Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.065.984 [Categoria DeCS]
Referências encontradas : 60 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6 ir para página                

  1 / 60 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28596029
[Au] Autor:Auranwiwat C; Wongsomboon P; Thaima T; Rattanajak R; Kamchonwongpaisan S; Willis AC; Lie W; Pyne SG; Limtharakul Née Ritthiwigrom T
[Ad] Endereço:Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand; The Graduate School, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand.
[Ti] Título:2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).
[So] Source:Fitoterapia;120:103-107, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A-C (1-3), and a new polyoxygenated cyclohexene derivative, (-)-uvaribonol F (4) together with six known compounds, 5-10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC values of 18.8±3.63 and 23.4±4.08µM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC value of 22.1±0.42µM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC value of 5.05±0.86µM and was nearly equally cytotoxic to the Vero cell line.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Naftalenos/farmacologia
Uvaria/química
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Cercopithecus aethiops
Cicloexenos/química
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Naftalenos/isolamento & purificação
Raízes de Plantas/química
Caules de Planta/química
Células Vero
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Antineoplastic Agents, Phytogenic); 0 (Cyclohexenes); 0 (Naphthalenes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  2 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28342587
[Au] Autor:Awale S; Tawila AM; Dibwe DF; Ueda JY; Sun S; Athikomkulchai S; Balachandran C; Saiki I; Matsumoto K; Esumi H
[Ad] Endereço:Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
[Ti] Título:Highly oxygenated antiausterity agents from the leaves of Uvaria dac.
[So] Source:Bioorg Med Chem Lett;27(9):1967-1971, 2017 05 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I-L (1-4) were isolated together with nine previously reported compounds (5-13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC , 20.1µM), PSN-1 (PC , 9.7µM), MIA PaCa-2 (PC , 29.1µM), Capan-1 (73.0µM) and KLM-1 (25.9µM).
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Cicloexenos/química
Cicloexenos/farmacologia
Oxigênio/química
Uvaria/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Cicloexenos/isolamento & purificação
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Pâncreas/efeitos dos fármacos
Neoplasias Pancreáticas/tratamento farmacológico
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cyclohexenes); 12L0P8F7GN (cyclohexene); S88TT14065 (Oxygen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE


  3 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27989370
[Au] Autor:Salae AW; Chairerk O; Sukkoet P; Chairat T; Prawat U; Tuntiwachwuttikul P; Chalermglin P; Ruchirawat S
[Ad] Endereço:Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand. Electronic address: wahab_a@pkru.ac.th.
[Ti] Título:Antiplasmodial dimeric chalcone derivatives from the roots of Uvaria siamensis.
[So] Source:Phytochemistry;135:135-143, 2017 Mar.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four dimeric chalcone derivatives, 8″,9″-dihydrowelwitschin H, uvarins A-C, a naphthalene derivative, 2-hydroxy-3-methoxy-6-(4'- hydroxyphenyl)naphthalene, and the known dimeric chalcones, dependensin and welwitschin E, flavonoids, a cyclohexane oxide derivative, an aromatic aldehyde were isolated from the roots of Uvaria siamensis (Annonaceae). The structures of the compounds were elucidated by spectroscopic analysis, as well as by comparison with literature data. The isolated compounds with a sufficient amount for biological assays were evaluated for their antimalarial, antimycobacterial, and cytotoxic activities. The dimeric chalcones 8″,9″-dihydrowelwitschin H, uvarins B and C, dependensin and welwitschin E showed strong antiplasmodial activity with IC values of 3.10, 3.02, 3.09, 4.21 and 3.99 µg/mL, respectively. A possible biosynthesis pathway of the dimeric chalcones is discussed.
[Mh] Termos MeSH primário: Antimaláricos/isolamento & purificação
Antimaláricos/farmacologia
Chalconas/farmacologia
Raízes de Plantas/química
Uvaria/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antimaláricos/química
Chalconas/química
Chalconas/isolamento & purificação
Flavonoides/química
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Concentração Inibidora 50
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antimalarials); 0 (Chalcones); 0 (Flavonoids)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE


  4 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27846886
[Au] Autor:Emordi JE; Agbaje EO; Oreagba IA; Iribhogbe OI
[Ad] Endereço:Department of Pharmacology and Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria. drjonathan.emordi@gmail.com.
[Ti] Título:Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats.
[So] Source:BMC Complement Altern Med;16(1):468, 2016 Nov 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus is a metabolic disorder of multiple aetiology characterised by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is a global epidemic ravaging both developed and developing countries. The situation will worsen if nothing is done urgently. In fact, the need to identify natural products with antidiabetic potentials is of great importance as supported by several research efforts all over the world, in search of antidiabetic plant based products that are safe and efficacious. Available literatures show that several phytochemicals with antidiabetic properties have been identified in certain plants amongst which include Uvaria chamae. The potentials of Uvaria chamae as an antidiabetic and hypolipidemic drug-candidate are thus tested. METHODS: Diabetes mellitus was experimentally induced after the rats were fasted overnight by administering intraperitoneally, 60 mg/kg streptozotocin. After 72 h, the rats with plasma glucose levels >200 mg/dl were classified as diabetic. A total of six groups containing five rats per group were used. One group of diabetic rats was untreated. Three diabetic groups, each were treated orally with 100, 250 and 400 mg/kg body weight of the extract. Another diabetic group was treated with insulin (0.5 IU/kg) subcutaneously. The control received 0.5 ml (2% solution) of acacia orally. The treatment was for 8 days. The effects of the extract on weight, plasma glucose and other biochemical parameters were evaluated using standard procedures. RESULTS: The diabetic rats treated with the extract showed significant reductions (p < 0.05) in weight, plasma glucose levels, low density lipoprotein and cholesterol compared with the control. The 100, 250 and 400 mg/kg body weight of the extract showed maximum glucose reduction of 85.16, 81.50 and 86.02% respectively. Histologically the pancreas of the diabetic rats treated with the extract, showed clusters of variably sized regenerated islet of Langerhans within sheets of normal exocrine pancreas, while the pancreas of diabetic rats treated with insulin showed no islet of Langerhans. CONCLUSION: The study showed that Uvaria chamae caused weight loss and has good hypoglycemic and hypolipidemic activities that may reduce the risk of developing cardiovascular diseases.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Hipolipemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
Uvaria/química
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Colesterol/sangue
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/fisiopatologia
Feminino
Seres Humanos
Insulina/sangue
Fígado/efeitos dos fármacos
Masculino
Raízes de Plantas/química
Ratos
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Insulin); 0 (Plant Extracts); 5W494URQ81 (Streptozocin); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


  5 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27732901
[Au] Autor:Buncharoen W; Saenphet K; Saenphet S; Thitaram C
[Ad] Endereço:Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: applepaleel@gmail.com.
[Ti] Título:Uvaria rufa Blume attenuates benign prostatic hyperplasia via inhibiting 5α-reductase and enhancing antioxidant status.
[So] Source:J Ethnopharmacol;194:483-494, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine has used Uvaria rufa Blume as an ethnomedicinal plant for treating fever, skin allergies, intestinal ulcers and prostate disorders including BPH. However, no scientific evidence supports the traditional use. AIM OF THE STUDY: This study aimed to evaluate the therapeutic potential of U. rufa on BPH using in vitro and in vivo models. MATERIALS AND METHODS: In vitro studies screened the efficacy of a 5α-reductase (5αR) inhibition and antioxidant activity of petroleum ether, ethyl acetate, ethanol and aqueous extracts from the stem of U. rufa. Phytochemical screening was performed to determine the active compound using high-performance liquid chromatography (HPLC). Ethyl acetate extract (UR-EtOAc) of U. rufa was used to evaluate the therapeutic efficacy in vivo models. BPH was induced by subcutaneous injection of testosterone propionate (3mg/kg) to male rats for 30 days. After 30 days of oral administration of UR-EtOAc at doses of 10 and 20mg/kg and finasteride at a dose of 1mg/kg, the prostate weight, prostate index (PI), testosterone and androgen receptor (AR) levels, and histopathological alteration of prostate gland were determined. Also, oxidative status and toxicity indices were assessed. RESULTS: UR-EtOAc exhibited the highest potency of inhibition of 5αR and possessed potent antioxidants rich in phenolics and flavonoids contents. The active compound analyzed by HPLC was ß-sitosterol. In vivo results show a significant reduction in prostate weight, PI, and AR in all treated groups when compared to the BPH model group (P<0.001). Also, the UR-EtOAc and finasteride treated groups had increased prostatic and serum testosterone levels when compared to the BPH model group. A histopathological investigation of the prostate glands supported the above results. UR-EtOAc elevated the antioxidant enzymes and reduced the malondialdehyde level in BPH-induced rats. Moreover, treatment of UR-EtOAc at all doses had no toxic effects on the vital organs and serum biochemical indices. CONCLUSIONS: UR-EtOAc from the stem of Uvaria rufa Blume appears to have the potential as a phytotherapeutic agent in the management of BPH, which provides the scientific evidence for traditional use.
[Mh] Termos MeSH primário: Inibidores de 5-alfa Redutase/farmacologia
Extratos Vegetais/farmacologia
Hiperplasia Prostática/prevenção & controle
Uvaria/química
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Masculino
Tamanho do Órgão/efeitos dos fármacos
Próstata/efeitos dos fármacos
Próstata/metabolismo
Próstata/patologia
Hiperplasia Prostática/patologia
Ratos
Receptores Androgênicos/metabolismo
Testosterona/sangue
Testosterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Plant Extracts); 0 (Receptors, Androgen); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


  6 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27686270
[Au] Autor:Popoola TD; Awodele O; Omisanya A; Obi N; Umezinwa C; Fatokun AA
[Ad] Endereço:Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Nigeria. Electronic address: tdpopoola@cmul.edu.ng.
[Ti] Título:Three indigenous plants used in anti-cancer remedies, Garcinia kola Heckel (stem bark), Uvaria chamae P. Beauv. (root) and Olax subscorpioidea Oliv. (root) show analgesic and anti-inflammatory activities in animal models.
[So] Source:J Ethnopharmacol;194:440-449, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Phytochemicals with anti-oxidative and anti-inflammatory properties are known to inhibit tumour initiation, promotion and progression. Hence, there is an increasingly-convincing rationale for employing remedies containing those phytochemicals in the treatment of cancers and also as analgesic and anti-inflammatory adjuvants in therapy. The plants Garcinia kola Heckel (Clusiaceae), stem bark; Uvaria chamae P. Beauv. (Annonaceae), root; and Olax subscorpioidea Oliv. (Olacaceae), root, have been documented to be part of various indigenous anti-cancer regimens. AIM OF THE STUDY: To determine if the three plants exhibit significant anti-oxidative and anti-inflammatory properties. MATERIALS AND METHODS: Using established models, the analgesic and anti-inflammatory activities of the three plants were investigated. RESULTS: Pre-treatment with the plant extracts at 100, 200 and 400mg/kg produced inhibition of writhes; G. kola and U. chamae showed no significant effect on formalin-induced pain, but O. subscorpioidea produced inhibition in both phases of the formalin test. Similarly, while G. kola and U. chamae did not produce any significant inhibitory effect in the xylene-induced ear oedema model, the oedema was significantly reduced by O. subscorpioidea pre-treatment. However, all the three plants significantly inhibited the time-dependent increase in paw circumference in the carrageenan- and formaldehyde-induced rat paw oedema tests, with peak effects observed at 400mg/kg, 6h after the induction of oedema, comparable in some cases to the effects of two standard drugs, the non-steroidal anti-inflammatory drug diclofenac and the anti-inflammatory antibiotic doxycycline. CONCLUSION: We conclude that the three plant extracts possess analgesic and anti-inflammatory properties, thus providing a scientific rationale for their inclusion in some traditional anti-cancer regimens.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Garcinia kola/química
Olacaceae/química
Extratos Vegetais/uso terapêutico
Uvaria/química
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Masculino
Camundongos
Estruturas Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE


  7 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26909907
[Au] Autor:Osathanunkul M; Madesis P; Ounjai S; Pumiputavon K; Somboonchai R; Lithanatudom P; Chaowasku T; Wipasa J; Suwannapoom C
[Ad] Endereço:Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Título:Identification of Uvaria sp by barcoding coupled with high-resolution melting analysis (Bar-HRM).
[So] Source:Genet Mol Res;15(1), 2016 Jan 13.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:DNA barcoding, which was developed about a decade ago, relies on short, standardized regions of the genome to identify plant and animal species. This method can be used to not only identify known species but also to discover novel ones. Numerous sequences are stored in online databases worldwide. One of the ways to save cost and time (by omitting the sequencing step) in species identification is to use available barcode data to design optimized primers for further analysis, such as high-resolution melting analysis (HRM). This study aimed to determine the effectiveness of the hybrid method Bar-HRM (DNA barcoding combined with HRM) to identify species that share similar external morphological features, rather than conduct traditional taxonomic identification that require major parts (leaf, flower, fruit) of the specimens. The specimens used for testing were those, which could not be identified at the species level and could either be Uvaria longipes or Uvaria wrayias, indicated by morphological identification. Primer pairs derived from chloroplast regions (matK, psbA-trnH, rbcL, and trnL) were used in the Bar-HRM. The results obtained from psbA-trnH primers were good enough to help in identifying the specimen while the rest were not. Bar-HRM analysis was proven to be a fast and cost-effective method for plant species identification.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico
DNA de Cloroplastos
Uvaria/genética
[Mh] Termos MeSH secundário: Desnaturação de Ácido Nucleico
Uvaria/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15017405


  8 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26732672
[Au] Autor:Hsu YM; Wu TY; Du YC; El-Shazly M; Beerhues L; Thang TD; Van Luu H; Hwang TL; Chang FR; Wu YC
[Ad] Endereço:Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
[Ti] Título:3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity.
[So] Source:Phytochemistry;122:184-192, 2016 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The phytochemical investigation of the methanolic extract of Uvaria flexuosa (Annonaceae) leaves led to the isolation of seven compounds including, 3-methyl-4,5-dihydro-oxepine (flexuvaroxepine A), four polyoxygenated seco-cyclohexene (flexuvarin A-D) and two polyoxygenated cyclohexene (flexuvarol A-B) derivatives, together with four known flavones. The structures of the isolated compounds were elucidated using different spectroscopic techniques. A plausible biogenetic route of the new compounds was discussed. The anti-inflammatory activity of the isolated compounds was evaluated by superoxide anion generation and elastase release assays. Among the tested compounds, flexuvarol B and chrysin showed the most potent anti-inflammatory effect by inhibiting superoxide anion generation and elastase release from human neutrophils in response to fMLP with IC50 2.25-5.55µM. Moreover, 5-hydroxy-6,7-dimethoxy-flavone showed selective inhibitory activity on superoxide anion generation (IC50=1.19±0.34µM).
[Mh] Termos MeSH primário: Annonaceae/química
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Cicloexenos/isolamento & purificação
Cicloexenos/farmacologia
Oxepinas/isolamento & purificação
Oxepinas/farmacologia
Uvaria/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Cicloexenos/química
Flavonoides/farmacologia
Seres Humanos
Estrutura Molecular
Oxepinas/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3-(benzoyloxymethyl)-4,5-dihydro-oxepine-4,5-diyldiacetate); 0 (3-methyl-4,5-dihydro-oxepine); 0 (Anti-Inflammatory Agents); 0 (Cyclohexenes); 0 (Flavonoids); 0 (Oxepins); 0 (flexuvarin); 3CN01F5ZJ5 (chrysin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE


  9 / 60 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26102180
[Au] Autor:Kongstad KT; Wubshet SG; Kjellerup L; Winther AM; Staerk D
[Ad] Endereço:Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: kenneth.kongstad@sund.ku.dk.
[Ti] Título:Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.
[So] Source:Fitoterapia;105:102-6, 2015 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In our ongoing efforts of finding natural fungicides to fight food and feed spoilage during production and storage, the antifungal potential of Ghanaian Uvaria chamae P. Beauv. was investigated, with emphasis on plant metabolites targeting the fungal plasma membrane (PM) H(+)-ATPase. Ethyl acetate extract of U. chamae was subjected to high-resolution fungal PM H(+)-ATPase inhibition screening followed by structural elucidation by high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-HRMS-SPE-NMR). This led to identification of a series of uncommon o-hydroxybenzylated flavanones and chalcones, i.e., chamanetin (8), isochamanetin (9), isouvaretin (10), uvaretin (11), dichamanetin (12), and diuvaretin (15). Preparative-scale isolation of the active metabolites allowed determination of IC50 values for inhibition of the PM H(+)-ATPase, and growth inhibition of Saccharomyces cerevisiae and Candida albicans. These revealed a strong correlation between o-hydroxybenzyl substituents and PM H(+)-ATPase activity, with dichamanetin being the most potent compound, but showing moderate activity in the fungal growth inhibition assays.
[Mh] Termos MeSH primário: Antifúngicos/química
Chalconas/química
Flavanonas/química
ATPases Translocadoras de Prótons/antagonistas & inibidores
Uvaria/química
[Mh] Termos MeSH secundário: Candida albicans/efeitos dos fármacos
Membrana Celular/enzimologia
Proteínas Fúngicas/antagonistas & inibidores
Estrutura Molecular
Casca de Planta/química
Saccharomyces cerevisiae/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Chalcones); 0 (Flavanones); 0 (Fungal Proteins); EC 3.6.3.14 (Proton-Translocating ATPases)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150624
[St] Status:MEDLINE


  10 / 60 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26077495
[Au] Autor:Ho DV; Kodama T; Le HT; Phan KV; Do TT; Bui TH; Le AT; Win NN; Imagawa H; Ito T; Morita H; Nguyen HT
[Ad] Endereço:Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Viet Nam.
[Ti] Título:A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora.
[So] Source:Bioorg Med Chem Lett;25(16):3246-50, 2015 Aug 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 µM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Cicloexanonas/isolamento & purificação
Cicloexanonas/farmacologia
Cicloexenos/isolamento & purificação
Cicloexenos/farmacologia
Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Norisoprenoides/isolamento & purificação
Norisoprenoides/farmacologia
Uvaria/química
[Mh] Termos MeSH secundário: Sequência de Carboidratos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Elipticinas/farmacologia
Glicosídeos
Seres Humanos
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Dados de Sequência Molecular
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cyclohexanones); 0 (Cyclohexenes); 0 (Ellipticines); 0 (Glucosides); 0 (Glycosides); 0 (Norisoprenoids); 0 (megastigmane); 117VLW7484 (ellipticine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150706
[Lr] Data última revisão:
150706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150617
[St] Status:MEDLINE



página 1 de 6 ir para página                
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde