Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.077 [Categoria DeCS]
Referências encontradas : 81 [refinar]
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[PMID]:28254010
[Au] Autor:El-Zaeddi H; Calín-Sánchez Á; Nowicka P; Martínez-Tomé J; Noguera-Artiaga L; Burló F; Wojdylo A; Carbonell-Barrachina ÁA
[Ad] Endereço:Universidad Miguel Hernández de Elche (UMH), Escuela Politécnica Superior de Orihuela (EPSO), Department of Agro-Food Technology, Research Group "Food Quality and Safety", Carretera Beniel, km 3.2, 03312-Orihuela, Alicante, Spain.
[Ti] Título:Preharvest treatments with malic, oxalic, and acetylsalicylic acids affect the phenolic composition and antioxidant capacity of coriander, dill and parsley.
[So] Source:Food Chem;226:179-186, 2017 Jul 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of a preharvest treatment with malic (MA), oxalic (OA), or acetylsalicylic (ASA) acid at three concentrations (1, 2 and 3mM) on the bioactivity and antioxidant capacity of coriander, dill, and parsley were investigated. The antioxidant capacity of the herbs extracts was assayed by spectrophotometric methods by using three different analytical methods: ORAC, FRAP, and ABTS; the effects of treatments were very positive in coriander, produced intermediate results in dill, and no effects were found in parsley plants. Polyphenol compounds were identified by LC-MS-QTof and quantified by UPLC-PDA-FL. Thirty phenolic compounds were identified in these three herbs. The major compounds were (i) coriander: dimethoxycinnamoyl hexoside and quercetin-3-O-rutinoside, (ii) dill: neochlorogenic acid and quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucoside (apiin) and isorhamnetin-3-O-hexoside. The application of these three organic acids favored the accumulation of phenolic compounds in coriander plants, but had no significant positive effects on dill and parsley. The treatments leading to the best results in all three plants were the application of MA or OA at 1mM.
[Mh] Termos MeSH primário: Anethum graveolens/química
Aspirina/química
Coriandrum/química
Malatos/química
Ácido Oxálico/química
Petroselinum/química
[Mh] Termos MeSH secundário: Antioxidantes
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Malates); 0 (Phenols); 817L1N4CKP (malic acid); 9E7R5L6H31 (Oxalic Acid); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:27916506
[Au] Autor:Taddeo VA; Genovese S; Medina P; Palmisano R; Epifano F; Fiorito S
[Ad] Endereço:Department of Pharmacy, University "G. d'Annunzio" - Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
[Ti] Título:Quantification of biologically active O-prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica).
[So] Source:J Pharm Biomed Anal;134:319-324, 2017 Feb 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An analytical strategy based on different extraction methodologies and HPLC with spectrophotometric (UV-vis) detection has been developed to investigate the presence of and to quantitate biologically active selected unprenylated and O-prenylated phenylpropanoids, namely umbelliferone, 4'-geranyloxyferulic acid, 7-isopentenyloxycoumarin, auraptene, and umbelliprenin in dill (Anethum graveolens L.), anise (Pimpinella anisum L.), and wild celery (Angelica archangelica L.). Absolute ethanol or 7:3 water/ethanol mixtures were seen to be the most powerful extraction solvents to perform "classic" maceration or ultrasound-assisted one in terms of yields in secondary metabolites. For anethum and anise, umbelliprenine was found to be the most abundant prenyloxy secondary metabolite, while in wild celery 4'-geranyloxyferulic acid recorded the highest concentration. Our experimental approach demonstrated to be efficient for the simultaneous identification and quantitation of the above mentioned prenyloxyphenylpropanoids in the title plant species, that is reported herein for the first time in the literature.
[Mh] Termos MeSH primário: Anethum graveolens
Angelica archangelica
Compostos Fitoquímicos/análise
Pimpinella
Extratos Vegetais/análise
Prenilação
[Mh] Termos MeSH secundário: Compostos Fitoquímicos/química
Extratos Vegetais/química
Raízes de Plantas
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27392118
[Au] Autor:El-Zaeddi H; Martínez-Tomé J; Calín-Sánchez Á; Burló F; Carbonell-Barrachina ÁA
[Ad] Endereço:Research Group 'Food Quality and Safety', Department of Agro-Food Technology, Universidad Miguel Hernández de Elche, Escuela Politécnica Superior de Orihuela, Carretera Beniel, km 3.2, E-03312, Orihuela, Alicante, Spain.
[Ti] Título:Irrigation dose and plant density affect the volatile composition and sensory quality of dill (Anethum graveolens L.).
[So] Source:J Sci Food Agric;97(2):427-433, 2017 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Two independent field experiments were carried out to investigate the influence of (i) three irrigation treatments (ID0 = 1585 m ha , considered as a control; ID1 = 1015 m ha ; and ID2 = 2180 m ha ) and (ii) three plant density treatments (PD0 = 5.56 plants m , considered as a control; PD1 = 4.44 plants m ; and PD2 = 7.41 plants m ) on the production, volatile composition of essential oil, and sensory quality of dill. RESULTS: The highest plant yield was obtained with intermediate conditions of both irrigation dose (ID0) and plant density (PD0). The main compounds of the essential oil were α-phellandrene, dill ether and ß-phellandrene. The highest irrigation dose (ID2) produced the highest concentrations of most of the main compounds: α-phellandrene (49.5 mg per 100 g), ß-phellandrene (6.89 mg per 100 g) and limonene (2.49 mg per 100 g). A similar pattern was found for the highest plant density (PD2): α-phellandrene (71.0 mg per 100 g), dill ether (16.7 mg per 100 g) and ß-phellandrene (9.70 mg per 100 g). The use of descriptive sensory analysis helped in reaching a final decision, and the dill plants with the highest sensory quality were those of the ID2 and PD0 treatments. CONCLUSION: The final recommendation is to use the irrigation dose ID2 and the plant density PD2 if the objective is to produce dill samples with the highest aromatic and sensory quality; however, if the only objective is to produce high amounts of dill, the best options are ID0 and PD0. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Agricultura/métodos
Anethum graveolens/química
Odorantes
Óleos Voláteis/química
Extratos Vegetais/química
Óleos Vegetais/química
Sementes/química
[Mh] Termos MeSH secundário: Adulto
Irrigação Agrícola
Anethum graveolens/crescimento & desenvolvimento
Cicloexenos/análise
Feminino
Seres Humanos
Masculino
Meia-Idade
Monoterpenos/análise
Terpenos/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils); 0 (Terpenes); 2KK225M001 (beta-phellandrene); 49JV13XE39 (alpha phellandrene); 9MC3I34447 (limonene)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.7890


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[PMID]:27782086
[Au] Autor:Snuossi M; Trabelsi N; Ben Taleb S; Dehmeni A; Flamini G; De Feo V
[Ad] Endereço:Laboratoire de Traitement et Valorisation des Rejets Hydriques (LR 15 CERTEO5), Technopole de Borj-Cédria, BP 273, Soliman 8020, Tunisie. snmejdi@yahoo.fr.
[Ti] Título:Laurus nobilis, Zingiber officinale and Anethum graveolens Essential Oils: Composition, Antioxidant and Antibacterial Activities against Bacteria Isolated from Fish and Shellfish.
[So] Source:Molecules;21(10), 2016 Oct 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Several bacterial strains were isolated from wild and reared fish and shellfish. The identification of these strains showed the dominance of the species in all seafood samples, followed by spp., , , , and . The isolates were studied for their ability to produce exoenzymes and biofilms. The chemical composition of the essential oils from leaves, rhizomes and aerial parts was studied by GC and GC/MS. The essential oils' antioxidant and antibacterial activities against the isolated microorganisms were studied. Low concentrations of the three essential oils were needed to inhibit the growth of the selected bacteria and the lowest MBCs values were obtained for the laurel essential oil. The selected essential oils can be used as a good natural preservative in fish food due to their antioxidant and antibacterial activities.
[Mh] Termos MeSH primário: Peixes/microbiologia
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Óleos Vegetais/química
Óleos Vegetais/farmacologia
Frutos do Mar/microbiologia
[Mh] Termos MeSH secundário: Anethum graveolens/química
Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Bactérias/classificação
Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Biofilmes/efeitos dos fármacos
Gengibre/química
Laurus/química
Testes de Sensibilidade Microbiana
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE


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[PMID]:27622989
[Au] Autor:Kalangi SK; Dayakar A; Gangappa D; Sathyavathi R; Maurya RS; Narayana Rao D
[Ad] Endereço:Dept. of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India.
[Ti] Título:Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine.
[So] Source:Exp Parasitol;170:184-192, 2016 Nov.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the existence of chemotherapy, there is no effective cure for leishmaniasis. In the light of recommended therapeutic regimen is attributed for toxicity and development of clinical resistance, exploration of an efficient method of drug delivery could be one of the option in reducing the dosage and toxicity of drugs. This work is aimed in such fashion to study the enhanced antileishmanial activity of miltefosine with silver-nanoparticles (AgNPs) synthesized by using Anethum graveolens (dill) leaf extract as reducing agent. AgNPs were synthesized in a single step process and characterized by UV-visible, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR) to understand the crystal structure and functional groups on their surface. TEM analysis showed that the synthesized AgNPs are of an average size of 35 nm. By performing MTT assay, we found that, AgNPs (between 20 and 100 µM) are biocompatible in nature through pertaining >80% viability of macrophages. Furthermore, AgNPs alone (50 µM) have not shown antileishmanial effect on promastigote stage of Leishmania parasite but in combination with miltefosine (12.5 µM and 25 µM), it magnifies the leishmanicidal effect of miltefosine by ∼2-folds (i.e. AgNPs cut down the IC of miltefosine about to half). Scanning electron microscopic (SEM) observation for morphological aberration and genomic DNA fragmentation in promastigotes confirmed the enhanced effect of meltefosine in combination with AgNPs (50 µM AgNPs plus 12.5 µM miltefosine). Similarly, this combination has likely shown a slight augmentation (p = 0.057) of miltefosine (2.5 µM) leishmanicidal efficacy on amastigote stage of the parasite in infected human macrophages by reducing their intracellular growth.
[Mh] Termos MeSH primário: Anethum graveolens/química
Antiprotozoários/farmacologia
Leishmania/efeitos dos fármacos
Nanopartículas Metálicas/ultraestrutura
Fosforilcolina/análogos & derivados
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Materiais Biocompatíveis/química
Linhagem Celular Tumoral
Quebras de DNA/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Leishmania/genética
Macrófagos/parasitologia
Nanopartículas Metálicas/química
Camundongos
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Fosforilcolina/farmacologia
Folhas de Planta/química
Prata
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Biocompatible Materials); 0 (Plant Extracts); 107-73-3 (Phosphorylcholine); 3M4G523W1G (Silver); 53EY29W7EC (miltefosine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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[PMID]:27100701
[Au] Autor:Semenov VV; Tsyganov DV; Semenova MN; Chuprov-Netochin RN; Raihstat MM; Konyushkin LD; Volynchuk PB; Marusich EI; Nazarenko VV; Leonov SV; Kiselyov AS
[Ad] Endereço:N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
[Ti] Título:Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity.
[So] Source:J Nat Prod;79(5):1429-38, 2016 May 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A concise six-step protocol for the synthesis of isoflavone glaziovianin A (GVA) and its alkoxyphenyl derivatives 9 starting with readily available plant metabolites from dill and parsley seeds was developed. The reaction sequence involved an efficient conversion of the key intermediate epoxides 7 into the respective ß-ketoaldehydes 8 followed by their Cu(I)-mediated cyclization into the target series 9. The biological activity of GVA and its derivatives was evaluated using a panel of seven human cancer cell lines and an in vivo sea urchin embryo assay. Both screening platforms confirmed the antimitotic effect of the parent GVA (9cg) and its alkoxy derivatives. Structure-activity relationship studies suggested that compounds 9cd and 9cf substituted with trimethoxy- and dillapiol-derived B-rings, respectively, were less active than the parent 9cg. Of the evaluated human cancer cell lines, the A375 melanoma cell line was the most sensitive to the tested molecules. Notably, the target compounds were not cytotoxic against human peripheral blood mononuclear cells up to 10 µM concentration. Phenotypic readouts from the sea urchin assay unequivocally suggest a direct microtubule-destabilizing effect of isoflavones 9cg, 9cd, and 9cf.
[Mh] Termos MeSH primário: Anethum graveolens/química
Antimitóticos/síntese química
Antineoplásicos/síntese química
Antineoplásicos/farmacologia
Isoflavonas/síntese química
Isoflavonas/farmacologia
Petroselinum/química
[Mh] Termos MeSH secundário: Animais
Antimitóticos/química
Antimitóticos/farmacologia
Antineoplásicos/química
Proliferação Celular/efeitos dos fármacos
Técnicas de Química Combinatória
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Isoflavonas/química
Leucócitos Mononucleares/efeitos dos fármacos
Estrutura Molecular
Ouriços-do-Mar/efeitos dos fármacos
Relação Estrutura-Atividade
Moduladores de Tubulina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimitotic Agents); 0 (Antineoplastic Agents); 0 (Isoflavones); 0 (Tubulin Modulators); 0 (glaziovianin A)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00173


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[PMID]:27028988
[Au] Autor:Danesi F; Govoni M; D'Antuono LF; Bordoni A
[Ad] Endereço:Department of Agri-Food Science and Technology (DISTAL), University of Bologna, Cesena, FC, Italy.
[Ti] Título:The molecular mechanism of the cholesterol-lowering effect of dill and kale: The influence of the food matrix components.
[So] Source:Electrophoresis;37(13):1805-13, 2016 07.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Foods are complex matrices containing many different compounds, all of which contribute to the overall effect of the food itself, although they have different mechanisms of action. While evaluating the effect of bioactive compounds, it is important to consider that the use of a single compound can hide the effects of the other molecules that can act synergistically or antagonistically in the same food. The aim of the present study was to evaluate the influence of food matrix components by comparing two edible plants (dill and kale) with cholesterol-lowering potential and similar contents of their most representative bioactive, quercetin. The molecular effects of the extracts were evaluated in HepG2 cells by measuring the expression of sterol-regulatory element-binding proteins (SREBPs), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and low density lipoprotein receptor (LDLR) at the mRNA and protein level. The results reported here show that both extracts reduced the cellular cholesterol level with a similar trend and magnitude. It is conceivable that the slightly different results are due to the diverse composition of minor bioactive compounds, indicating that only by considering food as a whole is it possible to understand the complex relationship between food, nutrition, and health in a foodomics vision.
[Mh] Termos MeSH primário: Anethum graveolens
Brassica
Colesterol/metabolismo
Análise de Alimentos
[Mh] Termos MeSH secundário: Células Hep G2
Seres Humanos
Hidroximetilglutaril-CoA Redutases/metabolismo
RNA Mensageiro/genética
Receptores de LDL/genética
Receptores de LDL/metabolismo
Proteína de Ligação a Elemento Regulador de Esterol 2/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Receptors, LDL); 0 (SREBF2 protein, human); 0 (Sterol Regulatory Element Binding Protein 2); 97C5T2UQ7J (Cholesterol); EC 1.1.1.- (HMGCR protein, human); EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600033


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[PMID]:26910798
[Au] Autor:Tsyganov DV; Krayushkin MM; Konyushkin LD; Strelenko YA; Semenova MN; Semenov VV
[Ad] Endereço:N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
[Ti] Título:Facile Synthesis of Natural Alkoxynaphthalene Analogues from Plant Alkoxybenzenes.
[So] Source:J Nat Prod;79(4):923-8, 2016 Apr 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Analogues of the bioactive natural alkoxynaphthalene pycnanthulignene D were synthesized by an efficient method. The starting plant allylalkoxybenzenes (1) are easily available from the plant essential oils of sassafras, dill, and parsley. The target 1-arylalkoxynaphthalenes (5) exhibited antiproliferative activity in a phenotypic sea urchin embryo assay.
[Mh] Termos MeSH primário: Lignanas/síntese química
[Mh] Termos MeSH secundário: Anethum graveolens/química
Animais
Antineoplásicos/farmacologia
Lignanas/química
Estrutura Molecular
Óleos Voláteis
Petroselinum/química
Óleos Vegetais/química
Sassafras/química
Ouriços-do-Mar/efeitos dos fármacos
Ouriços-do-Mar/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Lignans); 0 (Oils, Volatile); 0 (Plant Oils); 0 (pycnanthulignene D)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160422
[Lr] Data última revisão:
160422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b01007


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[PMID]:26872137
[Au] Autor:El Mansouri L; Bousta D; El Youbi-El Hamsas A; Boukhira S; Akdime H
[Ad] Endereço:1LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, LAMEC, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; 2LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; and 3Faculty of Sciences and Technics, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco.
[Ti] Título:Phytochemical Screening, Antidepressant and Analgesic Effects of Aqueous Extract of Anethum graveolens L. From Southeast of Morocco.
[So] Source:Am J Ther;23(6):e1695-e1699, 2016 Nov/Dec.
[Is] ISSN:1536-3686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to investigate the antidepressant and analgesic properties of the aqueous extract of Anethum graveolens L. from South of Morocco (Rissani-Errachidia region). Extract of plant is obtained by aqueous decoction and administered to Wistar rats orally. The extract has a significant antidepressant and analgesic effects compared with the drug references (sertraline and tramadol) without any adverse effects. The dose of 250 mg/kg, body weight shows the best antidepressant and analgesic effects than 1 g/kg, body weight. Phytochemical study of the aqueous extract of the plant has to show its highlight in polyphenols, flavonoids, and tannins.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anethum graveolens
Antidepressivos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Animais
Antidepressivos/química
Relação Dose-Resposta a Droga
Flavonoides
Masculino
Marrocos
Polifenóis
Ratos
Ratos Wistar
Sertralina/farmacologia
Taninos
Tramadol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Antidepressive Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tannins); 39J1LGJ30J (Tramadol); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE


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[PMID]:26680443
[Au] Autor:Melnikova DN; Mineev KS; Finkina EI; Arseniev AS; Ovchinnikova TV
[Ad] Endereço:Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str., 16/10, 117997, Moscow, Russia.
[Ti] Título:A novel lipid transfer protein from the dill Anethum graveolens L.: isolation, structure, heterologous expression, and functional characteristics.
[So] Source:J Pept Sci;22(1):59-66, 2016 Jan.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel lipid transfer protein, designated as Ag-LTP, was isolated from aerial parts of the dill Anethum graveolens L. Structural, antimicrobial, and lipid binding properties of the protein were studied. Complete amino acid sequence of Ag-LTP was determined. The protein has molecular mass of 9524.4 Da, consists of 93 amino acid residues including eight cysteines forming four disulfide bonds. The recombinant Ag-LTP was overexpressed in Escherichia coli and purified. NMR investigation shows that the Ag-LTP spatial structure contains four α-helices, forming the internal hydrophobic cavity, and a long C-terminal tail. The measured volume of the Ag-LTP hydrophobic cavity is equal to ~800 A(3), which is much larger than those of other plant LTP1s. Ag-LTP has weak antifungal activity and unpronounced lipid binding specificity but effectively binds plant hormone jasmonic acid. Our results afford further molecular insight into biological functions of LTP in plants.
[Mh] Termos MeSH primário: Anethum graveolens/química
Proteínas de Transporte/química
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Anethum graveolens/metabolismo
Proteínas de Transporte/genética
Proteínas de Transporte/metabolismo
Clonagem Molecular
Ciclopentanos/química
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Interações Hidrofóbicas e Hidrofílicas
Modelos Moleculares
Dados de Sequência Molecular
Peso Molecular
Oxilipinas/química
Componentes Aéreos da Planta/química
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Ligação Proteica
Estrutura Secundária de Proteína
Estrutura Terciária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Cyclopentanes); 0 (Oxylipins); 0 (Plant Proteins); 0 (Recombinant Proteins); 0 (lipid transfer protein); 6RI5N05OWW (jasmonic acid)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151219
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2840



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