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[PMID]:29111476
[Au] Autor:Lopes JC; Chatrou LW; Mello-Silva R; Rudall PJ; Sajo MG
[Ad] Endereço:Universidade de São Paulo, Instituto de Biociências, Departamento de Botânica, Rua do Matão, 277, 05508-090 São Paulo, SP, Brazil. Electronic address: jenifer.clopes@gmail.com.
[Ti] Título:Phylogenomics and evolution of floral traits in the Neotropical tribe Malmeeae (Annonaceae).
[So] Source:Mol Phylogenet Evol;118:379-391, 2018 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Androdioecy is the rarest sexual system among plants. The majority of androdioecious species are herbaceous plants that have evolved from dioecious ancestors. Nevertheless, some woody and androdioecious plants have hermaphrodite ancestors, as in the Annonaceae, where androdioecious genera have arisen several times in different lineages. The majority of androdioecious species of Annonaceae belong to the Neotropical tribe Malmeeae. In addition to these species, Pseudoxandra spiritus-sancti was recently confirmed to be androdioecious. Here, we describe the morphology of male and bisexual flowers of Pseudoxandra spiritus-sancti, and investigate the evolution of androdioecy in Malmeeae. The phylogeny of tribe Malmeeae was reconstructed using Bayesian inference, maximum parsimony and maximum likelihood of 32 taxa, using DNA sequences of 66 molecular markers of the chloroplast genome, sequenced by next generation sequencing. The reconstruction of ancestral states was performed for characters associated with sexual systems and floral morphology. The phylogenetic analyses reconstructed three main groups in Malmeeae, (Malmea (Cremastosperma, Pseudoxandra)) sister to the rest of the tribe, and (Unonopsis (Bocageopsis, Onychopetalum)) sister to (Mosannona, Ephedranthus, Klarobelia, Oxandra, Pseudephedranthus fragrans, Pseudomalmea, Ruizodendron ovale). Hermaphroditism is plesiomorphic in the tribe, with four independent evolutions of androdieocy, which represents a synapomorphy of two groups, one that includes three genera and 14 species, the other with a single genus of seven species. Male flowers are unisexual from inception and bisexual flowers possess staminodes and functional stamens. Pseudoxandra spiritus-sancti is structurally androdioecious.
[Mh] Termos MeSH primário: Annonaceae/classificação
[Mh] Termos MeSH secundário: Annonaceae/anatomia & histologia
Annonaceae/genética
Teorema de Bayes
Evolução Biológica
Cloroplastos/genética
DNA de Cloroplastos/química
DNA de Cloroplastos/isolamento & purificação
DNA de Cloroplastos/metabolismo
Flores/anatomia & histologia
Flores/genética
Funções Verossimilhança
Microscopia Eletrônica de Varredura
Fenótipo
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE


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[PMID]:28765708
[Au] Autor:Hong J; Sun Z; Li Y; Guo Y; Liao Y; Liu M; Wang X
[Ad] Endereço:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing.
[Ti] Título:Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy.
[So] Source:Int J Nanomedicine;12:5053-5067, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Annonaceous acetogenins (ACGs) are a large family of fatty acid derived natural products that are exclusively isolated from the species. Many members of this diverse family have a broad spectrum of biological activities, the most impressive of which is anticancer activity. However, their poor solubility and severe toxicity restrict their clinical application, and their complicated composition hinders their formulation and drug delivery. In this study, ß-cyclodextrin was modified with folic acid (FA) and then combined with soybean lecithin to prepare FA-modified ACGs nanosuspensions (FA-ACGs-NSps). The obtained FA-ACGs-NSps had a high drug payload of 57.59% and average particle size of 199.5 nm, and they exhibited sustained drug release within 142 hours. In comparison with ACGs-NSps, FA-ACGs-NSps showed significantly enhanced cytotoxicity and higher cell uptake toward folate receptor-positive 4T1 cell lines. An in vivo study demonstrated that FA-ACGs-NSps more effectively accumulated in tumors and enhanced the antitumor therapeutic efficacy with less toxicity in 4T1 tumor bearing mice. Therefore, FA-ACGs-NSps may be a promising drug delivery system for ACGs to improve their therapeutic window and may be suitable for clinical application to treat folate-positive tumors.
[Mh] Termos MeSH primário: Acetogeninas/química
Acetogeninas/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Sistemas de Liberação de Medicamentos/métodos
Ácido Fólico/química
[Mh] Termos MeSH secundário: Acetogeninas/farmacocinética
Animais
Annonaceae/química
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacocinética
Peso Corporal/efeitos dos fármacos
Linhagem Celular Tumoral
Feminino
Ácido Fólico/farmacologia
Seres Humanos
Lecitinas/química
Camundongos Endogâmicos BALB C
Nanoestruturas/química
Tamanho da Partícula
Solubilidade
Suspensões/química
Suspensões/farmacologia
Distribuição Tecidual
Ensaios Antitumorais Modelo de Xenoenxerto
beta-Ciclodextrinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetogenins); 0 (Antineoplastic Agents, Phytogenic); 0 (Lecithins); 0 (Suspensions); 0 (beta-Cyclodextrins); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S134284


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[PMID]:28583139
[Au] Autor:Pumiputavon K; Chaowasku T; Saenjum C; Osathanunkul M; Wungsintaweekul B; Chawansuntati K; Wipasa J; Lithanatudom P
[Ad] Endereço:Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
[Ti] Título:Cell cycle arrest and apoptosis induction by methanolic leaves extracts of four Annonaceae plants.
[So] Source:BMC Complement Altern Med;17(1):294, 2017 Jun 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Uvaria longipes (Craib) L.L.Zhou, Y.C.F.Su & R.M.K.Saunders, Artabotrys burmanicus A.DC, Marsypopetalum modestum (Pierre) B.Xue & R.M.K.Saunders and Dasymaschalon sp. have been used for traditional medicine to treat cancer-like symptoms in some ethnic groups of Thailand and Laos. METHODS: We evaluated the anti-cancer activity of these Annonaceae plants against several human cancer cell lines. The apoptosis induction was detected by Annexin/propidium iodide (PI) staining. Phytochemical screening was tested by standard protocols and bioactive compounds were determined by HPLC. RESULTS: The crude extracts from leaves of U. longipes, Dasymaschalon sp., A. burmanicus, and M. modestum showed particular effects that were found to vary depending on the cancer cell line, suggesting that the effect was in a cell-type specific manner. Interestingly, the induction of apoptotic cell death was prominent by the leaves-derived crude extract of M. modestum. This crude was, therefore, subjected to cell cycle analysis by PI staining. Results showed that this crude extract arrested cell cycle and increased the percentage of cells in the SubG1 phase in some cancer cell lines. The phytochemical screening tests indicated that all crude extracts contained tannins and flavonoids. HPLC of flavonoids using standards identified rutin as an active compound in U. longipes and Dasymaschalon sp., whereas quercetin was found in U. longipes and M. modestum. CONCLUSIONS: These crude extracts provide a new source for rutin and quercetin, which might be capable of inducing cancer cell apoptotic death in a cell-type specific manner. This suggests, by analyzing the major bioactive compounds, the potential use of these crudes for chemotherapy in the future.
[Mh] Termos MeSH primário: Annonaceae/química
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Annonaceae/classificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1811-3


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[PMID]:28415154
[Au] Autor:Tundis R; Xiao J; Loizzo MR
[Ad] Endereço:Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Cosenza, Italy.
[Ti] Título:Annona species (Annonaceae): a rich source of potential antitumor agents?
[So] Source:Ann N Y Acad Sci;1398(1):30-36, 2017 Jun.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants have provided the basis of traditional medicine systems throughout the world for thousands of years and continue to yield molecules for new remedies. We analyzed studies published from 2009 to 2016 on the Annona species (Annonaceae), including A. coriacea, A. crassifolia, A. hypoglauca, A. muricata, A. squamosa, A. sylvatica, and A. vepretorum, as sources of potential antitumor agents. Here, we report and discuss the mechanisms of action and structure-activity relationships of the most active Annona constituents. Annonaceous acetogenins are one of the most promising classes of natural products, owing to their potential antitumor activity. However, their neurotoxicity should not be underestimated.
[Mh] Termos MeSH primário: Acetogeninas/uso terapêutico
Annonaceae/química
Antineoplásicos Fitogênicos/uso terapêutico
Neoplasias/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetogeninas/química
Antineoplásicos Fitogênicos/química
Seres Humanos
Estrutura Molecular
Sementes/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Acetogenins); 0 (Antineoplastic Agents, Phytogenic)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13339


  5 / 401 MEDLINE  
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[PMID]:28323398
[Au] Autor:Nhiem NX; Tuong NT; Ky PT; Subedi L; Park SJ; Ngoc TM; Yen PH; Tai BH; Quang TH; Kiem PV; Kim SY; Kim SH
[Ad] Endereço:Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
[Ti] Título:Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells.
[So] Source:Chem Biodivers;14(8), 2017 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8'R)-9,9'-epoxy-3,5,3',5'-tetramethoxylignan-4,4',7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC values of 15.7 ± 1.2 µm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC values ranging from 22.6 to 25.3 µm.
[Mh] Termos MeSH primário: Annonaceae/química
Óxido Nítrico/metabolismo
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Annonaceae/metabolismo
Linhagem Celular
Dicroísmo Circular
Lignanas/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
Espectroscopia de Ressonância Magnética
Camundongos
Microglia/citologia
Microglia/efeitos dos fármacos
Microglia/metabolismo
Conformação Molecular
Extratos Vegetais/química
Folhas de Planta/metabolismo
Plantas Medicinais/química
Plantas Medicinais/metabolismo
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (Plant Extracts); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700013


  6 / 401 MEDLINE  
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[PMID]:28229940
[Au] Autor:Yu ZX; Niu ZG; Li XB; Zheng CJ; Song XM; Chen GY; Song XP; Han CR; Wu SX
[Ad] Endereço:Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
[Ti] Título:New phenylpropanoid and 6H-dibenzo[b,d]pyran-6-one derivatives from the stems of Dasymaschalon rostratum.
[So] Source:Fitoterapia;118:27-31, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5-11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated diketone as a substituent, and 3 is a unique cinnamic acid detective with a polymethyl substituted cyclohexene conjugated triketone as a substituent. Their structures were elucidated by extensive spectroscopic methods and chemical method, and 4 was further confirmed by the single crystal X-ray diffraction method. Compounds 1-4 and 7 showed weak anti-HIV-1 activities with EC values ranged from 16.44 to 25.91µM.
[Mh] Termos MeSH primário: Annonaceae/química
HIV-1/efeitos dos fármacos
Lactonas/química
Fenantrenos/química
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/química
Fármacos Anti-HIV/isolamento & purificação
Estrutura Molecular
Caules de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Lactones); 0 (Phenanthrenes); 2005-10-9 (6H-dibenzo-(b,d)-pyran-6-one)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  7 / 401 MEDLINE  
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[PMID]:28146564
[Au] Autor:Xue B; Shao YY; Saunders RM; Tan YH
[Ad] Endereço:Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, P.R. China.
[Ti] Título:Alphonsea glandulosa (Annonaceae), a New Species from Yunnan, China.
[So] Source:PLoS One;12(2):e0170107, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alphonsea glandulosa sp. nov. is described from Yunnan Province in south-west China. It is easily distinguished from all previously described Alphonsea species by the possession of glandular tissue at the base of the adaxial surface of the inner petals. Nectar was observed throughout the flowering period, including the pistillate phase and subsequent staminate phase. Small curculionid beetles were observed as floral visitors and are inferred to be effective pollinators since they carry pollen grains. A phylogenetic analysis was conducted to confirm the placement of this new species within Alphonsea and the evolution of the inner petal glands and specialized pollinator reward tissues throughout the family.
[Mh] Termos MeSH primário: Annonaceae/classificação
Annonaceae/genética
[Mh] Termos MeSH secundário: Annonaceae/anatomia & histologia
Evolução Biológica
China
DNA de Cloroplastos
DNA de Plantas
Frutas
Especificidade de Órgãos
Fenótipo
Filogenia
Pólen/ultraestrutura
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170107


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[PMID]:27898188
[Au] Autor:Padhi SK
[Ad] Endereço:Biocatalysis and Enzyme Engineering Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India.
[Ti] Título:Modern Approaches to Discovering New Hydroxynitrile Lyases for Biocatalysis.
[So] Source:Chembiochem;18(2):152-160, 2017 Jan 17.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hydroxynitrile lyases (HNLs) have grown in importance from laboratory to industry due to their potential to catalyze stereoselective C-C bond-formation reactions in the synthesis of several chiral intermediates, such as enantiopure α-cyanohydrins, ß-nitro alcohols, and their derivatives with multiple functional groups. With these wide applications, the demand for finding new HNLs has increased, and this has led to exploration not only of new HNLs but also of new ways to discover them. An exclusive review article on HNLs by Asano et al. in 2011 described the discovery of HNLs along with their applications. Since then many scientific advancements have been seen in this area. This article aims to highlight the modern HNL discovery approaches, based mainly on 1) genome mining, 2) use of INTMSAlign software, 3) rational design (based on a millipede HNL), 4) evolution of catalytic mechanisms, 5) protein engineering guided by catalytic mechanisms, and 6) screening of plants with cyanogen glycoside (CG) content. This description is followed by future prospects. Overall this review represents the present state and the future potential of HNL discovery approaches, and so might be hoped to be instrumental not only in exploration of new HNLs but also in the invention of methods for potential biotechnological applications.
[Mh] Termos MeSH primário: Aldeído Liases/metabolismo
[Mh] Termos MeSH secundário: Aldeído Liases/genética
Annonaceae/enzimologia
Arabidopsis/enzimologia
Biocatálise
Nitrilos/química
Nitrilos/metabolismo
Engenharia de Proteínas
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nitriles); 0 (cyanohydrin); EC 4.1.2.- (Aldehyde-Lyases); EC 4.1.2.10 (mandelonitrile lyase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201600495


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[PMID]:27664083
[Au] Autor:Ouattara ZA; Boti JB; Ahibo CA; Bekro YA; Janat M; Casanova J; Tomi F; Bighelli A
[Ad] Endereço:Equipe Chimie et Biomasse, Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, FR-20000, Ajaccio.
[Ti] Título:Composition and Chemical Variability of Cleistopholis patens Trunk Bark Oil from Côte d'Ivoire.
[So] Source:Chem Biodivers;14(2), 2017 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The chemical composition of trunk bark oil from Cleistopholis patens (Benth.) Engl. & Diels, growing wild in Côte d'Ivoire, has been investigated by GC (FID) in combination with retention indices, GC/MS and C-NMR. Moreover, one oil sample has been subjected to CC and all the fractions analyzed by GC (RI) and C-NMR. In total, 61 components have been identified, including various sesquiterpene esters scarcely found in essential oils. C-NMR was particularly efficient for the identification of a component not eluted on GC and for the quantification of heat-sensitive compounds. Then, 36 oil samples, isolated from trunk bark harvested in six Ivoirian forests have been analyzed. The content of the main components varied drastically from sample to sample: (E)-ß-caryophyllene (0.4 - 69.1%), ß-pinene (0 - 57%), α-phellandrene (0 - 33.2%), α-pinene (0.1 - 30.6%), ß-elemol (0.1 - 29.9%), germacrene D (0 - 25.4%), juvenile hormone III (0 - 22.9%), germacrene B (0 - 20.6%) and sabinene (tr-20.3%). Statistical analysis, hierarchical clustering and principal components analysis, carried out on the 36 compositions evidenced a fair chemical variability of the stem bark oil of this species. Indeed, three clusters have been distinguished: the composition of group I (ten samples) was dominated by ß-pinene and α-pinene, group II (nine samples) was represented by α-phellandrene and p-cymene and group III (16 samples) by ß-elemol. A sample displayed an atypical composition dominated by (E)-ß-caryophyllene.
[Mh] Termos MeSH primário: Annonaceae/química
Casca de Planta/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: África Ocidental
Cromatografia Gasosa-Espectrometria de Massas
Espectroscopia de Ressonância Magnética
Óleos Vegetais/isolamento & purificação
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600313


  10 / 401 MEDLINE  
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[PMID]:27405108
[Au] Autor:Zhou XM; Zheng CJ; Zhang YQ; Zhang XP; Song XP; Xu W; Chen GY
[Ad] Endereço:Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
[Ti] Título:Guaiane-Type Sesquiterpenoids from Fissistigma oldhamii Inhibit the Proliferation of Synoviocytes.
[So] Source:Planta Med;83(3-04):217-223, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Three guaiane-type sesquiterpenoids, dysodensiols G-I ( - ), together with five known sesquiterpenoids ( - ) were isolated from the stems of (Hemsl.) Merr. Compound represents the first example of an ene(6 → 5)- -14-norguaiane sesquiterpenoid derived from natural products. Their structures were elucidated by a combination of 1D and 2D NMR and MS spectra. The absolute configuration of was determined by an X-ray crystallographic analysis. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound showed a potent inhibitory effect on the proliferation of synoviocytes with an IC value of 1.0 M.
[Mh] Termos MeSH primário: Annonaceae/química
Medicamentos de Ervas Chinesas/química
Sesquiterpenos de Guaiano/química
Sesquiterpenos de Guaiano/farmacologia
Sesquiterpenos/química
Sesquiterpenos/farmacologia
Sinoviócitos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Cristalografia por Raios X/métodos
Concentração Inibidora 50
Espectroscopia de Ressonância Magnética/métodos
Espectrometria de Massas/métodos
Estrutura Molecular
Norisoprenoides/farmacologia
Caules de Planta/química
Ratos
Ratos Sprague-Dawley
Sesquiterpenos/isolamento & purificação
Sesquiterpenos de Guaiano/isolamento & purificação
Sinoviócitos/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Norisoprenoids); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Guaiane); 0 (guaiane)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-111440



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