Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.294 [Categoria DeCS]
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[PMID]:28332760
[Au] Autor:Cianfaglione K; Blomme EE; Quassinti L; Bramucci M; Lupidi G; Dall'Acqua S; Maggi F
[Ad] Endereço:Plant Diversity and Ecosystems Management Unit, School of Biosciences and Veterinary Medicine, University of Camerino, Via Pontoni 5, IT-62032, Camerino.
[Ti] Título:Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy.
[So] Source:Chem Biodivers;14(7), 2017 Jul.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analyzed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC/MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma), and HCT116 cells (human colon carcinoma), by the MTT assay. Furthermore, the Eryngium essential oils were evaluated for antioxidant and acetylcholinesterase (AChE) activities. The two essential oils were rich in sesquiterpene hydrocarbons, with germacrene D as the major compound, accompanied by allo-aromadendrene, ß-elemene, spathulenol, and ledol. They turned out to be highly cytotoxic on the tumor cells, with IC values (1.65 - 5.32 and 1.57 - 2.99 µg/ml for E. amethystinum and E. campestre, respectively) comparable or close to those of the anticancer drug cisplatin. The E. amethystinum essential oil exhibited a moderate antioxidant activity, whereas that of E. campestre a weak AChE inhibition.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Eryngium/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Linhagem Celular Tumoral
Inibidores da Colinesterase/isolamento & purificação
Inibidores da Colinesterase/farmacologia
Citotoxinas/isolamento & purificação
Seres Humanos
Itália
Componentes Aéreos da Planta/química
Sesquiterpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Cholinesterase Inhibitors); 0 (Cytotoxins); 0 (Oils, Volatile); 0 (Sesquiterpenes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700096


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[PMID]:27881119
[Au] Autor:Sadiq A; Ahmad S; Ali R; Ahmad F; Ahmad S; Zeb A; Ayaz M; Ullah F; Siddique AN
[Ad] Endereço:Department of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan. sadiquom@yahoo.com.
[Ti] Título:Antibacterial and antifungal potentials of the solvents extracts from Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum.
[So] Source:BMC Complement Altern Med;16(1):478, 2016 Nov 24.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of their purported traditional uses against various infectious diseases. METHODS: In this study, three plants were assayed for antibacterial and antifungal potentials. The antibacterial investigations were performed via well diffusion method and nutrient broth dilution method. The bacterial strains used in the study were Enterococcus faecalis, Proteus mirabilis, Escherichia coli, Salmonella typhi, Klebsiella pneumonia and Pseudomonas aeruginosa. The antifungal potential was investigated by dilution method of Muller-Hinton agar media of the plants' samples. The fungal strains used were Aspergillis fumigatus, Aspergillis flavus and Aspergillis niger. Ceftriaxone and nystatin were used as standard drugs in antibacterial and antifungal assays respectively. RESULTS: Different fractions from N. thomsonianum were tested against five bacterial strains while the samples from A. consanguineum and E. caeruleum were tested against six bacterial strains. All the samples exhibited prominent antibacterial activity against the tested strains. Overall, chloroform and ethyl acetate fractions were found most potent among the three plants' samples. N. thomsonianum excelled among the three plants in antibacterial activity. Similarly, in antifungal assay, N. thomsonianum exhibited strong antifungal activity against the fungal strains. The chloroform fraction displayed MFCs of 175.67 ± 5.20***, 29.33 ± 5.48*** and 63.00 ± 4.93*** µg/ml against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger respectively. The whole study demonstrates that all the three plant species were active against tested bacterial and fungal strains. CONCLUSION: It can be concluded from our findings that N. thomsonianum, A. consanguineum and E. caeruleum have broad antibacterial and antifungal potentials. In all of the plants' samples, chloroform and ethyl acetate fractions were more active. Furthermore, being the potent samples, the chloroform and ethyl acetate fractions of these plants can be subjected to column chromatography for the isolation of more effective antimicrobial drugs.
[Mh] Termos MeSH primário: Allium/química
Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Eryngium/química
Liliaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Testes de Sensibilidade Microbiana
Paquistão
Plantas Medicinais
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Extracts); 0 (Solvents)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE


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[PMID]:27631003
[Au] Autor:Kouitcheu Mabeku LB; Eyoum Bille B; Nguepi E
[Ad] Endereço:Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:In Vitro and In Vivo Anti-Helicobacter Activities of Eryngium foetidum (Apiaceae), Bidens pilosa (Asteraceae), and Galinsoga ciliata (Asteraceae) against Helicobacter pylori.
[So] Source:Biomed Res Int;2016:2171032, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was performed to evaluate the antimicrobial activities of extracts of Bidens pilosa, Galinsoga ciliata, and Eryngium foetidum against 6 clinical strains of Helicobacter pylori in vitro and in vivo. Broth microdilution method was used in vitro. In vivo, Swiss mice were inoculated with H. pylori and divided into 5 groups; the control group received the vehicle and the four others received 125, 250, and 500 mg/kg of methanol extract of Eryngium foetidum and ciprofloxacin (500 mg/kg) for 7 days, respectively. Helicobacter pylori colonization and number of colonies in gastric biopsies culture were assessed on days 1 and 7 after treatment. The lowest MIC value (64 µg/mL) and the best spectrum of bactericidal effect (MBC/MIC = 1) were obtained with the methanol extract of Eryngium foetidum. The number of H. pylori infected animals was 17% (plant-extract) and 0% (ciprofloxacin) compared to 100% for the infected untreated group. Plant-extract (381.9 ± 239.5 CFU) and ciprofloxacin (248 ± 153.2 CFU) significantly reduced bacterial load in gastric mucosa compared to untreated, inoculated mice (14350 ± 690 CFU). Conclusion. The present data provided evidence that methanol extract of Eryngium foetidum could be a rich source of metabolites with antimicrobial activity to fight Helicobacter pylori infections.
[Mh] Termos MeSH primário: Antibacterianos/química
Asteraceae/química
Bidens/química
Eryngium/química
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Biópsia
Ciprofloxacino/química
Meios de Cultura/química
Mucosa Gástrica
Camundongos
Testes de Sensibilidade Microbiana
Compostos Fitoquímicos/química
Extratos Vegetais/química
Células-Tronco
Estômago/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Culture Media); 0 (Phytochemicals); 0 (Plant Extracts); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1155/2016/2171032


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[PMID]:27451187
[Au] Autor:Zitouni M; Wewer V; Dörmann P; Abdelly C; Ben Youssef N
[Ad] Endereço:Laboratory of Extremophile Plants, Center of Biotechnology of Borj-Cedria, P. O. Box 901, 2050 Hammam-Lif, Tunisia. Electronic address: manel.zitouni@yahoo.fr.
[Ti] Título:Quadrupole time-of-flight mass spectrometry analysis of glycerophospholipid molecular species in the two halophyte seed oils: Eryngium maritimum and Cakile maritima.
[So] Source:Food Chem;213:319-328, 2016 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Future applications of lipids in clinical cohort studies demand detailed glycerophospholipid molecule information and the application of high-throughput lipidomics platforms. In the present work, a novel sensitive technique with high mass resolution and accuracy was applied to accomplish phospholipid analysis. Nanospray ionization quadrupole time-of-flight mass spectrometry was used to separate and quantify the glycerophospholipid classes as well as molecular species in two halophyte seed oils from Cakile maritima and Eryngium maritimum. Precursor or neutral loss scans of their polar head groups allowed the detection of molecular species within particular glycerophospholipid classes. Phosphatidylcholine was found to be the most abundant glycerophospholipid in both seed oils whereas phosphatidylethanolamine and phosphatidic acid were less abundant. Phosphatidylinositol, phosphatidylserine and phosphatidylglycerol were minor glycerophospholipids. Several molecular species within each class were detected and the main molecular species (C36:4, C36:3, C36:2, 34:2 and C34:1) were quantitatively different between the two halophytes and the different glycerophospholipids.
[Mh] Termos MeSH primário: Eryngium/metabolismo
Glicerofosfolipídeos/metabolismo
Óleos Vegetais/metabolismo
Plantas Tolerantes a Sal/metabolismo
[Mh] Termos MeSH secundário: Espectrometria de Massas
Fosfatidilcolinas/metabolismo
Sementes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Phosphatidylcholines); 0 (Plant Oils)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27448616
[Au] Autor:Landoulsi A; Roumy V; Duhal N; Skhiri FH; Rivière C; Sahpaz S; Neut C; Benhamida J; Hennebelle T
[Ad] Endereço:Unit of Functional Proteomics and Organic Food Preservation, Higher Institute of Applied Biological Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
[Ti] Título:Chemical Composition and Antimicrobial Activity of the Essential Oil from Aerial Parts and Roots of Eryngium barrelieri Boiss. and Eryngium glomeratum Lam. from Tunisia.
[So] Source:Chem Biodivers;13(12):1720-1729, 2016 Dec.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The study of chemical composition and biological activity of unexplored essential oils may open new perspectives on their potential use in facing major health concerns such as drug-resistant infections. The present study investigates the chemical composition and antimicrobial effects of previously unstudied essential oils obtained from genus Eryngium: Eryngium glomeratum Lam. and Eryngium barrelieri Boiss. The chemical compositions of the essential oils from aerial parts and roots of both species were studied using GC and GC/MS analytical technics. The analysis led to the identification of 102 compounds totalizing 85 - 94% of all detected compounds. Essential oils were characterized by the predominance of oxygenated sesquiterpenes. The oils obtained from aerial parts were tested against 36 microbial strains by agar dilution method and showed minimum inhibitory concentrations (MIC) in the range of 2 - 625 µg/ml. A strong antibacterial activity against multiresistant Pseudomonas aeruginosa was observed especially from E. glomeratum essential oil with MIC value up to 2 µg/ml. These findings give significant information about the pharmacological activity of these essential oils, which suggest their potential use to develop new remedies, or as sources of active compounds.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Eryngium/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Relação Dose-Resposta a Droga
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Óleos Voláteis/isolamento & purificação
Pseudomonas aeruginosa/efeitos dos fármacos
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oils, Volatile)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170120
[Lr] Data última revisão:
170120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600136


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[PMID]:27340790
[Au] Autor:Bouzergoune F; Ciavatta ML; Bitam F; Carbone M; Aberkane MC; Gavagnin M
[Ad] Endereço:Laboratoire de Chimie et Chimie de l'environnement (L. C. C. E.), Faculté des Sciences de la Matière, Département de Chimie, Université de Batna 1, Batna, Algérie.
[Ti] Título:Phytochemical Study of Eryngium triquetrum: Isolation of Polyacetylenes and Lignans.
[So] Source:Planta Med;82(16):1438-1445, 2016 Nov.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the ethyl acetate extract from the aerial parts of Vahl resulted in the isolation of new polyacetylenes, triquetridiol ( ) and epoxy-triquetrol ( / , diastereomeric mixture), and the lignan demethoxy carolignan Z ( / , pair), together with a series of related known metabolites. Additionally, some already reported phenolic and flavonoid compounds were also identified in the extract. Structural elucidation of the new compounds was made by spectroscopic analysis, mainly NMR and mass spectrometry. To the best of our knowledge, this is the first report of polyacetylenes and lignans from .
[Mh] Termos MeSH primário: Eryngium/química
Lignanas/isolamento & purificação
Poliacetilenos/isolamento & purificação
[Mh] Termos MeSH secundário: Lignanas/química
Poliacetilenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 25067-58-7 (Polyacetylenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:27010155
[Au] Autor:Motallebi Riekandeh S; Mazandarani M; Ebrahimzadeh MA; Zargari M
[Ad] Endereço:Department of Biology, Science and Research Branch, Islamic Azad University, Fars, Iran. zadeh20@gmail.com.
[Ti] Título:Antioxidant activities of Eryngium caucasicum inflorescence.
[So] Source:Eur Rev Med Pharmacol Sci;20(5):946-9, 2016 Mar.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Medicinal plants are good sources for discovery of safe and new antioxidants. The aim of present study was to evaluate the efficiencies of three methods for evaluated for antioxidants from Eryngium caucasicum. MATERIALS AND METHODS: Ultrasonically assisted extraction, Soxhlet extraction and percolation method were evaluated for the extraction of antioxidants from E. caucasicum inflorescence. Antioxidant activities of extracts were evaluated with four different in vitro tests. RESULTS: Soxhlet extract had higher total phenolic and flavonoid contents than other extracts. Soxhlet extract showed the highest activity in DPPH radical scavenging (IC50 = 83.1 ± 2.1 µg ml-1). Soxhlet extract showed the best activity in iron chelatory (IC50 = 272 ± 6.3 µg ml-1) followed by ultrasonic extract. Percolation extract showed higher NO radical scavenging (IC50 = 390 ± 11.4 µg ml-1) than other extracts. Extracts showed good reducing power (p > 0.05). CONCLUSIONS: The results obtained indicated that all three extraction methods especially Soxhlet method could effectively extract antioxidants from this plant.
[Mh] Termos MeSH primário: Antioxidantes/química
Eryngium
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Flavonoides/análise
Inflorescência
Ferro/química
Óxido Nítrico/química
Oxirredução
Fenóis/análise
Picratos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); E1UOL152H7 (Iron)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE


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[PMID]:26810928
[Au] Autor:Klein-Júnior LC; dos Santos Passos C; Tasso de Souza TJ; Gobbi de Bitencourt F; Salton J; de Loreto Bordignon SA; Henriques AT
[Ad] Endereço:a Laboratory of Pharmacognosy and Quality Control of Phytomedicines, Faculty of Pharmacy , Universidade Federal Do Rio Grande Do Sul , Porto Alegre , Brazil ;
[Ti] Título:The monoamine oxidase inhibitory activity of essential oils obtained from Eryngium species and their chemical composition.
[So] Source:Pharm Biol;54(6):1071-6, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Monoamine oxidase (MAO) inhibitors are used in the treatment of depression, anxiety disorders, and the symptomatic treatment of Parkinson's disease. Eryngium, the most representative of the Apiaceae family, is well known for the presence of essential oils (EOs), which have already demonstrated MAO inhibitory potential. OBJECTIVE: The objective of this study is to evaluate the MAO inhibitory capacity of the EOs obtained from Eryngium floribundum Cham. & Schlecht. (EF), E. eriophorum Cham. & Schlecht. (EE), E. nudicaule Lam. (EN), E. horridum Malme (EH), and E. pandanifolium Cham. & Schlecht. (EP). MATERIALS AND METHODS: EOs were obtained from fresh whole plants by hydrodistillation (3 h). Chemical analyses were performed by GC/MS using apolar and polar columns, with oven temperature from 60 to 300 °C at 3 °C/min. The MAO-A and -B activities were evaluated in vitro by an end-point method using kynuramine as the substrate and mitochondrial suspension or human recombinant enzymes as the enzymatic source. DMSO 2%, clorgyline 10(-7) M, and pargyline 10(-6) M were used as controls. RESULTS AND DISCUSSION: EFEO, EEEO, ENEO, EHEO, and EPEO GC/MS analysis showed (E)-caryophyllene (4.9-10.8%), germacrene D (0.6-35.1%), bicyclogermacrene (10.4-17.2), spathulenol (0.4-36.0%), and globulol (1.4-18.6%) as main constituents. None of the EOs inhibited MAO-A activity (4 and 40 µg/mL). However, EHEO inhibited MAO-B activity with an IC50 value of 5.65 µg/mL (1-200 µg/mL). Pentadecane (10 µM), its major constituent (53.5%), did not display significant MAO-B inhibition. CONCLUSION: The study demonstrates the promising application of Eryngium species as a source of potential central nervous system bioactive secondary metabolites, specially related to neurodegenerative disorders.
[Mh] Termos MeSH primário: Eryngium/química
Mitocôndrias/enzimologia
Inibidores da Monoaminoxidase/farmacologia
Monoaminoxidase/metabolismo
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Técnicas In Vitro
Inibidores da Monoaminoxidase/isolamento & purificação
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoamine Oxidase Inhibitors); 0 (Oils, Volatile); 0 (Plant Oils); EC 1.4.3.4 (Monoamine Oxidase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1102949


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[PMID]:26771664
[Au] Autor:Promtes K; Kupradinun P; Rungsipipat A; Tuntipopipat S; Butryee C
[Ad] Endereço:a Institute of Nutrition, Mahidol University , Nakhon Pathom , Thailand.
[Ti] Título:Chemopreventive Effects of Eryngium foetidum L. Leaves on COX-2 Reduction in Mice Induced Colorectal Carcinogenesis.
[So] Source:Nutr Cancer;68(1):144-53, 2016.
[Is] ISSN:1532-7914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate the potential effects of Eryngium foetidum Linn. leaves (EF) in colitis-induced colorectal carcinogenesis in mice by azoxymethane (AOM) and dextran sulfate sodium (DSS), 39 ICR male mice were studied and divided into 6 groups. The mice were received a modified AIN-76 diet in Group 1, whereas Group 2 was given an AOM, DSS, and AIN-76 diet. Groups 3 and 4 were fed with 0.8% and 3.2% freeze-dried EF with AIN-76 diets, for 5 wk. Groups 5 and 6 were fed with 0.8% and 3.2% EF diets for 5 wk during AOM/DSS administration. The mice were necropsied at Week 20 and their colons were collected. The results indicated that the incidences of tumors in Groups 2, 5, and 6 was 100%, 75%, and 88%, with multiplicities (mean ±SE) of 3.75 ±0.92, 2.38 ± 0.96 and 4.25 ± 0.79, respectively. Interestingly, there was a significant difference in COX-2 expression in mice received 3.2% EF in their diet, but the proliferative cell nuclear antigen index and iNOS protein expression were not significantly different. We concluded that EF at a dose level of 3.2% in their diet had a preventive effect on colorectal carcinogenesis via the proinflammatory cytokine, COX-2.
[Mh] Termos MeSH primário: Neoplasias Colorretais/prevenção & controle
Ciclo-Oxigenase 2/metabolismo
Eryngium
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Neoplasias Colorretais/enzimologia
Neoplasias Colorretais/patologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Óxido Nítrico Sintase Tipo II/metabolismo
Folhas de Planta
Antígeno Nuclear de Célula em Proliferação/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Proliferating Cell Nuclear Antigen); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE
[do] DOI:10.1080/01635581.2016.1115103


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[PMID]:26667677
[Au] Autor:Erdem SA; Nabavi SF; Orhan IE; Daglia M; Izadi M; Nabavi SM
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara, Turkey.
[Ti] Título:Blessings in disguise: a review of phytochemical composition and antimicrobial activity of plants belonging to the genus Eryngium.
[So] Source:Daru;23:53, 2015 Dec 14.
[Is] ISSN:2008-2231
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Medicinal and edible plants play a crucial role in the prevention and/or mitigation of different human diseases from ancient times to today. In folk medicine, there are different plants used for infectious disease treatment. During the past two decades, much attention has been paid to plants as novel alternative therapeutic agents for the treatment of infectious diseases due to their bioactive natural compounds such as phenol, flavonoids, tannins, etc. The genus Eryngium (Apiaceae) contains more than 250 flowering plant species, which are commonly used as edible and medicinal plants in different countries. In fact, some genus Eryngium species are used as spices and are cultivated throughout the world and others species are used for the treatment of hypertension, gastrointestinal problems, asthma, burns, fevers, diarrhea, malaria, etc. Phytochemical analysis has shown that genus Eryngium species are a rich source of flavonoids, tannins, saponins, and triterpenoids. Moreover, eryngial, one the most important and major compounds of genus Eryngium plant essential oil, possesses a significant antibacterial effect. Thus, the objective of this review is to critically review the scientific literature on the phytochemical composition and antibacterial effects of the genus Eryngium plants. In addition, we provide some information about traditional uses, cultivation, as well as phytochemistry.
[Mh] Termos MeSH primário: Aldeídos/farmacologia
Anti-Infecciosos/farmacologia
Eryngium/química
[Mh] Termos MeSH secundário: Aldeídos/química
Anti-Infecciosos/química
Eryngium/classificação
Seres Humanos
Óleos Vegetais/análise
Óleos Vegetais/farmacologia
Plantas Comestíveis/química
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aldehydes); 0 (Anti-Infective Agents); 0 (Plant Oils); 0 (trans-2-dodecenal)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE
[do] DOI:10.1186/s40199-015-0136-3



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