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Pesquisa : B01.650.940.800.575.912.250.065.875 [Categoria DeCS]
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  1 / 11 MEDLINE  
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[PMID]:28011169
[Au] Autor:Ferreira C; Passos CL; Soares DC; Costa KP; Rezende MJ; Lobão AQ; Pinto AC; Hamerski L; Saraiva EM
[Ad] Endereço:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Título:Leishmanicidal activity of the alkaloid-rich fraction from Guatteria latifolia.
[So] Source:Exp Parasitol;172:51-60, 2017 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania and includes cutaneous, mucocutaneous and visceral clinical forms. The drugs currently available for leishmaniasis treatment are pentavalent antimonials, amphotericin B and miltefosine, which present high toxicity, elevated cost and development of parasite resistance. The natural products constitute an important source of substances with leishmanicidal potential. Here we evaluated in vitro the anti-Leishmania amazonensis activity of crude extracts of branches, leaves and fruits of Guatteria latifolia. The branch extract (GCE) exhibited promising leishmanicidal activity against promastigotes (IC 51.7 µg/ml), and was submitted to fractionation guided by in vitro assays. Among the seven subfractions obtained, GF1 and GF2 were the most actives against promastigotes with IC 25.6 and 16 µg/ml, respectively. Since GCE, GF1 and GF2 were not toxic for macrophages, next, we tested their effect on intracellular amastigotes, and the IC values obtained were, respectively 30.5, 10.4 and 7.4 µg/ml, after 24 h treatment. The selectivity index for GCE, GF1 and GF2 were >6.5, >19.2 and > 27, respectively. Additionally, GCE, GF1 and GF2 affected the division pattern of the promastigotes by increasing 6.7, 9.4 and 7-fold the cells in Sub-G0/G1 phase, and decreasing 1.6, 2.5 and 1.8-fold the cells in G0/G1 phase, respectively. To assess the GCE and GFs capacity to modulate microbicidal mechanisms of macrophages, nitric oxide (NO) and TNF-α production were tested. Our results indicated that at the IC GCE, GF1 and GF2 decreased NO production of infected macrophages stimulated with IFN-γ and LPS, besides, only GF1 decreased the production of TNF-α. Our data warrant further studies of GCE, GF1 and GF2 to identify active compounds against Leishmania parasites.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Antiprotozoários/farmacologia
Guatteria
Leishmania mexicana/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/análise
Alcaloides/isolamento & purificação
Antiprotozoários/química
Antiprotozoários/isolamento & purificação
Ciclo Celular/efeitos dos fármacos
Interferon gama/biossíntese
Leishmania mexicana/citologia
Leishmania mexicana/metabolismo
Ativação de Macrófagos
Macrófagos/imunologia
Macrófagos/parasitologia
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Óxido Nítrico/metabolismo
Extratos Vegetais/química
Fator de Necrose Tumoral alfa/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antiprotozoal Agents); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


  2 / 11 MEDLINE  
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Carvalho, Joäo Ernesto de
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[PMID]:27300257
[Au] Autor:Costa EV; Pinheiro ML; Maia BH; Marques FA; Ruiz AL; Marchetti GM; Carvalho JE; Soares MB; Costa CO; Galvão AF; Lopes NP; Koolen HH; Bezerra DP; Barison A
[Ad] Endereço:Department of Chemistry, Federal University of Amazonas , Manaus 69077-000, Brazil.
[Ti] Título:7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana.
[So] Source:J Nat Prod;79(6):1524-31, 2016 Jun 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Aporfinas/isolamento & purificação
Guatteria/química
Casca de Planta/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Aporfinas/química
Aporfinas/farmacologia
Brasil
Ensaios de Seleção de Medicamentos Antitumorais
Células HL-60
Células Hep G2
Seres Humanos
Camundongos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7,7-dimethylaporphine); 0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Aporphines)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b01037


  3 / 11 MEDLINE  
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[PMID]:27107335
[Au] Autor:Andreazza NL; Caramano de Lourenço C; Hernandez-Tasco ÁJ; Pinheiro ML; Alves Stefanello MÉ; Vilaça Costa E; Salvador MJ
[Ad] Endereço:Departamento de Biologia Vegetal, PPG BTPB and PPG BV, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil. Electronic address: nathilu@gmail.com.
[Ti] Título:Antimicrobial photodynamic effect of extracts and oxoaporphine alkaloid isomoschatoline from Guatteria blepharophylla.
[So] Source:J Photochem Photobiol B;160:154-62, 2016 Jul.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Photodynamic Therapy, a tumor therapy idealized at the beginning of the last century, emerges nowadays as a promising treatment alternative against infectious diseases. In this study we report a bioguided study of Guatteria blepharophylla phytoderivatives for antimicrobial PDT. Crude extracts and fraction from the species bark were obtained and further fractionated for substances isolation. All samples were evaluated in relation to their photophysical (absorbance and fluorescence) and photochemical properties (1,3-DPBF bleaching method). Then, bioassays were conducted using as biological models bacteria and yeast strains and a diode laser as a light source. Phytochemical analyses lead to the isolation of 5 isoquinoline alkaloids from oxoaporphine subclass, denominated GB1 to GB5. Photophysical and photochemical analysis showed that extracts, fraction and GB1 (isomoschatoline) presented absorption profile with bands at 600-700nm and were positive for singlet oxygen production. Photobiological assays indicate that these samples presented photodynamic antimicrobial activity against both gram-positive and gram-negative bacterial and some Candida ssp. yeast strains at sub-inhibitory concentrations. The susceptibility of gram-negative bacteria was significantly enhanced when CaCl2 or MgCl2 were employed. Greater energy doses and double sample's dosage also decreased microbial survival. It is suggested that GB1 photodynamic activity happens through both types I and II photochemical mechanisms, but with a predominance of the latter. Phytoderivatives of G. blepharophylla promoted antimicrobial effect, however more detailed study concerning chemical composition of the crude extracts and fractions as also photophysical and photochemical characteristics of GB1 are necessary to ensure their potential as photosensitizers at antimicrobial photodynamic inactivation.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Antibacterianos/farmacologia
Aporfinas/farmacologia
Guatteria/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Testes de Sensibilidade Microbiana
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Aporphines); 0 (Plant Extracts); 13NS2KTD6H (aporphine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE


  4 / 11 MEDLINE  
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[PMID]:25845063
[Au] Autor:Lúcio AS; Almeida JR; Da-Cunha EV; Tavares JF; Barbosa Filho JM
[Ti] Título:Alkaloids of the Annonaceae: occurrence and a compilation of their biological activities.
[So] Source:Alkaloids Chem Biol;74:233-409, 2015.
[Is] ISSN:1099-4831
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided. The alkaloids of the aporphine type represent the predominant group in this family. Many of the isolated alkaloids exhibit unique structures. In addition to the chemical structures, the pharmacological activities of some alkaloids are also presented in this chapter. Thus, the leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids are highlighted. The chapter is presented as a contribution for the scientific community, mainly to enable the search for alkaloids in species belonging to the Annonaceae family.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides/farmacologia
Annonaceae/química
[Mh] Termos MeSH secundário: Alcaloides/classificação
Annona/química
Annonaceae/classificação
Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Antimaláricos/química
Antimaláricos/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Aporfinas/química
Aporfinas/farmacologia
Guatteria/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Infective Agents); 0 (Antimalarials); 0 (Antineoplastic Agents, Phytogenic); 0 (Aporphines); 13NS2KTD6H (aporphine)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150408
[St] Status:MEDLINE


  5 / 11 MEDLINE  
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[PMID]:25710362
[Au] Autor:Siqueira CA; Serain AF; Pascoal AC; Andreazza NL; de Lourenço CC; Ruiz AL; de Carvalho JE; de Souza AC; Mesquita JT; Tempone AG; Salvador MJ
[Ad] Endereço:a Departamento de Biologia Vegetal , Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas , SP , Brazil.
[Ti] Título:Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil.
[So] Source:Nat Prod Res;29(20):1966-9, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC-MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 µg/ml) and HT-29 (TGI = 32.81 µg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 µg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 µg/ml), as well as small antioxidant activity (457 µmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.
[Mh] Termos MeSH primário: Antibacterianos/química
Antineoplásicos Fitogênicos/química
Antiprotozoários/química
Guatteria/química
Óleos Voláteis/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antiprotozoários/isolamento & purificação
Células HT29
Seres Humanos
Folhas de Planta/química
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos de Germacrano/química
Sesquiterpenos de Germacrano/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Antiprotozoal Agents); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); BHW853AU9H (caryophyllene); V2I9ATG34E (germacrene D)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1015017


  6 / 11 MEDLINE  
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[PMID]:23576358
[Au] Autor:do N Fontes JE; Ferraz RP; Britto AC; Carvalho AA; Moraes MO; Pessoa C; Costa EV; Bezerra DP
[Ad] Endereço:Department of Chemistry, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
[Ti] Título:Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae).
[So] Source:Chem Biodivers;10(4):722-9, 2013 Apr.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Guatteria pogonopus Martius, a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were γ-patchoulene (13.55%), (E)-caryophyllene (11.36%), ß-pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), α-pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither (E)-caryophyllene nor ß-pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC50 values ranged from 3.8 to 20.8 µg/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Guatteria/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/uso terapêutico
Antineoplásicos Fitogênicos/toxicidade
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Masculino
Camundongos
Neoplasias/tratamento farmacológico
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/toxicidade
Folhas de Planta/química
Sarcoma/tratamento farmacológico
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Oils, Volatile)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:130411
[Lr] Data última revisão:
130411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130412
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201200304


  7 / 11 MEDLINE  
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[PMID]:22274812
[Au] Autor:Britto AC; de Oliveira AC; Henriques RM; Cardoso GM; Bomfim DS; Carvalho AA; Moraes MO; Pessoa C; Pinheiro ML; Costa EV; Bezerra DP
[Ad] Endereço:Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
[Ti] Título:In vitro and in vivo antitumor effects of the essential oil from the leaves of Guatteria friesiana.
[So] Source:Planta Med;78(5):409-14, 2012 Mar.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Guatteria friesiana (W. A. Rodrigues) Erkens & Maas (synonym Guatteriopsis friesiana W. A. Rodrigues), popularly known as "envireira", is a medicinal plant found in the Brazilian and Colombian Amazon basin that is used in traditional medicine for various purposes. Recent studies on this species have demonstrated antimicrobial activity. In this study, the antitumor activity of the essential oil from the leaves of G. friesiana (EOGF) and its main components ( α-, ß-, and γ-eudesmol) were determined using experimental models. In the in vitro study, EOGF and its components α-, ß-, and γ-eudesmol displayed cytotoxicity against tumor cell lines, showing IC50 values in the range of 1.7 to 9.4 µg/mL in the HCT-8 and HL-60 cell lines for EOGF, 5.7 to 19.4 µg/mL in the HL-60 and MDA-MB-435 cell lines for α-eudesmol, 24.1 to > 25 µg/mL in the SF-295 and MDA-MB-435 cell lines for ß-eudesmol, and 7.1 to 20.6 µg/mL in the SF-295 and MDA-MB-435 cell lines for γ-eudesmol, respectively. In the in vivo study, the antitumor effect of EOGF was evaluated in mice inoculated with sarcoma 180 tumor cells. Tumor growth inhibition rates were 43.4-54.2 % and 6.6-42.8 % for the EOGF treatment by intraperitoneal (50 and 100 mg/kg/day) and oral (100 and 200 mg/kg/day) administration, respectively. The treatment with EOGF did not significantly affect body mass, macroscopy of the organs, or blood leukocyte counts. Based on these results, we can conclude that EOGF possesses significant antitumor activity and has only low systemic toxicity. These effects could be assigned to its components α-, ß-, and γ-eudesmol.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/administração & dosagem
Guatteria/química
Óleos Voláteis/administração & dosagem
Óleos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antineoplásicos Fitogênicos/uso terapêutico
Brasil
Linhagem Celular Tumoral
Colômbia
Seres Humanos
Concentração Inibidora 50
Injeções Intraperitoneais
Masculino
Camundongos
Estrutura Molecular
Óleos Voláteis/uso terapêutico
Folhas de Planta/química
Óleos Vegetais/uso terapêutico
Plantas Medicinais/química
Sarcoma 180
Sesquiterpenos de Eudesmano/administração & dosagem
Sesquiterpenos de Eudesmano/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes, Eudesmane); 0 (gamma-eudesmol); 473-15-4 (beta-eudesmol); 473-16-5 (alpha-eudesmol)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:120329
[Lr] Data última revisão:
120329
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120126
[St] Status:MEDLINE
[do] DOI:10.1055/s-0031-1298173


  8 / 11 MEDLINE  
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[PMID]:21567357
[Au] Autor:Munigunti R; Nelson N; Mulabagal V; Gupta MP; Brun R; Calderón AI
[Ad] Endereço:Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, USA.
[Ti] Título:Identification of oleamide in Guatteria recurvisepala by LC/MS-based Plasmodium falciparum thioredoxin reductase ligand binding method.
[So] Source:Planta Med;77(15):1749-53, 2011 Oct.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Our current research on applications of mass spectrometry to natural product drug discovery against malaria aims to screen plant extracts for new ligands to Plasmodium falciparum thioredoxin reductase (PfTrxR) followed by their identification and structure elucidation. PfTrxR is involved in the antioxidant defense and redox regulation of the parasite and is validated as a promising target for therapeutic intervention against malaria. In the present study, detannified methanol extracts from Guatteria recurvisepala, Licania kallunkiae, and Topobea watsonii were screened for ligands to PfTrxR using ultrafiltration and liquid chromatography/mass spectrometry-based binding experiments. The PfTrxR ligand identified in the extract of Guatteria recurvisepala displayed a relative binding affinity of 3.5-fold when incubated with 1 µM PfTrxR. The ligand corresponding to the protonated molecule m/z 282.2792 [M+ H]+ was eluted at a retention time of 17.95 min in a 20-min gradient of 95% B consisting of (A) 0.1%formic acid in 95% H2O-5% ACN, and (B) 0.1% formic acid in 95% ACN-5% H2O in an LC-QTOF-MS.Tandem MS of the protonated molecule m/z 282.2792 [M + H]+, C18H36NO (DBE: 2; error: 1.13 ppm) resulted in two daughter ions m/z 265.2516[M + H-NH3]+ (DBE: 3; error: 0.35 ppm) and m/z 247.2405 [M + H-NH3-H2O] +, (DBE: 4; error:2.26 ppm). The PfTrxR ligand was identified as oleamide and confirmed by comparison of the retention time, molecular formula, accurate mass,and double bond equivalence with the standard oleamide. This is the first report on the identification of oleamide as a PfTrxR ligand from Guatteria recurvisepala R. E. Fr. and the corresponding in vitro activity against P. falciparum strain K1 (IC50 4.29 µg/mL).
[Mh] Termos MeSH primário: Antimaláricos/química
Guatteria/química
Ácidos Oleicos/química
Extratos Vegetais/química
Plasmodium falciparum/enzimologia
Tiorredoxina Dissulfeto Redutase/metabolismo
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Linhagem Celular
Sobrevivência Celular
Cromatografia Líquida
Chrysobalanaceae/química
Descoberta de Drogas
Concentração Inibidora 50
Ligantes
Espectrometria de Massas
Melastomataceae/química
Ácidos Oleicos/isolamento & purificação
Panamá
Extratos Vegetais/isolamento & purificação
Ratos
Padrões de Referência
Ultrafiltração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Ligands); 0 (Oleic Acids); 0 (Plant Extracts); 7L25QK8BWO (oleylamide); EC 1.8.1.9 (Thioredoxin-Disulfide Reductase)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:111018
[Lr] Data última revisão:
111018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110514
[St] Status:MEDLINE
[do] DOI:10.1055/s-0030-1271080


  9 / 11 MEDLINE  
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[PMID]:20476748
[Au] Autor:Costa EV; Pinheiro ML; Barison A; Campos FR; Salvador MJ; Maia BH; Cabral EC; Eberlin MN
[Ad] Endereço:Departamento de Quimica, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Rosa Elze, 49100-000, Sao Cristovao, SE, Brazil. emmanoelvilaca@yahoo.com.br
[Ti] Título:Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
[So] Source:J Nat Prod;73(6):1180-3, 2010 Jun 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Guatteria/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Alcaloides/química
Antibacterianos/química
Antifúngicos/química
Antioxidantes/química
Aporfinas/química
Brasil
Candida/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Casca de Planta/química
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (9-methoxy-O-methylmoschatoline); 0 (9-methoxyisomoschatoline); 0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antioxidants); 0 (Aporphines); 0 (isocerasonine); 517-71-5 (xylopine)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:100625
[Lr] Data última revisão:
100625
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100519
[St] Status:MEDLINE
[do] DOI:10.1021/np100013r


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Fotocópia
[PMID]:16534735
[Au] Autor:Correa JE; Ríos CH; del Rosario Castillo A; Romero LI; Ortega-Barría E; Coley PD; Kursar TA; Heller MV; Gerwick WH; Rios LC
[Ad] Endereço:Laboratorio de Bioorgánica Tropical, Universidad de Panamá, República de Panamá.
[Ti] Título:Minor alkaloids from Guatteria dumetorum with antileishmanial activity.
[So] Source:Planta Med;72(3):270-2, 2006 Feb.
[Is] ISSN:0032-0943
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine ( 3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1-4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.
[Mh] Termos MeSH primário: Guatteria
Leishmania mexicana/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
Tripanossomicidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Cercopithecus aethiops
Seres Humanos
Leishmaniose Cutânea/tratamento farmacológico
Macrófagos/efeitos dos fármacos
Camundongos
Testes de Sensibilidade Parasitária
Extratos Vegetais/administração & dosagem
Extratos Vegetais/uso terapêutico
Folhas de Planta
Tripanossomicidas/administração & dosagem
Tripanossomicidas/uso terapêutico
Células Vero/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Trypanocidal Agents)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060315
[St] Status:MEDLINE



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