Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.211 [Categoria DeCS]
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[PMID]:28468251
[Au] Autor:Han X; Xue X; Zhao Y; Li Y; Liu W; Zhang J; Fan S
[Ad] Endereço:Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College and Chinese Academy of Medical Science, Tianjin 300192, China. hanxiaodan1202@gmail.com.
[Ti] Título:Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.
[So] Source:Int J Mol Sci;18(5), 2017 Apr 29.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Hematopoietic injury is a major cause of mortality in radiation accidents and a primary side effect in patients undergoing radiotherapy. Ionizing radiation (IR)-induced myelosuppression is largely attributed to the injury of hematopoietic stem and progenitor cells (HSPCs). Coriander is a culinary herb with multiple pharmacological effects and has been widely used in traditional medicine. In this study, flavonoids were identified as the main component of coriander extract with rutin being the leading compound (rutin-enriched coriander extract; RE-CE). We evaluated the radioprotective effect of RE-CE against IR-induced HSPCs injury. Results showed that RE-CE treatment markedly improved survival, ameliorated organ injuries and myelosuppression, elevated HSPCs frequency, and promoted differentiation and proliferation of HSPCs in irradiated mice. The protective role of RE-CE in hematopoietic injury is probably attributed to its anti-apoptotic and anti-DNA damage effect in irradiated HSPCs. Moreover, these changes were associated with reduced reactive oxygen species (ROS) and enhanced antioxidant enzymatic activities in irradiated HSPCs. Collectively, these findings demonstrate that RE-CE is able to ameliorate IR-induced hematopoietic injury partly by reducing IR-induced oxidative stress.
[Mh] Termos MeSH primário: Coriandrum/química
Células-Tronco Hematopoéticas/efeitos dos fármacos
Células-Tronco Hematopoéticas/efeitos da radiação
Lesões por Radiação/tratamento farmacológico
Protetores contra Radiação/uso terapêutico
Rutina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Células Cultivadas
Dano ao DNA/efeitos dos fármacos
Células-Tronco Hematopoéticas/metabolismo
Células-Tronco Hematopoéticas/patologia
Masculino
Camundongos Endogâmicos C57BL
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/efeitos da radiação
Lesões por Radiação/genética
Lesões por Radiação/metabolismo
Lesões por Radiação/patologia
Radiação Ionizante
Protetores contra Radiação/química
Espécies Reativas de Oxigênio/metabolismo
Rutina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiation-Protective Agents); 0 (Reactive Oxygen Species); 5G06TVY3R7 (Rutin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:28573226
[Au] Autor:Téllez-López MÁ; Mora-Tovar G; Ceniceros-Méndez IM; García-Lujan C; Puente-Valenzuela CO; Vega-Menchaca MDC; Serrano-Gallardo LB; Garza RG; Morán-Martínez J
[Ad] Endereço:Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango. Articulo 123 S/N Fraccionamiento Filadelfia. Gómez Palacio Durango, C.P. 35010, México.
[Ti] Título:EVALUATION OF THE CHELATING EFFECT OF METHANOLIC EXTRACT OF AND ITS FRACTIONS ON WISTAR RATS POISONED WITH LEAD ACETATE.
[So] Source:Afr J Tradit Complement Altern Med;14(2):92-102, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead. MATERIALS AND METHODS: In this research, male Wistar rats were poisoned with 50 mg/kg of lead acetate and treated with 50 mg/kg of methanol extract and its fractions. The extract and its fractions were administered to four treatment groups. Positive and negative controls were established. Hemoglobin, hematocrit and lead concentrations were analyzed; liver was evaluated histologically in control and treatment groups. RESULTS: The methanol extract of coriander presented a LD >1000 mg/dL. The group administered with the methanol extract showed significant difference in the levels of hemoglobin and hematocrit compared to the negative control group. Lead concentration in treatment groups showed a decrease compared to the positive control. Histological evaluation of tissue showed less damage in groups administered with methanolic extract and its fractions compared to the positive control which presented structural alterations. CONCLUSION: Coriander extracts protect liver and lower lead concentration in rats intoxicated with lead in contrast to the positive control group.
[Mh] Termos MeSH primário: Quelantes/uso terapêutico
Coriandrum
Intoxicação por Chumbo/tratamento farmacológico
Chumbo/sangue
Fígado/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Quelantes/farmacologia
Hematócrito
Hemoglobinas/metabolismo
Intoxicação por Chumbo/sangue
Intoxicação por Chumbo/patologia
Fígado/patologia
Masculino
Compostos Organometálicos
Extratos Vegetais/farmacologia
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Hemoglobins); 0 (Organometallic Compounds); 0 (Plant Extracts); 2P299V784P (Lead); RX077P88RY (lead acetate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.11


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[PMID]:28254010
[Au] Autor:El-Zaeddi H; Calín-Sánchez Á; Nowicka P; Martínez-Tomé J; Noguera-Artiaga L; Burló F; Wojdylo A; Carbonell-Barrachina ÁA
[Ad] Endereço:Universidad Miguel Hernández de Elche (UMH), Escuela Politécnica Superior de Orihuela (EPSO), Department of Agro-Food Technology, Research Group "Food Quality and Safety", Carretera Beniel, km 3.2, 03312-Orihuela, Alicante, Spain.
[Ti] Título:Preharvest treatments with malic, oxalic, and acetylsalicylic acids affect the phenolic composition and antioxidant capacity of coriander, dill and parsley.
[So] Source:Food Chem;226:179-186, 2017 Jul 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of a preharvest treatment with malic (MA), oxalic (OA), or acetylsalicylic (ASA) acid at three concentrations (1, 2 and 3mM) on the bioactivity and antioxidant capacity of coriander, dill, and parsley were investigated. The antioxidant capacity of the herbs extracts was assayed by spectrophotometric methods by using three different analytical methods: ORAC, FRAP, and ABTS; the effects of treatments were very positive in coriander, produced intermediate results in dill, and no effects were found in parsley plants. Polyphenol compounds were identified by LC-MS-QTof and quantified by UPLC-PDA-FL. Thirty phenolic compounds were identified in these three herbs. The major compounds were (i) coriander: dimethoxycinnamoyl hexoside and quercetin-3-O-rutinoside, (ii) dill: neochlorogenic acid and quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucoside (apiin) and isorhamnetin-3-O-hexoside. The application of these three organic acids favored the accumulation of phenolic compounds in coriander plants, but had no significant positive effects on dill and parsley. The treatments leading to the best results in all three plants were the application of MA or OA at 1mM.
[Mh] Termos MeSH primário: Anethum graveolens/química
Aspirina/química
Coriandrum/química
Malatos/química
Ácido Oxálico/química
Petroselinum/química
[Mh] Termos MeSH secundário: Antioxidantes
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Malates); 0 (Phenols); 817L1N4CKP (malic acid); 9E7R5L6H31 (Oxalic Acid); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28056572
[Au] Autor:Ibrahim FM; Attia HN; Maklad YA; Ahmed KA; Ramadan MF
[Ad] Endereço:a Department of Medicinal and Aromatic Plants Research, Pharmaceutical and Drug Industries Division , National Research Centre , Dokki , Giza , Egypt.
[Ti] Título:Biochemical characterization, anti-inflammatory properties and ulcerogenic traits of some cold-pressed oils in experimental animals.
[So] Source:Pharm Biol;55(1):740-748, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cold-pressed oils (CPO) are commercially available in the market and characterized by their health-promoting properties. OBJECTIVE: Clove oil (CLO), coriander seed oil (COO) and black cumin oil (BCO) were evaluated for their bioactive lipids. Pharmacological screening was performed to evaluate acute toxicity, anti-inflammatory and ulcerogenic effects as well as histopathological changes in tissues of albino rats fed with CPO. MATERIALS AND METHODS: Fatty acids, tocols and total phenolics were analyzed. The acute toxicity test for each CPO was estimated during 14 d. Carrageenan-induced rat paw oedema was used for assessment of anti-inflammatory activity of CPO. Animals were fasted overnight, and via oral gavage given indomethacin (10 mg/kg) or CPO (400 mg/kg) to investigate ulcerogenecity. Histopathological changes in liver, kidney, heart, spleen and stomach were screened. RESULTS: Amounts of α-, ß-, γ- and δ-tocopherols in CLO were 1495, 58, 4177 and 177 mg/kg oil, respectively. In COO, α, ß, γ and δ-tocopherols were 10.0, 18.2, 5.1 and 34.8%, respectively. In BCO, ß-tocotrienol was the main constituent. CLO, COO and BCO contained 4.6, 4.2 and 3.6 mg GAE/g, respectively. Acute toxicity test determined that 400 mg/kg of CPO to be used. In the carrageenan model of inflammation, pretreatment of rats with indomethacin (10 mg/kg) or CLO (400 mg/kg) induced a significant (p < 0.05) reduction by 31.3 and 27.4%, respectively, in rat paw oedema as compared with the carrageenan-treated group. Indomethacin induced a significant ulcerogenic effect with an ulcer index of 19. Oral treatment of CPO showed no ulcerogenic effect, wherein no histopathological changes were observed. CONCLUSIONS: CPO, particularly CLO, could minimize acute inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Óleos Vegetais/farmacologia
Úlcera Gástrica/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Óleo de Cravo/análise
Óleo de Cravo/farmacologia
Temperatura Baixa
Coriandrum/química
Feminino
Nigella sativa/química
Óleos Vegetais/toxicidade
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Clove Oil); 0 (Plant Oils)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2016.1275705


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[PMID]:27979283
[Au] Autor:Ranjitha K; Shivashankara KS; Sudhakar Rao DV; Oberoi HS; Roy TK; Bharathamma H
[Ad] Endereço:Division of Post Harvest Technology and Agricultural Engineering, ICAR-Indian Institute of Horticultural Research, Hessaraghatta, Bengaluru 560089, India. Electronic address: ranjiha@iihr.res.in.
[Ti] Título:Improvement in shelf life of minimally processed cilantro leaves through integration of kinetin pretreatment and packaging interventions: Studies on microbial population dynamics, biochemical characteristics and flavour retention.
[So] Source:Food Chem;221:844-854, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Effect of integrating optimized combination of pretreatment with packaging on shelf life of minimally processed cilantro leaves (MPCL) was appraised through analysis of their sensory attributes, biochemical characteristics, microbial population and flavour profile during storage. Minimally pretreated cilantro leaves pretreated with 50ppm kinetin and packed in 25µ polypropylene bags showed a shelf life of 21days. Optimized combination helped in efficiently maintaining sensory parameters, flavour profile, and retention of antioxidants in MPCL until 21days. Studies conducted on the effect of optimized combination on microbial population and flavour profile revealed that among different microorganisms, pectinolysers had a significant effect on spoilage of MPCL and their population of ⩽3.59logcfu/g was found to be acceptable. Principal component analysis of headspace volatiles revealed that (E)-2-undecenal, (E)-2-hexadecenal, (E)-2-tetradecenal & (E)-2-tetradecen-1-ol in stored samples clustered with fresh samples and therefore, could be considered as freshness indicators for MPCL.
[Mh] Termos MeSH primário: Coriandrum/microbiologia
Embalagem de Alimentos
Conservação de Alimentos
Cinetina/química
Folhas de Planta/microbiologia
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Comportamento do Consumidor
Relação Dose-Resposta a Droga
Contaminação de Alimentos/prevenção & controle
Microbiologia de Alimentos
Qualidade dos Alimentos
Seres Humanos
Paladar
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Volatile Organic Compounds); P39Y9652YJ (Kinetin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27807783
[Au] Autor:Pereira AL; Azevedo J; Vasconcelos V
[Ad] Endereço:Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), BBE (Blue Biotechnology and Ecotoxicology), University of Porto, Rua dos Bragas 289, 4050-123, Porto, Portugal. anapereira271268@yahoo.com.
[Ti] Título:Assessment of uptake and phytotoxicity of cyanobacterial extracts containing microcystins or cylindrospermopsin on parsley (Petroselinum crispum L.) and coriander (Coriandrum sativum L).
[So] Source:Environ Sci Pollut Res Int;24(2):1999-2009, 2017 Jan.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Blooms of harmful cyanobacteria that synthesize cyanotoxins are increasing worldwide. Agronomic plants can uptake these cyanotoxins and given that plants are ultimately ingested by humans, this represents a public health problem. In this research, parsley and coriander grown in soil and watered through 7 days with crude extracts containing microcystins (MCs) or cylindrospermopsin (CYN) in 0.1-1 µg mL concentration range were evaluated concerning their biomass, biochemical parameters and uptake of cyanotoxins. Although biomass, chlorophylls (a and b), carotenoids and glutathione-S-transferase of parsley and coriander exposed to the crude extracts containing MC or CYN had shown variations, these values were not statistically significantly different. Protein synthesis is not inhibited in coriander exposed to MC or CYN and in parsley exposed to MC. Also, glutathione reductase (GR) and glutathione peroxidase (GPx) in parsley and coriander was not affected by exposure to MC, and in coriander, the CYN did not induce statistically significant differences in these two antioxidative enzymes. Only parsley showed statistically significant increase in protein content exposed to 0.5 µg CYN mL (3.981 ± 0.099 mg g FW) compared to control (2.484 ± 0.145 mg g FW), statistically significant decrease in GR exposed to 0.1 µg CYN mL (0.684 ± 0.117 nmol min mg protein) compared to control (1.30 ± 0.06 nmol min mg protein) and statistically significant increase in GPx exposed to 1 µg CYN mL (0.054 ± 0.026 nmol min mg protein) compared to 0.5 µg CYN mL (0.003 ± 0.001 nmol min mg protein). These changes may be due to the induction of defensive mechanisms by plants by the presence of toxic compounds in the soil or probably to a low generation of reactive oxygen species. Furthermore, the parsley and coriander leaves and stems after 10 days of exposure did not accumulate microcystins or cylindrospermopsin.
[Mh] Termos MeSH primário: Toxinas Bacterianas/metabolismo
Coriandrum/efeitos dos fármacos
Cianobactérias/química
Microcistinas/metabolismo
Petroselinum/efeitos dos fármacos
Uracila/análogos & derivados
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Toxinas Bacterianas/toxicidade
Clorofila/metabolismo
Glutationa Peroxidase/metabolismo
Glutationa Redutase/metabolismo
Glutationa Transferase/metabolismo
Microcistinas/toxicidade
Uracila/metabolismo
Uracila/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Bacterial Toxins); 0 (Microcystins); 1406-65-1 (Chlorophyll); 2JIZ556BA3 (cylindrospermopsin); 56HH86ZVCT (Uracil); 77238-39-2 (microcystin); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.8.1.7 (Glutathione Reductase); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7910-8


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[PMID]:26910351
[Au] Autor:Ali M; Mujib A; Tonk D; Zafar N
[Ad] Endereço:Cellular Differentiation and Molecular Genetics Section, Department of Botany, Hamdard University, New Delhi, 110062, India.
[Ti] Título:Plant regeneration through somatic embryogenesis and genome size analysis of Coriandrum sativum L.
[So] Source:Protoplasma;254(1):343-352, 2017 Jan.
[Is] ISSN:1615-6102
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:In the present study, an improved plant regeneration protocol via primary and secondary somatic embryogenesis was established in two Co-1 and Rajendra Swathi (RS) varieties of Coriandrum sativum L. Callus was induced from root explants on 2, 4-D (0.5-2.0 mg/l) supplemented MS. The addition of BA (0.2 mg/l) improved callus induction and proliferation response significantly. The maximum callus induction frequency was on 1.0 mg/l 2, 4-D and 0.2 mg/l BA added MS medium (77.5 % in Co-1 and 72.3 % in RS). The callus transformed into embryogenic callus on 2, 4-D added MS with maximum embryogenic frequency was on 1.0 mg/l. The granular embryogenic callus differentiated into globular embryos on induction medium, which later progressed to heart-, torpedo- and cotyledonary embryos on medium amended with 0.5 mg/l NAA and 0.2 mg/l BA. On an average, 2-3 secondary somatic embryos (SEs) were developed on mature primary SEs, which increased the total embryo numbers in culture. Histology and scanning electron microscopy (SEM) studies are presented for the origin, development of primary and secondary embryos in coriander. Later, these induced embryos converted into plantlets on 1.0 mg/l BA and 0.2 mg/l NAA-amended medium. The regenerated plantlets were cultured on 0.5 mg/l IBA added ½ MS for promotion of roots. The well-rooted plantlets were acclimatized and transferred to soil. The genetic stability of embryo-regenerated plant was analyzed by flow cytometry with optimized Pongamia pinnata as standard. The 2C DNA content of RS coriander variety was estimated to 5.1 pg; the primary and secondary somatic embryo-derived plants had 5.26 and 5.44 pg 2C DNA content, respectively. The regenerated plants were genetically stable, genome size similar to seed-germinated coriander plants.
[Mh] Termos MeSH primário: Coriandrum/embriologia
Coriandrum/genética
Tamanho do Genoma
Técnicas de Embriogênese Somática de Plantas/métodos
Regeneração
[Mh] Termos MeSH secundário: Ácido 2,4-Diclorofenoxiacético/farmacologia
Aclimatação/efeitos dos fármacos
Biomassa
Proliferação Celular/efeitos dos fármacos
Coriandrum/citologia
Coriandrum/efeitos dos fármacos
DNA de Plantas/metabolismo
Instabilidade Genômica/efeitos dos fármacos
Reguladores de Crescimento de Planta/farmacologia
Regeneração/efeitos dos fármacos
Regeneração/genética
Sementes/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Plant Growth Regulators); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.1007/s00709-016-0954-2


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[PMID]:25831119
[Au] Autor:Silva F; Domingues FC
[Ad] Endereço:a CICS-UBI-Health Sciences Research Centre, University of Beira Interior , Avenida Infante D. Henrique, Covilhã , Portugal.
[Ti] Título:Antimicrobial activity of coriander oil and its effectiveness as food preservative.
[So] Source:Crit Rev Food Sci Nutr;57(1):35-47, 2017 Jan 02.
[Is] ISSN:1549-7852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:ABTRACT Foodborne illness represents a major economic burden worldwide and a serious public health threat, with around 48 million people affected and 3,000 death each year only in the USA. One of the possible strategies to reduce foodborne infections is the development of effective preservation strategies capable of eradicating microbial contamination of foods. Over the last years, new challenges for the food industry have arisen such as the increase of antimicrobial resistance of foodborne pathogens to common preservatives and consumers demand for naturally based products. In order to overcome this, new approaches using natural or bio-based products as food preservatives need to be investigated. Coriander (Coriandrum sativum L.) is a well-known herb widely used as spice, or in folk medicine, and in the pharmacy and food industries. Coriander seed oil is the world's second most relevant essential oil, exhibiting antimicrobial activity against Gram-positive and Gram-negative bacteria, some yeasts, dermatophytes and filamentous fungi. This review highlights coriander oil antimicrobial activity and possible mechanisms of action in microbial cells and discusses the ability of coriander oil usage as a food preservative, pointing out possible paths for the successful evolution for these strategies towards a successful development of a food preservation strategy using coriander oil.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Coriandrum/química
Conservantes de Alimentos/química
Modelos Biológicos
Óleos Voláteis/química
Óleos Vegetais/química
Sementes/química
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/efeitos adversos
Anti-Infecciosos/metabolismo
Comportamento do Consumidor
Coriandrum/crescimento & desenvolvimento
Coriandrum/metabolismo
Contaminação de Alimentos/prevenção & controle
Conservação de Alimentos
Conservantes de Alimentos/efeitos adversos
Conservantes de Alimentos/metabolismo
Tecnologia de Alimentos/tendências
Doenças Transmitidas por Alimentos/prevenção & controle
Fungos/crescimento & desenvolvimento
Fungos/metabolismo
Bactérias Gram-Negativas/crescimento & desenvolvimento
Bactérias Gram-Negativas/metabolismo
Bactérias Gram-Positivas/crescimento & desenvolvimento
Bactérias Gram-Positivas/metabolismo
Seres Humanos
Monoterpenos/efeitos adversos
Monoterpenos/química
Monoterpenos/metabolismo
Óleos Voláteis/efeitos adversos
Óleos Voláteis/metabolismo
Óleos Vegetais/efeitos adversos
Óleos Vegetais/metabolismo
Sementes/crescimento & desenvolvimento
Sementes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Food Preservatives); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Oils); 0 (coriander oil); D81QY6I88E (linalool)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170222
[Lr] Data última revisão:
170222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150402
[St] Status:MEDLINE


  9 / 216 MEDLINE  
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[PMID]:28487896
[Au] Autor:Al-Haidari RA; Shaaban MI; Ibrahim SRM; Mohamed GA
[Ad] Endereço:Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia.
[Ti] Título:ANTI-QUORUM SENSING ACTIVITY OF SOME MEDICINAL PLANTS.
[So] Source:Afr J Tradit Complement Altern Med;13(5):67-71, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Quorum sensing is the key regulator of virulence factors of such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of . MATERIAL AND METHODS: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from PA14. RESULTS: The extracts of , and exhibited potent quorum quenching effect. On the other hand, and extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of PA14. In addition, they significantly inhibited twitching and swimming motilities of PA14. CONCLUSION: This study illustrated, for the first time, the importance of , and as quorum sensing inhibitors and virulence suppressors of . Thus, these plants could provide a natural source for the elimination of pathogenesis.
[Mh] Termos MeSH primário: Magnoliopsida/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Pseudomonas aeruginosa/efeitos dos fármacos
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Camellia sinensis/química
Chromobacterium/patogenicidade
Coriandrum/química
Elettaria/química
Laurus/química
Cebolas/química
Pseudomonas aeruginosa/patogenicidade
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Virulence Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i5.10


  10 / 216 MEDLINE  
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[PMID]:27916876
[Au] Autor:Caputo L; Souza LF; Alloisio S; Cornara L; De Feo V
[Ad] Endereço:Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. lcaputo@unisa.it.
[Ti] Título:Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System.
[So] Source:Int J Mol Sci;17(12), 2016 Nov 30.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aims of this study are to determine the chemical composition of Mill. and L. essential oils, to evaluate their cytotoxic effects in SH-SY5Y human neuroblastoma cells, to investigate whether an alteration of adenylate cyclase 1 (ADCY1) and of extracellular signal-regulated kinase (ERK) expression can take part in the molecular mechanisms of the essential oils, and to study their possible neuronal electrophysiological effects. The essential oils were obtained by hydrodistillation, and studied by GC and GC-MS. In the oils from and , linalool was the main component (33.1% and 67.8%, respectively). SH-SY5Y cells were incubated with different concentrations of essential oils and of linalool. Cell viability and effects on ADCY1 and ERK expression were analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT and Western blotting, respectively. Variation in cellular electrophysiology was studied in primary cultures of rat cortical neurons with a multi-electrode array (MEA)-based approach. The essential oils and linalool revealed different cytotoxic activities. Linalool inhibited ADCY1 and ERK expression. Neuronal networks subjected to and essential oils showed a concentration-dependent inhibition of spontaneous electrical activity.
[Mh] Termos MeSH primário: Coriandrum/química
Lavandula/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Adenilil Ciclases/genética
Adenilil Ciclases/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sistema Nervoso Central/efeitos dos fármacos
Sistema Nervoso Central/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/genética
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 4.6.1.1 (Adenylyl Cyclases); EC 4.6.1.1 (adenylyl cyclase 1)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE



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