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[PMID]:28738241
[Au] Autor:Tang Y; Xiong J; Zou Y; Wang W; Huang C; Zhang HY; Hu JF
[Ad] Endereço:Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai, 201203, PR China.
[Ti] Título:Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum.
[So] Source:Phytochemistry;143:1-11, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven lycopodine-type (annotinolide F and lycoannotines A-F), two lycodine-type (lycoannotines G and H), and one fawcettimine-type (lycoannotine I) previously undescribed naturally occurring Lycopodium alkaloids together with thirteen known ones were isolated from the whole plant of Lycopodium annotinum. Their structures and absolute configurations were determined by extensive spectroscopic methods, single-crystal X-ray diffraction, chemical transformation, and electronic circular dichroism (ECD) calculations. Among the isolates, annotinolide F, lycoannotines A and B are unusual 7,8-seco-lycopodane derivatives, and annotinolide F even further possesses a rare 8,5-lactone framework through a lactonization after the C-7/C-8 bond cleavage. Lycoannotine C is an uncommon 8,15-seco lycopodine-type alkaloid, whereas lycoannotine I represents the first example of a naturally occurring C-9/N bond cleavage product of fawcettimine-type alkaloid. Among them, only lycoannotine I was found to show considerable anti-butyrylcholinesterase (anti-BuChE) activity.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Inibidores da Colinesterase/isolamento & purificação
Lycopodium/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Inibidores da Colinesterase/química
Inibidores da Colinesterase/farmacologia
Cristalografia por Raios X
Estrutura Molecular
Quinolizinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Quinolizines); 0 (fawcettimine); 2P5MU968XW (lycopodine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


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[PMID]:28698023
[Au] Autor:Nguyen VT; Zhao BT; Seong SH; Kim JA; Woo MH; Choi JS; Min BS
[Ad] Endereço:College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 38430, Republic of Korea; Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi, Viet Nam.
[Ti] Título:Inhibitory effects of serratene-type triterpenoids from Lycopodium complanatum on cholinesterases and ß-secretase 1.
[So] Source:Chem Biol Interact;274:150-157, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of Lycopodium complanatum whole plants led to the isolation of two new serratene-type triterpenoids (1 and 2) along with eight known triterpenoids (3-10). Their structures were established using 1D and 2D NMR spectroscopic techniques and mass spectrometry. These compounds did not inhibit acetylcholinesterases (AChE) and butyrylcholinesterase (BChE), but did inhibit ß-secretase 1 (BACE1). Compounds 1 and 6 showed potent BACE1 inhibition with IC values of 2.79 ± 0.28 and 2.49 ± 0.12 µM, respectively. The kinetic study of BACE1 inhibition revealed that compound 1 showed competitive inhibition, whereas 6 showed mixed-type inhibition. Furthermore, molecular docking results showed that the tested inhibitors 1 and 6 exhibited good binding affinities toward BACE1, with binding energies of -8.8 and -10.3 kcal/mol, respectively.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores
Butirilcolinesterase/metabolismo
Lycopodium/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Secretases da Proteína Precursora do Amiloide/metabolismo
Sítios de Ligação
Butirilcolinesterase/química
Transferência Ressonante de Energia de Fluorescência
Concentração Inibidora 50
Cinética
Lycopodium/metabolismo
Espectroscopia de Ressonância Magnética
Conformação Molecular
Simulação de Acoplamento Molecular
Extratos Vegetais/química
Ligação Proteica
Estrutura Terciária de Proteína
Termodinâmica
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Triterpenes); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); EC 3.4.- (Amyloid Precursor Protein Secretases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28089246
[Au] Autor:Xu B; Lei L; Zhu X; Zhou Y; Xiao Y
[Ad] Endereço:CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China; University of Chinese Academy of Sciences, Beijing, 100039, Ch
[Ti] Título:Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid.
[So] Source:Phytochemistry;136:23-30, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lysine decarboxylation is the first biosynthetic step of Huperzine A (HupA). Six cDNAs encoding lysine decarboxylases (LDCs) were cloned from Huperzia serrata by degenerate PCR and rapid amplification of cDNA ends (RACE). One HsLDC isoform was functionally characterized as lysine decarboxylase. The HsLDC exhibited greatest catalytic efficiency (k /K , 2.11 s mM ) toward L-lysine in vitro among all reported plant-LDCs. Moreover, transient expression of the HsLDC in tobacco leaves specifically increased cadaverine content from zero to 0.75 mg per gram of dry mass. Additionally, a convenient and reliable method used to detect the two catalytic products was developed. With the novel method, the enzymatic products of HsLDC and HsCAO, namely cadaverine and 5-aminopentanal, respectively, were detected simultaneously both in assay with purified enzymes and in transgenic tobacco leaves. This work not only provides direct evidence of the first two-step in biosynthetic pathway of HupA in Huperzia serrata and paves the way for further elucidation of the pathway, but also enables engineering heterologous production of HupA.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Amina Oxidase (contendo Cobre)/metabolismo
Carboxiliases/metabolismo
Huperzia/enzimologia
Lycopodium/química
Sesquiterpenos/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/biossíntese
Alcaloides/química
Cadaverina/análise
Carboxiliases/farmacocinética
DNA Complementar/metabolismo
Lisina/metabolismo
Redes e Vias Metabólicas
Estrutura Molecular
Folhas de Planta/química
Plantas Geneticamente Modificadas/metabolismo
Reação em Cadeia da Polimerase
Sesquiterpenos/análise
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (DNA, Complementary); 0 (Sesquiterpenes); 0111871I23 (huperzine A); EC 1.4.3.21 (Amine Oxidase (Copper-Containing)); EC 4.1.1.- (Carboxy-Lyases); EC 4.1.1.18 (lysine decarboxylase); K3Z4F929H6 (Lysine); L90BEN6OLL (Cadaverine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:27894616
[Au] Autor:Pereira AV; Góis MB; Lera KR; Falkowski-Temporini GJ; Massini PF; Drozino RN; Aleixo DL; Miranda MM; da Silva Watanabe P; Conchon-Costa I; da Costa IN; Dos Anjos Neto Filho M; de Araújo SM; Pavanelli WR
[Ad] Endereço:Department of Experimental Pathology, State University of Londrina, Londrina, PR, Brazil.
[Ti] Título:Histopathological lesions in encephalon and heart of mice infected with Toxoplasma gondii increase after Lycopodium clavatum 200dH treatment.
[So] Source:Pathol Res Pract;213(1):50-57, 2017 Jan.
[Is] ISSN:1618-0631
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In many cases, symptoms of toxoplasmosis are mistaken for the ones of other infectious diseases. Clinical signs are rare in immunocompetent people. However, when they arise, in the acute phase of infection, several organs are affected due to the rapid spread of tachyzoites through the bloodstream. In the present study, the reduction of tachyzoites in peripheral blood of mice of G72 (infected 72h after treatment) and G48 (infected 48h after treatment and treated three more times), when compared with IC (infected and non-treated), suggests protective effect exerted by Lycopodium clavatum. If on the one hand L. clavatum brought benefits, reducing parasitemia, on the other hand, the parasitism became exacerbated. Histopathological analysis demonstrated focal, multifocal and diffuse inflammatory infiltrates, ranging from absent, discreet, moderate to intense, in heart and encephalon of mice of NIC (non-infected and non-treated), IC, G48 and G72 groups, respectively. In the perivascular region and meninges, the injuries were enlarged. The presence of tachyzoites was demonstrated through immunohistochemical (IHC) assay in myocardium. Toxoplasma gondii induced increase of collagen fibers in myocardium of mice of G72 and G48 groups, compared with IC (p<0.05) and NIC (p<0.001). The presence of inflammatory infiltrates, as well as the progressive fibrosis, caused myocardial remodeling in animals treated with L. clavatum. Counterstaining with H&E suggests TGF-ß expression by mononuclear cells in the inflammatory infiltrate. Based on our results, we can conclude that the adopted regimen and potency exerted a protective effect, reducing parasitemia. However, it intensified the histopathological lesions in encephalon and heart of mice infected with T. gondii.
[Mh] Termos MeSH primário: Encéfalo/patologia
Coração/parasitologia
Lycopodium
Miocárdio/patologia
Extratos Vegetais/uso terapêutico
Toxoplasma/isolamento & purificação
Toxoplasmose Animal/patologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/efeitos dos fármacos
Encéfalo/parasitologia
Coração/efeitos dos fármacos
Masculino
Camundongos
Toxoplasmose Animal/tratamento farmacológico
Toxoplasmose Animal/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


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[PMID]:27416018
[Au] Autor:Sun ZH; Li W; Tang GH; Yin S
[Ad] Endereço:a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , China.
[Ti] Título:A new serratene triterpenoid from Lycopodium japonicum.
[So] Source:J Asian Nat Prod Res;19(3):299-303, 2017 Mar.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation on the herbs of Lycopodium japonicum led to the isolation of a new serratene triterpenoid, 3α,21α-dihydroxy-16-oxoserrat-14-en-24-yl p-coumarate (1), together with two known ones, lycernuic ketone C (2) and tohogenol (3). Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR and HR-ESI-MS. The C NMR data of tohogenol was first reported.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Lycopodium/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3alpha,21alpha-dihydroxy-16-oxoserrat-14-en-24-yl p-coumarate); 0 (Drugs, Chinese Herbal); 0 (Triterpenes); 0 (lycernuic ketone C); 0 (tohogenol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1208182


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[PMID]:27151143
[Au] Autor:Bunsupa S; Yamazaki M; Saito K
[Ad] Endereço:Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
[Ti] Título:Lysine-derived Alkaloids: Overview and Update on Biosynthesis and Medicinal Applications with Emphasis on Quinolizidine Alkaloids.
[So] Source:Mini Rev Med Chem;17(12):1002-1012, 2017.
[Is] ISSN:1875-5607
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants produce a vast variety of specialized metabolites which can be a rich source for lead compounds for the development of new drugs. Alkaloids are one the largest groups of plant specialized metabolites important for natural product based pharmaceuticals. Of these, lysine (Lys)-derived alkaloids exhibit a wide range of pharmacological properties which are beneficial for humans. For instance they have anticancer, anti-Alzheimer's disease, anti-inflammatory, hypocholesterolemic and antiarrhtymic effects. Lys-derived alkaloids are widely distributed throughout the plant kingdom: they can be found in various species from clubmosses to flowering plants. Lys is one of the most essential amino acids for humans and livestock and is synthesized in the plastids of land plants. Lys-derived alkaloids can be divided into four major groups including quinolizidine, lycopodium, piperidine, and indolizidine alkaloids. Despite the importance of these compounds, the biosynthetic pathways of Lys-derived alkaloids are not well understood. With the exception of indolizidine alkaloids, Lys decarboxylase (LDC) is the enzyme involved in the first committed step of the biosynthesis by catalyzing the transformation of L-Lys into cadaverine. Cadaverine is then oxidized by copper amine oxidase (CuAO) and spontaneously cyclized to Δ1-piperideine Schiff base which is a universal intermediate for the production of various Lys-derived alkaloids. CONCLUSION: In this review, we briefly summarize the recent understanding about the structures, occurrences, analytical procedures, biosyntheses, and potential health effects and medical applications of Lys-derived alkaloids with emphasis on quinolizidine alkaloids (QAs).
[Mh] Termos MeSH primário: Alcaloides/biossíntese
Lisina/química
Quinolizidinas/química
[Mh] Termos MeSH secundário: Alcaloides/química
Indolizidinas/química
Lycopodium/química
Lycopodium/metabolismo
Piperidinas/química
Plantas/química
Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indolizidines); 0 (Piperidines); 0 (Quinolizidines); 67I85E138Y (piperidine); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.2174/1389557516666160506151213


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[PMID]:27870586
[Au] Autor:Gordon PR; Sephton MA
[Ad] Endereço:Impacts and Astromaterials Research Centre, Department of Earth Science and Engineering, Imperial College London , London, UK.
[Ti] Título:Organic Matter Detection on Mars by Pyrolysis-FTIR: An Analysis of Sensitivity and Mineral Matrix Effects.
[So] Source:Astrobiology;16(11):831-845, 2016 Nov.
[Is] ISSN:1557-8070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Returning samples from Mars will require an effective method to assess and select the highest-priority geological materials. The ideal instrument for sample triage would be simple in operation, limited in its demand for resources, and rich in produced diagnostic information. Pyrolysis-Fourier infrared spectroscopy (pyrolysis-FTIR) is a potentially attractive triage instrument that considers both the past habitability of the sample depositional environment and the presence of organic matter that may reflect actual habitation. An important consideration for triage protocols is the sensitivity of the instrumental method. Experimental data indicate pyrolysis-FTIR sensitivities for organic matter at the tens of parts per million level. The mineral matrix in which the organic matter is hosted also has an influence on organic detection. To provide an insight into matrix effects, we mixed well-characterized organic matter with a variety of dry minerals, to represent the various inorganic matrices of Mars samples, prior to analysis. During pyrolysis-FTIR, serpentinites analogous to those on Mars indicative of the Phyllocian Era led to no negative effects on organic matter detection; sulfates analogous to those of the Theiikian Era led, in some instances, to the combustion of organic matter; and palagonites, which may represent samples from the Siderikian Era, led, in some instances, to the chlorination of organic matter. Any negative consequences brought about by these mineral effects can be mitigated by the correct choice of thermal extraction temperature. Our results offer an improved understanding of how pyrolysis-FTIR can perform during sample triage on Mars. Key Words: Mars-Life-detection instruments-Search for Mars' organics-Biosignatures. Astrobiology 16, 831-845.
[Mh] Termos MeSH primário: Meio Ambiente Extraterreno
Marte
Minerais/análise
Compostos Orgânicos/análise
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
Temperatura Ambiente
[Mh] Termos MeSH secundário: Silicatos de Alumínio/química
Hidrocarbonetos/análise
Modelos Logísticos
Lycopodium
Probabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Hydrocarbons); 0 (Minerals); 0 (Organic Chemicals); 1302-87-0 (clay)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


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[PMID]:27303024
[Au] Autor:Bunsupa S; Hanada K; Maruyama A; Aoyagi K; Komatsu K; Ueno H; Yamashita M; Sasaki R; Oikawa A; Saito K; Yamazaki M
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan (S.B., A.M., K.A., K.K., H.U., Mad.Y., K.S., Mam.Y.);Faculty of Pharmacy, Mahidol University, Ratchathewi, Bangkok 10400, Thailand (S.B.);Kyushu Institute of Technology, Iizuka-shi, Fukuoka 820-8502, Japan (
[Ti] Título:Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis.
[So] Source:Plant Physiol;171(4):2432-44, 2016 08.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lycopodium alkaloids (LAs) are derived from lysine (Lys) and are found mainly in Huperziaceae and Lycopodiaceae. LAs are potentially useful against Alzheimer's disease, schizophrenia, and myasthenia gravis. Here, we cloned the bifunctional lysine/ornithine decarboxylase (L/ODC), the first gene involved in LA biosynthesis, from the LA-producing plants Lycopodium clavatum and Huperzia serrata We describe the in vitro and in vivo functional characterization of the L. clavatum L/ODC (LcL/ODC). The recombinant LcL/ODC preferentially catalyzed the decarboxylation of l-Lys over l-ornithine (l-Orn) by about 5 times. Transient expression of LcL/ODC fused with the amino or carboxyl terminus of green fluorescent protein, in onion (Allium cepa) epidermal cells and Nicotiana benthamiana leaves, showed LcL/ODC localization in the cytosol. Transgenic tobacco (Nicotiana tabacum) hairy roots and Arabidopsis (Arabidopsis thaliana) plants expressing LcL/ODC enhanced the production of a Lys-derived alkaloid, anabasine, and cadaverine, respectively, thus, confirming the function of LcL/ODC in plants. In addition, we present an example of the convergent evolution of plant Lys decarboxylase that resulted in the production of Lys-derived alkaloids in Leguminosae (legumes) and Lycopodiaceae (clubmosses). This convergent evolution event probably occurred via the promiscuous functions of the ancestral Orn decarboxylase, which is an enzyme involved in the primary metabolism of polyamine. The positive selection sites were detected by statistical analyses using phylogenetic trees and were confirmed by site-directed mutagenesis, suggesting the importance of those sites in granting the promiscuous function to Lys decarboxylase while retaining the ancestral Orn decarboxylase function. This study contributes to a better understanding of LA biosynthesis and the molecular evolution of plant Lys decarboxylase.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Carboxiliases/metabolismo
Evolução Molecular
Huperzia/enzimologia
Lycopodium/enzimologia
Ornitina Descarboxilase/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Arabidopsis/genética
Arabidopsis/metabolismo
Vias Biossintéticas
Carboxiliases/genética
Descarboxilação
Huperzia/química
Huperzia/genética
Lycopodium/química
Lycopodium/genética
Lisina/metabolismo
Mutagênese Sítio-Dirigida
Cebolas/genética
Cebolas/metabolismo
Ornitina Descarboxilase/genética
Filogenia
Folhas de Planta/química
Folhas de Planta/enzimologia
Folhas de Planta/genética
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Raízes de Plantas/química
Raízes de Plantas/enzimologia
Raízes de Plantas/genética
Plantas Geneticamente Modificadas
Proteínas Recombinantes
Tabaco/genética
Tabaco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Proteins); 0 (Recombinant Proteins); EC 4.1.1.- (Carboxy-Lyases); EC 4.1.1.17 (Ornithine Decarboxylase); EC 4.1.1.18 (lysine decarboxylase); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1104/pp.16.00639


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[PMID]:27211326
[Au] Autor:Lopes CR; Falkowski GJ; Brustolin CF; Massini PF; Ferreira ÉC; Moreira NM; Aleixo DL; Kaneshima EN; de Araújo SM
[Ad] Endereço:Universidade Estadual de Maringá, Departamento de Ciências Básicas da Saúde/Parasitologia, Maringá, PR, Brazil. Electronic address: carinaedaniel@hotmail.com.
[Ti] Título:Highly diluted medication reduces tissue parasitism and inflammation in mice infected by Trypanosoma cruzi.
[So] Source:Homeopathy;105(2):186-93, 2016 May.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the effects of Kalium causticum, Conium maculatum, and Lycopodium clavatum 13cH in mice infected by Trypanosoma cruzi. MATERIALS AND METHODS: In a blind, controlled, randomized study, 102 male Swiss mice, 8 weeks old, were inoculated with 1400 trypomastigotes of the Y strain of T. cruzi and distributed into the following groups: CI (treated with 7% hydroalcoholic solution), Ca (treated with Kalium causticum 13cH), Co (treated with Conium maculatum 13cH), and Ly (treated with Lycopodium clavatum 13cH). The treatments were performed 48 h before and 48, 96, and 144 h after infection. The medication was repertorized and prepared in 13cH, according to Brazilian Homeopathic Pharmacopoeia. The following parameters were evaluated: infectivity, prepatent period, parasitemia peak, total parasitemia, tissue tropism, inflammatory infiltrate, and survival. Statistical analysis was conduced considering 5% of significance. RESULTS: The prepatent period was greater in the Ly group than in the CI group (p = 0.02). The number of trypomastigotes on the 8th day after infection was lower in the Ca group than in the CI group (p < 0.05). Total parasitemia was significantly lower in the Ca, Co, and Ly groups than in the CI group. On the 12th day after infection, the Ca, Co, and Ly groups had fewer nests and amastigotes/nest in the heart than the CI group (p < 0.05). Decreases in the number of nests and amastigotes in the intestine were observed in the Ly group compared with the CI group (p < 0.05). In the liver (day 12), Ly significantly prevented the formation of inflammatory foci compared with the other groups. In skeletal muscle, Co and Ly decreased the formation of inflammatory foci compared with CI (p < 0.05). Ly afforded greater animal survival compared with CI, Ca, and Co (p < 0.05). The animals in the Co group died prematurely compared with the CI group (p = 0.03). CONCLUSIONS: Ly with 13cH potency had significantly more benefits in the treatment of mice infected with T. cruzi, reducing the number of blood parasites, amastigote nests in tissue, and the number of amastigotes per nest and increasing animal survival.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Doença de Chagas/tratamento farmacológico
Homeopatia
Inflamação/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Estreptófitas
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/administração & dosagem
Antiprotozoários/farmacologia
Doença de Chagas/parasitologia
Conium
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Inflamação/patologia
Lycopodium
Masculino
Camundongos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Distribuição Aleatória
Trypanosoma cruzi/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


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[PMID]:27086123
[Au] Autor:Ishiuchi K; Jiang WP; Fujiwara Y; Wu JB; Kitanaka S
[Ad] Endereço:School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan; Graduate School of Pharmaceutical Sciences, Nagoya-City University, 3-1, Tanabe-Dori, Mizuho-ku, Nagoya 467-8603, Aichi, Japan.
[Ti] Título:Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages.
[So] Source:Bioorg Med Chem Lett;26(11):2636-40, 2016 06 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new Lycopodium alkaloids, serralongamines B-D (1-3), have been isolated from the club moss Lycopodium serratum var. longipetiolatum, and the structures were elucidated on the basis of spectroscopic data and chemical transformation. 1 and 3 significantly exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.
[Mh] Termos MeSH primário: Células Espumosas/efeitos dos fármacos
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Lycopodium/química
Macrófagos/efeitos dos fármacos
Quinolinas/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Compostos Heterocíclicos de 4 ou mais Anéis/química
Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação
Seres Humanos
Estrutura Molecular
Quinolinas/química
Quinolinas/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 4 or More Rings); 0 (Quinolines); 0 (serralongamine B); 0 (serralongamine D)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE



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