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Pesquisa : B01.650.940.800.575.912.250.065.500 [Categoria DeCS]
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[PMID]:28880962
[Au] Autor:Gaisberger H; Kindt R; Loo J; Schmidt M; Bognounou F; Da SS; Diallo OB; Ganaba S; Gnoumou A; Lompo D; Lykke AM; Mbayngone E; Nacoulma BMI; Ouedraogo M; Ouédraogo O; Parkouda C; Porembski S; Savadogo P; Thiombiano A; Zerbo G; Vinceti B
[Ad] Endereço:Bioversity International, Via dei Tre Denari 472/a, Maccarese (Rome), Italy.
[Ti] Título:Spatially explicit multi-threat assessment of food tree species in Burkina Faso: A fine-scale approach.
[So] Source:PLoS One;12(9):e0184457, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Over the last decades agroforestry parklands in Burkina Faso have come under increasing demographic as well as climatic pressures, which are threatening indigenous tree species that contribute substantially to income generation and nutrition in rural households. Analyzing the threats as well as the species vulnerability to them is fundamental for priority setting in conservation planning. Guided by literature and local experts we selected 16 important food tree species (Acacia macrostachya, Acacia senegal, Adansonia digitata, Annona senegalensis, Balanites aegyptiaca, Bombax costatum, Boscia senegalensis, Detarium microcarpum, Lannea microcarpa, Parkia biglobosa, Sclerocarya birrea, Strychnos spinosa, Tamarindus indica, Vitellaria paradoxa, Ximenia americana, Ziziphus mauritiana) and six key threats to them (overexploitation, overgrazing, fire, cotton production, mining and climate change). We developed a species-specific and spatially explicit approach combining freely accessible datasets, species distribution models (SDMs), climate models and expert survey results to predict, at fine scale, where these threats are likely to have the greatest impact. We find that all species face serious threats throughout much of their distribution in Burkina Faso and that climate change is predicted to be the most prevalent threat in the long term, whereas overexploitation and cotton production are the most important short-term threats. Tree populations growing in areas designated as 'highly threatened' due to climate change should be used as seed sources for ex situ conservation and planting in areas where future climate is predicting suitable habitats. Assisted regeneration is suggested for populations in areas where suitable habitat under future climate conditions coincides with high threat levels due to short-term threats. In the case of Vitellaria paradoxa, we suggest collecting seed along the northern margins of its distribution and considering assisted regeneration in the central part where the current threat level is high due to overexploitation. In the same way, population-specific recommendations can be derived from the individual and combined threat maps of the other 15 food tree species. The approach can be easily transferred to other countries and can be used to analyze general and species specific threats at finer and more local as well as at broader (continental) scales in order to plan more selective and efficient conservation actions in time. The concept can be applied anywhere as long as appropriate spatial data are available as well as knowledgeable experts.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
Alimentos
[Mh] Termos MeSH secundário: Acacia
Adansonia
Anacardiaceae
Annona
Balanites
Bombax
Burkina Faso
Mudança Climática
Ecossistema
Olacaceae
Tamarindus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184457


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[PMID]:28800757
[Au] Autor:Ngouateu Teufack SE; NMbogning Tayo G; Ngangout Alidou M; Yondo J; Djiomene AF; Wabo Poné J; Mbida FM
[Ad] Endereço:Research Unit of Biology and Applied Ecology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon.
[Ti] Título:Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea).
[So] Source:BMC Complement Altern Med;17(1):400, 2017 Aug 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pushed scientists to turn to plants with anthelminthic properties. Hence, the aim of this work was to contribute to the fight against helminths of medical and veterinary importance in general, and also to clear the environment of their free living stages. METHODS: Fresh eggs of Heligmosomoides bakeri were obtained from the faeces of experimentally infected mice. L and L larval stages were obtained after 48 and 72 h of coproculture respectively. Methylene Chloride-Methanol (1:1) extracts of Annona senegalensis and Nauclea latifolia were diluted in DMSO or Tween 80 to prepare the following concentrations: 625, 1250, 2500, 3750 and 5000 µg/ml. The effects of extract solutions were evaluated on the embryonation of eggs, egg hatching and on L and L survival after 48, 10 and 24 h of incubation. Negative controls were 1.5% DMSO, 4% Tween 80 and a mixture of these solvents. The TLC was carried out and the profiles of secondary metabolites were made. RESULTS: Negative controls had no effect on the embryonation, eggs hatching and on larval mortality. However, it was found that, the extracts affected the free living stages of H. bakeri in a concentration-dependant manner. At the highest concentration (5000 µg/ml), the rate of inhibition of embryonation obtained were 20.80%, 38.15% and 84.83% for Methylene Chloride-Methanol of Annona senegalensis (MCM As), Nauclea latifolia (MCM Nl) extracts and mixture of Annona senegalensis and Nauclea latifolia (MCM As-Nl) extract respectively. For egg hatch, the inhibition rate was 16.10%, 46.24% and 87.07% for the above three extracts respectively at the same concentration of 5000 µg/ml. On L and L larval stages after 24 h of exposure to extracts, the mortality rates of 100%, 54.76% and 96.77% against 98%, 51.44% and 100% were obtained for MCM As, MCM Nl and MCM As-Nl respectively at the highest concentration. The Methylene Chloride-Methanol of A.senegalensis, N. latifolia extracts showed the presence of alkaloids except in N. latifolia extract, flavonoids, sterols, triterpens, tanins, polyphenols, anthraquinons, saponins and terpenoids. CONCLUSION: These findings suggest that, the mixture of the two plant extracts showed an additive (synergetic effect) ovicidal effect and a slight larval mortality on L as compared to the effect of MCM As extract alone. These effects were due to the presence ao secondary metabolites identifies in the plant extracts. Thus, they may be used as possible «disinfectants¼ for soil transmitted nematodes.
[Mh] Termos MeSH primário: Annona/química
Anti-Helmínticos/farmacologia
Larva/efeitos dos fármacos
Nematoides/efeitos dos fármacos
Infecções por Nematoides/parasitologia
Extratos Vegetais/farmacologia
Rubiaceae/química
[Mh] Termos MeSH secundário: Animais
Camarões
Sinergismo Farmacológico
Estágios do Ciclo de Vida/efeitos dos fármacos
Medicina Tradicional Africana
Camundongos
Nematoides/crescimento & desenvolvimento
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1908-8


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[PMID]:28659034
[Au] Autor:Ma C; Chen Y; Chen J; Li X; Chen Y
[Ad] Endereço:1 Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China.
[Ti] Título:A Review on Annona squamosa L.: Phytochemicals and Biological Activities.
[So] Source:Am J Chin Med;45(5):933-964, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Annona squamosa L. (Annonaceae) is a fruit tree with a long history of traditional uses. A. squamosa is an evergreen plant mainly located in tropical and subtropical regions. Srikayas, the fruits of A. squamosa, are extensively used to prepare candies, ice creams and beverages. A wide range of ethno-medicinal uses has been related to different portions of A. squamosa, such as tonic, apophlegmatisant, cool medicine, abortient and heart sedative. Numerous research projects on A. squamosa have found that it has anticancer, anti-oxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidel and molluscicidal activities. Phytochemistry investigations on A. squamosa have considered annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs) and cyclopeptides (CPs) as the main constituents. Until 2016, 33 DITs, 19 ALKs, 88 ACGs and 13 CPs from this species were reported. On the basis of the multiple researches on A. squamosa, this review strives to integrate available information on its phytochemicals, folklore uses and bioactivities, hoping to promote a better understanding of its medicinal values.
[Mh] Termos MeSH primário: Annona/química
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
[Mh] Termos MeSH secundário: Acetogeninas/isolamento & purificação
Acetogeninas/farmacologia
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Anti-Hipertensivos
Antimaláricos
Antineoplásicos Fitogênicos
Antioxidantes
Antiparasitários
Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Hipoglicemiantes
Peptídeos Cíclicos/isolamento & purificação
Peptídeos Cíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Acetogenins); 0 (Alkaloids); 0 (Antihypertensive Agents); 0 (Antimalarials); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Antiparasitic Agents); 0 (Diterpenes); 0 (Hypoglycemic Agents); 0 (Peptides, Cyclic); 0 (Phytochemicals)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500501


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[PMID]:28613374
[Au] Autor:Sánchez CFB; Teodoro PE; Londoño S; Silva LA; Peixoto LA; Bhering LL
[Ad] Endereço:Departamento Ciencias Agronómicas, , , Colombia.
[Ti] Título:Minimum number of measurements for evaluating soursop (Annona muricata L.) yield.
[So] Source:Genet Mol Res;16(2), 2017 May 31.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Repeatability studies on fruit species are of great importance to identify the minimum number of measurements necessary to accurately select superior genotypes. This study aimed to identify the most efficient method to estimate the repeatability coefficient (r) and predict the minimum number of measurements needed for a more accurate evaluation of soursop (Annona muricata L.) genotypes based on fruit yield. Sixteen measurements of fruit yield from 71 soursop genotypes were carried out between 2000 and 2016. In order to estimate r with the best accuracy, four procedures were used: analysis of variance, principal component analysis based on the correlation matrix, principal component analysis based on the phenotypic variance and covariance matrix, and structural analysis based on the correlation matrix. The minimum number of measurements needed to predict the actual value of individuals was estimated. Principal component analysis using the phenotypic variance and covariance matrix provided the most accurate estimates of both r and the number of measurements required for accurate evaluation of fruit yield in soursop. Our results indicate that selection of soursop genotypes with high fruit yield can be performed based on the third and fourth measurements in the early years and/or based on the eighth and ninth measurements at more advanced stages.
[Mh] Termos MeSH primário: Annona/genética
Frutas/anatomia & histologia
Fenótipo
Melhoramento Vegetal/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Annona/anatomia & histologia
Interpretação Estatística de Dados
Frutas/genética
Variação Genética
Característica Quantitativa Herdável
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16029594


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[PMID]:28582808
[Au] Autor:Indrawati L; Ascobat P; Bela B; Abdullah M; Surono IS
[Ad] Endereço:Department of Pharmacotherapy, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia. Email: lili_zain@yahoo.com.
[Ti] Título:The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial.
[So] Source:Asia Pac J Clin Nutr;26(4):606-612, 2017.
[Is] ISSN:0964-7058
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Annona muricata leaf infusion has traditionally been consumed to maintain health, but is now considered for use in treating cancer patients. The objective of this study was to elucidate the effects of A. muricata leaf extract in humans and human cell lines. METHODS AND STUDY DESIGN: Thirty outpatients with colorectal cancer who had undergone primary tumor resection were enrolled in a randomized double-blind placebo- controlled pre-post-trial. They were divided into two groups: those who ingested A. muricata leaf extract (n=14) and those who ingested a placebo (n=14) daily for 8 weeks. Twenty-eight subjects completed the trial; they were equally distributed between the two groups. Serum from patients of both groups was compared for cytotoxicity against colorectal cancer cell lines. The nutritional status of patients was monitored throughout the study. RESULTS: Ex vivo and clinical studies showed higher cytotoxicity in the supplemented group compared with the placebo group. Further research is required to investigate the long-term effect of A.muricata leaf extract, particularly on parameters directly related to cytotoxic activity toward colorectal cancer cells and nutrition status.
[Mh] Termos MeSH primário: Annona/química
Neoplasias Colorretais/tratamento farmacológico
Estado Nutricional
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Método Duplo-Cego
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.6133/apjcn.062016.02


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[PMID]:28514152
[Au] Autor:Justino AB; Pereira MN; Peixoto LG; Vilela DD; Caixeta DC; de Souza AV; Teixeira RR; Silva HCG; de Moura FBR; Moraes IB; Espindola FS
[Ad] Endereço:Institute of Genetics and Biochemistry, Federal University of Uberlândia , Uberlândia, Brazil.
[Ti] Título:Hepatoprotective Properties of a Polyphenol-Enriched Fraction from Annona crassiflora Mart. Fruit Peel against Diabetes-Induced Oxidative and Nitrosative Stress.
[So] Source:J Agric Food Chem;65(22):4428-4438, 2017 Jun 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A polyphenol-enriched fraction from Annona crassiflora fruit peel (Ac-Pef) containing chlorogenic acid, (epi)catechin, procyanidin B2, and caffeoyl-glucoside was investigated against hepatic oxidative and nitrosative stress in streptozotocin-induced diabetic rats. Serum biochemical parameters, hepatic oxidative and nitrosative status, glutathione defense system analysis, and in silico assessment of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the main compounds of Ac-Pef were carried out. Ac-Pef treatment during 30 days decreased serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, as well as hepatic lipid peroxidation, protein carbonylation and nitration, inducible nitric oxide synthase level, and activities and expressions of glutathione peroxidase, superoxide dismutase, and catalase. There were increases in antioxidant capacity, glutathione reductase activity, and reduced glutathione level. ADMET predictions of Ac-Pef compounds showed favorable absorption and distribution, with no hepatotoxicity. A. crassiflora fruit peel showed hepatoprotective properties, indicating a promising natural source of bioactive molecules for prevention and therapy of diabetes complications.
[Mh] Termos MeSH primário: Annona/química
Diabetes Mellitus Experimental/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Polifenóis/administração & dosagem
Substâncias Protetoras/administração & dosagem
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/administração & dosagem
Antioxidantes/química
Aspartato Aminotransferases/sangue
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/metabolismo
Frutas/química
Glutationa Peroxidase/sangue
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Estrutura Molecular
Extratos Vegetais/química
Polifenóis/química
Substâncias Protetoras/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Polyphenols); 0 (Protective Agents); EC 1.11.1.9 (Glutathione Peroxidase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01355


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[PMID]:28498122
[Au] Autor:Saranya N; Nakeeran E; Giri Nandagopal MS; Selvaraju N
[Ad] Endereço:Department of Chemical Engineering, National Institute of Technology Calicut, Calicut 673601, Kerala, India E-mail: selvaraju@nitc.ac.in.
[Ti] Título:Optimization of adsorption process parameters by response surface methodology for hexavalent chromium removal from aqueous solutions using Annona reticulata Linn peel microparticles.
[So] Source:Water Sci Technol;75(9-10):2094-2107, 2017 May.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fruit peel microparticles of Annona reticulata Linn were used as biosorbent for the sequestration of hexavalent chromium (CR(VI)). Characterization of the biosorbent was done using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), Fourier transfer infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GCMS), carbon, hydrogen, nitrogen and sulphur (CHNS) elemental analysis, mercury intrusion porosimetry and point of zero charge. Influential parameters were optimized using response surface methodology (RSM) with a total of 17 experimental runs based on the Box-Behnken design and found to be pH 1.0, temperature 25 °C and 100 mg/L initial chromium concentration. pH and concentration were found to be more influential than temperature. The analysis of variance indicated that a second-order polynomial regression equation was the most suitable for fitting the experimental data. The experimental runs showed a good correlation with the predicted responses (R = 0.9956). The biosorption process fitted well with the Langmuir isotherm with an adsorption capacity of 108. 32 mg/g out of the other isotherms such as Freundlich and Dubinin-Radushkevich that were analyzed. Non linear pseudo first order, pseudo second order, and intraparticle diffusion kinetics were applied to describe the interaction between the biosorbent and Cr(VI). Desorption and regeneration performances showed that fruit peels of Annona reticulata Linn can be an environmental friendly option for hexavalent chromium removal from aqueous solutions.
[Mh] Termos MeSH primário: Annona/química
Cromo/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Difusão
Cromatografia Gasosa-Espectrometria de Massas
Concentração de Íons de Hidrogênio
Cinética
Microscopia Eletrônica de Varredura
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solutions); 0 (Water Pollutants, Chemical); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.092


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[PMID]:28351591
[Au] Autor:Chen YY; Cao YZ; Li FQ; Zhu XL; Peng CX; Lu JH; Chen JW; Li X; Chen Y
[Ad] Endereço:College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.
[Ti] Título:Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract.
[So] Source:Bioorg Med Chem Lett;27(9):1907-1910, 2017 05 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the anti-hepatoma activity of different extracts from A. squamosa pericarps, phytochemistry of the ethyl acetate (EtOAc) fraction and possible anti-hepatoma mechanism of active constituents. The anti-hepatoma activity of different extracts from A. squamosa pericarps were evaluated by MTT assay against SMMC-7721 cells in vitro and verified by using H xenografts bearing mice. Phytochemical investigation of the active pericarp extract was carried out. The pro-apoptosis and cycle arrest effects of active constituents were observed by fluorescent microscope and flow cytometry. Western blot assay was conducted to find the possible anti-hepatoma mechanisms of active constituents. The result showed that EtOAc extract was the active fraction. Two ent-kaurane diterpenoids, named ent-kauran-16-en-19-oic acid and ent-kauran-15-en-19-oic acid, were isolated from the active EtOAc fraction. The pro-apoptosis and G1 phase arrest effects of these diterpenoids were found. Western blot assay showed that ent-kauran-16-en-19-oic acid could activate caspase-3,-8,-9, up-regulate of Bax and down-regulate of Bcl-2.
[Mh] Termos MeSH primário: Annona/química
Antineoplásicos Fitogênicos/uso terapêutico
Carcinoma Hepatocelular/tratamento farmacológico
Diterpenos Caurânicos/uso terapêutico
Neoplasias Hepáticas/tratamento farmacológico
Fígado/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Diterpenos Caurânicos/química
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Seres Humanos
Fígado/patologia
Neoplasias Hepáticas/patologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Kaurane)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28256049
[Au] Autor:Oliveira AP; Sá I; Pereira DM; Gonçalves RF; Andrade PB; Valentão P
[Ad] Endereço:REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, no. 228, PT-4050-313, Porto.
[Ti] Título:Exploratory Studies on the in Vitro Anti-inflammatory Potential of Two Herbal Teas (Annona muricata L. and Jasminum grandiflorum L.), and Relation with Their Phenolic Composition.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The need of new anti-inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. This work aimed to explore the anti-inflammatory potential of aqueous extracts from two herbal teas (Annona muricata L. and Jasminum grandiflorum L.) in RAW 264.7 macrophages cells and in cell-free assays. Furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by HPLC-DAD, in order to establish possible relationships with the biological activity. In a general way, A. muricata displayed a stronger capacity to inhibit nitric oxide (NO) production and the activity of phospholipase A (PLA ), displaying an IC value of 142 µg/ml against this enzyme. A deeper look at phenolic compounds revealed that aglycones had more capacity to inhibit NO and PLA than their corresponding glycosides, quercetin being clearly the most potent one (IC  = 7.47 and 1.36 µm, respectively). In addition, 5-O-caffeoylquinic acid, at 1.56 µm, could also inhibit PLA (ca. 35%). Our findings suggest that the consumption of both herbal teas may be a preventive approach to inflammatory disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Chás de Ervas
[Mh] Termos MeSH secundário: Animais
Annona/química
Anti-Inflamatórios/farmacologia
Sistema Livre de Células/efeitos dos fármacos
Jasminum/química
Camundongos
Óxido Nítrico/antagonistas & inibidores
Fenóis/análise
Fenóis/farmacologia
Inibidores de Fosfolipase A2
Extratos Vegetais
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Phenols); 0 (Phospholipase A2 Inhibitors); 0 (Plant Extracts); 0 (Teas, Herbal); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700002


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[PMID]:28254016
[Au] Autor:Bonneau N; Baloul L; Bajin Ba Ndob I; Sénéjoux F; Champy P
[Ad] Endereço:Laboratoire de Pharmacognosie, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, UFR Pharmacie, 5 rue J.-B. Clément, 92290 Châtenay-Malabry, France.
[Ti] Título:The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis.
[So] Source:Food Chem;226:32-40, 2017 Jul 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Annonaceous acetogenins (AAGs) are neurotoxins possibly responsible for atypical Parkinsonism/dementia clusters, via the consumption of edible Annonaceae fruits. Their presence was investigated in fruit pulps of Annona squamosa from different locations. Qualitative analysis of other AAGs was performed. We here report the identification of squamocin in batches from Asia, the Caribbean Basin and the Indian Ocean. This molecule was quantified by HPLC-UV, evidencing a content of 13.5-36.4mg/fruit. HPLC-ESI-Q-TOF allowed the detection of 25 different raw formulas matching with AAGs. LC-MS/MS methodological development was performed using 4 representative standards. The main AAGs could be annotated, including bullatacin (rolliniastatin-2) and annonacin. This study evidences a remarkable homogeneity for the main AAGs within the species, and discrepancies for minor compounds. These findings indicate that A. squamosa should be considered a risk factor for neurodegenerative disorders.
[Mh] Termos MeSH primário: Acetogeninas/análise
Annona/química
Frutas/química
Furanos/análise
Lactonas/análise
Neurotoxinas/análise
[Mh] Termos MeSH secundário: Ásia
Região do Caribe
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetogenins); 0 (Furans); 0 (Lactones); 0 (Neurotoxins); 120298-30-8 (squamocin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE



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