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Pesquisa : B01.650.940.800.575.156.577.222 [Categoria DeCS]
Referências encontradas : 344 [refinar]
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[PMID]:29172693
[Au] Autor:Ojeda-Montes MJ; Ardid-Ruiz A; Tomás-Hernández S; Gimeno A; Cereto-Massagué A; Beltrán-Debón R; Mulero M; Garcia-Vallvé S; Pujadas G; Valls C
[Ad] Endereço:Research group in Cheminformatics & Nutrition, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Campus de Sescelades, Tarragona, Catalonia 43007, Spain.
[Ti] Título:Ephedrine as a lead compound for the development of new DPP-IV inhibitors.
[So] Source:Future Med Chem;9(18):2129-2146, 2017 12.
[Is] ISSN:1756-8927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Extracts from Ephedra species have been reported to be effective as antidiabetics. A previous in silico study predicted that ephedrine and five ephedrine derivatives could contribute to the described antidiabetic effect of Ephedra extracts by inhibiting dipeptidyl peptidase IV (DPP-IV). Finding selective DPP-IV inhibitors is a current therapeutic strategy for Type 2 diabetes mellitus management. Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors. Materials & methods: The DPP-IV inhibition of Ephedra's alkaloids was determined via a competitive-binding assay. Then, computational analyses were used in order to find out the protein-ligand interactions and to perform a lead optimization. RESULTS: Our results show that all six molecules are DPP-IV inhibitors, with IC ranging from 124 µM for ephedrine to 28 mM for N-methylpseudoephedrine. CONCLUSION: Further computational analysis shows how Ephedra's alkaloids could be used as promising lead molecules for designing more potent and selective DPP-IV inhibitors.
[Mh] Termos MeSH primário: Dipeptidil Peptidase 4/metabolismo
Inibidores da Dipeptidil Peptidase IV/química
Efedrina/análogos & derivados
Hipoglicemiantes/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/metabolismo
Sítios de Ligação
Ligação Competitiva
Dipeptidil Peptidase 4/química
Desenho de Drogas
Ephedra/química
Ephedra/metabolismo
Efedrina/metabolismo
Hipoglicemiantes/metabolismo
Concentração Inibidora 50
Simulação de Acoplamento Molecular
Fenilpropanolamina/química
Extratos Vegetais/química
Isoformas de Proteínas/antagonistas & inibidores
Isoformas de Proteínas/metabolismo
Estrutura Terciária de Proteína
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Protein Isoforms); 33RU150WUN (Phenylpropanolamine); EC 3.4.14.5 (Dipeptidyl Peptidase 4); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.4155/fmc-2017-0080


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[PMID]:28827820
[Au] Autor:Neghme C; Santamaría L; Calviño-Cancela M
[Ad] Endereço:Department of Biology, University of La Serena, La Serena, Chile.
[Ti] Título:Strong dependence of a pioneer shrub on seed dispersal services provided by an endemic endangered lizard in a Mediterranean island ecosystem.
[So] Source:PLoS One;12(8):e0183072, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The accelerating rate of vertebrate extinctions and population declines threatens to disrupt important ecological interactions, altering key ecosystem processes such as animal seed dispersal. The study of highly specialized mutualistic interactions is crucial to predict the consequences of population declines and extinctions. Islands offer unique opportunities to study highly specialized interactions, as they often have naturally depauperated faunas and are experiencing high rates of human-driven extinctions. In this study, we assess the effect of seed dispersal on seedling recruitment of Ephedra fragilis (Ephedraceae) on a Mediterranean island ecosystem. We used field data and stochastic simulation modeling to estimate seed fate and recruitment patterns of this pioneer shrub typical of arid and semiarid areas, and to estimate the dependence of recruitment on the lizard Podarcis lilfordi (Lacertidae), its only known seed disperser. Ephedra fragilis recruitment highly depended on lizards: lizards produced 3.8 times more newly-emerged seedlings than non-dispersed seeds and no seedlings from undispersed seeds survived the study period. Seed dispersal by lizards was mostly to open sites, which was key for the increased success observed, while undispersed seeds, falling under mother plants, suffered higher predation and lower seedling emergence and survival. The ability of this pioneer shrub to get established in open ground is crucial for vegetation colonization and restoration, especially on degraded lands affected by desertification, where they act as nurse plants for other species. Lizards are key in this process, which has important consequences for community structure and ecosystem functioning.
[Mh] Termos MeSH primário: Ecossistema
Espécies em Perigo de Extinção
Ephedra/fisiologia
Lagartos
Sementes
[Mh] Termos MeSH secundário: Animais
Ilhas do Mediterrâneo
Processos Estocásticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183072


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[PMID]:28573229
[Au] Autor:Al-Rimawi F; Abu-Lafi S; Abbadi J; Alamarneh AAA; Sawahreh RA; Odeh I
[Ad] Endereço:Chemistry Department, Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine.
[Ti] Título:ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY.
[So] Source:Afr J Tradit Complement Altern Med;14(2):130-141, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ephedra is among Palestinian medicinal plants that are traditionally used in folkloric medicine for treating many diseases. Ephedra is known to have antibacterial and antioxidant effects. The goal of this study is to evaluate the antioxidant activity of different extracts from the plant growing wild in Palestine, and to analyze their phenolic and flavonoid constituents by HPLC/PDA and HPLC/MS. MATERIALS AND METHODS: Samples of the plant grown wild in Palestine were extracted with three different solvents namely, 100% water, 80% ethanol, and 100% ethanol. The extracts were analyzed for their total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (AA), as well as phenolic and flavonoids content by HPLC/PDA/MS. RESULTS: The results revealed that the polarity of the extraction solvent affects the TPC, TFC, and AA of extracts. It was found that both TPC and AA are highest for plant extracted with 80% ethanol, followed by 100% ethanol, and finally with 100% water. TFC however was highest in the following order: 100% ethanol > 80% ethanol > water. Pearson correlation indicated that there is a significant correlation between AA and TPC, but there is no correlation between AA and TFC. Simultaneous HPLC-PDA and UHPLC-MS analysis of the ethanolic plant extracts revealed the presence of Luteolin-7-O-glucuronide flavone, Myricetin 3-rhamnoside and some other major polyphenolic compounds that share myricetin skeleton. CONCLUSION: extract is rich in potent falvonoid glycosidic compounds as revealed by their similar overlaid UV-Vis spectra and UHPLC-MS results. On the basis of these findings, it is concluded that constitutes a natural source of potent antioxidants that may prevent many diseases and could be potentially used in food, cosmetics, and pharmaceutical products.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Ephedra/química
Flavonoides/farmacologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Cromatografia Líquida de Alta Pressão
Flavonas/análise
Flavonas/farmacologia
Flavonoides/análise
Glicosídeos/análise
Glicosídeos/farmacologia
Luteolina/análise
Luteolina/farmacologia
Espectrometria de Massas/métodos
Oxirredução
Fenóis/análise
Extratos Vegetais/química
Polifenóis/análise
Polifenóis/farmacologia
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavones); 0 (Flavonoids); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols); 0 (Solvents); 0 (luteolin-7-O-glucuronide); 76XC01FTOJ (myricetin); KUX1ZNC9J2 (Luteolin); S2V45N7G3B (flavone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.14


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[PMID]:28545666
[Au] Autor:Wang Z; Cui Y; Ding G; Zhou M; Ma X; Hou Y; Jiang M; Liu D; Bai G
[Ad] Endereço:State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
[Ti] Título:Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing ß -adrenoceptor/cAMP signaling pathway.
[So] Source:Phytomedicine;30:18-27, 2017 Jul 01.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Based on the traditional application of traditional Chinese Medicines (TCMs), Ephedra Herba (EH) is used to cure cold fever by inducing sweating, whereas Ephedra Radix (ER) is used to treat hyperhidrosis. Although they come from the same plant, Ephedra sinica Stapf, but have play opposing roles in clinical applications. EH is known to contain ephedrine alkaloids, which is the driver of the physiological changes in sweating, heart rate and blood pressure. However, the active pharmacological ingredients (APIs) of ER and the mechanisms by which it restricts sweating remain unknown. PURPOSE: The current work aims to discover the hidroschesis APIs from ER, as well as to establish its action mechanism. METHODS: UPLC-Q/TOF-MS, PCA, and heat map were utilized for identifying the differences between EH and ER. HPLC integrated with a ß -adrenoceptor (ß -AR) activity luciferase reporter assay system was used to screen active inhibitors; molecular docking and a series of biological assays centered on ß -AR-related signaling pathways were evaluated to understand the roles of APIs. RESULTS: The opposite effect on sweating of EH and ER can be attributed to the APIs of amphetamine-type alkaloids and flavonoid derivatives. Mahuannin B is an effective anti-hydrotic agent, inhibiting the production of cAMP via suppression of adenylate cyclase (AC) activity. CONCLUSION: The effects of EH and ER on sweat and ß -AR-related signaling pathway are opposite due to different alkaloids and flavonoids of APIs in EH and ER. The present work not only sheds light on the hidroschesis action of mahuannin B, but also presents a potential target of AC in the treatment of hyperhidrosis.
[Mh] Termos MeSH primário: Inibidores de Adenilil Ciclase/farmacologia
Alcaloides/farmacologia
AMP Cíclico/metabolismo
Medicamentos de Ervas Chinesas/farmacologia
Ephedra/química
Flavonoides/farmacologia
Receptores Adrenérgicos beta 2/metabolismo
[Mh] Termos MeSH secundário: Inibidores de Adenilil Ciclase/química
Antagonistas de Receptores Adrenérgicos beta 2/química
Antagonistas de Receptores Adrenérgicos beta 2/farmacologia
Alcaloides/química
Animais
Cromatografia Líquida de Alta Pressão
Avaliação Pré-Clínica de Medicamentos/métodos
Medicamentos de Ervas Chinesas/química
Ephedra sinica/química
Efedrina/farmacologia
Flavonoides/química
Masculino
Camundongos
Simulação de Acoplamento Molecular
Receptores Adrenérgicos
Transdução de Sinais/efeitos dos fármacos
Especificidade da Espécie
Sudorese/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adenylyl Cyclase Inhibitors); 0 (Adrenergic beta-2 Receptor Antagonists); 0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Receptors, Adrenergic); 0 (Receptors, Adrenergic, beta-2); 0 (mahuannin B); E0399OZS9N (Cyclic AMP); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


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[PMID]:28545248
[Au] Autor:Wang JH; Kim BS; Han K; Kim H
[Ad] Endereço:Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa, Goyang, Gyeonggi-do 10326, Korea. ewccwang@gmail.com.
[Ti] Título:Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats.
[So] Source:Int J Environ Res Public Health;14(6), 2017 May 23.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Changes in gut microbiota (GM) are closely associated with metabolic syndrome, obesity, type 2 diabetes and so on. Several medicinal herbs, including (Es), have anti-obesity effects that ameliorate metabolic disorders. Therefore, in this study we evaluated whether Es maintains its anti-obesity effect through Es-altered gut microbiota (EsM) transplantation. GM was isolated from cecal contents of Es treated and untreated rats following repeated transplants into obese rats via oral gavage over three weeks. High-fat-diet (HFD)-induced obese rats transplanted with EsM lost significant body weight, epididymal fat, and perirenal fat weight, but no remarkable changes were observed in abdominal fat, liver, cecum weight and food efficiency ratio. In addition, treatment with EsM also significantly lowered the fasting blood glucose, serum insulin level, and insulin resistance index. Meanwhile, EsM transplantation significantly reduced gene expression of proinflammatory cytokines interleukin-1 and monocyte chemotactic protein-1. Rats treated with EsM also showed changed GM composition, especially blautia, roseburia and clostridium, significantly reduced the level of endotoxin and markedly increased the acetic acid in feces. Overall, our results demonstrated that EsM ameliorates HFD-induced obesity and related metabolic disorders, like hyperglycemia and insulin resistance, and is strongly associated with modulating the distribution of GM, enterogenous endotoxin and enteral acetic acid.
[Mh] Termos MeSH primário: Ephedra
Transplante de Microbiota Fecal
Microbioma Gastrointestinal
Doenças Metabólicas/terapia
Obesidade/terapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Tecido Adiposo
Animais
Glicemia/análise
Peso Corporal
Ceco/microbiologia
Quimiocina CCL2
Citocinas/genética
Dieta Hiperlipídica
Microbioma Gastrointestinal/efeitos dos fármacos
Expressão Gênica
Insulina/sangue
Resistência à Insulina
Fígado
Masculino
Doenças Metabólicas/sangue
Obesidade/sangue
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (CCL2 protein, human); 0 (Chemokine CCL2); 0 (Cytokines); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


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[PMID]:28209447
[Au] Autor:Kittana N; Abu-Rass H; Sabra R; Manasra L; Hanany H; Jaradat N; Hussein F; Zaid AN
[Ad] Endereço:Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus - P.O. Box 7, Palestine. Electronic address: naim.kittana@najah.edu.
[Ti] Título:Topical aqueous extract of Ephedra alata can improve wound healing in an animal model.
[So] Source:Chin J Traumatol;20(2):108-113, 2017 Apr.
[Is] ISSN:1008-1275
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. METHODS: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis. RESULTS: Phytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers. CONCLUSION: E. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically.
[Mh] Termos MeSH primário: Ephedra
Extratos Vegetais/uso terapêutico
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Queimaduras/tratamento farmacológico
Modelos Animais de Doenças
Ephedra/química
Masculino
Mesocricetus
Pomadas
Extratos Vegetais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ointments); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28154331
[Au] Autor:Odaguchi H
[Ad] Endereço:Oriental Medicine Research Center, Kitasato University.
[Ti] Título:Clinical Research Testing the Usefulness of Ephedrine Alkaloids-free Ephedra Herb Extract.
[So] Source:Yakugaku Zasshi;137(2):195-197, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We aimed to test the clinical usefulness of ephedrine alkaloids-free Ephedra Herb extract (EFE), which has been proven to be effective and safe in animal studies. First, we performed a safety trial with 7 healthy volunteers, and increased white blood cell counts were observed in 2. However, it was unknown whether this observation was a result of EFE administration. Then, we implemented a controlled, double-blind, randomized crossover trial as the second safety trial for EFE. The trial was conducted under strict conditions, and the participants were managed in the hospital and monitored using an increased number of endpoints. Twelve healthy volunteers were randomly allocated to group 1, who were administered EFE first, or group 2, who were administered Ephedra Herb first. In both groups, the drug was administered for 6 d. After a 4-week washout period with no drug administration, each group was administered the alternate drug for 6 d. In the third stage, a dose-response trial is planned to test the effectiveness and safety of EFE on chronic joint pain. Patients with chronic knee joint pain will be randomly allocated to three groups, and each group will be administered EFE prepared from different amounts of Ephedra Herb. Until this stage, the studies will be conducted as investigator-initiated clinical trials. In the fourth stage, industry-sponsored clinical trials will be planned. This multicenter trial will involve 300 patients with joint pain, neuralgia, and/or muscle pain.
[Mh] Termos MeSH primário: Artralgia/tratamento farmacológico
Ephedra
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Alcaloides
Doença Crônica
Estudos Cross-Over
Relação Dose-Resposta a Droga
Método Duplo-Cego
Efedrina
Feminino
Seres Humanos
Masculino
Meia-Idade
Extratos Vegetais/efeitos adversos
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00233-6


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[PMID]:28154329
[Au] Autor:Hyuga S
[Ad] Endereço:Department of Clinical Research, Oriental Medicine Research Center, Kitasato University.
[Ti] Título:The Pharmacological Actions of Ephedrine Alkaloids-free Ephreda Herb Extract and Preparation for Clinical Application.
[So] Source:Yakugaku Zasshi;137(2):179-186, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Ephedra Herb is defined in the 17th edition of the Japanese Pharmacopoeia as the terrestrial stem of Ephedra sinica STAPF., Ephedra intermedia SCHRENK et C.A. MEYER, or Ephedra equisetina BUNGE (Ephedraceae) which contains more than 0.7% ephedrine alkaloids (ephedrine and pseudoephedrine). The primary effects and adverse effects of Ephedra Herb are traditionally believed to be mediated by ephedrine alkaloids. We recently reported that Ephedra Herb extract (EHE) exhibits antimetastatic and antitumor effects by suppressing the hepatocyte growth factor-c-Met signaling pathway through the inhibition of c-Met tyrosine kinase activity. We confirmed that the non-alkaloidal fraction of EHE had c-Met-inhibitory activity. Moreover, we discovered herbacetin glycosides in EHE and demonstrated that herbacetin, the aglycone of the glycosides, shows c-Met-inhibitory activity and analgesic action. These findings suggest that some pharmacological actions of EHE may be produced by its non-alkaloidal fraction, which does not cause the adverse effects of ephedrine alkaloids. Therefore, we prepared ephedrine alkaloids-free EHE (EFE) by removing ephedrine alkaloids from EHE using ion-exchange column chromatography. EFE had c-Met-inhibitory action, analgesic effects, and antiinfluenza activity similar to EHE but had no toxicity. Now, we are evaluating the safety of EFE in healthy volunteers and its efficacy in patients to obtain licensing approval for its therapeutic use in the future.
[Mh] Termos MeSH primário: Ephedra/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Alcaloides/efeitos adversos
Alcaloides/isolamento & purificação
Analgésicos
Animais
Antineoplásicos Fitogênicos
Antivirais
Cromatografia por Troca Iônica
Efedrina/efeitos adversos
Efedrina/isolamento & purificação
Feminino
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Seres Humanos
Masculino
Camundongos
Extratos Vegetais/análise
Extratos Vegetais/toxicidade
Receptores Proteína Tirosina Quinases/antagonistas & inibidores
Tecnologia Farmacêutica/métodos
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Antineoplastic Agents, Phytogenic); 0 (Antiviral Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (herbacetin); EC 2.7.10.1 (RON protein); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00233-4


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[PMID]:28154330
[Au] Autor:Kobayashi Y
[Ad] Endereço:School of Pharmacy, Kitasato University.
[Ti] Título:Analgesic Effects and Side Effects of Ephedra Herb Extract and Ephedrine Alkaloids-free Ephedra Herb Extract.
[So] Source:Yakugaku Zasshi;137(2):187-194, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Ephedra Herb is classified "pungent, slightly bitter, and warm" in tastes and natures, and is used to provide warmth to the body, dispel coldness, remove dampness, and reduce pain. Similar herbs are "pungent and hot" chili peppers, "pungent and hot" evodia fruit," "pungent and warm" ginger, "pungent and hot" processed ginger, "pungent and hot" Zanthoxylum fruit, etc. These herbs are prescribed to provide heat to the outer or inner body. Some pungent components such as capsaicin, evodiamine, gingerol, and shogaol are known to be activators of transient receptor potential vanilloid 1 (TRPV1). TRPV1, a pain receptor, is activated in response to irritant chemicals such as capsaicin and high heat (>43℃) and strongly acidic conditions (pH<6). The typical TRPV1 activator capsaicin has various effects such as improvement of peripheral circulation, enhancement of thermogenesis, and pain relief. These effects are commonly observed for the "pungent and hot/warm" herbs, suggesting that TRPV1 stimulation plays an important part in their pharmacological action. In this study, we demonstrated that Ephedra Herb extract (EHE) shows strong TRPV1 activation, although ephedrine didn't show such effects. Both EHE and ephedrine alkaloids-free EHE (EFE) expressed similar analgesic action following oral administration, suggesting the presence of active components other than ephedrine alkaloids. Furthermore, EFE did not show side effects such as loss of sleep and irregular heartbeat in mice. Caution needs to be exercised while prescribing Ephedra Herb because it contains ephedrine. The application of EFE in Kampo medicine might be a better alternative in some cases.
[Mh] Termos MeSH primário: Analgésicos
Ephedra/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Alcaloides/efeitos adversos
Animais
Capsaicina
Células Cultivadas
Efedrina/efeitos adversos
Seres Humanos
Camundongos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/análise
Extratos Vegetais/uso terapêutico
Canais de Cátion TRPV/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Plant Extracts); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); GN83C131XS (Ephedrine); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00233-5


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[PMID]:28154328
[Au] Autor:Oshima N
[Ad] Endereço:Department of Pharmaceutical Sciences, International University of Health and Welfare.
[Ti] Título:Efficient Preparation of Ephedrine Alkaloids-free Ephedra Herb Extract and Its Antitumor Effect and Putative Marker Compound.
[So] Source:Yakugaku Zasshi;137(2):173-177, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Ephedra Herb is a crude drug for the treatment of headache, bronchial asthma, nasal inflammation, and the common cold. Although it has been considered that ephedrine alkaloids (EAs) are the principal active ingredients of Ephedra Herb, EAs are known to induce palpitations, hypertension, insomnia, and dysuria as major side effects. Therefore, the administration of EAs-containing drugs to patients with cardiovascular-related diseases is strongly contraindicated. Previously, we isolated herbacetin 7-O-neohesperidoside from Ephedra Herb. In addition, we found that herbacetin, a flavonoid aglycone in Ephedra Herb, had antiproliferative and analgesic effects. Therefore, the prospect of preparing safer natural medicines without the adverse effects associated with EAs was appealing. In this symposium review, to achieve the aim of producting a clinically useful Ephedra Herb extract with none of the adverse effects associated with EAs, I present an efficient preparation method of EAs-free Ephedra Herb extract, together with its chemical composition, antiproliferative effects, and a putative marker for quality control.
[Mh] Termos MeSH primário: Analgésicos
Antineoplásicos Fitogênicos
Ephedra/química
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Extratos Vegetais/análise
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Alcaloides/efeitos adversos
Doenças Cardiovasculares
Contraindicações
Efedrina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (Plant Extracts); 0 (herbacetin); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00233-3



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