hep-G2 and colon LoVo cancer cell lines. Thirty endophytic fungal strains showed both high antimicrobial and antitumor activities. Moreover, the analyses of the diversity of the 30 highly active strains showed they belonged to 20 species from 14 genera, and this is the first report of endophytic fungi Albonectria rigidiuscula, Colletotrichum magnisporum, and Nemania diffusa being isolated from Cephalotaxus plants. These findings suggest that natural antibacterial products for humans and tilapia; antifungal compounds for rice, rape, and banana; and antitumor compounds for leukemia therapy could be isolated from fungal strains derived from C. hainanensis Li.
[Mh] Termos MeSH primário: Cephalotaxus/microbiologia
Colletotrichum
Endófitos
Fusarium
[Mh] Termos MeSH secundário: Anti-Infecciosos
Antineoplásicos
Produtos Biológicos/química
Produtos Biológicos/farmacologia
Linhagem Celular Tumoral
Células HL-60
Células Hep G2
Seres Humanos
Células K562
Medicina Tradicional Chinesa
Testes de Sensibilidade Microbiana
Folhas de Planta/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Biological Products)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15028633


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[PMID]:27263005
[Au] Autor:Hu X; Li W; Yuan M; Li C; Liu S; Jiang C; Wu Y; Cai K; Liu Y
[Ad] Endereço:College of Food Science and Technology, Hainan University, Haikou, 570228, China.
[Ti] Título:Homoharringtonine production by endophytic fungus isolated from Cephalotaxus hainanensis Li.
[So] Source:World J Microbiol Biotechnol;32(7):110, 2016 Jul.
[Is] ISSN:1573-0972
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Homoharringtonine (HHT), a natural plant alkaloid derived from Cephalotaxus, has demonstrated to have a broad antitumor activity and efficacy in treating human chronic myeloid leukemia. An alternative source is required to substitute for the slow-growing and scarce Cephalotaxus to meet the increasing demand of the drug market. The objective of this study was to screen HHT-producing endophytic fungi from Cephalotaxus hainanensis Li. By screening 213 fungal isolates obtained from the bark parts of Cephalotaxus hainanensis Li, one isolate was found to be capable of biosynthesizing HHT. The fungus was identified as Alternaria tenuissima by morphological characteristics and internal transcribed spacer (ITS) sequence analysis and was named as CH1307. HHT obtained from CH1307 was analyzed through the HPLC and LC-MS/MS and NMR spectroscopy. The extract of the fermentation broth of CH1307 showed antiproliferative activities against K562 (chronic myelocytic leukemia), NB4 (acute promyelocytic leukemia), and HL-60 (promyelocytic leukemia) human cancer cell lines with IC50 values of 67.25 ± 4.26, 65.02 ± 4.75, and 99.23 ± 4.26 µg/mL, respectively. The findings suggest that HHT-producing endophytic fungus, Alternaria tenuissima CH1307 might provide a promising source for the research and application of HHT.
[Mh] Termos MeSH primário: Cephalotaxus/microbiologia
Endófitos/isolamento & purificação
Endófitos/metabolismo
Harringtoninas/biossíntese
[Mh] Termos MeSH secundário: Alcaloides/biossíntese
Alcaloides/química
Alternaria/genética
Alternaria/crescimento & desenvolvimento
Alternaria/isolamento & purificação
Alternaria/metabolismo
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Endófitos/genética
Endófitos/crescimento & desenvolvimento
Fermentação
Células HL-60
Harringtoninas/química
Harringtoninas/metabolismo
Harringtoninas/farmacologia
Seres Humanos
Células K562
Leucemia Promielocítica Aguda/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents); 0 (Harringtonines); 6FG8041S5B (homoharringtonine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE
[do] DOI:10.1007/s11274-016-2073-9


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[PMID]:27045089
[Au] Autor:Pirone-Davies C; Prior N; von Aderkas P; Smith D; Hardie D; Friedman WE; Mathews S
[Ad] Endereço:The Arnold Arboretum of Harvard University, Boston, MA, USA, carypirone@fas.harvard.edu sarah.mathews@csiro.au.
[Ti] Título:Insights from the pollination drop proteome and the ovule transcriptome of Cephalotaxus at the time of pollination drop production.
[So] Source:Ann Bot;117(6):973-84, 2016 May.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Many gymnosperms produce an ovular secretion, the pollination drop, during reproduction. The drops serve as a landing site for pollen, but also contain a suite of ions and organic compounds, including proteins, that suggests diverse roles for the drop during pollination. Proteins in the drops of species of Chamaecyparis, Juniperus, Taxus, Pseudotsuga, Ephedra and Welwitschia are thought to function in the conversion of sugars, defence against pathogens, and pollen growth and development. To better understand gymnosperm pollination biology, the pollination drop proteomes of pollination drops from two species of Cephalotaxus have been characterized and an ovular transcriptome for C. sinensis has been assembled. METHODS: Mass spectrometry was used to identify proteins in the pollination drops of Cephalotaxus sinensis and C. koreana RNA-sequencing (RNA-Seq) was employed to assemble a transcriptome and identify transcripts present in the ovules of C. sinensis at the time of pollination drop production. KEY RESULTS: About 30 proteins were detected in the pollination drops of both species. Many of these have been detected in the drops of other gymnosperms and probably function in defence, polysaccharide metabolism and pollen tube growth. Other proteins appear to be unique to Cephalotaxus, and their putative functions include starch and callose degradation, among others. Together, the proteins appear either to have been secreted into the drop or to occur there due to breakdown of ovular cells during drop production. Ovular transcripts represent a wide range of gene ontology categories, and some may be involved in drop formation, ovule development and pollen-ovule interactions. CONCLUSIONS: The proteome of Cephalotaxus pollination drops shares a number of components with those of other conifers and gnetophytes, including proteins for defence such as chitinases and for carbohydrate modification such as ß-galactosidase. Proteins likely to be of intracellular origin, however, form a larger component of drops from Cephalotaxus than expected from studies of other conifers. This is consistent with the observation of nucellar breakdown during drop formation in Cephalotaxus The transcriptome data provide a framework for understanding multiple metabolic processes that occur within the ovule and the pollination drop just before fertilization. They reveal the deep conservation of WUSCHEL expression in ovules and raise questions about whether any of the S-locus transcripts in Cephalotaxus ovules might be involved in pollen-ovule recognition.
[Mh] Termos MeSH primário: Cephalotaxus/fisiologia
Óvulo Vegetal/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Polinização
[Mh] Termos MeSH secundário: Cephalotaxus/metabolismo
Óvulo Vegetal/genética
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160406
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw026


  8 / 63 MEDLINE  
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[PMID]:27042943
[Au] Autor:Ni G; Zhang H; Fan YY; Liu HC; Ding J; Yue JM
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
[Ti] Título:Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids.
[So] Source:Org Lett;18(8):1880-3, 2016 Apr 15.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three new diterpenoids, mannolides A-C (1-3), and two new Cephalotaxus troponoids, 4 and 5, were isolated from Cephalotaxus mannii and structurally characterized by spectroscopic data and X-ray crystallography. The discovery of compounds 1-3 featuring a new intact carbon skeleton, proposed as cephalotane, sheds new light on the biogenesis of Cephalotaxus troponoids, a rare class of antitumor C19 norditerpenoids. Antitumor tests showed that the tropone motif is essential for the activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/biossíntese
Cephalotaxus/química
Diterpenos/metabolismo
Diterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cristalografia por Raios X
Diterpenos/química
Ensaios de Seleção de Medicamentos Antitumorais
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (mannolide A); 0 (mannolide B); 0 (mannolide C)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160415
[Lr] Data última revisão:
160415
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.6b00653


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[PMID]:25942282
[Au] Autor:Ma YM; Ma CC; Li T; Wang J
[Ad] Endereço:a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021 , P.R. China.
[Ti] Título:A new furan derivative from an endophytic Aspergillus flavus of Cephalotaxus fortunei.
[So] Source:Nat Prod Res;30(1):79-84, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new furan derivative named 5-acetoxymethylfuran-3-carboxylic acid (2), together with a known furan compound, 5-hydroxymethylfuran-3-carboxylic acid (1), were isolated from the fermentation of Aspergillus flavus, endophytic fungi in Cephalotaxus fortunei. The structures of 1 and 2 were elucidated by NMR, IR, UV and MS data, as well as compared with literature data. The compounds 1 and 2 exhibited potent antibacterial activity against Staphylococcus aureus with MIC values of 31.3 and 15.6 µg/mL, respectively. The compound 2 showed moderate antioxidant activity.
[Mh] Termos MeSH primário: Acetatos/química
Acetatos/farmacologia
Aspergillus flavus/química
Cephalotaxus/microbiologia
Furanos/química
Furanos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Fermentação
Fungos/química
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Modelos Moleculares
Espectrometria de Massas por Ionização por Electrospray
Espectrofotometria Infravermelho
Espectrofotometria Ultravioleta
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5-acetoxymethylfuran-3-carboxylic acid); 0 (Acetates); 0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Furans); UC0XV6A8N9 (furan)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150506
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1038262


  10 / 63 MEDLINE  
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[PMID]:26280451
[Au] Autor:Yang HR; Hu XP; Jiang CJ; Qi J; Wu YC; Li W; Zeng YJ; Li CF; Liu SX
[Ad] Endereço:College of Food Science and Technology, Hainan University, Haikou, China.
[Ti] Título:Diversity and antimicrobial activity of endophytic fungi isolated from Cephalotaxus hainanensis Li, a well-known medicinal plant in China.
[So] Source:Lett Appl Microbiol;61(5):484-90, 2015 Nov.
[Is] ISSN:1472-765X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: About 1051 endophytic fungi were isolated from leaves, branches, barks and stems of Cephalotaxus hainanensis Li from four sites in Hainan, China. The fungi were identified as 21 genera by morphology and ITS sequences. One dominant species was Phomopsis quercella in Hainan Tropical Botanical Garden and Bawangling Nature Reserve, with relative frequency of 42·06 and 34·88% respectively. Another dominant species was Colletotrichum boninense in Wuzhishan and Jianfengling Nature Reserves, with relative frequency of 36·84 and 46·97% respectively. Among the selected 21 endophytic fungi, 17 strains (80·95%) had activity against at least one pathogenic bacteria, and 14 strains (66·67%) exhibited activity against at least one fungal pathogens. Neonectria macroconidialis showed strong inhibition against Staphylococcus aureus (inhibition zone being 20 mm), Bacillus subtilis (14 mm) and Streptococcus agalactiae (28 mm). Xylaria sp. showed strong inhibition against Escherichia coli (20 mm), Rhizoctonia solani (20 mm) and Sclerotinia sclerotiorum (17 mm). Verticillium bulbillosum showed great activity against Strep. agalactiae (32 mm) and Fusarium oxysporum (22 mm). These endophytic fungi showed potentials in medicine development. SIGNIFICANCE AND IMPACT OF THE STUDY: Endophytic fungi from medicinal plants are an important source of novel and viable drugs. Cephalotaxus hainanensis Li is well known for leukaemia treatment and its endophytic fungi were isolated to investigate the diversity and antimicrobial activity. It was found that Ce. hainanensis Li had rich endophytic fungi, and some fungi showed strong antimicrobial activity against certain pathogens. These fungi can be used in medicine development.
[Mh] Termos MeSH primário: Anti-Infecciosos/metabolismo
Cephalotaxus/microbiologia
Endófitos/metabolismo
Plantas Medicinais/microbiologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Ascomicetos/classificação
Ascomicetos/efeitos dos fármacos
Bacillus subtilis/efeitos dos fármacos
China
Colletotrichum/efeitos dos fármacos
Endófitos/isolamento & purificação
Fusarium/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Folhas de Planta/microbiologia
Caules de Planta/microbiologia
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151014
[Lr] Data última revisão:
151014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150818
[St] Status:MEDLINE
[do] DOI:10.1111/lam.12483



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