| [PMID]: | 27914569 |
| [Au] Autor: | Karp JC; Sanchez C; Guilbert P; Mina W; Demonceaux A; Curé H |
| [Ad] Endereço: | Centre Hospitalier de Troyes, 101, Avenue Anatole France, 10000 Troyes, France. Electronic address: jckarp001@rss.fr. |
| [Ti] Título: | Treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may reduce joint pain and stiffness linked to aromatase inhibitors in women with early breast cancer: results of a pilot observational study. |
| [So] Source: | Homeopathy;105(4):299-308, 2016 Nov. |
| [Is] ISSN: | 1476-4245 |
| [Cp] País de publicação: | Scotland |
| [La] Idioma: | eng |
| [Ab] Resumo: | OBJECTIVE: To determine the possible effect of two homeopathic medicines, Ruta graveolens 5CH and Rhus toxicodendron 9CH, in the prevention of aromatase inhibitor (AI) associated joint pain and/or stiffness in women with early, hormone-receptor positive, breast cancer. METHODS: This prospective, unrandomized observational study was carried out between April and October 2014. Women were recruited in two groups, according to which of the two study centres they attended: one receiving homeopathy in addition to standard treatment (group H) and a control group, receiving standard treatment (group C). All women were treated with an AI. In addition, women in group H also took Ruta graveolens 5CH and Rhus toxicodendron 9CH (5 granules, twice a day) up to 7 days before starting AI treatment. The homeopathic medicines were continued for 3 months. Demographic and clinical data were recorded using a self-assessment questionnaire at inclusion (T0) and 3 months (T3). Primary evaluation criteria were the evolution of scores for joint pain and stiffness, the impact of pain on sleep and analgesic consumption in the two groups after 3 months of treatment. RESULTS: Forty patients (mean age 64.9±8.1 years) were recruited, 20 in each group. Two-thirds of the patients had joint pain before starting AI treatment. There was a significant difference in the evolution of mean composite pain score between T0 and T3 in the two groups (-1.3 in group H vs. +3.4 in group C; p=0.0001). The individual components of the pain score (frequency, intensity and number of sites of pain) also decreased significantly in group H. Nine patients in group C (45%) vs. 1 (5%) in group H increased their analgesic consumption between T0 and T3 (p=0.0076). After 3 months of treatment, joint pain had a worse impact on sleep in patients in group C (35% vs. 0% of patients; p=0.0083). The differences observed in the evolution of morning and daytime stiffness between the two groups were smaller (p=0.053 and p=0.33, respectively), with the exception of time necessary for the disappearance of morning stiffness which was greater in group C (37.7±23.0 vs. 17.9±20.1 min; p=0.0173). CONCLUSION: These preliminary results suggest that treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may decrease joint pain/stiffness in breast cancer patients treated with AIs. A larger-scale randomized study is required to confirm these results. |
| [Mh] Termos MeSH primário: |
Inibidores da Aromatase/efeitos adversos
Artralgia/tratamento farmacológico
Neoplasias da Mama/tratamento farmacológico
Homeopatia
Fitoterapia
Ruta/química
Toxicodendron/química
|
| [Mh] Termos MeSH secundário: |
Idoso
Idoso de 80 Anos ou mais
Analgésicos/uso terapêutico
Feminino
Seres Humanos
Meia-Idade
Projetos Piloto
Estudos Prospectivos
Sono
|
| [Pt] Tipo de publicação: | JOURNAL ARTICLE; OBSERVATIONAL STUDY |
[Nm] Nome de substância:
| 0 (Analgesics); 0 (Aromatase Inhibitors) |
| [Em] Mês de entrada: | 1704 |
| [Cu] Atualização por classe: | 170817 |
[Lr] Data última revisão:
| 170817 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 161205 |
| [St] Status: | MEDLINE |
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