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Pesquisa : B01.650.940.800.575.912.063.750.666 [Categoria DeCS]
Referências encontradas : 266 [refinar]
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[PMID]:29247933
[Au] Autor:Ma J; Lei E; Lei M; Liu Y; Chen T
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China; Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin 300191, PR China; College of Natural Resources and Environment, South China Agricultural University, Guang
[Ti] Título:Remediation of Arsenic contaminated soil using malposed intercropping of Pteris vittata L. and maize.
[So] Source:Chemosphere;194:737-744, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intercropping of arsenic (As) hyperaccumulator and cash crops during remediation of contaminated soil has been applied in farmland remediation project. However, little is known about the fate of As fractions in the soil profile and As uptake within the intercropping plants under field condition. In this study, As removal, uptake, and translocation were investigated within an intercropping system of Pteris vittata L. (P. vittata) and maize (Zea mays). Results indicated that the concentration of As associated with amorphous Fe (hydr)oxides in the 10-20 cm soil layer was significantly lower under malposed intercropping of P. vittata and maize, and As accumulation in P. vittata and biomass of P. vittata were simultaneously higher under malposed intercropping than under coordinate intercropping, leading to a 2.4 times higher rate of As removal. Although maize roots absorbed over 13.4 mg kg As and maize leaves and flowers accumulated over 21.5 mg kg As (translocation factor higher than 1), grains produced in all intercropping modes accumulated lower levels of As, satisfying the standard for human consumption. Our results suggested that malposed intercropping of a hyperaccumulator and a low-accumulation cash crop was an ideal planting pattern for As remediation in soil. Furthermore, timely harvest of P. vittata, agronomic strategies during remediation, and appropriate management of the above ground parts of P. vittata and high-As tissues of cash crops may further improve remediation efficiency.
[Mh] Termos MeSH primário: Arsênico/farmacocinética
Pteris
Poluentes do Solo/análise
Zea mays/metabolismo
[Mh] Termos MeSH secundário: Arsênico/análise
Arsênico/metabolismo
Biodegradação Ambiental
Biomassa
Seres Humanos
Componentes Aéreos da Planta/química
Raízes de Plantas/química
Solo/química
Poluentes do Solo/metabolismo
Poluentes do Solo/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); N712M78A8G (Arsenic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:28679153
[Au] Autor:Praveen A; Mehrotra S; Singh N
[Ad] Endereço:Plant Ecology and Environmental Science Division, National Botanical Research Institute, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), India. Electronic address: aashishpraveen45@gmail.com.
[Ti] Título:Rice planted along with accumulators in arsenic amended plots reduced arsenic uptake in grains and shoots.
[So] Source:Chemosphere;184:1327-1333, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An experiment was designed using phytoremadiation technology to obtain grains of rice safe for consumption. Sixteen plots of size 2 × 2 m were prepared (8 plots were treated with 50 mg kg of sodium arsenate and rest 8 without any treatment). The study was done for two plantations (1st and 2nd plantation). Rice was planted with three accumulators (Phragmites australis, Vetiveria zizanioides and Pteris vitatta) in treated and untreated plot. Arsenic in grains of Actr (R + Pt, R + Ph and R + Vt) for 1st plantation was 0.4, 0.2 and 0.2 mg kg where as in the case of wActr (Ras) it was 3 mg kg . In 2nd plantation the concentration of arsenic in grain of Actr (R + Pt, R + Ph and R + Vt) was 0.1, 0.1 and 0.1 mg kg where as in the case of wActr (Ras) it was 2 mg kg . Significant differences in growth and yield parameters of rice between Actr and wActr in 1st plantation, while for 2nd plantation the activity was reduced in combinations except R + Pt and no significant difference was observed between Actr, Acntr and wActr. The study concluded that combinations of accumulators with crops could be useful for the survival and safe grains in As-contaminated soils but with some amendments in long-term remediation.
[Mh] Termos MeSH primário: Arsênico/análise
Recuperação e Remediação Ambiental
Oryza/química
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Arseniatos
Produtos Agrícolas
Grãos Comestíveis/química
Poluição Ambiental
Oryza/crescimento & desenvolvimento
Oryza/metabolismo
Pteris
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Soil Pollutants); 7XO134LHLN (sodium arsenate); N712M78A8G (Arsenic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28647229
[Au] Autor:Yan X; Liu Q; Wang J; Liao X
[Ad] Endereço:Beijing Key Laboratory of Environmental Damage Assessment and Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resour
[Ti] Título:A combined process coupling phytoremediation and in situ flushing for removal of arsenic in contaminated soil.
[So] Source:J Environ Sci (China);57:104-109, 2017 Jul.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytoremediation and soil washing are both potentially useful for remediating arsenic (As)-contaminated soils. We evaluated the effectiveness of a combined process coupling phytoremediation and in situ soil flushing for removal of As in contaminated soil through a pilot study. The results showed that growing Pteris vittata L. (P.v.) accompanied by soil flushing of phosphate (P.v./Flushing treatment) could significantly decrease the total As concentration of soil over a 37day flushing period compared with the single flushing (Flushing treatment). The P.v./Flushing treatment removed 54.04% of soil As from contaminated soil compared to 47.16% in Flushing treatment, suggesting that the growth of P. vittata was beneficial for promoting the removal efficiency. We analyzed the As fractionation in soil and As concentration in soil solution to reveal the mechanism behind this combined process. Results showed that comparing with the control treatment, the percent of labile arsenate fraction significantly increased by 17% under P.v./Flushing treatment. As concentration in soil solution remained a high lever during the middle and later periods (51.26-56.22mg/L), which was significantly higher than the Flushing treatment. Although soil flushing of phosphate for more than a month, P. vittata still had good accumulation and transfer capacity of As of the soil. The results of the research revealed that combination of phytoremediation and in situ soil flushing is available to remediate As-contaminated soils.
[Mh] Termos MeSH primário: Arsênico/análise
Biodegradação Ambiental
Recuperação e Remediação Ambiental/métodos
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Projetos Piloto
Pteris
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); N712M78A8G (Arsenic)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


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[PMID]:28532669
[Au] Autor:Kim JW; Kim HP; Sung SH
[Ad] Endereço:College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 08826, Republic of Korea.
[Ti] Título:Cytotoxic pterosins from Pteris multifida roots against HCT116 human colon cancer cells.
[So] Source:Bioorg Med Chem Lett;27(14):3144-3147, 2017 07 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new pterosin glycosides, (2S,3S)-pterosin C 3-O-ß-d-(4'-(E)-caffeoyl)-glucopyranoside (1) and (2S,3S)-pterosin C 3-O-ß-d-(6'-(E)-p-coumaroyl)-glucopyranoside (2), were isolated from Pteris multifida (Pteridaceae) roots along with ten known pterosin compounds (3-12). The chemical structures of the isolated compounds were elucidated by extensive analysis of the 1D, 2D NMR, HRESIMS, and CD spectroscopic data. The cytotoxicities of 1-12 against HCT116 human colorectal cancer cell line were evaluated. Among the isolates, compound 1 showed moderate antiproliferative activity in HCT116 cells with an IC value of 8.0±1.7µM. Additionally, 1 induced the upregulation of the caspase-9 and procaspase-9 levels in Western blots and increased the annexin V/propidium iodide (PI)-positive cell population in flow cytometry.
[Mh] Termos MeSH primário: Indanos/química
Indanos/farmacologia
Pteris/química
Sesquiterpenos/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/toxicidade
Caspase 9/metabolismo
Proliferação Celular/efeitos dos fármacos
Dicroísmo Circular
Neoplasias do Colo
Células HCT116
Seres Humanos
Indanos/isolamento & purificação
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Conformação Molecular
Extratos Vegetais/química
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Pteris/metabolismo
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 ((2S,3S)-pterosin C 3-O-beta-D-(40-(E)-caffeoyl)-glucopyranoside); 0 ((2S,3S)-pterosin C 3-O-beta-D-(6'-(E)-p-coumaroyl)-glucopyranoside); 0 (Antineoplastic Agents, Phytogenic); 0 (Indans); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (pterosin); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28501771
[Au] Autor:Han YH; Liu X; Rathinasabapathi B; Li HB; Chen Y; Ma LQ
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu, 210046, China.
[Ti] Título:Mechanisms of efficient As solubilization in soils and As accumulation by As-hyperaccumulator Pteris vittata.
[So] Source:Environ Pollut;227:569-577, 2017 Aug.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Arsenic (As) in soils is of major environmental concern due to its ubiquity and carcinogenicity. Pteris vittata (Chinese brake fern) is the first known As-hyperaccumulator, which is highly efficient in extracting As from soils and translocating it to the fronds, making it possible to be used for phytoremediation of As-contaminated soils. In addition, P. vittata has served as a model plant to study As metabolisms in plants. Based on the recent advances, we reviewed the mechanisms of efficient As solubilization and transformation in rhizosphere soils of P. vittata and effective As uptake, translocation and detoxification in P. vittata. We also provided future research perspectives to further improve As phytoremediation by P. vittata.
[Mh] Termos MeSH primário: Arsênico/química
Pteris/metabolismo
Poluentes do Solo/química
[Mh] Termos MeSH secundário: Arsênico/análise
Arsênico/metabolismo
Biodegradação Ambiental
Rizosfera
Solo/química
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); N712M78A8G (Arsenic)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE


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[PMID]:28432964
[Au] Autor:Liu X; Fu JW; Tang N; da Silva EB; Cao Y; Turner BL; Chen Y; Ma LQ
[Ad] Endereço:State Key Lab of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu 210023, China.
[Ti] Título:Phytate induced arsenic uptake and plant growth in arsenic-hyperaccumulator Pteris vittata.
[So] Source:Environ Pollut;226:212-218, 2017 Jul.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytate is abundant in soils, which is stable and unavailable for plant uptake. However, it occurs in root exudates of As-hyperaccumulator Pteris vittata (PV). To elucidate its effect on As uptake and growth, P. vittata were grown on agar media (63 µM P) containing 50 µM As and/or 50 or 500 µM phytate with non As-hyperaccumulator Pteris ensiformis (PE) as a congeneric control for 60 d. Phytate induced efficient As and P uptake, and enhanced growth in PV, but had little effects on PE. The As concentrations in PV fronds and roots were 157 and 31 mg kg in As +phytate , 2.2- and 3.1-fold that of As treatment. Phosphorus uptake by PV was reduced by 27% in As treatment than the control (P vs. P+As) but increased by 73% comparing phytate to phytate +As, indicating that PV effectively took up P from phytate. Neither As nor phytate affected Fe accumulation in PV, but phytate reduced root Fe concentration in PE (46-56%). As such, the increased As and P and the unsuppressed Fe uptake in PV probably promoted PV growth. Thus, supplying phytate to As-contaminated soils may promote As uptake and growth in PV and its phytoremediation ability.
[Mh] Termos MeSH primário: Arsênico/metabolismo
Ácido Fítico/metabolismo
Pteris/fisiologia
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Arsênico/análise
Biodegradação Ambiental
Fósforo
Desenvolvimento Vegetal/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
Solo
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 27YLU75U4W (Phosphorus); 7IGF0S7R8I (Phytic Acid); N712M78A8G (Arsenic)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


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[PMID]:28419958
[Au] Autor:Das S; de Oliveira LM; da Silva E; Ma LQ
[Ad] Endereço:Soil and Water Science Department, University of Florida, Gainesville, FL, 32611, United States; Life Science and Bioinformatics, Assam University, Silchar, India.
[Ti] Título:Arsenate and fluoride enhanced each other's uptake in As-sensitive plant Pteris ensiformis.
[So] Source:Chemosphere;180:448-454, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the effects of arsenate (AsV) and fluoride (F) on each other's uptake in an As-sensitive plant Pteris ensiformis. Plants were exposed to 1) 0.1 × Hoagland solution control, 2) 3.75 mg L As and 1.9, 3.8, or 7.6 mg L F, or 3) 1 mg L F and 3.75 mg L or 7.5 mg L As for 7 d in hydroponics. P. ensiformis accumulated 14.7-32.6 mg kg As at 3.75 mg L AsV, and 99-145 mg kg F at 1 mg L F. Our study revealed that AsV and F increased each other's uptake when co-present. At 1.9 mg L , F increased frond As uptake from 14.7 to 40.3 mg kg , while 7.5 mg L As increased frond F uptake from 99 to 371 mg kg . Although, AsV was the predominant As species in all tissues, F enhanced AsIII levels in the rhizomes and fronds, while the reverse was observed in the roots. Increasing As concentrations also enhanced TBARS and H O in tissues, indicating oxidative stress. However, F alleviated As stress by lowering their levels in the fronds. Frond and root membrane leakage were also evident due to As or F exposure. The results may facilitate better understanding of the mechanisms underlying the co-uptake of As and F in plants. However, the mechanisms of how they enhance each other's uptake in P. ensiformis need further investigation.
[Mh] Termos MeSH primário: Arseniatos/metabolismo
Fluoretos/metabolismo
Pteris/fisiologia
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Arseniatos/química
Arsênico/análise
Fluoretos/química
Peróxido de Hidrogênio/metabolismo
Hidroponia
Fosfatos
Raízes de Plantas/efeitos dos fármacos
Pteris/efeitos dos fármacos
Poluentes do Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Phosphates); 0 (Soil Pollutants); 15181-43-8 (fluorophosphate); BBX060AN9V (Hydrogen Peroxide); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28273532
[Au] Autor:de Oliveira LM; Suchismita D; Gress J; Rathinasabapathi B; Chen Y; Ma LQ
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu 210046, China; Soil and Water Science Department, University of Florida, Gainesville, FL 32611, USA.
[Ti] Título:Arsenic uptake by lettuce from As-contaminated soil remediated with Pteris vittata and organic amendment.
[So] Source:Chemosphere;176:249-254, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Leaching of inorganic arsenic (As) from chromated copper arsenate (CCA)-treated wood may elevate soil As levels. Thus, an environmental concern arises regarding As accumulation in vegetables grown in these soils. In this study, a greenhouse experiment was conducted to investigate the ability of As-hyperaccumulator P. vittata and organic amendments in reducing As uptake by lettuce (Lactuca sativa) from a soil contaminated from CCA-treated wood (63.9 mg kg As). P. vittata was grown for 150 d in a CCA-contaminated soil amended with biochar, activated carbon or coffee grounds at 1%, followed by lettuce for another 55 d. After harvest, plant biomass and As concentrations in plant and soil were determined. The presence of P. vittata reduced As content in lettuce by 21% from 27.3 to 21.5 mg kg while amendment further reduced As in lettuce by 5.6-18%, with activated C being most effective. Our data showed that both P. vittata and organic amendments were effective in reducing As concentration in lettuce. Though no health-based standard for As in vegetables exists in USA, care should be taken when growing lettuce in contaminated soils. Our data showed that application of organic amendments with P. vittata reduced As hazards in CCA-contaminated soils.
[Mh] Termos MeSH primário: Arsênico/farmacocinética
Biodegradação Ambiental
Alface/metabolismo
Pteris/química
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Arseniatos
Arsênico/análise
Biomassa
Solo/química
Verduras/metabolismo
Madeira/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Soil); 0 (Soil Pollutants); 37337-13-6 (chromated copper arsenate); N712M78A8G (Arsenic)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:28252343
[Au] Autor:Shi YS; Zhang Y; Hu WZ; Zhang LH; Chen X; Zhang N; Li G; Tan LY
[Ad] Endereço:a Key Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education , College of Life Science, Dalian Nationalities University , Dalian 116600 , China.
[Ti] Título:Cytotoxic diterpenoids from Pteris ensiformis.
[So] Source:J Asian Nat Prod Res;19(2):188-193, 2017 Feb.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6ß,16α-diol-3-one (1), along with five known diterpenoids (2-6) and three known sesquiterpenes (7-9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1-9) were evaluated for their antitumor activity against three cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Pteris/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Diterpenos/química
Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Diterpenos Caurânicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (Diterpenes, Kaurane); 0 (ent-kaurane-6beta,16alpha-diol-3-one)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1274307


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[PMID]:28192882
[Au] Autor:Kaur P; Kumar M; Singh AP; Kaur S
[Ad] Endereço:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
[Ti] Título:Ethyl acetate fraction of Pteris vittata L. alleviates 2-acetylaminofluorene induced hepatic alterations in male Wistar rats.
[So] Source:Biomed Pharmacother;88:1080-1089, 2017 Apr.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Pteris vittata L. commonly called 'Brake Fern' possesses some interesting medicinal properties but its chemopreventive potential largely remains unexplored. Therefore, this study was designed to explore the chemopreventive efficacy of P. vittata L. ethyl acetate fraction (PVEA) against 2-acetylaminofluorene (2-AAF) induced liver toxicity in Wistar rats. Antioxidant activity of PVEA was evaluated using various in vitro antioxidant assays. The protective effects of PVEA were evaluated against 2-acetylaminofluorene (2-AAF) induced hepatic damage in Wistar rats. p53 expression in liver tissue was checked using immunohistochemical staining. Phytochemical composition of PVEA was determined using high performance liquid chromatography (HPLC). PVEA showed promising radical scavenging activity with an EC (concentration of a drug that gives half-maximal response) of 41.18µg/ml in DPPH assay, 26.99µg/ml in site specific deoxyribose degradation assay, 13.43µg/ml in non site specific deoxyribose degradation assay and 21.88µg/ml in superoxide anion scavenging assay. Three different doses of PVEA 100, 200 and 400mg/kg body weight (b.w.) followed by administration of 2-AAF (50mg/kg b.w. i.p.) for five consecutive days induced significant changes in activity of liver marker enzymes, thiobarbituric acid reactive substances, lipid hydroperoxides, reduced glutathione content and phase I and II enzymes. Activity of hepatic enzymes and normal hepatic architecture was restored following PVEA treatment. PVEA modulated the expression of p53 in liver tissue as compared to 2-AAF treated group. HPLC analysis of the fraction revealed the abundance of epicatechin (20.809ppm) and umbelliferone (22.308ppm) as major polyphenols. The present study highlights the potentiality of P. vittata in cancer chemoprevention which warrants further investigations.
[Mh] Termos MeSH primário: Acetatos/química
Fígado/patologia
Extratos Vegetais/farmacologia
Pteris/química
[Mh] Termos MeSH secundário: 2-Acetilaminofluoreno
Fosfatase Alcalina/sangue
Animais
Antioxidantes/metabolismo
Compostos de Bifenilo/química
Fracionamento Químico
Cromatografia Líquida de Alta Pressão
Depuradores de Radicais Livres/química
Glutationa/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Desentoxicação Metabólica Fase I
Desintoxicação Metabólica Fase II
Estresse Oxidativo/efeitos dos fármacos
Compostos Fitoquímicos/análise
Picratos/química
Substâncias Protetoras/farmacologia
Ratos Wistar
Transaminases/sangue
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Phytochemicals); 0 (Picrates); 0 (Plant Extracts); 0 (Protective Agents); 0 (Tumor Suppressor Protein p53); 76845O8NMZ (ethyl acetate); 9M98QLJ2DL (2-Acetylaminofluorene); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 2.6.1.- (Transaminases); EC 2.6.1.- (glutamate aminotransferase); EC 3.1.3.1 (Alkaline Phosphatase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE



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