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  1 / 151 MEDLINE  
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[PMID]:29385990
[Au] Autor:Schoendorfer N; Sharp N; Seipel T; Schauss AG; Ahuja KDK
[Ad] Endereço:School of Medicine, University of Queensland, Herston, Australia.
[Ti] Título:Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial.
[So] Source:BMC Complement Altern Med;18(1):42, 2018 Jan 31.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence (UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines have been documented both empirically and in emerging scientific research to have varying benefits in reducing bladder symptoms. We assessed the efficacy of Urox®, a proprietary combination of phytomedicine extracts including, Cratevox™ (Crataeva nurvala) stem bark, Equisetem arvense stem and Lindera aggregata root, in reducing symptoms of OAB and UI. METHODS: Efficacy of the herbal combination on a variety of bladder symptoms compared to an identical placebo, were documented in a randomised, double-blind, placebo controlled trial conducted at two primary care centres. Data were collected at baseline, 2, 4 and 8 weeks, with the primary outcome being self-reported urinary frequency. Statistical analysis included mixed effects ordered logistic regression with post hoc Holm's test to account for repeated measures, and included an intention-to-treat analysis. RESULTS: One hundred and fifty participants (59% female, aged; mean ± SD; 63.5 ± 13.1 years) took part in the study. At week 8, urinary day frequency was significantly lower (OR 0.01; 95%CI 0.01 to 0.02; p < 0.001) in response to treatment (mean ± SD; 7.69 ± 2.15/day) compared to placebo (10.95 ± 2.47/day). Similarly, episodes of nocturia were significantly fewer (OR 0.03; 95%CI 0.02 to 0.05) after 8 weeks of treatment (2.16 ± 1.49/night) versus placebo (3.14 ± 1.36/night). Symptoms of urgency (OR 0.02; 95%CI 0.01 to 0.03), and total incontinence (OR 0.03; 95% CI 0.01 to 0.06) were also lower (all p < 0.01) in the treatment group. Significant improvements in quality of life were reported after treatment in comparison to placebo. No significant side effects were observed resulting in withdrawal from treatment. CONCLUSIONS: The outcome of this study demonstrated both statistical significance and clinical relevance in reducing symptoms of OAB, urinary frequency and/or urgency and incontinence. The demonstrated viability of the herbal combination to serve as an effective treatment, with minimal side-effects, warrants further longer term research and consideration by clinicians. TRIAL REGISTRATION: NCT02396160 (registered on 17 March 2015 - before any statistical analyses commenced).
[Mh] Termos MeSH primário: Extratos Vegetais/uso terapêutico
Bexiga Urinária Hiperativa/tratamento farmacológico
Incontinência Urinária/tratamento farmacológico
Agentes Urológicos/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Capparaceae
Equisetum
Feminino
Seres Humanos
Lindera
Masculino
Registros Médicos
Meia-Idade
Fitoterapia
Extratos Vegetais/farmacologia
Micção/efeitos dos fármacos
Agentes Urológicos/farmacologia
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Urological Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2101-4


  2 / 151 MEDLINE  
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[PMID]:28458431
[Au] Autor:Ali S; Omer MO; Chaudhry MA; Ashraf M; Bukhsh A
[Ad] Endereço:Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, 54000, Punjab, Pakistan.
[Ti] Título:A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Roxb.
[So] Source:Indian J Pharmacol;49(1):98-101, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The study was designed to evaluate possible antihistaminic and anticholinergic activities of . MATERIALS AND METHODS: Effects of crude ethanolic (Ed.Eth) and effects of crude aqueous (Ed.Aq) extracts of were studied using isolated guinea pig ileum, rabbit jejunum, and rabbit trachea. Tissue responses were recorded using isotonic and isometric transducers, connected with PowerLab data acquisition system. RESULTS: A dose-dependent (0.1-0.3 mg/ml) rightward shift was demonstrated in histamine concentration-response curves. Whereas a complete relaxation of carbachol (1 µM)-induced contractions in isolated rabbit jejunum (3 mg/ml) and tracheal (10 mg/ml) preparations was observed, similar to dicyclomine at 1 and 3 µM, respectively. However, no significant difference between the effects of Ed.Eth and Ed.Aq was observed. CONCLUSION: Study provides pharmacological evidence for the presence of antihistaminic and anticholinergic activities in crude extracts of and also highlight its medicinal significance in the management of airway and gastrointestinal disorders.
[Mh] Termos MeSH primário: Antagonistas Colinérgicos/farmacologia
Equisetum/química
Antagonistas dos Receptores Histamínicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antagonistas Colinérgicos/administração & dosagem
Antagonistas Colinérgicos/isolamento & purificação
Diciclomina/administração & dosagem
Diciclomina/farmacologia
Relação Dose-Resposta a Droga
Feminino
Cobaias
Antagonistas dos Receptores Histamínicos/administração & dosagem
Íleo/efeitos dos fármacos
Íleo/metabolismo
Jejuno/efeitos dos fármacos
Jejuno/metabolismo
Masculino
Extratos Vegetais/administração & dosagem
Coelhos
Traqueia/efeitos dos fármacos
Traqueia/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Antagonists); 0 (Histamine Antagonists); 0 (Plant Extracts); 4KV4X8IF6V (Dicyclomine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201017


  3 / 151 MEDLINE  
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[PMID]:28365757
[Au] Autor:Tomescu AM; Escapa IH; Rothwell GW; Elgorriaga A; Cúneo NR
[Ad] Endereço:Department of Biological Sciences, Humboldt State University, Arcata, CA 95521, USA.
[Ti] Título:Developmental programmes in the evolution of Equisetum reproductive morphology: a hierarchical modularity hypothesis.
[So] Source:Ann Bot;119(4):489-505, 2017 Mar 01.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: The origin of the Equisetum strobilus has long been debated and the fossil record has played an important role in these discussions. The paradigm underlying these debates has been the perspective of the shoot as node-internode alternation, with sporangiophores attached at nodes. However, fossils historically excluded from these discussions (e.g. Cruciaetheca and Peltotheca ) exhibit reproductive morphologies that suggest attachment of sporangiophores along internodes, challenging traditional views. This has rekindled discussions around the evolution of the Equisetum strobilus, but lack of mechanistic explanations has led discussions to a stalemate. Scope: A shift of focus from the node-internode view to a perspective emphasizing the phytomer as a modular unit of the shoot, frees the debate of homology constraints on the nature of the sporangiophore and inspires a mechanism-based hypothesis for the evolution of the strobilus. The hypothesis, drawing on data from developmental anatomy, regulatory mechanisms and the fossil record, rests on two tenets: (1) the equisetalean shoot grows by combined activity of the apical meristem, laying down the phytomer pattern, and intercalary meristems responsible for internode elongation; and (2) activation of reproductive growth programmes in the intercalary meristem produces sporangiophore whorls along internodes. Conclusions: Hierarchical expression of regulatory modules responsible for (1) transition to reproductive growth; (2) determinacy of apical growth; and (3) node-internode differentiation within phytomers, can explain reproductive morphologies illustrated by Cruciaetheca (module 1 only), Peltotheca (modules 1 and 2) and Equisetum (all three modules). This model has implications - testable by studies of the fossil record, phylogeny and development - for directionality in the evolution of reproductive morphology ( Cruciaetheca - Peltotheca - Equisetum ) and for the homology of the Equisetum stobilus. Furthermore, this model implies that sporangiophore development is independent of node-internode identity, suggesting that the sporangiophore represents the expression of an ancestral euphyllophyte developmental module that pre-dates the evolution of leaves.
[Mh] Termos MeSH primário: Equisetum/anatomia & histologia
[Mh] Termos MeSH secundário: Evolução Biológica
Equisetum/crescimento & desenvolvimento
Fósseis/anatomia & histologia
Modelos Biológicos
Estruturas Vegetais/anatomia & histologia
Estruturas Vegetais/crescimento & desenvolvimento
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw273


  4 / 151 MEDLINE  
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[PMID]:28164200
[Au] Autor:Jabeur I; Martins N; Barros L; Calhelha RC; Vaz J; Achour L; Santos-Buelga C; Ferreira IC
[Ad] Endereço:Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. iferreira@ipb.pt lillian@ipb.pt and Laboratoire de Recherche "Bioressources": Biologie Intégrative & Valorisation", Institut Supérieur de Biotechnologie de Monast
[Ti] Título:Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.
[So] Source:Food Funct;8(3):975-984, 2017 Mar 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Naturally-occurring phytochemicals have received pivotal attention in the last few years, due to the increasing evidence of biological activities. Thus, in the present study, the antioxidant, anti-inflammatory and antitumor potentials of hydroethanolic extracts rich in phenolic compounds obtained from Equisetum giganteum L. and Tilia platyphyllos Scop. were assessed and directly correlated with their content of phenolic compounds, by using HPLC-DAD-ESI/MS analysis. T. platyphyllos showed the higher bioactive potential, evaluated in terms of antioxidant (radical scavenging effects - 105 µg mL , reducing power - 123 µg mL , ß-carotene bleaching inhibition - 167 µg mL , and lipid peroxidation inhibition - 56 µg mL ), anti-inflammatory (225 µg mL inhibited 50% of nitric oxide production) and antitumor (breast - 224 µg mL ; lung - 247 µg mL ; cervical - 195 µg mL and hepatocellular - 173 µg mL carcinoma cells) activity, without having cytotoxic effects (>400 µg mL ). These biological properties were positively correlated with its content and composition of phenolic compounds. Flavonoid contents were markedly higher than the content of phenolic acids, in both samples, being respectively 50.4 mg g and 11.65 mg g for T. platyphyllos, and 21.7 mg g and 4.98 mg g for E. giganteum. Moreover, while in E. giganteum extract, kaempferol-O-glucoside-O-rutinoside was the most abundant flavonoid, in T. platyphyllos extract protocatechuic acid and (-)-epicatechin were the most abundant phenolic acid and flavonoid, respectively. In relation to their content of phenolic acids, protocatechuic and caffeic acids existed in higher abundance in T. platyphyllos and E. giganteum hydroethanolic extracts, respectively. However, it would be interesting to evaluate the in vivo efficacy of both plant extracts to unveil the involved modes of action and to establish effective therapeutic doses.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Antineoplásicos Fitogênicos/química
Antioxidantes/química
Equisetum/química
Extratos Vegetais/química
Tilia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Seres Humanos
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Camundongos
Extratos Vegetais/farmacologia
Células RAW 264.7
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01778a


  5 / 151 MEDLINE  
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[PMID]:28108640
[Au] Autor:Simmons TJ; Fry SC
[Ad] Endereço:The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, The University of Edinburgh, The King's Buildings, Edinburgh EH9 3BF, U.K.
[Ti] Título:Bonds broken and formed during the mixed-linkage glucan : xyloglucan endotransglucosylase reaction catalysed by hetero-trans-ß-glucanase.
[So] Source:Biochem J;474(7):1055-1070, 2017 Mar 08.
[Is] ISSN:1470-8728
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mixed-linkage glucan∶xyloglucan endotransglucosylase (MXE) is one of the three activities of the recently characterised hetero-trans-ß-glucanase (HTG), which among land plants is known only from species. The biochemical details of the MXE reaction were incompletely understood - details that would promote understanding of MXE's role and enable its full technological exploitation. We investigated HTG's site of attack on one of its donor substrates, mixed-linkage (1→3),(1→4)-ß-d-glucan (MLG), with radioactive oligosaccharides of xyloglucan as the acceptor substrate. Comparing three different MLG preparations, we showed that the enzyme favours those with a high content of cellotetraose blocks. The reaction products were analysed by enzymic digestion, thin-layer chromatography (TLC), high-pressure liquid chromatography (HPLC) and gel-permeation chromatography (GPC). HTG consistently cleaved the MLG at the third consecutive ß-(1→4)-bond following (towards the reducing terminus) a ß-(1→3)-bond. It then formed a ß-(1→4)-bond between the MLG and the non-reducing terminal glucose residue of the xyloglucan oligosaccharide, consistent with its xyloglucan endotransglucosylase/hydrolase subfamily membership. Using size-homogeneous barley MLG as the donor substrate, we showed that HTG does not favour any particular region of the MLG chain relative to the polysaccharide's reducing and non-reducing termini; rather, it selects its target cellotetraosyl unit stochastically along the MLG molecule. This work improves our understanding of how enzymes can exhibit promiscuous substrate specificities and provides the foundations to explore strategies for engineering novel substrate specificities into transglycanases.
[Mh] Termos MeSH primário: Celulose/análogos & derivados
Equisetum/enzimologia
Glucanos/química
Glicosiltransferases/metabolismo
Proteínas de Plantas/metabolismo
Tetroses/química
Xilanos/química
beta-Glucanas/química
[Mh] Termos MeSH secundário: Biocatálise
Sequência de Carboidratos
Parede Celular/química
Parede Celular/enzimologia
Celulose/química
Celulose/metabolismo
Ensaios Enzimáticos
Equisetum/química
Glucanos/metabolismo
Extratos Vegetais/química
Especificidade por Substrato
Tetroses/metabolismo
Xilanos/metabolismo
beta-Glucanas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucans); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Tetroses); 0 (Xylans); 0 (beta-Glucans); 37294-28-3 (xyloglucan); 38819-01-1 (cellotetraose); 9004-34-6 (Cellulose); EC 2.4.- (Glycosyltransferases); EC 2.4.1.207 (xyloglucan - xyloglucosyltransferase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE
[do] DOI:10.1042/BCJ20160935


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[PMID]:28064363
[Au] Autor:Zajaczkowska U; Kucharski S; Nowak Z; Grabowska K
[Ad] Endereço:Department of Forest Botany, Faculty of Forestry, Warsaw University of Life Sciences, 159 Nowoursynowska St., 02-776, Warsaw, Poland. urszula.zajaczkowska@wl.sggw.pl.
[Ti] Título:Morphometric and mechanical characteristics of Equisetum hyemale stem enhance its vibration.
[So] Source:Planta;245(4):835-848, 2017 Apr.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: The order of the internodes, and their geometry and mechanical characteristics influence the capability of the Equisetum stem to vibrate, potentially stimulating spore liberation at the optimum stress setting along the stem. Equisetum hyemale L. plants represent a special example of cellular solid construction with mechanical stability achieved by a high second moment of area and relatively high resistance against local buckling. We proposed the hypothesis that the order of E. hyemale L. stem internodes, their geometry and mechanical characteristics influence the capability of the stem to vibrate, stimulating spore liberation at the minimum stress setting value along the stem. An analysis of apex vibration was done based on videos presenting the behavior of an Equisetum clump filmed in a wind tunnel and also as a result of excitation by bending the stem by 20°. We compared these data with the vibrations of stems of the same size but deprived of the three topmost internodes. Also, we created a finite element model (FEM), upon which we have based the 'natural' stem vibration as a copy of the real object, 'random' with reshuffled internodes and 'uniform', created as one tube with the characters averaged from all internodes. The natural internode arrangement influences the frequency and amplitude of the apex vibration, maintaining an equal stress distribution in the stem, which may influence the capability for efficient spore spreading.
[Mh] Termos MeSH primário: Equisetum/fisiologia
Caules de Planta/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos/fisiologia
Equisetum/anatomia & histologia
Caules de Planta/anatomia & histologia
Esporos/fisiologia
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-017-2648-1


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[PMID]:27933496
[Au] Autor:Bordbar M; Mortazavimanesh N
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Qom, Qom, 37185-359, Iran. m.bordbare@gmail.com.
[Ti] Título:Green synthesis of Pd/walnut shell nanocomposite using Equisetum arvense L. leaf extract and its application for the reduction of 4-nitrophenol and organic dyes in a very short time.
[So] Source:Environ Sci Pollut Res Int;24(4):4093-4104, 2017 Feb.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Palladium nanoparticles (PdNPs) have been immobilized on the surface of walnut shell powder using Equisetum arvense L. leaf extract as reducing and stabilizing agents in this work. FT-IR spectroscopy, UV-Vis spectroscopy, photoluminescence spectroscopy, X-ray diffraction (XRD) pattern, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM) have been used in the characterization of the nanocomposites thus prepared. High catalytic activity was shown by these nanocomposites in the reduction of different dyes. The PdNPs' diameter on the walnut shell was predominantly found within the 5-12-nm range. The advantages of these catalysts include facile and clean synthesis, simple preparation procedure, excellent properties, alterable supports, and low cost, which make them applicable in reduction of 4-nitrophenol (4-NP), Congo red (CR), methylene blue (MB), and rhodamine B (RhB) in the presence of aqueous NaBH at room temperature. Pd/walnut shell nanocomposites were highly active catalysts for reduction of these dyes. Moreover, Pd/walnut shell nanocomposite can be recovered and recycled seven times without any appreciable loss of catalytic activity. Graphical abstract Waste walnut shell as a natural valuable resource support for green synthesis of Pd/walnut shell nanocomposite using Equisetum arvense L. leaf extract and its application for the reduction of 4-nitrophenol and organic dyes in a very short time.
[Mh] Termos MeSH primário: Equisetum/química
Juglans/química
Nanocompostos/química
Nitrofenóis/química
Paládio/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Catálise
Azul de Metileno/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrophenols); 0 (Plant Extracts); 5TWQ1V240M (Palladium); T42P99266K (Methylene Blue); Y92ZL45L4R (4-nitrophenol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8183-y


  8 / 151 MEDLINE  
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[PMID]:27925492
[Au] Autor:Nunes R; Pasko P; Tyszka-Czochara M; Szewczyk A; Szlosarczyk M; Carvalho IS
[Ad] Endereço:a MeditBio, Faculty of Sciences and Technology , University of Algarve , Campus de Gambelas , Faro , Portugal.
[Ti] Título:Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.
[So] Source:Pharm Biol;55(1):114-123, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. OBJECTIVE: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. MATERIAL AND METHODS: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. RESULTS: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 µg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. CONCLUSION: The most promising plants for further studies are CM, LS and GP.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Equisetum/química
Neoplasias Hepáticas/tratamento farmacológico
Extratos Vegetais/farmacologia
Zinco/análise
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Bactérias/crescimento & desenvolvimento
Cloretos/química
Cromatografia Líquida de Alta Pressão
Cromatografia de Fase Reversa
Relação Dose-Resposta a Droga
Compostos Férricos/química
Células Hep G2
Seres Humanos
Neoplasias Hepáticas/patologia
Testes de Sensibilidade Microbiana
Oxirredução
Fenóis/análise
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Portugal
Solventes/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Chlorides); 0 (Ferric Compounds); 0 (Phenols); 0 (Plant Extracts); 0 (Solvents); J41CSQ7QDS (Zinc); U38V3ZVV3V (ferric chloride)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE


  9 / 151 MEDLINE  
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[PMID]:27754712
[Au] Autor:Das G; Patra JK; Baek KH
[Ad] Endereço:1 Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul , Ilsandong-gu, Republic of Korea.
[Ti] Título:Antibacterial Properties of Endophytic Bacteria Isolated from a Fern Species Equisetum arvense L. Against Foodborne Pathogenic Bacteria Staphylococcus aureus and Escherichia coli O157:H7.
[So] Source:Foodborne Pathog Dis;14(1):50-58, 2017 Jan.
[Is] ISSN:1556-7125
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endophytic bacteria (EB) are a rich source of secondary metabolites with medicinal importance. In this study, EB were isolated from the bottle brush herb Equisetum arvense and identified based on 16S rRNA sequencing. Evaluation of its antibacterial potential was conducted using two common foodborne pathogenic bacteria, Staphylococcus aureus ATCC 12600 and Escherichia coli O157:H7 ATCC 43890. Out of 103 identified EB, three species, Streptomyces albolongus, Dermacoccus sp., and Mycobacterium sp., showed significant antibacterial activity against S. aureus with inhibition zones of 45.34 ± 0.15, 43.28 ± 0.19, and 22.98 ± 0.18 mm, respectively, whereas only two species, Streptomyces griseoaurantiacus (EAL196) and Paenibacillus sp. (EAS116), showed moderate antibacterial activity against E. coli O157:H7 with inhibition zones of 9.41 ± 0.29 and 10.44 ± 0.31 mm, respectively. Furthermore, ethyl acetate extract of S. albolongus, Mycobacterium sp., and Dermacoccus sp. showed antibacterial activity against S. aureus, with inhibition zones of 23.43 ± 0.21, 21.18 ± 0.22, and 19.72 ± 0.10 mm, respectively. The methanol extract of Dermacoccus sp. and Paenibacillus sp. showed antibacterial activity against S. aureus and E. coli O157:H7, with inhibition zones of 11.30 ± 0.17 and 10.01 ± 0.21 mm, respectively. Scanning electron microscopy indicated swollen and lysed cell membranes of pathogens treated with ethyl acetate extract. A possible reason might be, likely due to EB metabolites penetrating the bacterial cell membranes and affecting various metabolic functions resulting in lysis. To the best of our knowledge, this is the first study to report that EB from E. arvense can be used as a source of natural antibacterial compounds against foodborne pathogenic bacteria.
[Mh] Termos MeSH primário: Antibiose
Equisetum/microbiologia
Mycobacterium/fisiologia
Paenibacillus/fisiologia
Streptomyces/fisiologia
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Escherichia coli O157/crescimento & desenvolvimento
Microbiologia de Alimentos
Testes de Sensibilidade Microbiana
RNA Ribossômico 16S/isolamento & purificação
Staphylococcus aureus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE
[do] DOI:10.1089/fpd.2016.2192


  10 / 151 MEDLINE  
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[PMID]:28078844
[Au] Autor:Menghini L; Ferrante C; Leporini L; Recinella L; Chiavaroli A; Leone S; Pintore G; Vacca M; Orlando G; Brunetti L
[Ad] Endereço:Department of Pharmacy, “G. d’Annunzio” University, Chieti, Italy.
[Ti] Título:A natural formula containing lactoferrin, Equisetum arvensis, soy isoflavones and vitamin D3 modulates bone remodeling and inflammatory markers in young and aged rats.
[So] Source:J Biol Regul Homeost Agents;30(4):985-996, 2016 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:A pivotal role in osteoporosis development is played by radical oxygen species (ROS), the increased production of which is related to inhibited osteoblastic activity and bone formation. A new field of research could involve medicinal plants with antioxidant and protective effects in osteoporosis. Furthermore, considering the multifactorial metabolic aspects of osteoporosis, the pharmacological association of multiple medicinal plants could improve patient response. The aim of the present study is to evaluate in vitro and in vivo the protective effects of a natural formula containing lactoferrin 12%, Equisetum arvensis ES 54%, soy isoflavones 34% and vitamin D3 0.002%, in PBMC and C2C12 cells and in the bone matrix of young (3-month-old) and aged (12-month-old) female Sprague-Dawley rats, following chronic (21 days) administration. In this context, we assayed the activities of several inflammation and bone homeostasis mediators, such as IL-6, TNFα, PGE2, osteoprotegerin, RANK, RANKL and NFkB. In vitro studies showed that natural formula (5-1000µg/ml) was able to significantly inhibit ROS and PGE2 production. In the same concentration range, the natural formula inhibited both TNFα and IL-6 gene expression. In the in vivo studies, we administered to young and aged female rats the natural formula at 5mg/rat for 21 days, finding a significant reduction in inflammatory PGE2 and NFkB activity. Nevertheless, we observed a significant increase in osteoprotegerin/RANKL ratio only in aged rats, compared to the respective control group. In conclusion, our findings corroborate the rational use of natural formula in the prevention and management of osteoporotic disease.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Conservadores da Densidade Óssea/farmacologia
Remodelação Óssea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Biomarcadores/análise
Osso e Ossos/efeitos dos fármacos
Colecalciferol/farmacologia
Modelos Animais de Doenças
Equisetum
Feminino
Inflamação
Isoflavonas/farmacologia
Lactoferrina/farmacologia
Osteoporose/complicações
Reação em Cadeia da Polimerase
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Feijão de Soja
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Bone Density Conservation Agents); 0 (Isoflavones); 1C6V77QF41 (Cholecalciferol); EC 3.4.21.- (Lactoferrin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE



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