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Pesquisa : B01.650.940.800.575.912.125 [Categoria DeCS]
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  1 / 2573 MEDLINE  
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[PMID]:28449688
[Au] Autor:Li ZY; Chung YH; Shin EJ; Dang DK; Jeong JH; Ko SK; Nah SY; Baik TG; Jhoo JH; Ong WY; Nabeshima T; Kim HC
[Ad] Endereço:Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
[Ti] Título:YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by ß-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2.
[So] Source:J Neuroinflammation;14(1):94, 2017 Apr 27.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened extract of G. biloba, showed anti-inflammatory, neurotrophic, and antioxidant effects. RESULTS: We investigated the pharmacological potential of YY-1224 in ß-amyloid (Aß) (1-42)-induced memory impairment using cyclooxygenase-2 (COX-2) knockout (-/-) and APPswe/PS1dE9 transgenic (APP/PS1 Tg) mice. Repeated treatment with YY-1224 significantly attenuated Aß (1-42)-induced memory impairment in COX-2 (+/+) mice, but not in COX-2 (-/-) mice. YY-1224 significantly attenuated Aß (1-42)-induced upregulation of platelet-activating factor (PAF) receptor gene expression, reactive oxygen species, and pro-inflammatory factors. In addition, YY-1224 significantly inhibited Aß (1-42)-induced downregulation of PAF-acetylhydrolase-1 (PAF-AH-1) and peroxisome proliferator-activated receptor γ (PPARγ) gene expression. These changes were more pronounced in COX-2 (+/+) mice than in COX-2 (-/-) mice. YY-1224 significantly attenuated learning impairment, Aß deposition, and pro-inflammatory microglial activation in APP/PS1 Tg mice, whereas it significantly enhanced PAF-AH and PPARγ expression. A preferential COX-2 inhibitor, meloxicam, did not affect the pharmacological activity by YY-1224, suggesting that the COX-2 gene is a critical mediator of the neuroprotective effects of YY-1224. The protective activity of YY-1224 appeared to be more efficacious than a standard G. biloba extract (Gb) against Aß insult. CONCLUSIONS: Our results suggest that the protective effects of YY-1224 against Aß toxicity may be associated with its PAF antagonistic- and PPARγ agonistic-potential as well as inhibition of the Aß-mediated pro-inflammatory switch of microglia phenotypes through suppression of COX-2 expression.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/toxicidade
Ciclo-Oxigenase 2/metabolismo
Ginkgo biloba
Doenças Neurodegenerativas/metabolismo
Fragmentos de Peptídeos/toxicidade
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Doença de Alzheimer/tratamento farmacológico
Doença de Alzheimer/genética
Doença de Alzheimer/metabolismo
Precursor de Proteína beta-Amiloide/biossíntese
Precursor de Proteína beta-Amiloide/genética
Animais
Expressão Gênica
Lactonas/isolamento & purificação
Lactonas/uso terapêutico
Camundongos
Camundongos Knockout
Camundongos Transgênicos
Doenças Neurodegenerativas/genética
Doenças Neurodegenerativas/prevenção & controle
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Presenilina-1/biossíntese
Presenilina-1/genética
Espécies Reativas de Oxigênio/antagonistas & inibidores
Espécies Reativas de Oxigênio/metabolismo
Terpenos/isolamento & purificação
Terpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Amyloid beta-Protein Precursor); 0 (Lactones); 0 (Peptide Fragments); 0 (Plant Extracts); 0 (Presenilin-1); 0 (Reactive Oxygen Species); 0 (Terpenes); 0 (amyloid beta-protein (1-42)); 0 (trilactone); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0866-x


  2 / 2573 MEDLINE  
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[PMID]:29206653
[Au] Autor:Kang JM; Lin S
[Ad] Endereço:Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
[Ti] Título:Ginkgo biloba and its potential role in glaucoma.
[So] Source:Curr Opin Ophthalmol;29(2):116-120, 2018 Mar.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This study will review the research on the effect of ginkgo biloba extract (GBE) on patients with glaucoma. RECENT FINDINGS: GBE appears to increase ocular blood flow in those with glaucoma. However, data on visual field outcomes are inconclusive. SUMMARY: GBE has been shown to have antioxidant and vascular effects, making it potentially effective in treating glaucoma. Published data are limited but show an increase in ocular blood flow after GBE administration. Conclusive evidence is lacking regarding the effect of GBE on clinical outcomes in glaucoma patients such as visual field performance.
[Mh] Termos MeSH primário: Terapias Complementares
Glaucoma/tratamento farmacológico
Pressão Intraocular/efeitos dos fármacos
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Ginkgo biloba/química
Glaucoma/fisiopatologia
Seres Humanos
Pressão Intraocular/fisiologia
Fluxo Sanguíneo Regional/fisiologia
Campos Visuais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 19FUJ2C58T (Ginkgo biloba extract)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000459


  3 / 2573 MEDLINE  
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[PMID]:29357859
[Au] Autor:Bonassi S; Prinzi G; Lamonaca P; Russo P; Paximadas I; Rasoni G; Rossi R; Ruggi M; Malandrino S; Sánchez-Flores M; Valdiglesias V; Benassi B; Pacchierotti F; Villani P; Panatta M; Cordelli E
[Ad] Endereço:Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, San Raffaele University, Via di Val Cannuta 247, 00166, Rome, Italy. stefano.bonassi@sanraffaele.it.
[Ti] Título:Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect®Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx].
[So] Source:BMC Complement Altern Med;18(1):22, 2018 Jan 22.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Numerous health benefits have been attributed to the Ginkgo biloba leaf extract (GBLE), one of the most extensively used phytopharmaceutical drugs worldwide. Recently, concerns of the safety of the extract have been raised after a report from US National Toxicology Program (NTP) claimed high doses of GBLE increased liver and thyroid cancer incidence in mice and rats. A safety study has been designed to assess, in a population of elderly residents in nursing homes, clinical and genomic risks associated to GBLE treatment. METHODS: GiBiEx is a multicentre randomized clinical trial, placebo controlled, double blinded, which compared subjects randomized to twice-daily doses of either 120-mg of IDN 5933 (also known as Ginkgoselect®Plus) or to placebo for a 6-months period. IDN 5933 is extracted from dried leaves and contains 24.3% flavone glycosides and 6.1% of terpene lactones (2.9% bilobalide, 1.38% ginkgolide A, 0.66% ginkgolide B, 1.12% ginkgolide C) as determined by HPLC. The study was completed by 47 subjects, 20 in the placebo group and 27 in the treatment group. Clinical (adverse clinical effect and liver injury) and genomic (micronucleus frequency, comet assay, c-myc, p53, and ctnnb1 expression profile in lymphocytes) endpoints were assessed at the start and at the end of the study. RESULTS: No adverse clinical effects or increase of liver injury markers were reported in the treatment group. The frequency of micronuclei [Mean Ratio (MR) = 1.01, 95% Confidence Intervals (95% CI) 0.86-1.18), and DNA breaks (comet assay) (MR = 0.91; 95% CI 0.58-1.43), did not differ in the two study groups. No significant difference was found in the expression profile of the three genes investigated. CONCLUSIONS: None of the markers investigated revealed a higher risk in the treatment group, supporting the safety of IDN 5933 at doses prescribed and for duration of six months. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03004508 , December 20, 2016. Trial retrospectively registered.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Ginkgo biloba/química
Extratos Vegetais
Folhas de Planta/química
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Genoma/efeitos dos fármacos
Seres Humanos
Fígado/efeitos dos fármacos
Testes de Função Hepática
Masculino
Testes para Micronúcleos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/efeitos adversos
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2080-5


  4 / 2573 MEDLINE  
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[PMID]:29197355
[Au] Autor:Wang H; Wu X; Lezmi S; Li Q; Helferich WG; Xu Y; Chen H
[Ad] Endereço:Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
[Ti] Título:Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model.
[So] Source:BMC Complement Altern Med;17(1):516, 2017 Dec 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Metastasis refers to the spread of a primary tumor cell from the primary site to other locations in the body and it is generally associated with the severity of a tumor. Extract of Ginkgo biloba (EGb) contains various bioactive compounds and it exerts beneficial effects including improvements in brain function and reduced risk of cardiovascular diseases. On the other hand, increased risk of thyroid and liver cancers by EGb have been reported in animals. METHODS: A colon cancer metastasis model was established using intrasplenic injection of a human colon cancer cell line, SW620-luc in athymic mice to investigate the potential impact of EGb on colon cancer progression. After tumor establishment, EGb was intraperitonically injected daily for 5 wks. RESULTS: EGb significantly increased the rate of metastasis in mouse liver and decreased the number of necrotic and apoptotic cells in the metastatic liver when compared to the control. Meanwhile, EGb significantly induced proliferation of tumor cells in the metastatic liver, indicated by increased staining of Ki67 and H3S10p. mRNA expression of genes involved in cell cycle, metastasis, apoptosis, and oxidative stress were altered by EGb treatment in livers with tumors. Moreover, EGb activated the stress-responsive MAPK pathways in the liver with metastatic tumors. CONCLUSIONS: EGb exacerbated liver metastasis in a mouse colon cancer metastasis model. This is potentially due to the increased tumor cell proliferation involving stimulated MAPK pathways.
[Mh] Termos MeSH primário: Neoplasias do Colo
Ginkgo biloba
Neoplasias Hepáticas
Fígado/efeitos dos fármacos
Extratos Vegetais
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/metabolismo
Neoplasias do Colo/patologia
Modelos Animais de Doenças
Expressão Gênica/efeitos dos fármacos
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/secundário
Camundongos
Camundongos Nus
Metástase Neoplásica
Extratos Vegetais/efeitos adversos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2014-7


  5 / 2573 MEDLINE  
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[PMID]:28886111
[Au] Autor:Roodt D; Lohaus R; Sterck L; Swanepoel RL; Van de Peer Y; Mizrachi E
[Ad] Endereço:Department of Genetics, Forestry and Agricultural Biotechnology Institute, University of Pretoria, Private bag X20, Pretoria, South Africa.
[Ti] Título:Evidence for an ancient whole genome duplication in the cycad lineage.
[So] Source:PLoS One;12(9):e0184454, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contrary to the many whole genome duplication events recorded for angiosperms (flowering plants), whole genome duplications in gymnosperms (non-flowering seed plants) seem to be much rarer. Although ancient whole genome duplications have been reported for most gymnosperm lineages as well, some are still contested and need to be confirmed. For instance, data for ginkgo, but particularly cycads have remained inconclusive so far, likely due to the quality of the data available and flaws in the analysis. We extracted and sequenced RNA from both the cycad Encephalartos natalensis and Ginkgo biloba. This was followed by transcriptome assembly, after which these data were used to build paralog age distributions. Based on these distributions, we identified remnants of an ancient whole genome duplication in both cycads and ginkgo. The most parsimonious explanation would be that this whole genome duplication event was shared between both species and had occurred prior to their divergence, about 300 million years ago.
[Mh] Termos MeSH primário: Cycadopsida/genética
Duplicação Gênica
Genoma de Planta
Genômica
[Mh] Termos MeSH secundário: Cycadopsida/classificação
Perfilação da Expressão Gênica
Genômica/métodos
Ginkgo biloba/genética
Filogenia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184454


  6 / 2573 MEDLINE  
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[PMID]:28800704
[Au] Autor:Wang T; Hu XC; Cai ZP; Voglmeir J; Liu L
[Ad] Endereço:Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210014, China.
[Ti] Título:Qualitative and Quantitative Analysis of Carbohydrate Modification on Glycoproteins from Seeds of Ginkgo biloba.
[So] Source:J Agric Food Chem;65(35):7669-7679, 2017 Sep 06.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent progress in the relationship between carbohydrate cross-reactive determinants (CCDs) and allergic response highlights the importance of carbohydrate moieties in the innate immune system. Previous research pointed out that the protein allergen in Ginkgo biloba seeds is glycosylated, and the oligosaccharides conjugated to these proteins might also contribute to the allergy. The aim of this study was to analyze carbohydrate moieties, especially N-linked glycans, of glycoproteins from Ginkgo seeds originating from different places for detailed structures, to enable further research on the role played by N-glycans in Ginkgo-caused allergy. Results of monosaccharide composition and immunoblotting assays indicated the existence of N-glycans. Detailed structural elucidation of the N-glycans was further carried out by means of hydrophilic interaction ultraperformance liquid chromatography (HILIC-UPLC) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In total, 14 out of 16 structures detected by UPLC were confirmed by MALDI-TOF-MS and tandem mass spectrometry, among which complex-type N-glycans bearing Lewis A determinants and high-mannose-type N-glycans were identified from Ginkgo seeds for the first time. Precise quantification of N-glycans was performed by use of an external standard, and both the absolute amount of each N-glycan and the percentage of different types of N-glycan showed significant diversity among the samples without any pattern of geographic variation.
[Mh] Termos MeSH primário: Ginkgo biloba/metabolismo
Glicoproteínas/metabolismo
Proteínas de Plantas/metabolismo
Sementes/química
[Mh] Termos MeSH secundário: Sequência de Carboidratos
Cromatografia Líquida de Alta Pressão
Ginkgo biloba/química
Glicoproteínas/química
Dados de Sequência Molecular
Proteínas de Plantas/química
Polissacarídeos/química
Polissacarídeos/metabolismo
Sementes/metabolismo
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoproteins); 0 (Plant Proteins); 0 (Polysaccharides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01690


  7 / 2573 MEDLINE  
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[PMID]:28672255
[Au] Autor:Zhang S; Zhuang J; Yue G; Wang Y; Liu M; Zhang B; Du Z; Ma Q
[Ad] Endereço:School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
[Ti] Título:Lipidomics to investigate the pharmacologic mechanisms of ginkgo folium in the hyperuricemic rat model.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1060:407-415, 2017 Aug 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hyperuricemia caused by purine metabolic abnormalities is reported to have close correlation with lipid metabolic disorders. Ginkgo folium, a frequently-used lipid-lowering medicine, has significant anti-hyperuricemia effects. However, it is poorly known about the interaction between lowering uric acid and regulation of lipid metabolic disorders. In this study, hyperuricemic rat model was induced by orally administration with fructose. Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with pattern recognition approaches were used to determine different lipid metabolites in serum of control group, model group, and different doses of ginkgo folium groups. Principal component analysis (PCA) was applied to analyze the MS data to assess the establishment of model, partial least squares-discriminate analysis (PLS-DA) and independent samples T-test were performed to indicate the differences between different groups of rats and to find biomarkers. Metabolomics pathway analysis (MetPA) was introduced to reveal the pharmacologic mechanisms of ginkgo folium. 19 potential biomarkers associated with hyperuricemia were found. After intervened by ginkgo folium, these biomarkers were returning to normal level. Among these biomarkers, 13 lipid biomarkers were significantly reversed. Ginkgo filum can lower uric acid via adjusting back the level of PCs and LPCs, which suggested that its treatment mechanisms may be related to reducing the activity of PLA2. In sum, the lipidomics analysis in the system level have enhanced our understanding to pathogenesis of hyperuricemia and the results suggested that ginkgo folium could alleviate the abnormal metabolic status of hyperuricemia. These results demonstrated a new mechanism for lowering uric acid, which was helpful to the early treatment for hyperuricemia.
[Mh] Termos MeSH primário: Ginkgo biloba/química
Hiperuricemia
Metabolismo dos Lipídeos/efeitos dos fármacos
Lipídeos/sangue
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Biologia Computacional
Modelos Animais de Doenças
Frutose/administração & dosagem
Frutose/metabolismo
Hiperuricemia/tratamento farmacológico
Hiperuricemia/metabolismo
Masculino
Espectrometria de Massas/métodos
Redes e Vias Metabólicas
Extratos Vegetais/administração & dosagem
Extratos Vegetais/uso terapêutico
Ratos
Ratos Sprague-Dawley
Ácido Úrico/sangue
Ácido Úrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipids); 0 (Plant Extracts); 268B43MJ25 (Uric Acid); 30237-26-4 (Fructose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


  8 / 2573 MEDLINE  
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[PMID]:28622621
[Au] Autor:Wang T; Xiao J; Hou H; Li P; Yuan Z; Xu H; Liu R; Li Q; Bi K
[Ad] Endereço:School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
[Ti] Título:Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1060:173-181, 2017 Aug 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C chromatographic column (100mm×2.1mm, 3µm) by means of gradient elution. 0.1% formic acid-water and methanol system was used as the mobile phase. Mass spectrometric inspection was conducted on a 4000Q UFLC-MS/MS system with turbo ion spray source in patterns of negative ion and multiple reaction-monitoring (MRM). All calibration curves proved favorable linearity (R ≥0.9918) in linear ranges. Intra-day and inter-day precisions didn't exceed 14.0% for all the analytes, and the accuracy was within 6.9%. Extraction recoveries of analytes and IS were less than ±15.0% of nominal concentrations. This method has been under thorough and firm verification for a comparative pharmacokinetic research after gavage between Ginkgo biloba extract and single pure ginkgo flavonoids. The results demonstrated that there're evident pharmacokinetic discrepancies, and possible structural influences were innovatively proposed. Generally, substitution with 3-hydroxylation, a double bond in ring C, ring B methoxylation often confer longer onset period. The existence of ring B catechol group gives rise to faster clearance.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Flavonoides/sangue
Flavonoides/farmacocinética
Ginkgo biloba/química
Extratos Vegetais/farmacocinética
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Flavonoides/administração & dosagem
Flavonoides/química
Modelos Lineares
Masculino
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE


  9 / 2573 MEDLINE  
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[PMID]:28346534
[Au] Autor:Park CK; Ho CH; Jeong SJ; Lee EJ; Kim J
[Ad] Endereço:School of Earth and Environmental Sciences, Seoul National University, Seoul, Republic of Korea.
[Ti] Título:Spatial and temporal changes in leaf coloring date of Acer palmatum and Ginkgo biloba in response to temperature increases in South Korea.
[So] Source:PLoS One;12(3):e0174390, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding shifts in autumn phenology associated with climate changes is critical for preserving forest ecosystems. This study examines the changes in the leaf coloring date (LCD) of two temperate deciduous tree species, Acer palmatum (Acer) and Ginkgo biloba (Ginkgo), in response to surface air temperature (Ts) changes at 54 stations of South Korea for the period 1989-2007. The variations of Acer and Ginkgo in South Korea are very similar: they show the same mean LCD of 295th day of the year and delays of about 0.45 days year-1 during the observation period. The delaying trend is closely correlated (correlation coefficient > 0.77) with increases in Ts in mid-autumn by 2.8 days °C-1. It is noted that the LCD delaying and temperature sensitivity (days °C-1) for both tree species show negligible dependences on latitudes and elevations. Given the significant LCD-Ts relation, we project LCD changes for 2016-35 and 2046-65 using a process-based model forced by temperature from climate model simulation. The projections indicate that the mean LCD would be further delayed by 3.2 (3.7) days in 2016-35 (2046-65) due to mid-autumn Ts increases. This study suggests that the mid-autumn warming is largely responsible for the observed LCD changes in South Korea and will intensify the delaying trends in the future.
[Mh] Termos MeSH primário: Acer/fisiologia
Cor
Ginkgo biloba/fisiologia
Folhas de Planta/fisiologia
Estações do Ano
Temperatura Ambiente
[Mh] Termos MeSH secundário: Mudança Climática
Ecossistema
Modelos Teóricos
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174390


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[PMID]:28333443
[Au] Autor:Yang Y; Li Y; Wang J; Sun K; Tao W; Wang Z; Xiao W; Pan Y; Zhang S; Wang Y
[Ad] Endereço:Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Department of Materials Sciences and Chemical Engineering, Dalian University of Technology , Dalian, Liaoning 116024, China.
[Ti] Título:Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model.
[So] Source:ACS Chem Biol;12(5):1363-1372, 2017 May 19.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Globally, cardio-cerebrovascular diseases (CCVDs) are the leading cause of death, and thus the development of novel strategies for preventing and treating such diseases is in urgent need. Traditional Chinese medicine (TCM), used for thousands of years in Asia and other regions, has been proven effective in certain disorders. As a long-time medicinal herb in TCM, Ginkgo biloba leaves (GBLs), have been widely used to treat various diseases including CCVDs. However, the underlying molecular mechanisms of medicinal herbs in treating these diseases are still unclear. Presently, by incorporating pharmacokinetic prescreening, target fishing, and network analysis, an innovative systems-pharmacology platform was introduced to systematically decipher the pharmacological mechanism of action of GBLs for the treatment of CCVDs. The results show that GBLs exhibit a protective effect on CCVDs probably through regulating multiple pathways and hitting on multiple targets involved in several biological pathways. Our work successfully explains the mechanism of efficiency of GBLs for treating CCVDs and, meanwhile, demonstrates that GDJ, an injection generated from GBLs, could be used as a preventive or therapeutic agent in cerebral ischemia. The approach developed in this work offers a new paradigm for systematically understanding the action mechanisms of herb medicine, which will promote the development and application of TCM.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/terapia
Transtornos Cerebrovasculares/terapia
Ginkgo biloba/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Medicina Tradicional Chinesa
Modelos Animais
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.6b00762



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