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Pesquisa : B01.650.940.800.575.912.250.022 [Categoria DeCS]
Referências encontradas : 28 [refinar]
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  1 / 28 MEDLINE  
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[PMID]:29199255
[Au] Autor:Tanahashi T
[Ad] Endereço:Kobe Pharmaceutical University.
[Ti] Título:[Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts].
[So] Source:Yakugaku Zasshi;137(12):1443-1482, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Glicosídeos/isolamento & purificação
Líquens/metabolismo
Plantas Medicinais/metabolismo
[Mh] Termos MeSH secundário: Alangiaceae/metabolismo
Alcaloides/biossíntese
Alcaloides/química
Benzilisoquinolinas
Cephaelis/metabolismo
Eschscholzia/metabolismo
Glicosídeos/biossíntese
Glicosídeos/química
Iridoides
Monoterpenos
Oleaceae/metabolismo
Rubiaceae/metabolismo
Stephania/metabolismo
Tetra-Hidroisoquinolinas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E (1,2,3,4-tetrahydroisoquinoline)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00147


  2 / 28 MEDLINE  
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[PMID]:28733150
[Au] Autor:Ren J; Xie YG; Huang YY; Zhu SL; Yan SK; Jin HZ; Zhang WD
[Ad] Endereço:School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
[Ti] Título:Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium.
[So] Source:Fitoterapia;121:152-158, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis CI1304, Aeromonas hydrophila CI1008, Escherichia coli CI151012, Vibrio parahaemolyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302. Their minimum inhibitory concentrations (MICs) were determined by serial dilution in 96-well culture plates.
[Mh] Termos MeSH primário: Alangiaceae/química
Antibacterianos/química
Glicosídeos/química
Lignanas/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Glicosídeos/isolamento & purificação
Lignanas/isolamento & purificação
Testes de Sensibilidade Microbiana
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Lignans); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


  3 / 28 MEDLINE  
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[PMID]:26778440
[Au] Autor:Selin-Rani S; Senthil-Nathan S; Revathi K; Chandrasekaran R; Thanigaivel A; Vasantha-Srinivasan P; Ponsankar A; Edwin ES; Pradeepa V
[Ad] Endereço:Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi-627 412, Tirunelveli, Tamil Nadu, India.
[Ti] Título:Toxicity of Alangium salvifolium Wang chemical constituents against the tobacco cutworm Spodoptera litura Fab.
[So] Source:Pestic Biochem Physiol;126:92-101, 2016 Jan.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Widespread use of synthetic pesticides has resulted in the development of insecticide-resistant populations of pests and harmful effects on human health and the environment. There is a need to identify alternative pest management strategies to reduce our reliance on conventional chemical pesticides. In recent years the use of botanical pesticides for protecting crops from insect pests has assumed greater importance. Methanol extract of Alangium salvifolium (L.f.) Wang has potential insecticidal activity against Spodoptera litura Fab. The active fractions were identified through chromatographic techniques as F-IV (Rf value=0.45) and F-VI (Rf value=0.63) and were subjected to GC-MS (GCMATE II). Fifty, 100 and 200ppm of active fractions were applied to fourth instar larvae and the mortality increased with higher concentrations. Relative consumption rate, relative growth rate, efficiency of conversion of ingested food and efficiency of conversion of digested food values all decreased in treated larvae, but approximate digestibility rate increased after treatment. The hydrolytic enzymes, such as acid phosphatase, alkaline phosphatase and the glycolytic enzyme lactate dehydrogenase were inhibited in treated larvae compared with controls. The histopathology study revealed that the epithelial columnar cells were enlarged, completely atrophied; intercellular spaces were swollen, and also noted a cytoplasmic ooze of cell material that mixed with food column. The present study clearly showed the active fractions from A. salvifolium as potential botanicals to control the larvae of S. litura. This is the first report for nutritional indices, enzymatic activities and histological effects of A. salvifolium chemical constituents against S. litura. Thus probably, this will be used as an alternative for synthetic pesticides against the polyphagous pest like S. litura.
[Mh] Termos MeSH primário: Alangiaceae
Inseticidas/toxicidade
Extratos Vegetais/toxicidade
Spodoptera/efeitos dos fármacos
[Mh] Termos MeSH secundário: Fosfatase Ácida/metabolismo
Fosfatase Alcalina/metabolismo
Animais
Ingestão de Alimentos/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Inseticidas/química
Intestinos/efeitos dos fármacos
Intestinos/enzimologia
Intestinos/patologia
L-Lactato Desidrogenase/metabolismo
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/toxicidade
Extratos Vegetais/química
Folhas de Planta
Spodoptera/anatomia & histologia
Spodoptera/crescimento & desenvolvimento
Spodoptera/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Phytochemicals); 0 (Plant Extracts); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.3.2 (Acid Phosphatase)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


  4 / 28 MEDLINE  
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[PMID]:26498463
[Au] Autor:Zhang Y; Liu YB; Li Y; Li L; Ma SG; Qu J; Jiang JD; Chen XG; Zhang D; Yu SS
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Terpenoids from the roots of Alangium chinense.
[So] Source:J Asian Nat Prod Res;17(11):1025-38, 2015.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new norditerpenoids (1 and 2), four new sesquiterpenoids (3-6), and 22 known compounds (7-28) were isolated from an ethanolic extract of roots of Alangium chinense. The absolute configurations of 1-6 were assigned by experimental and calculated ECD spectra. The skeleton of the compounds (1 and 2) has been reported only one time so far. Compounds 1, 13, and 23 exhibited antiviral activity against coxsackie virus B3 with IC50 values of 38-67 µM. Compounds 8 and 9 displayed neuritis inhibitory activity against microglial inflammation factor, with IC50 values of 6.4 and 10.1 µM, respectively. None of the compounds were cytotoxic in the MTT assay.
[Mh] Termos MeSH primário: Alangiaceae/química
Antivirais/isolamento & purificação
Diterpenos/isolamento & purificação
Enterovirus/efeitos dos fármacos
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Antivirais/química
Antivirais/farmacologia
Diterpenos/química
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Raízes de Plantas/química
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Diterpenes); 0 (Sesquiterpenes)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151110
[Lr] Data última revisão:
151110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1082551


  5 / 28 MEDLINE  
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[PMID]:25645740
[Au] Autor:Pailee P; Prachyawarakorn V; Ruchirawat S; Mahidol C
[Ad] Endereço:Laboratory of Natural Products, Chulabhorn Research Institute, Kamphang Phet 6 Road, Bangkok 10210 (Thailand).
[Ti] Título:Bioactive cardinane sesquiterpenes from the stems of Alangium salviifolium.
[So] Source:Chem Asian J;10(4):910-4, 2015 Apr.
[Is] ISSN:1861-471X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A dichloromethane extract of the stems of Alangium salviifolium afforded twelve cardinane sesquiterpenes, seven of which are new alangenes A-G (1-7) and five known compounds (8-12). Their structures were elucidated on the basis of spectroscopic techniques including UV, IR, and NMR spectroscopies, and mass spectrometry. Most of the tested compounds exhibited very potent aromatase inhibition properties, especially in the case of the cardinane sesquiterpenes 1, 5-8, and 10 (IC50 values of 0.09, 0.13, 0.30, 0.06, 2.05, and 1.19 µM, respectively), which are significantly better than that of the positive control (ketoconazole, IC50 of 2.4 µM). Compounds 1 and 4 exhibited selective cytotoxicity against the MOLT-3 cancer cell line with IC50 values of 7.9 and 2.1 µg mL(-1) , respectively.
[Mh] Termos MeSH primário: Alangiaceae/química
Caules de Planta/química
Sesquiterpenos/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Seres Humanos
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Sesquiterpenes)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150326
[Lr] Data última revisão:
150326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150204
[St] Status:MEDLINE
[do] DOI:10.1002/asia.201403253


  6 / 28 MEDLINE  
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[PMID]:25452263
[Au] Autor:Yagi N; Nakahashi H; Kashima Y; Miyazawa M
[Ad] Endereço:Picaso Cosmetics Laboratory Limited.
[Ti] Título:Isolation and biological activity of a novel cadinane-type sesquiterpenoid from the essential oil of Alangium salviifolium.
[So] Source:J Oleo Sci;63(12):1223-9, 2014.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The components of the essential oil from the roots of Alangium salviifolium were analyzed by capillary gas chromatography-mass spectrometry (GC-MS). Ninety compounds, representing 74.5% of the total oil, were identified; the main components of the oil were epi-α-cadinol, followed by trans-2-hydroxycalamenene, cadalene, and cadina-4,10(15)-dien-3-one. A further unknown component comprised 5.5% of the oil. Therefore, the essential oil was purified by flash column chromatography to isolate this component. Its structure was established using extensive spectroscopic data analyses, including NMR, HR-EI-MS, and IR. The results showed that this isolated compound was (-)-7, 8-dihydroxycalamenal, which is a novel cadinane-type sesquiterpenoid. This compound was tested for its antioxidant activity and inhibition of tyrosinase, and showed particularly strong inhibition effects.
[Mh] Termos MeSH primário: Alangiaceae/química
Antioxidantes
Inibidores Enzimáticos
Monofenol Mono-Oxigenase/antagonistas & inibidores
Óleos Voláteis/química
Óleos Vegetais/química
Raízes de Plantas/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
Tetra-Hidronaftalenos/isolamento & purificação
Tetra-Hidronaftalenos/farmacologia
[Mh] Termos MeSH secundário: Cromatografia/métodos
Cromatografia Gasosa-Espectrometria de Massas/métodos
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Sesquiterpenos/análise
Sesquiterpenos/química
Tetra-Hidronaftalenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7,8-dihydroxycalamenal); 0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (Tetrahydronaphthalenes); 0 (cadinane); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  7 / 28 MEDLINE  
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[PMID]:24502168
[Au] Autor:Zahan R; Nahar L; Nesa ML
[Ad] Endereço:Department of Pharmacy, University of Rajshahi, Rajshahi-6025, Bangladesh.
[Ti] Título:Antinociceptive and anti-inflammatory activities of flower (Alangium salvifolium) extract.
[So] Source:Pak J Biol Sci;16(19):1040-5, 2013 Oct 01.
[Is] ISSN:1028-8880
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg(-1)) of flower of AS followed by chloroform extract (100 mg kg(-1)) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions.
[Mh] Termos MeSH primário: Alangiaceae/química
Analgésicos/química
Analgésicos/farmacologia
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Animais
Flavonoides/química
Flavonoides/farmacologia
Flores/química
Masculino
Camundongos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:150311
[Lr] Data última revisão:
150311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140208
[St] Status:MEDLINE


  8 / 28 MEDLINE  
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[PMID]:23734721
[Au] Autor:Zhang Y; Liu YB; Li Y; Ma SG; Li L; Qu J; Zhang D; Chen XG; Jiang JD; Yu SS
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
[Ti] Título:Sesquiterpenes and alkaloids from the roots of Alangium chinense.
[So] Source:J Nat Prod;76(6):1058-63, 2013 Jun 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Four new sesquiterpenes (1-4), four new alkaloids (5a, 6a, 6b, and 7), and nine known compounds (5b and 8-15) were isolated from an ethanolic extract of roots of Alangium chinense. The structure of 1 was confirmed by X-ray crystallography. The configurations of 5 and 6 were assigned by chiral HPLC analysis and CD spectra. Compounds 3, 4, 8-13, and 15 exhibited antiviral activity against Coxsackie virus B3 with IC50 values of 1.4-15.4 µM. Compounds 2-4, 7, and 9-13 showed antioxidant activities against Fe(2+)-cysteine-induced rat liver microsomal lipid peroxidation, with IC50 values of 3.8-45.7 µM. Compound 5b displayed neuritis inhibitory activity against microglial inflammation factor, with an IC50 value of 6.7 µM. None of the compounds exhibited detectable cytotoxic activity toward any of five tumor cell lines (A549, Be-17402, BGC-823, HCT-8, and A2780) in the MTT assay.
[Mh] Termos MeSH primário: Alangiaceae/química
Alcaloides/isolamento & purificação
Antivirais/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Animais
Antivirais/química
Antivirais/farmacologia
Cercopithecus aethiops
Cristalografia por Raios X
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Enterovirus/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Conformação Molecular
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Raízes de Plantas/química
Ratos
Sesquiterpenos/química
Sesquiterpenos/farmacologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 ((2S)-N-hydroxybenzylanabasine); 0 (Alkaloids); 0 (Antiviral Agents); 0 (Drugs, Chinese Herbal); 0 (Sesquiterpenes)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:130628
[Lr] Data última revisão:
130628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130606
[St] Status:MEDLINE
[do] DOI:10.1021/np4000747


  9 / 28 MEDLINE  
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[PMID]:23074898
[Au] Autor:Chakraborty M; Mukhopadhyay S
[Ad] Endereço:Department of Chemistry, Taki Government College, Taki, North 24 Parganas, West Bengal, India. mumu_chak@yahoo.com
[Ti] Título:Angustinine--a new benzopyridoquinolizine alkaloid from Alangium lamarckii.
[So] Source:Nat Prod Commun;7(9):1169-70, 2012 Sep.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new benzopyridoquinolizine alkaloid, designated as angustinine (1), was isolated from the root bark of Alangium lamarckii Thwaites, along with the known ipecac alkaloid, emetine. Investigation of the stem bark of the same plant resulted in the isolation of another known ipecac alkaloid, cephaeline. The structure of the new alkaloid (1) was elucidated on the basis of 2D NMR spectralanalysis.
[Mh] Termos MeSH primário: Alangiaceae/química
Alcaloides/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Espectroscopia de Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (angustinine)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:121018
[Lr] Data última revisão:
121018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121019
[St] Status:MEDLINE


  10 / 28 MEDLINE  
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[PMID]:22008064
[Au] Autor:Ahad HA; Padmaja BS; Sravanthi M; Ramyasree P; Kavitha K
[Ad] Endereço:Department of Pharmaceutics, College of Pharmacy, Sri Krishnadevaraya University, Anantapur- 515003, Andhra Pradesh, India. abdulhindustan@rediffmail.com
[Ti] Título:Phytochemical screening and anti-inflammatory actions of Alangium salviifolium root extract.
[So] Source:Nat Prod Res;26(17):1649-53, 2012.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alangium salviifolium root was screened for phytochemical and anti-inflammatory properties. The percentage inhibition of carrageenan induced paw oedema was studied in rats. Alangium salvifolium gave maximum extractive values with Ethanol and the Loss on Drying value, total ash value and acid-insoluble ash and water soluble ash values were within limits. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The extract was free from glycosides, saponins, tannins, proteins and amino acids. In acute toxicity studies, Alangium salviifolium root extract was found to be safe up to 3000 mg kg⁻¹, p.o. in the albino rats. The Alangium salviifolium root gave significant per cent inhibition of the maximal paw oedema and very highly significant per cent inhibition of total paw oedema during 6 h. This study revealed that Alangium salviifolium root has good anti-inflammatory actions when compared with Diclofenac sodium.
[Mh] Termos MeSH primário: Alangiaceae/química
Anti-Inflamatórios/química
Anti-Inflamatórios/uso terapêutico
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Diclofenaco/uso terapêutico
Edema/tratamento farmacológico
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 144O8QL0L1 (Diclofenac)
[Em] Mês de entrada:1212
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111020
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2011.589054



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