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Pesquisa : B01.650.940.800.575.912.250.075.199 [Categoria DeCS]
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[PMID]:28513464
[Au] Autor:Jarzab A; Grabarska A; Skalicka-Wozniak K; Stepulak A
[Ad] Endereço:Katedra i Zaklad Biochemii i Biologii Molekularnej Uniwersytetu Medycznego w Lublinie.
[Ti] Título:Pharmacological features of osthole.
[So] Source:Postepy Hig Med Dosw (Online);71(0):411-421, 2017 May 15.
[Is] ISSN:1732-2693
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osthole with other anti-tumor substances has been also reported. Modification of its chemical structure led to the synthesis of many derivatives with significant anticancer effects. To sum up, osthole is an interesting therapeutic option, due to both its direct effect on tumor cells, as well as its neuroprotective or anti-inflammatory properties. Thus, there is a chance to use osthole or its synthetic derivatives in the treatment of cancer.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antineoplásicos/farmacologia
Cumarínicos/farmacologia
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/uso terapêutico
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Cnidium/química
Cumarínicos/uso terapêutico
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents); 0 (Coumarins); 0 (Neuroprotective Agents); 0 (Plant Extracts); XH1TI1759C (osthol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


  2 / 125 MEDLINE  
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[PMID]:27671368
[Au] Autor:Malla B; Chang BY; Kim SB; Park H; Lee MK; Kim SY
[Ad] Endereço:Department of Pharmacology, Dandaki Medical College, Pokhara, Nepal.
[Ti] Título:Potential of the Cnidium monnieri fruits as an immune enhancer in Escherichia coli infection model.
[So] Source:J Pharm Pharmacol;68(11):1430-1439, 2016 Nov.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The Cnidium monnieri fruits (CMF) were studied how they act on immune system as a novel immunostimulator against the infectious disease. METHODS: Macrophages were treated with CMF, and nitric oxide (NO) and tumour necrosis factor-α (TNF-α) were measured, and phagocytosis of macrophages was detected using FITC-labelled Escherichia coli. The protective effect of CMF against E. coli infection in mice was examined. The survival rate was monitored daily for up to 5 days. And then the viable bacteria count of serum and the immunological mediator (NO, TNF-α, interleukin (IL)-12 and IL-6) of serum, splenocyte and peritoneal macrophages were analysed. KEY FINDINGS: The CMF significantly enhanced the concentrations of NO and TNF-α and the phagocytosis activity in macrophages. The oral administration of CMF for five consecutive days before infection prolonged the survival rate. Treatment with CMF significantly stimulated the phagocytosis of peritoneal macrophages and induced the immunological mediator of serum, splenocyte and peritoneal macrophages against the E. coli infection. CONCLUSIONS: The host-protective effects of CMF might be archived by improving immune response, and CMF could act to prevent pathogenic microbial infections with immunomodulation.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Cnidium/química
Infecções por Escherichia coli/tratamento farmacológico
Escherichia coli/patogenicidade
Frutas/química
Macrófagos/efeitos dos fármacos
Fagocitose/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/isolamento & purificação
Animais
Proliferação Celular/efeitos dos fármacos
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Escherichia coli/imunologia
Infecções por Escherichia coli/sangue
Infecções por Escherichia coli/imunologia
Infecções por Escherichia coli/microbiologia
Interações Hospedeiro-Patógeno
Interleucina-12/sangue
Interleucina-6/sangue
Macrófagos/imunologia
Macrófagos/metabolismo
Macrófagos/microbiologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Óxido Nítrico/sangue
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Células RAW 264.7
Baço/efeitos dos fármacos
Baço/imunologia
Baço/metabolismo
Baço/microbiologia
Fatores de Tempo
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 187348-17-0 (Interleukin-12); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12625


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[PMID]:27591413
[Au] Autor:Lee WS; Shin JS; Jang DS; Lee KT
[Ad] Endereço:Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea; Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
[Ti] Título:Cnidilide, an alkylphthalide isolated from the roots of Cnidium officinale, suppresses LPS-induced NO, PGE , IL-1ß, IL-6 and TNF-α production by AP-1 and NF-κB inactivation in RAW 264.7 macrophages.
[So] Source:Int Immunopharmacol;40:146-155, 2016 Nov.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cnidilide, an alkyl phthalide isolated from the rhizome of Cnidium officinale, has been reported to possess antispasmodic and sedative effects. However, the anti-inflammatory capacity and molecular mechanism of cnidilide have not been studied to date. In the present study, we investigated the inhibitory effects of cnidilide on LPS-induced pro-inflammatory mediators and the underlying molecular mechanisms in RAW 264.7 macrophages. Our results indicated that cnidilide potently inhibits inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression at the protein and mRNA levels and their promoter activities, causing attendant decreases in the production of nitric oxide (NO) and prostaglandin E (PGE ). In addition, cnidilide reduced LPS-induced production and mRNA expression of interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α (TNF-α) in a dose-dependent manner. Molecular data revealed that cnidilide inhibited LPS-induced transcriptional activity of activator protein-1 (AP-1) by reducing the phosphorylation and nuclear translocation of c-Fos and c-Jun. In addition, cnidilide attenuated LPS-induced transcriptional activity of nuclear factor-κB (NF-κB), and this reduction was accompanied by parallel reduction in the phosphorylation, but not in the translocation of p65 NF-κB. In addition, cnidilide inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and mitogen- and stress-activated protein kinase 1(MSK-1), a downstream kinase. Moreover, the phosphorylation of c-Jun N-terminal kinase (JNK) was suppressed by cnidilide in a concentration-dependent manner, whereas it did not inhibit the extracellular signal-regulated kinase (ERK) phosphorylation in LPS-stimulated RAW 264.7 macrophages. Taken together, our findings suggest that cnidilide has anti-inflammatory properties by inhibiting p38 MAPK, JNK, AP-1, and the NF-κB pathway in LPS-stimulated RAW 264.7 macrophages.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzofuranos/farmacologia
Macrófagos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cnidium
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Dinoprostona/metabolismo
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Interleucina-6/genética
Interleucina-6/metabolismo
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Lipopolissacarídeos
Macrófagos/metabolismo
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Raízes de Plantas
Células RAW 264.7
Fator de Transcrição AP-1/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzofurans); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Transcription Factor AP-1); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 31C4KY9ESH (Nitric Oxide); 3674-03-1 (cnidilide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE


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[PMID]:27473958
[Au] Autor:Jia M; Li Y; Xin HL; Hou TT; Zhang ND; Xu HT; Zhang QY; Qin LP
[Ad] Endereço:Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
[Ti] Título:Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells.
[So] Source:Chin J Nat Med;14(6):413-20, 2016 Jun.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy (HRT). The present study was designed to investigate the in vitro effects of estrogen-like activities of two widespread coumarins, osthole and imperatorin, using the MCF-7 cell proliferation assay and their alkaline phosphatase (ALP) activities in osteoblasts Saos-2 cells. The two compounds were found to strongly stimulate the proliferation of MCF-7 cells. The estrogen receptor-regulated ERα, progesterone receptor (PR) and PS2 mRNA levels were increased by treatment with osthole and imperatorin. All these effects were significantly inhibited by the specific estrogen receptor antagonist ICI182, 780. Cell cycle analysis revealed that their proliferation stimulatory effect was associated with a marked increase in the number of MCF-7 cells in S phase, which was similar to that observed with estradiol. It was also observed that they significantly increased ALP activity, which was reversed by ICI182,780. These results suggested that osthole and imperatorin could stimulate osteoblastic activity by displaying estrogenic properties or through the ER pathway. In conclusion, osthole and imperatorin may represent new pharmacological tools for the treatment of osteoporosis.
[Mh] Termos MeSH primário: Cnidium/química
Cumarínicos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Furocumarinas/farmacologia
Osteoblastos/efeitos dos fármacos
Fitoestrógenos/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/genética
Fosfatase Alcalina/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Células MCF-7
Osteoblastos/citologia
Osteoblastos/enzimologia
Receptores Estrogênicos/genética
Receptores Estrogênicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Furocoumarins); 0 (Phytoestrogens); 0 (Receptors, Estrogen); EC 3.1.3.1 (Alkaline Phosphatase); K713N25C78 (imperatorin); XH1TI1759C (osthol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE


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[PMID]:27435599
[Au] Autor:Lee YM; Lee YR; Kim CS; Jo K; Sohn E; Kim JS; Kim J
[Ad] Endereço:Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Daejeon, 34054, South Korea.
[Ti] Título:Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo.
[So] Source:BMC Complement Altern Med;16:231, 2016 Jul 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retinal neovascularization, which is the pathological growth of new blood vessels, is associated with retinopathy of prematurity, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. In this study, we evaluated the effect of an extract of Cnidium officinale Makino (COE) and its bioactive compound, butylidenephthalide (BP), on the migration and tube formation of human umbilical vein endothelial cells (HUVECs), and on retinal pathogenic neovascularization in the oxygen-induced retinopathy (OIR) mouse model. METHOD: The HUVECs were incubated with COE and BP (0.1-10 µg/ml). The mice were exposed to 75 % oxygen for 5 days starting on the 7(th) postnatal day (P7-P12). Then, the mice were returned to room air and intraperitoneally injected with COE (100 mg/kg) and BP (5 mg/kg) once per day for 5 days (P12-P16). On P17, we measured retinal neovascularization and analyzed the angiogenesis-related proteins expression using protein arrays. RESULTS: COE and BP inhibit the HUVECs migration and the tube formation in a dose-dependent manner. In addition, COE significantly decreased retinal neovascularization in the OIR mice. COE reduced the expression levels of AREG, ANG, DLL4, Endostatin, IGFBP-2 and VEGF. Additionally, BP also inhibited the retinal neovascularization and down-regulated the expression of AREG, ANG, DLL4 and VEGF. CONCLUSION: These results suggest that COE and BP exerts antiangiogenic effects on retinal neovascularization by inhibiting the expression of AREG, ANG, DLL4 and VEGF, indicating that antiangiogenic activities of COE may be in part due to its bioactive compound, BP.
[Mh] Termos MeSH primário: Cnidium/química
Anidridos Ftálicos/farmacologia
Extratos Vegetais/farmacologia
Neovascularização Retiniana/metabolismo
[Mh] Termos MeSH secundário: Animais
Movimento Celular/efeitos dos fármacos
Células Cultivadas
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Camundongos
Anidridos Ftálicos/química
Extratos Vegetais/química
Ribonuclease Pancreático/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phthalic Anhydrides); 0 (Plant Extracts); 0 (Vascular Endothelial Growth Factor A); EC 3.1.27.- (angiogenin); EC 3.1.27.5 (Ribonuclease, Pancreatic); S9178G4B3F (butylidenephthalide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1216-8


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[PMID]:27143283
[Au] Autor:Beom Kim S; Kim C; Liu Q; Hee Jo Y; Joo Choi H; Hwang BY; Kyum Kim S; Kyeong Lee M
[Ad] Endereço:a College of Pharmacy, Chungbuk National University , Cheongju , Korea ;
[Ti] Título:Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits.
[So] Source:Pharm Biol;54(8):1373-9, 2016 Aug.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Coumarin derivatives have been reported to inhibit melanin biosynthesis. OBJECTIVE: The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of osthol from C. monnieri fruits were investigated. MATERIALS AND METHODS: B16F10 melanomas were treated with osthol at concentration of 1, 3, and 10 µM for 72 h. The expression of melanogenesis genes, such as tyrosinase, TRP-1, and TRP-2 was also assessed. For optimization, extraction factors such as extraction solvent, extraction time, and sample/solvent ratio were tested and optimized for maximum yield of osthol using response surface methodology with the Box-Behnken design (BBD). RESULTS: Osthol inhibits melanin content in B16F10 melanoma cells with an IC50 value of 4.9 µM. The melanogenesis inhibitory activity of osthol was achieved not by direct inhibition of tyrosinase activity but by inhibiting melanogenic enzyme expressions, such as tyrosinase, TRP-1, and TRP-2. The optimal condition was obtained as a sample/solvent ratio, 1500 mg/10 ml; an extraction time 30.3 min; and a methanol concentration of 97.7%. The osthol yield under optimal conditions was found to be 15.0 mg/g dried samples, which were well matched with the predicted value of 14.9 mg/g dried samples. CONCLUSION: These results will provide useful information about optimized extraction conditions for the development of osthol as cosmetic therapeutics to reduce skin hyperpigmentation.
[Mh] Termos MeSH primário: Cnidium/química
Cumarínicos/isolamento & purificação
Frutas/química
Extratos Vegetais/isolamento & purificação
Preparações Clareadoras de Pele/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Fracionamento Químico
Cromatografia Líquida de Alta Pressão
Cumarínicos/farmacologia
Relação Dose-Resposta a Droga
Oxirredutases Intramoleculares/metabolismo
Melaninas/biossíntese
Melanoma Experimental/enzimologia
Camundongos
Oxirredutases/metabolismo
Fitoterapia
Extratos Vegetais/farmacologia
Plantas Medicinais
Preparações Clareadoras de Pele/farmacologia
Pigmentação da Pele/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Melanins); 0 (Plant Extracts); 0 (Skin Lightening Preparations); EC 1.- (Oxidoreductases); EC 1.14.18.- (tyrosinase-related protein-1); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.3.12 (dopachrome isomerase); XH1TI1759C (osthol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160505
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1078382


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[PMID]:27082059
[Au] Autor:Lim EG; Kim GT; Lee SH; Kim SY; Kim YM
[Ad] Endereço:Department of Biological Sciences and Biotechnology, College of Life Science and Nanotechnology, Hannam University, Yuseong­gu, Daejeon 305­811, Republic of Korea.
[Ti] Título:Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells.
[So] Source:Mol Med Rep;13(6):4681-8, 2016 Jun.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Colon cancer, a common malignancy, can occur due to poor eating habits and increasing age. Consequently, careful regulation of eating habits may serve as a possible method for preventing the occurrence or progression of colon cancer. Extracts of the fruit of Cnidium monnieri (L.) Cusson are well­known as an effective herbal medicine for the treatment of pain in female genitalia and carbuncle. However, there have been no studies on the apoptotic effects of Cnidium monnieri (L.) Cusson (CME). Adenosine monophosphate­activated protein kinase (AMPK), the major regulator of energy metabolism, is activated by metabolic stress, including hypoxia and glucose deprivation. Activation of AMPK inhibits cell proliferation and induces apoptosis through the inhibition of phosphorylated (p)­Akt and control of B­cell lymphoma 2 (Bcl­2) family members. The pro­apoptotic proteins Bcl­2­associated X protein (Bax) and Bcl­2­homologous antagonist killer (Bak), are activated by their translocation to mitochondria from the cytosol. Translocation of Bax/Bak induces outer membrane permeabilization and is likely to lead to apoptosis through cytochrome C release and caspase activity. In the present study, the apoptotic effects and influence on mitochondria­mediated apoptotic proteins of CME in HCT116 cells were assessed. We hypothesized that CME may have an effect on the inhibition of p­Akt in an AMPK­independent pathway. The present study demonstrated that CME induced the release of LDH and apoptosis through its inhibition of p­Akt to control Bcl­2 and activate Bax and Bak. Co­treatment with CME and AMPK inhibitors showed that CME­induced apoptosis does not occurr through a AMPK­dependent pathway. Therefore, the present study determined, for the first time, that CME induced apoptosis as a result of causing metabolic stresses due to directly regulation of the de­phosphorylation of Akt, whereas it did not control the AMPK-dependent pathway in HCT116 colon cancer cells.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Cnidium/química
Neoplasias do Colo/tratamento farmacológico
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Colo/efeitos dos fármacos
Colo/metabolismo
Colo/patologia
Neoplasias do Colo/metabolismo
Neoplasias do Colo/patologia
Células HCT116
Seres Humanos
Fosforilação/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo
Proteína X Associada a bcl-2
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (bcl-2 Homologous Antagonist-Killer Protein); 0 (bcl-2-Associated X Protein); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5115


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[PMID]:26701790
[Au] Autor:Byun AR; Kwon S; Kim S
[Ad] Endereço:Department of Family Medicine, Ewha Womans University School of Medicine, Mokdong Hospital, Seoul, Republic of Korea.
[Ti] Título:Administration of Herbal Complexes, Dangguijakyak-san (TJ-23) and Coix Seeds, for Treating Verruca Planae: A Case Report.
[So] Source:Explore (NY);12(1):65-7, 2016 Jan-Feb.
[Is] ISSN:1878-7541
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Verruca planae (VP) are warts caused by the human papillomavirus. Many patients develop resistance to the conventional therapy for these lesions. Therefore, alternative therapies are needed. We encountered a patient with VP who showed resistance to conventional therapy and was subsequently treated with Dangguijakyak-san (TJ-23; Tsumura, Japan; and Tokishakuyakusan in Japanese) and coix seed tablets with favorable outcomes. A 29-year-old woman had typical VP on her left upper extremity for >11 years. She had been receiving conventional therapies such as immunotherapy with diphenylcyclopropenone, and tretinoin and imiquimod ointments. However, her VP symptoms persisted. Therefore, she was given herbal medication therapy consisting of Dangguijakyak-san (TJ-23) and coix seeds (500mg coix seed extract; Kracie, Japan). At the four-month follow-up, the papules were found to have disappeared. Therefore, we stopped the TJ-23 + coix seed therapy. Until September 2014, the patient has had no recurrence. We believe that Dangguijakyak-san with coix seeds remedy can have an effect on the immune system and consequently treat VP.
[Mh] Termos MeSH primário: Coix
Medicamentos de Ervas Chinesas/uso terapêutico
Fitoterapia
Pele/efeitos dos fármacos
Verrugas/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Alisma
Atractylodes
Cnidium
Medicamentos de Ervas Chinesas/farmacologia
Feminino
Seres Humanos
Magnoliopsida
Paeonia
Poria
Sementes
Pele/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (kang-lai-te); 0 (toki-shakuyaku-san)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151225
[St] Status:MEDLINE


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[PMID]:26549213
[Au] Autor:Duan J; Yang Y; Liu H; Dou PC; Tan SY
[Ad] Endereço:Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
[Ti] Título:Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK.
[So] Source:Int J Mol Med;37(1):207-16, 2016 Jan.
[Is] ISSN:1791-244X
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Osthole, the active constituent of Cnidium monnieri extracts, has been shown to have a diverse range of pharmacological properties. In the present study, we aimed to evaluate the cardioprotective effects of osthole in a rat model of acute myocardial infarction (AMI). The rats with AMI were treated with 1, 3 and 10 mg/kg of osthole or the vehicle for 4 weeks. The infarct size of the rats with AMI was measured, and casein kinase (CK), the MB isoenzyme of creatine kinase (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in the rats with AMI were analyzed using commercially available kits. The nuclear factor-κB (NF-κB), tumor necrosis factor­α (TNF-α), interleukin (IL)-1ß and IL-6 levels in whole blood from rats with AMI were also detected using commercially available kits. The levels of Toll-like receptors 2/4 (TLR2/4) and nucleotide-binding oligomerization domain-containing protein 1/2 (NOD1/2) were also detected by RT-qPCR. Moreover, the protein expression levels of endothelial nitric oxide synthase (eNOS) and mitogen-activated protein kinase (MAPK) cascades, including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38, cyclooxygenase-2 (COX-2), as well as matrix metalloproteinase-2 (MMP-2) were all assayed by western blot analysis. Our results revealed that osthole markedly reduced the infarct size, and the levels of CK, CK-MB, LDH and cTnT in the rats with AMI, and that these cardioprotective effects may be associated with the inhibition of inflammatory reactions, the reduction in MMP-2 activity and the activation of MAPK cascades.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/uso terapêutico
Cumarínicos/uso terapêutico
Regulação da Expressão Gênica/efeitos dos fármacos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Metaloproteinase 2 da Matriz/genética
Infarto do Miocárdio/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Adjuvantes Imunológicos/química
Adjuvantes Imunológicos/farmacologia
Animais
Cnidium/química
Cumarínicos/química
Cumarínicos/farmacologia
Ciclo-Oxigenase 2/genética
Coração/efeitos dos fármacos
Interleucina-1beta/sangue
Interleucina-1beta/imunologia
Interleucina-6/sangue
Interleucina-6/imunologia
Masculino
Infarto do Miocárdio/sangue
Infarto do Miocárdio/genética
Infarto do Miocárdio/imunologia
Miocárdio/imunologia
Miocárdio/metabolismo
Miocárdio/patologia
NF-kappa B/sangue
NF-kappa B/imunologia
Proteína Adaptadora de Sinalização NOD1/genética
Proteína Adaptadora de Sinalização NOD2/genética
Ratos
Ratos Wistar
Receptor 2 Toll-Like/genética
Receptor 4 Toll-Like/genética
Fator de Necrose Tumoral alfa/sangue
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Coumarins); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (NF-kappa B); 0 (NOD2 protein, rat); 0 (Nod1 Signaling Adaptor Protein); 0 (Nod2 Signaling Adaptor Protein); 0 (Toll-Like Receptor 2); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); EC 1.14.99.1 (Cyclooxygenase 2); EC 3.4.24.24 (Matrix Metalloproteinase 2); XH1TI1759C (osthol)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151110
[St] Status:MEDLINE
[do] DOI:10.3892/ijmm.2015.2402


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[PMID]:26983206
[Au] Autor:Duan XH; Zhang YZ; He P; Ma ZM; Pei L
[Ti] Título:[Studies on coumarins from fruit of Cnidium monnieri and their cytotoxic activities].
[So] Source:Zhongguo Zhong Yao Za Zhi;40(18):3594-7, 2015 Sep.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:This study is to study is to investigate the coumarins from Fruit of Cnidium monnieri and their cytotoxic activities. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time. Compounds 1,5,10 and 11 showed significant cytotoxic activities against L1210 cell lines at a concentration of 1 x 10(-5) mol x L(-1) with inhibitory rates of were 70.13, 63.10, 55.77, and 75.08% respectively.
[Mh] Termos MeSH primário: Cnidium/química
Cumarínicos/toxicidade
Medicamentos de Ervas Chinesas/toxicidade
Frutas/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Cnidium/toxicidade
Cumarínicos/química
Cumarínicos/isolamento & purificação
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Frutas/toxicidade
Camundongos
Estrutura Molecular
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coumarins); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160317
[Lr] Data última revisão:
160317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE



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