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[PMID]:28485213
[Au] Autor:Kitajima S; Imamura T; Iibushi J; Ikenaga M; Tachibana Y; Andoh N; Oyabu H; Hirooka K; Shiina T; Ishizaki Y
[Ad] Endereço:a Department of Applied Biology , Kyoto Institute of Technology , Kyoto , Japan.
[Ti] Título:Ferritin 2 domain-containing protein found in lacquer tree (Toxicodendron vernicifluum) sap has negative effects on laccase and peroxidase reactions.
[So] Source:Biosci Biotechnol Biochem;81(6):1165-1175, 2017 Jun.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lacquer tree sap, a raw material of traditional paints in East Asia, is hardened through laccase-catalyzed oxidation and the following polymerization of phenolic compound urushiol. In the sap's water-insoluble fraction, we found two plantacyanins and a ferritin 2 domain-containing protein (TvFe2D, a homolog of Arabidopsis AT1G47980 and AT3G62730). The recombinant TvFe2D protein suppressed the accumulation of laccase-catalyzed oxidation products of a model substrate syringaldazine without decreasing oxygen consumption, the second substrate of laccase. The suppression was also observed when another substrate guaiacol or another oxidizing enzyme peroxidase was used. The functional domain of the suppression was the C-terminal half, downstream of the ferritin 2 domain. The results suggest that this protein may be involved in regulating the sap polymerization/hardening. We also discuss the possibility that homologous proteins of TvFe2D in other plants might be involved in the laccase- or peroxidase-mediated polymerization of phenolic compounds, such as lignin and flavonoids.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica de Plantas
Lacase/metabolismo
Laca/análise
Metaloproteínas/metabolismo
Peroxidases/metabolismo
Proteínas de Plantas/metabolismo
Toxicodendron/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Biocatálise
Catecóis/metabolismo
Clonagem Molecular
Escherichia coli/genética
Escherichia coli/metabolismo
Ferritinas/química
Guaiacol/metabolismo
Hidrazonas/metabolismo
Cinética
Lacase/genética
Lignina/metabolismo
Metaloproteínas/genética
Oxirredução
Consumo de Oxigênio
Peroxidases/genética
Proteínas de Plantas/genética
Polimerização
Domínios Proteicos
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Especificidade por Substrato
Toxicodendron/química
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Hydrazones); 0 (Metalloproteins); 0 (Plant Proteins); 0 (Recombinant Proteins); 14414-32-5 (syringaldazine); 53237-59-5 (urushiol); 6JKA7MAH9C (Guaiacol); 9005-53-2 (Lignin); 9007-73-2 (Ferritins); EC 1.10.3.2 (Laccase); EC 1.11.1.- (Peroxidases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1289814


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[PMID]:28329482
[Au] Autor:Signore RJ
[Ad] Endereço:Dermatology, Private Practice, Tinley Park, Illinois. rjsignore@hotmail.com.
[Ti] Título:Prevention of poison ivy dermatitis with oral homeopathic Rhus toxicodendron.
[So] Source:Dermatol Online J;23(1), 2017 Jan 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute allergic contact dermatitis to poison ivy is acommon and miserable dermatosis which affectsmillions of Americans each year. Preventativemeasures, such as avoidance, protective clothing,barrier creams, soaps, and solvents often fail despiteour patients' best attempts. Severe allergic reactionsto poison ivy are a significant source of decreasedemployee productivity owing to inability to work anda major health care expenditure. Patients may haveto leave their jobs and discontinue favorite outdoorrecreational activities as a result of severe urushiolsensitivity. Thus, a simple and effective method ofpreventing poison ivy dermatitis would be of greatbenefit to clinical dermatologists and their patients.Complementary and alternative medical practitionerscommonly prescribe homeopathic poison ivyproducts by mouth for the prevention of poisonivy dermatitis. Yet, conventional dermatologists aremostly unaware of this little known clinical pearl. Theauthor discusses two open studies and anecdotalexperience with administration of homeopathicpoison ivy in the prevention of acute allergic contactdermatitis related to poison ivy exposure. Potentialadvantages could include patient acceptability,ease of administration, affordability, and availability.Randomized clinical trials are needed to furtherevaluate the safety and efficacy of this interesting andpromising clinical tip.
[Mh] Termos MeSH primário: Dermatite por Toxicodendron/prevenção & controle
Materia Medica
Extratos Vegetais/uso terapêutico
Folhas de Planta
Toxicodendron
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Materia Medica); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28087871
[Au] Autor:Vaught CK; Mold JW
[Ad] Endereço:Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Email: cara-vaught@ouhsc.edu.
[Ti] Título:Poison ivy: How effective are available treatments?
[So] Source:J Fam Pract;65(11):801-809, 2016 Nov.
[Is] ISSN:1533-7294
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, only one treatment approach significantly reduced pruritus. Three approaches were often associated with recurrences of rash or symptoms.
[Mh] Termos MeSH primário: Corticosteroides/uso terapêutico
Prurido/tratamento farmacológico
Prurido/etiologia
Toxicodendron/efeitos adversos
[Mh] Termos MeSH secundário: Estudos de Coortes
Seres Humanos
Oklahoma
Estudos Prospectivos
Prurido/diagnóstico
Prurido/patologia
[Pt] Tipo de publicação:OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


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[PMID]:27914569
[Au] Autor:Karp JC; Sanchez C; Guilbert P; Mina W; Demonceaux A; Curé H
[Ad] Endereço:Centre Hospitalier de Troyes, 101, Avenue Anatole France, 10000 Troyes, France. Electronic address: jckarp001@rss.fr.
[Ti] Título:Treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may reduce joint pain and stiffness linked to aromatase inhibitors in women with early breast cancer: results of a pilot observational study.
[So] Source:Homeopathy;105(4):299-308, 2016 Nov.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the possible effect of two homeopathic medicines, Ruta graveolens 5CH and Rhus toxicodendron 9CH, in the prevention of aromatase inhibitor (AI) associated joint pain and/or stiffness in women with early, hormone-receptor positive, breast cancer. METHODS: This prospective, unrandomized observational study was carried out between April and October 2014. Women were recruited in two groups, according to which of the two study centres they attended: one receiving homeopathy in addition to standard treatment (group H) and a control group, receiving standard treatment (group C). All women were treated with an AI. In addition, women in group H also took Ruta graveolens 5CH and Rhus toxicodendron 9CH (5 granules, twice a day) up to 7 days before starting AI treatment. The homeopathic medicines were continued for 3 months. Demographic and clinical data were recorded using a self-assessment questionnaire at inclusion (T0) and 3 months (T3). Primary evaluation criteria were the evolution of scores for joint pain and stiffness, the impact of pain on sleep and analgesic consumption in the two groups after 3 months of treatment. RESULTS: Forty patients (mean age 64.9±8.1 years) were recruited, 20 in each group. Two-thirds of the patients had joint pain before starting AI treatment. There was a significant difference in the evolution of mean composite pain score between T0 and T3 in the two groups (-1.3 in group H vs. +3.4 in group C; p=0.0001). The individual components of the pain score (frequency, intensity and number of sites of pain) also decreased significantly in group H. Nine patients in group C (45%) vs. 1 (5%) in group H increased their analgesic consumption between T0 and T3 (p=0.0076). After 3 months of treatment, joint pain had a worse impact on sleep in patients in group C (35% vs. 0% of patients; p=0.0083). The differences observed in the evolution of morning and daytime stiffness between the two groups were smaller (p=0.053 and p=0.33, respectively), with the exception of time necessary for the disappearance of morning stiffness which was greater in group C (37.7±23.0 vs. 17.9±20.1 min; p=0.0173). CONCLUSION: These preliminary results suggest that treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may decrease joint pain/stiffness in breast cancer patients treated with AIs. A larger-scale randomized study is required to confirm these results.
[Mh] Termos MeSH primário: Inibidores da Aromatase/efeitos adversos
Artralgia/tratamento farmacológico
Neoplasias da Mama/tratamento farmacológico
Homeopatia
Fitoterapia
Ruta/química
Toxicodendron/química
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Analgésicos/uso terapêutico
Feminino
Seres Humanos
Meia-Idade
Projetos Piloto
Estudos Prospectivos
Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Analgesics); 0 (Aromatase Inhibitors)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27783290
[Au] Autor:Rodionova OM; Glebov VV; Artamonova EV; Butenin MA; Anikina EV
[Ad] Endereço:Peoples' Friendship University of Russia, Moscow, Russia.
[Ti] Título:Effect of Herbal Homeopathic Monopreparations on the Rate of Tissue Lymphatic Drainage in Healthy Mice.
[So] Source:Bull Exp Biol Med;161(6):786-787, 2016 Oct.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We studied the effects of homeopathic monopreparations of plant origin Atropa Belladonna and Rhus toxicodendron in three dilutions (potencies) on interstitial humoral transport in healthy laboratory mice assessed by the rate of excretion of the lymphotropic label from the mesentery according to the Oyvin's method (vital biomicroscopy of intestinal mesentery in small animals). The homeopathic monopreparations exerted a dose-dependent inhibitory effect on the interstitial transport and lymphatic drainage in tissues of healthy mice.
[Mh] Termos MeSH primário: Atropa belladonna/química
Vasos Linfáticos/efeitos dos fármacos
Tecido Linfoide/efeitos dos fármacos
Extratos Vegetais/farmacologia
Toxicodendron/química
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/efeitos dos fármacos
Corantes
Azul Evans
Cinética
Vasos Linfáticos/metabolismo
Tecido Linfoide/metabolismo
Mesentério/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Plant Extracts); 45PG892GO1 (Evans Blue)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE


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[PMID]:27548435
[Au] Autor:Kim JH; Hu Y; Yongqing T; Kim J; Hughes VA; Le Nours J; Marquez EA; Purcell AW; Wan Q; Sugita M; Rossjohn J; Winau F
[Ad] Endereço:Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:CD1a on Langerhans cells controls inflammatory skin disease.
[So] Source:Nat Immunol;17(10):1159-66, 2016 Oct.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CD1a is a lipid-presenting molecule that is abundantly expressed on Langerhans cells. However, the in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice. Through the use of mice with transgenic expression of CD1a, we found that the plant-derived lipid urushiol triggered CD1a-dependent skin inflammation driven by CD4(+) helper T cells that produced the cytokines IL-17 and IL-22 (TH17 cells). Human subjects with poison-ivy dermatitis had a similar cytokine signature following CD1a-mediated recognition of urushiol. Among various urushiol congeners, we identified diunsaturated pentadecylcatechol (C15:2) as the dominant antigen for CD1a-restricted T cells. We determined the crystal structure of the CD1a-urushiol (C15:2) complex, demonstrating the molecular basis of urushiol interaction with the antigen-binding cleft of CD1a. In a mouse model and in patients with psoriasis, CD1a amplified inflammatory responses that were mediated by TH17 cells that reacted to self lipid antigens. Treatment with blocking antibodies to CD1a alleviated skin inflammation. Thus, we propose CD1a as a potential therapeutic target in inflammatory skin diseases.
[Mh] Termos MeSH primário: Antígenos CD1/metabolismo
Autoantígenos/metabolismo
Catecóis/metabolismo
Dermatite por Toxicodendron/imunologia
Células de Langerhans/imunologia
Psoríase/imunologia
Células Th17/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Bloqueadores/administração & dosagem
Antígenos CD1/genética
Antígenos CD1/imunologia
Catecóis/química
Cristalografia por Raios X
Modelos Animais de Doenças
Seres Humanos
Interleucina-17/metabolismo
Interleucinas/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos Transgênicos
Conformação Proteica
Toxicodendron/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Blocking); 0 (Antigens, CD1); 0 (Autoantigens); 0 (CD1a antigen); 0 (Catechols); 0 (Interleukin-17); 0 (Interleukins); 0 (interleukin-22); 53237-59-5 (urushiol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1038/ni.3523


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[PMID]:27376942
[Au] Autor:Umebayashi T; Utsumi Y; Koga S; Murata I; Fukuda K
[Ad] Endereço:Laboratory of Evaluation of Natural Environment, Department of Natural Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan. toshiumebayashi@gmail.com.
[Ti] Título:Differences in drought- and freeze-induced embolisms in deciduous ring-porous plant species in Japan.
[So] Source:Planta;244(3):753-60, 2016 Sep.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: Deciduous ring-porous species in Japan shed all of their leaves under severe water stress before large vessels in earlywood are embolized, and embolization take place during winter. Water in deciduous ring-porous species is mainly conducted upward via large earlywood vessels of the current year. Water columns in large vessels are vulnerable to drought-induced and freeze stress-induced embolisms. Although a vulnerability curve can be created to estimate the hydraulic capacity of plants, it remains unclear why the loss of conductivity in potted plants of ring-porous species does not reach 100 % under severe drought stress. In this study, two deciduous ring-porous species in Japan (Kalopanax septemlobus and Toxicodendron trichocarpum) were used to explain the species-specific pattern in the water-conducting pathway of the stem. We monitored and visualized the spatial distribution of xylem embolisms in the stem of K. septemlobus saplings under drought stress and freeze stress using compact magnetic resonance imaging and cryo-scanning microscopy. In addition, we evaluated the water ascent in the stems of both species using a dye uptake method. Although embolisms of large vessels were observed under drought stress and in winter, all leaves were dropped to avoid fatal water loss after embolization of some large vessels. In contrast, all large vessels were embolized in winter. Larger-diameter vessels of latewood in T. trichocarpum tended to function in trees growing in the warm temperate zone. Thus, our results suggest that the unclear curve may be derived from a discrepancy between leaf water potential and actual water potential in the xylem under severe drought stress. The frequency of xylem embolisms in deciduous ring-porous species in Japan mainly depends on the number of freeze-thaw cycles.
[Mh] Termos MeSH primário: Kalopanax/fisiologia
Toxicodendron/fisiologia
Água/fisiologia
Xilema/fisiologia
[Mh] Termos MeSH secundário: Secas
Congelamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-016-2564-9


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[PMID]:27156871
[Au] Autor:Xie Y; Zhang J; Liu W; Xie N; Feng F; Qu W
[Ad] Endereço:Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:New urushiols with platelet aggregation inhibitory activities from resin of Toxicodendron vernicifluum.
[So] Source:Fitoterapia;112:38-44, 2016 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Eight new urushiol-type compounds (1-7b), along with seven known compounds were isolated from the resin of Toxicodendron vernicifluum Stokes. Their structures were determined by extensive spectroscopic methods, included (1)H NMR, (13)C NMR, HMQC, HMBC, HRESIMS, EI-MS in combination with CD methods. All the compounds except 7a and 7b were evaluated for their anti-platelet aggregation activities in vitro. Among them, compound 5 (IC50=5.12±0.85µmol/L), with a vic-diol moiety in the long alkyl chain showed the most potent inhibitory of platelet aggregation activity induced by ADP. In addition, compound 6 showed the effect of anti-platelet aggregation induced by AA with the IC50 value of 3.09±0.70µmol/L. Thus, these compounds might be the active components to the traditional use of Resina Toxicodendri for breaking up blood stasis, which could be related to the anti-platelet aggregation.
[Mh] Termos MeSH primário: Catecóis/química
Agregação Plaquetária/efeitos dos fármacos
Resinas Vegetais/química
Toxicodendron/química
[Mh] Termos MeSH secundário: Animais
Catecóis/isolamento & purificação
Estrutura Molecular
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Resins, Plant); 53237-59-5 (urushiol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE


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[PMID]:26827997
[Au] Autor:Jadhav HP; Chaudhari GG; Patil DD; Jadhav RB; Reddy NM; Shirkhedkar AA; Goyal SN; Patil CR
[Ad] Endereço:Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist.: Dhule, MS, 425405, India.
[Ti] Título:Standardization of homeopathic mother tincture of Toxicodendron pubescens and correlation of its flavonoid markers with the biological activity.
[So] Source:Homeopathy;105(1):48-54, 2016 Feb.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Standardization and quality control of homeopathic drugs is very challenging. As mother tinctures are derived from complex natural resources, there is a need of systematic evaluation of chemical markers which correlate with the proposed biological activities of mother tinctures. METHODS: In present study, High-Performance Thin-Layer Chromatography (HPTLC) standardization method of homeopathic mother tinctures of Toxicodendron pubescens using quercitrin and rutin as chemical markers is validated and correlations of content of these markers with its anti-inflammatory effects are established. For HPTLC analysis, precoated silica gel plates were used as stationary phase. Two flavonoids, namely quercitrin and rutin were used as markers. Separation was achieved using methylene chloride:methanol:water:glacial acetic acid (15:1.5:1:8 v/v/v) as mobile phase. The developed plates were scanned at 365 nm. RESULTS: It was observed that quercitrin (Rf value 0.63) and Rutin (Rf value 0.41) are well resolved. The minimum detectable concentrations for quercitrin and rutin were 5 ng/spot. The linearity range was between 100 and 2000 ng/spot for both the markers. Subsequently, anti-inflammatory activity of these formulations was determined against carrageenan-induced paw edema in rats, pain threshold determined by electronic Von-Frey apparatus and paw withdrawal latency (PWL) on hot-plate. All the tested formulations of Rhus Tox showed anti-inflammatory and analgesic activity against carrageenan induced paw edema in rats. Quantitative correlation between the content of markers and anti-inflammatory activity of mother tinctures was established. RESULTS: Anti-inflammatory effect as well as effect on paw withdrawal and pain threshold, at third hour after carrageenan injection, correlated with quercitrin and rutin content in the respective formulations. CONCLUSIONS: This study validates a quantitative HPTLC method for standardization of homeopathic mother tincture of Rhus Tox and establishes quercitrin and rutin as markers corresponding its biological activity. Contents of quercitrin and rutin in T. pubescens mother tincture correlates with its anti-inflammatory and analgesic actions and the validated HPTLC method can be used in standardization of homeopathic mother tincture of T. pubescens.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Flavonoides/uso terapêutico
Extratos Vegetais/farmacologia
Toxicodendron
[Mh] Termos MeSH secundário: Animais
Biomarcadores Farmacológicos
Carragenina/efeitos adversos
Modelos Animais de Doenças
Homeopatia/métodos
Masculino
Fitoterapia/métodos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biomarkers, Pharmacological); 0 (Flavonoids); 0 (Plant Extracts); 9000-07-1 (Carrageenan)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE


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[PMID]:26827996
[Au] Autor:Lee KJ; Yeo MG
[Ad] Endereço:Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea.
[Ti] Título:Homeopathic Rhus toxicodendron has dual effects on the inflammatory response in the mouse preosteoblastic cell line MC3T3-e1.
[So] Source:Homeopathy;105(1):42-7, 2016 Feb.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Homeopathic remedy Rhus toxicodendron (Rhus tox) is used for several symptoms including skin irritations, rheumatic pains, mucous membrane afflictions, and typhoid type fever. Previously, we reported that Rhus tox treatment increased the cyclooxygenase-2 (COX-2) mRNA expression in primary cultured mouse chondrocytes. METHODS: A preosteoblastic mouse cell line, MC3T3-e1, was treated with different homeopathic dilutions of Rhus tox and the COX-2 mRNA and protein expression was examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblotting. Additionally, nitric oxide (NO) generation was examined in LPS-induced MC3T3-e1 cells using a Griess reaction assay. RESULTS: Stimulation with different concentrations of Rhus tox increased the expression of Cox2 mRNA, with 30X Rhus tox showing the most prominent increase in mRNA expression. In addition, treatment with 30X Rhus tox significantly increased prostaglandin E2 (PGE2) release compared with other homeopathic dilutions. However, the COX-2 protein expression level differed slightly from its mRNA expression, because the 30C Rhus tox treatment increased COX-2 protein to a greater extent compared with other dilutions. NO generation was dramatically decreased in MC3T3-e1 cells after Rhus tox treatment co-stimulated with lipopolysaccharide. CONCLUSION: Homeopathic dilution of Rhus tox has a dual activity that increases COX-2 expression and decreases NO generation, thus modulating inflammation. Further study is needed to examine the cellular signaling mechanisms that are associated with inflammatory regulation by Rhus tox treatment in greater detail.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Inibidores de Ciclo-Oxigenase 2/uso terapêutico
Mediadores da Inflamação/farmacologia
Extratos Vegetais/farmacologia
Toxicodendron
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte/efeitos dos fármacos
Inibidores de Ciclo-Oxigenase 2/farmacologia
Citocinas/efeitos dos fármacos
Modelos Animais de Doenças
Homeopatia/métodos
Camundongos
Fitoterapia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Carrier Proteins); 0 (Cyclooxygenase 2 Inhibitors); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Plant Extracts); 134034-50-7 (pleiotrophin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE



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