Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.044.705 [Categoria DeCS]
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[PMID]:26983094
[Au] Autor:Kubba A; Batrani M; Vadrevu R
[Ad] Endereço:Diplomate American Board of Pathology; Diplomate American Board of Pathology in Dermatopathology Delhi Dermpath Laboratory, Delhi Dermatology Group, New Delhi, India Delhi Dermpath Laboratory, Delhi Dermatology Group, New Delhi, India meenakshibatrani@yahoo.co.in Sai Sudha Hospital, Kakinada, Andhra Pradesh, India.
[Ti] Título:When Marking Nut Traveled to Washington, DC.
[So] Source:Dermatitis;27(2):72-3, 2016 Mar-Apr.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/diagnóstico
Dermatoses Faciais/diagnóstico
Semecarpus/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Dermatite Alérgica de Contato/etiologia
Dermatite Alérgica de Contato/patologia
Dermatoses Faciais/etiologia
Seres Humanos
Masculino
Tronco/patologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170106
[Lr] Data última revisão:
170106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE
[do] DOI:10.1097/DER.0000000000000173


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[PMID]:26341099
[Au] Autor:Ghorpade A
[Ad] Endereço:Department of Dermatology & Venereology, J.L.N. Hospital & Research Centre, Bhilai Steel Plant, Bhilai, 490009, India.
[Ti] Título:Targetoid skin lesions with marking nut hair dye.
[So] Source:Int J Dermatol;54(12):1414-5, 2015 Dec.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite por Toxicodendron/etiologia
Tinturas para Cabelo/efeitos adversos
Exposição Ocupacional/efeitos adversos
Óleos Vegetais/efeitos adversos
Semecarpus/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Barbearia
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hair Dyes); 0 (Plant Oils)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151120
[Lr] Data última revisão:
151120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150906
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13027


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[PMID]:26267092
[Au] Autor:Ghosh S; Tiwari SS; Srivastava S; Kumar S; Sharma AK; Nagar G; Kumar KG; Kumar R; Rawat AK
[Ad] Endereço:Entomology Laboratory, Parasitology Division, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly, UP, India. Electronic address: sghoshtick@gmail.com.
[Ti] Título:In vitro acaricidal properties of Semecarpus anacardium fruit and Datura stramonium leaf extracts against acaricide susceptible (IVRI-I line) and resistant (IVRI-V line) Rhipicephalus (Boophilus) microplus.
[So] Source:Res Vet Sci;101:69-74, 2015 Aug.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In an attempt to identify plants having anti-tick properties, the 95% ethanolic and 50% hydro-ethanolic extracts of the fruits of Semecarpus anacardium and leaves of Datura stramonium were evaluated against reference tick lines of Rhipicephalus (Boophilus) microplus. The 95% ethanolic extracts of S. anacardium and D. stramonium caused 50% and 20% mortality, respectively, within 72 h of treatment by adult immersion test. The LC90 value of the ethanolic fruit extract of S. anacardium was determined as 13.5% (CI 12.05-15.12). The extract was also found efficacious (73.3%±3.3%) against the multi-acaricide-resistant IVRI-V line of R.(B.) microplus. The S. anacardium extract significantly affected the reproductive physiology of treated ticks by inhibiting the oviposition and was found safe. The HPTLC fingerprinting profile revealed the presence of pyrocatechol as a marker compound. The acaricidal property of S. anacardium against chemical acaricide-resistant R. (B.) microplus was discussed.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Datura stramonium/química
Frutas/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Rhipicephalus/efeitos dos fármacos
Semecarpus/química
[Mh] Termos MeSH secundário: Acaricidas/análise
Animais
Feminino
Larva/efeitos dos fármacos
Oviposição/efeitos dos fármacos
Extratos Vegetais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150813
[Lr] Data última revisão:
150813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150813
[St] Status:MEDLINE


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[PMID]:25943985
[Au] Autor:Khan HB; Vani S; Palanivelu S; Panchanadham S
[Ad] Endereço:Dr ALM P-G IBMS, University of Madras, Chennai, Tamil Nadu, India.
[Ti] Título:Erythrocyte Protoporphyrin Fluorescence as a Biomarker to Monitor the Anticancer Effect of Semecarpus Anacardium in DMBA Induced Mammary Carcinoma Rat Model.
[So] Source:J Fluoresc;25(4):907-15, 2015 Jul.
[Is] ISSN:1573-4994
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Endogenous fluorescence has been proposed as a means of aiding the diagnosis of various malignancies. It has been suggested that erythrocytes may be the carriers of fluorophors that accumulate in cancer tissue and may be useful in the diagnosis and treatment of malignancies. Hence, the present study was designed to explore the spectrofluorimetric analysis of blood components as a marker for the analysis of mammary carcinoma treatment and also to bring about the protective effect of the drug Semecarpus anacardium on oxidative stress mediated damage of erythrocytes. Fluorescence spectra of the blood components were studied and also the level of lipid per oxides and antioxidant enzymes status in erythrocytes were determined in DMBA induced mammary carcinoma rats treated with Semecarpus anacardium Linn nut milk extract. Fluorescence emission spectroscopy of blood components are altered under cancer conditions and the drug effectively ameliorated these alterations in mammary carcinoma induced rats. The drug also effectively reduced the oxidative stress induced erythrocyte damage thereby restoring the erythrocytes antioxidant status. These results suggest that erythrocytes may be the carriers of fluorophors that accumulate in cancer tissue and hence acts as new biomarkers for the diagnosis and treatment.
[Mh] Termos MeSH primário: 9,10-Dimetil-1,2-benzantraceno/toxicidade
Biomarcadores/análise
Eritrócitos/patologia
Neoplasias Mamárias Experimentais/patologia
Extratos Vegetais/farmacologia
Protoporfirinas/química
Semecarpus/química
Espectrometria de Fluorescência/métodos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Carcinógenos/toxicidade
Modelos Animais de Doenças
Eritrócitos/efeitos dos fármacos
Feminino
Peroxidação de Lipídeos/efeitos dos fármacos
Neoplasias Mamárias Experimentais/tratamento farmacológico
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Carcinogens); 0 (Plant Extracts); 0 (Protoporphyrins); 57-97-6 (9,10-Dimethyl-1,2-benzanthracene); C2K325S808 (protoporphyrin IX)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150507
[St] Status:MEDLINE
[do] DOI:10.1007/s10895-015-1571-8


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[PMID]:25925864
[Au] Autor:Ali MA; Wahed MI; Khatune NA; Rahman BM; Barman RK; Islam MR
[Ad] Endereço:Department of Pharmaceutical Engineering & Drug Delivery Science, Graduate School of Integrated Pharmaceutical & Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan. ashrafali025@gmail.com.
[Ti] Título:Antidiabetic and antioxidant activities of ethanolic extract of Semecarpus anacardium (Linn.) bark.
[So] Source:BMC Complement Altern Med;15:138, 2015 Apr 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus is a global health problem and constantly increasing day by day. The number of diabetic people in world is expected to rise to 366 million in 2030. The available drugs for diabetes, insulin or oral hypoglycemic agents have one or more side effects and search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenging for us. The present study was undertaken to investigate the antidiabetic and antioxidant activity of Semecarpus anacardium (Linn.) (abbreviated as SF). METHODS: The antidiabetic activity was determined by using alloxan-induced diabetic rats. After 15 days of treatment, serum biochemical parameters such as TC, TG, LDL, HDL, SGOT and SGPT were estimated. The survival rate, body weight, organ weight, liver glycogen and blood parameters (RBC and Hb) were also measured. The antioxidant activity was measured by DPPH free radical scavenging assay. Phytochemical screening, total phenolic and total flavonoid content were determined by using standard methods. RESULTS: The results showed that the survival rate was 100% in rats of Group SA 400. The effect of extract on blood glucose level in Groups SA 100, SA 200 and SA 400 were dose-dependent throughout the treatment period. No significant changes in organ weight to body weight ratio were observed, liver weights significantly improved in Groups SA 200 and SA 400. The bark extract exhibited significant (p < 0.05) anti-diabetic activity with lowering TC, TG, LDL level dose-dependently and protected liver which may be partially explained by attenuation of SGOT and SGPT levels and increases liver glycogen. The percentage of Hb and RBC counts were negatively correlated with the doses of extracts. In DPPH scavenging assay, IC50 values of SA extract and ascorbic acid were found 72.24 µg/ml and 17.81 µg/ml, respectively. Phytochemical screening showed the presence of steroids, triterpenoids, flavonoids, glycosides, saponins, and tannins that were contribute to biological activity. CONCLUSIONS: These results indicated that stem barks of S. anacardium possess strong anti-diabetic and antioxidant potentials and support traditional medicinal use for the treatment of diabetes mellitus and good source for natural antioxidants.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Glicemia/metabolismo
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Fitoterapia
Extratos Vegetais/uso terapêutico
Semecarpus/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Ácido Ascórbico/farmacologia
Compostos de Bifenilo/metabolismo
Diabetes Mellitus Experimental/sangue
Flavonoides/análise
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Hipoglicemiantes/farmacologia
Insulina/sangue
Masculino
Fenóis/análise
Fenóis/farmacologia
Fenóis/uso terapêutico
Picratos/metabolismo
Casca de Planta
Extratos Vegetais/farmacologia
Caules de Planta
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Blood Glucose); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150501
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0662-z


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[PMID]:24409976
[Au] Autor:Subramaniam S; Khan HB; Gomathy G; Palanvelu S; Panchanadham ST
[Ad] Endereço:1Department of Medical Biochemistry, Dr ALM P-G IBMS, University of Madras, Chennai, India.
[Ti] Título:Effect of Semecaprus anacardium on diabetes-induced alterations in the activities of marker enzymes and antioxidant enzymes in type 2 diabetes induced cardiac vascular damage model in rats.
[So] Source:J Diet Suppl;11(4):347-60, 2014 Dec.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Semecarpus anacardium is a commonly used drug in the Siddha system of medicine for curing various metabolic disorders. The cardio protective effect of the drug in Type 2 diabetes-induced cardiovascular complications was studied in rats by feeding them with a high fat diet for 2 weeks followed by intra peritoneal injection of streptozotocin at a moderate dosage of 2*35 mg/kg/ b.wt 24 hr apart and leaving them for 8 weeks to develop cardiovascular complications. The effect of the drug was studied by analyzing levels of blood glucose, insulin, HbA1c, marker enzymes, the antioxidative enzymes and the levels of lipid peroxides in Type 2 diabetic rats. Diabetic rats were treated with SA at a dosage of 300 mg/kg/b.wt. for 8 weeks and the results were compared with diabetic rats treated with the combination therapy drugs metformin at a dosage of 100 mg/kg/b.wt and atorvastatin at a dosage of 10 mg/kg/b.wt for 8 weeks. The drug SA significantly decreased the blood glucose levels and also HbA1c levels while improving glucose tolerance at the same time. The levels of marker enzymes and lipid peroxides were significantly increased in diabetic rats when compared with control rats. On the other hand significant decreases in the levels of antioxidative enzymes were observed in diabetic rats. Upon treatment with the drug SA, all of these abnormalities were restored to near normalcy. The present study thereby establishes the protective effect of the drug against diabetes-induced cardiac damage.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Glicemia/metabolismo
Diabetes Mellitus Tipo 2/tratamento farmacológico
Angiopatias Diabéticas/prevenção & controle
Fitoterapia
Extratos Vegetais/uso terapêutico
Semecarpus
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Biomarcadores/sangue
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/complicações
Angiopatias Diabéticas/sangue
Intolerância à Glucose/tratamento farmacológico
Intolerância à Glucose/metabolismo
Hemoglobina A Glicada/metabolismo
Hipoglicemiantes/farmacologia
Hipoglicemiantes/uso terapêutico
Insulina/sangue
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Extratos Vegetais/farmacologia
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140114
[St] Status:MEDLINE
[do] DOI:10.3109/19390211.2013.859219


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[PMID]:23557070
[Au] Autor:Ghorpade A
[Ad] Endereço:Department of Dermatology and Venereology, JLN Hospital and Research Centre, Bhilai Steel Plant, Bhilai, India E-mail: draghorpade@yahoo.com.
[Ti] Título:Contact dermatitis caused by Indian marking nut juice used to relieve ankle pain.
[So] Source:Int J Dermatol;53(2):e117-9, 2014 Feb.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite de Contato/etiologia
Óleos Vegetais/efeitos adversos
Semecarpus
[Mh] Termos MeSH secundário: Tornozelo
Dermatite de Contato/tratamento farmacológico
Dermatoses Faciais/induzido quimicamente
Feminino
Seres Humanos
Perna (Membro)
Meia-Idade
Dor Musculoesquelética/tratamento farmacológico
Pescoço
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Plant Oils)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140121
[Lr] Data última revisão:
140121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130406
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-4632.2012.05632.x


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[PMID]:24311839
[Au] Autor:Joseph JP; Raval SK; Sadariya KA; Jhala M; Kumar P
[Ad] Endereço:Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, Gujarat, India., Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat (INDIA).
[Ti] Título:Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
[So] Source:Afr J Tradit Complement Altern Med;10(5):299-304, 2013.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:The objective of the study was to determine the anticancerous efficacy of Ayurvedic preparation made of Semecarpus anacardium (SA) nuts. Five groups of rats were used for the study. Group I served as water control. Hepatocellular carcinoma (HCC) was induced in groups II, III and IV animals using N-nitrosodiethylamine as inducing agent followed by phenobarbitone as promoter for 13 weeks. Group-II animals were kept untreated as hepatocellular carcinoma control. Group-III animals were treated with Ayurvedic milk extract of Semecarpus anacardium nuts at dose mentioned in Ashtangahridaya, an authentic book of Ayurveda for 49 days and group-IV animals were treated with doxorubicin as reference drug at dose of 1mg/kg twice a week for 7 weeks. Group V animals were kept as drug (SA nut milk extract) control for studying the effect of nut milk extract on normal rats. After 154 days of experiment, all animals were subjected to screening for HCC by estimation of liver enzymes, HCC marker (alpha-2 macroglobulin) and histopathology. Both liver enzymes and HCC marker were increased in hepatocellular carcinoma control along with neoplastic changes in liver and were decreased in Semecarpus anacardium nut milk extract treated group. The Ayurvedic drug showed positive correlation with the action of doxorubicin. This study demonstrated the efficacy of Semecarpus anacardium nut milk extract for the treatment of hepatocellular carcinoma either alone or along with chemotherapy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Carcinoma Hepatocelular/tratamento farmacológico
Neoplasias Hepáticas/tratamento farmacológico
Fígado/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/uso terapêutico
Semecarpus
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/farmacologia
Carcinoma Hepatocelular/induzido quimicamente
Carcinoma Hepatocelular/enzimologia
Carcinoma Hepatocelular/patologia
Dietilnitrosamina
Feminino
Fígado/enzimologia
Neoplasias Hepáticas/induzido quimicamente
Neoplasias Hepáticas/enzimologia
Neoplasias Hepáticas/patologia
Medicina Ayurvédica
Leite
Nozes
Fenobarbital
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 3IQ78TTX1A (Diethylnitrosamine); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131207
[St] Status:MEDLINE


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[PMID]:23589261
[Au] Autor:Iyappan K; Ponrasu T; Sangeethapriya V; Gayathri VS; Suguna L
[Ad] Endereço:Department of Chemical Engineering, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai, 600 020, India.
[Ti] Título:An eco-friendly method for short term preservation of skins/hides using Semecarpus anacardium nut extract.
[So] Source:Environ Sci Pollut Res Int;20(9):6324-30, 2013 Sep.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Preservation or curing of hides and skins is performed as the primary step of leather processing. Common salt is employed as the conventional agent for curing purpose. Use of salt enhances the pollution load of tannery effluent which becomes highly contaminated with increased total dissolved solids and chlorides. To overcome this hurdle, researchers are in constant search of alternative preservation techniques which are either totally void of salt or use only a meager amount of salt. In the present study, we had explored the possibility of using Semecarpus anacardium nut extract as an alternative to salt for the curing process by assessing different parameters like hair slip, putrefaction odor, volatile nitrogen content, moisture content, bacterial count, and shrinkage temperature in comparison to the salt curing method. The antibacterial property of the plant extract was also investigated. The results obtained substantiated that the nut extract of S. anacardium effectively could preserve the skins for more than a month, by its antibacterial activity along with the dehydrating property of acetone.
[Mh] Termos MeSH primário: Nozes/química
Extratos Vegetais/química
Semecarpus/química
Curtume/métodos
[Mh] Termos MeSH secundário: Animais
Cabras
Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130417
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-013-1683-0


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[PMID]:23527893
[Au] Autor:Das S; Mukherjee H; Ahmed SM; Haldar PK; Mandal AB; Mahapatra A; Mukherjee PK; Chakraborti S; Chattopadhyay D
[Ad] Endereço:Directorate of Seed Research, Kushmaur, Maunath Bhanjan, Uttar Pradesh, India.
[Ti] Título:Evaluation of an ethnomedicinal combination containing Semecarpus kurzii and Hernandia peltata used for the management of inflammation.
[So] Source:Pharm Biol;51(6):677-85, 2013 Jun.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Scientific validation of an ethnomedicinal combination consisting of Semecarpus kurzii Engler (Anacardeaceae) leaves (SKL) and Hernandia peltata Meisn (Hernandeaceae) stem-bark (HPB), traditionally used in ailments related to inflammation, pain and fever. OBJECTIVE: To validate in vivo and in vitro analgesic and antiinflammatory activities of methanol extract of SKL, HPB and their combination. MATERIALS AND METHODS: Analgesic activity was tested by acetic acid induced writhing reflex and tail flick in Swiss albino mice, while the anti-inflammatory activity was studied in acute, subacute and chronic model on Wistar rats. The vascular permeability, membrane stabilization and protein denaturation were examined to know the possible mode of action. RESULTS: Significant (p < 0.01) analgesic (78.04% inhibition of writhing) and antiinflammatory (72.54% inhibition of paw edema) activity was observed in combination of SKL and HPB extracts at 250 mg/kg each. The SKL extract alone inhibits acetic acid-induced vascular permeability (64.4%) at 500 mg/kg, while in combination at 250 mg/kg each, the inhibition was 69.49% (p < 0.01). Furthermore, SKL in combination with HPB (0.25 mg/mL each) prevent RBC hemolysis (61.91%) and inhibition of protein denaturation (76.52%)-like indomethacin. DISCUSSION AND CONCLUSION: The SKL and HPB extract, alone (500 mg/kg) and in combination, (250 mg/kg each) had significant analgesic and antiinflammatory activity, probably by inhibiting the release of certain inflammatory mediators and membrane stabilization, due to the presence of triterpenes, tannins and related phytochemicals in the extracts. Thus, our results demonstrated that this combination provide the scientific rationale of its folk use.
[Mh] Termos MeSH primário: Hernandiaceae/química
Extratos Vegetais/farmacologia
Semecarpus/química
[Mh] Termos MeSH secundário: Dor Aguda/tratamento farmacológico
Analgésicos/administração & dosagem
Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Dor Crônica/tratamento farmacológico
Modelos Animais de Doenças
Quimioterapia Combinada
Inflamação/tratamento farmacológico
Mediadores da Inflamação/metabolismo
Masculino
Medicina Tradicional
Camundongos
Casca de Planta
Extratos Vegetais/administração & dosagem
Folhas de Planta
Caules de Planta
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Inflammation Mediators); 0 (Plant Extracts)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:140731
[Lr] Data última revisão:
140731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130327
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2012.762405



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