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Pesquisa : B01.650.940.800.575.912.250.075.333 [Categoria DeCS]
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[PMID]:28892803
[Au] Autor:Xiao Z; Chen J; Niu Y; Chen F
[Ad] Endereço:School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, PR China.
[Ti] Título:Characterization of the key odorants of fennel essential oils of different regions using GC-MS and GC-O combined with partial least squares regression.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:226-234, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The key odorants and the aroma profile of six fennel essential oils from different regions were investigated by using gas chromatography-olfactometry (GC-O), gas chromatography-mass spectrometry (GC-MS) and sensory evaluation. A total of 30 volatile compounds were determined by GC-O with aroma extract dilution analysis (AEDA) and the odor activity values (OAV) of them were calculated. Among these compounds, α-pinene, α-phellandrene, limonene, α-cubebene, ß-caryophyllene, estragole, α-humulene, trans-anethole, δ-cadinene and p-anisaldehyde contributed greatly to the aroma of fennel essential oil due to their high flavor dilution (FD) factors and high OAVs. The aroma of fennel essential oils was described by 7 sensory terms as spicy, woody, grassy, floral, musty, sweet and green, and was correlated to the key odorants by partial least squares regression (PLSR). It was showed that spicy, woody, grassy, musty and green attributes were covaried well with aroma compounds. In addition, hierarchical cluster analysis (HCA) was used to find out the similarities among different samples and the result indicated that three main groups were identified.
[Mh] Termos MeSH primário: Foeniculum/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Odorantes/análise
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Análise por Conglomerados
Análise dos Mínimos Quadrados
Modelos Lineares
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


  2 / 203 MEDLINE  
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[PMID]:28426256
[Au] Autor:Keskin I; Gunal Y; Ayla S; Kolbasi B; Sakul A; Kilic U; Gok O; Koroglu K; Ozbek H
[Ad] Endereço:a Departments of Histology and Embryology.
[Ti] Título:Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing.
[So] Source:Biotech Histochem;92(4):274-282, 2017.
[Is] ISSN:1473-7760
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and limonene were applied topically to the wounds once daily, separately or together, for 10 days. Tissue sections from the wounds were evaluated for histopathology. The healing potential was assessed by comparison to an untreated control group and an olive oil treated sham group. We scored wound healing based on epidermal regeneration, granulation tissue thickness and angiogenesis. After day 6, wound contraction with limonene was significantly better than for the control group. Ten days after treatment, a significant increase was observed in wound contraction and re-epithelialization in both fenchone and limonene oil treated groups compared to the sham group. Groups treated with fenchone and with fenchone + limonene scored significantly higher than the control group, but the difference was not statistically significant compared to the olive oil treated group. Our findings support the beneficial effects of fenchone and limonene for augmenting wound healing. The anti-inflammatory and antimicrobial activities of fenchone and limonene oil increased collagen synthesis and decreased the number of inflammatory cells during wound healing and may be useful for treating skin wounds.
[Mh] Termos MeSH primário: Cicloexenos/farmacologia
Foeniculum/química
Norbornanos/farmacologia
Óleos Voláteis/farmacologia
Terpenos/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cicloexenos/química
Imuno-Histoquímica
Masculino
Microscopia Eletrônica de Transmissão
Norbornanos/química
Azeite de Oliva/farmacologia
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
Pele/efeitos dos fármacos
Terpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Norbornanes); 0 (Oils, Volatile); 0 (Olive Oil); 0 (Plant Extracts); 0 (Terpenes); 1195-79-5 (fenchone); 9MC3I34447 (limonene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1080/10520295.2017.1306882


  3 / 203 MEDLINE  
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[PMID]:28397764
[Au] Autor:Al Akeel R; Mateen A; Syed R; Alyousef AA; Shaik MR
[Ad] Endereço:Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia. raalakeel@ksu.edu.sa.
[Ti] Título:Screening, Purification and Characterization of Anionic Antimicrobial Proteins from Foeniculum Vulgare.
[So] Source:Molecules;22(4), 2017 Apr 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mill., commonly called fennel, is a medicinal plant belonging to the Umbelliferae (Apiaceae) family, and is used in traditional medicine. Antibacterial peptides were isolated using sodium phosphate citrate buffer and, for extraction, cetyltrimethyl ammonium bromide (CTAB) buffer with pH 6, have been employed and antimicrobial activity tested against four reference strains. The extracted protein was subjected to 3 kDa dialysis and separation was carried out by DEAE-ion exchange chromatography and further proteins were identified by 2D gel electrophoresis. The results of elutes obtained from DEAE-ion exchange chromatography were tested for antibacterial activity. Elute 3 shows the highest antibacterial activity on with a diameter of a zone of inhibition of 16 mm and IC value 25.02 (mcg/mL). Based on the findings of the wide usage in treatment of various ailments and day-to-day life, seeds were used in the present research and have shown promising antibacterial effects, which requires further proteomic research to authenticate the role of the anticipated proteins.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Foeniculum/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Proteínas de Plantas/química
Proteínas de Plantas/isolamento & purificação
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Extratos Vegetais/farmacologia
Proteínas de Plantas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 0 (Plant Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE


  4 / 203 MEDLINE  
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[PMID]:28076987
[Au] Autor:Arantes S; Piçarra A; Candeias F; Caldeira AT; Martins MR; Teixeira D
[Ad] Endereço:a Departamento de Química, Escola de Ciências e Tecnologia , Universidade de Évora , Évora , Portugal.
[Ti] Título:Antioxidant activity and cholinesterase inhibition studies of four flavouring herbs from Alentejo.
[So] Source:Nat Prod Res;31(18):2183-2187, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Essential oils (EOs) and aqueous extracts of aerial parts of four aromatic species, Calamintha nepeta, Foeniculum vulgare, Mentha spicata and Thymus mastichina, from southwest of Portugal were characterised chemically and analysed in order to evaluate their antioxidant potential and cholinesterase inhibitory activities. The main components of EOs were oxygenated monoterpenes, and aqueous extracts were rich in phenol and flavonoid compounds. EOs and aqueous extracts presented a high antioxidant potential, with ability to protect the lipid substrate, free radical scavenging and iron reducing power. Furthermore, EOs and extracts showed AChE and BChE inhibitory activities higher than rivastigmine, the standard drug. Results suggested the potential use of EOs and aqueous extracts of these flavouring herbs as nutraceutical or pharmaceutical preparations to minimise the oxidative stress and the progression of degenerative diseases.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Inibidores da Colinesterase/farmacologia
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/química
Inibidores da Colinesterase/química
Avaliação Pré-Clínica de Medicamentos/métodos
Flavonoides/análise
Aromatizantes/química
Foeniculum/química
Lamiaceae
Mentha spicata/química
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Fenóis/análise
Extratos Vegetais/química
Portugal
Thymus (Planta)/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholinesterase Inhibitors); 0 (Flavonoids); 0 (Flavoring Agents); 0 (Oils, Volatile); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1278598


  5 / 203 MEDLINE  
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[PMID]:28063208
[Au] Autor:Saeedi S; Dayani O; Tahmasbi R; Khezri A
[Ad] Endereço:Department of Animal Science, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran.
[Ti] Título:Effect of supplementation of calf starter with fennel powder on performance, weaning age and fermentation characteristics in Holstein dairy calves.
[So] Source:J Anim Physiol Anim Nutr (Berl);101(1):81-87, 2017 Feb.
[Is] ISSN:1439-0396
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The objective of this experiment was to investigate the effects on performance, weaning age and rumen fermentation characteristics in Holstein calves when fennel powder was added to their starter diets. Thirty Holstein calves with a mean birth weight 40 kg (SD = 0.5) were allocated randomly to one of the following experimental diets: (i) control (starter diet without fennel powder), (ii) starter diet containing 0.4% of fennel powder and (iii) starter diet containing 0.8% of fennel powder (DM basis). The effect of treatments on mean dry matter intake was significant (p < 0.05) in the post-weaning and total experimental periods. Average daily weight gain before (0.38, 0.49 and 0.47 kg/day) and after (0.6, 1.01 and 0.83 kg/day) weaning and during the entire study (0.45, 0.7 and 0.58 kg/day) was influenced by diets of 1, 2 and 3, respectively (p < 0.05). Maximum daily weight gain and the best feed conversion ratio were achieved with 0.4% fennel powder. Mean weaning age of the calves supplemented with fennel powder was lower (p < 0.05) than that of the control group. Ruminal fluid pH in calves offered starter containing 0.8% fennel powder was lower (p < 0.05) compared to calves fed the other diets. Ammonia nitrogen content increased (p < 0.05) in the third week of feeding fennel powder. The mean concentration of total short-chain fatty acids (SCFA) and propionate molar percentage in the ruminal fluid of the calves fed with the fennel powder were higher (p < 0.05) at 6 weeks and 2 weeks after weaning than control group; however, acetate-to-propionate molar ratio was lower (p < 0.05). The results showed that adding 0.4% fennel powder to the starter increased the propionate molar percentage in the rumen and improved the calf performance, allowing the calves to be weaned at an earlier age.
[Mh] Termos MeSH primário: Ração Animal/análise
Suplementos Nutricionais
Foeniculum
[Mh] Termos MeSH secundário: Envelhecimento
Fenômenos Fisiológicos da Nutrição Animal
Animais
Bovinos
Dieta/veterinária
Feminino
Fermentação
Masculino
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1111/jpn.12511


  6 / 203 MEDLINE  
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[PMID]:27917696
[Au] Autor:Mihats D; Pilsbacher L; Gabernig R; Routil M; Gutternigg M; Laenger R
[Ad] Endereço:a Data, Statistics & Risk Assessment , Austrian Agency for Health and Food Safety , Vienna , Austria.
[Ti] Título:Levels of estragole in fennel teas marketed in Austria and assessment of dietary exposure.
[So] Source:Int J Food Sci Nutr;68(5):569-576, 2017 Aug.
[Is] ISSN:1465-3478
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Levels of estragole in fennel teas (n = 42) on the Austrian market and the associated dietary exposure were assessed in this study. The estimated daily exposure from consumption of fennel teas ranged from 0.25 to 5.04 µg kg d , 0.32 to 6.42 µg kg d , and 0.15 to 2.93 µg kg d for children, women, and men, respectively. Daily estragole exposures for infants were 0.008-20.78 µg kg d . Despite MOE values are above 10,000 for nearly half of the fennel teas analyzed, there are still MOEs below this value indicating a potential risk for human health and a priority for risk management. However, fennel teas are generally consumed only for short periods of gastrointestinal disorders. Estimated daily intakes may, therefore, be conservative and tend to overestimate the potential risk for human health.
[Mh] Termos MeSH primário: Anisóis/análise
Bebidas
Dieta
Foeniculum/química
[Mh] Termos MeSH secundário: Anisóis/química
Áustria
Exposição Ambiental
Frutas/química
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 9NIW07V3ET (estragole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1080/09637486.2016.1262334


  7 / 203 MEDLINE  
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[PMID]:27596429
[Au] Autor:Caleja C; Barros L; Antonio AL; Oliveira MB; Ferreira IC
[Ad] Endereço:Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal; Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, IPB, Campus de Santa Apolónia, 1134, 5301-857 Bragança, Portugal; REQUIMTE/LA
[Ti] Título:A comparative study between natural and synthetic antioxidants: Evaluation of their performance after incorporation into biscuits.
[So] Source:Food Chem;216:342-6, 2017 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Currently, the food industry is focused in replacing the use of synthetic by natural antioxidants. The present study focused on the use of fennel and chamomile extracts, rich in phenolic compounds, as natural antioxidants in biscuits and compared their performance with a synthetic antioxidant widely used, the butylated hydroxyl anisole (BHA). The complete nutritional profile, free sugars, fatty acids and antioxidant activity were determined immediately after baking and also after 15, 30, 45 and 60days of storage. The results showed that the incorporation of natural and synthetic additives did not cause significant changes in colour or in nutritional value of biscuits when compared with control samples. Both natural and synthetic additives conferred similar antioxidant activity to the biscuits. Therefore, natural additives are a more convenient solution for consumers who prefer foods "free" from synthetic additives. Additionally, natural additives were obtained by aqueous extraction, an environment friendly and safe process.
[Mh] Termos MeSH primário: Antioxidantes/química
Hidroxianisol Butilado/química
Alimentos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Camomila/química
Foeniculum/química
Fenóis/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 25013-16-5 (Butylated Hydroxyanisole)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


  8 / 203 MEDLINE  
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[PMID]:27558813
[Au] Autor:Salami M; Rahimmalek M; Ehtemam MH
[Ad] Endereço:Department of Agronomy and Plant Breeding, College of Agriculture, Isfahan University of Technology, Isfahan, 84156 83111, Iran.
[Ti] Título:Comprehensive Research on Essential Oil and Phenolic Variation in Different Foeniculum vulgare Populations During Transition from Vegetative to Reproductive Stage.
[So] Source:Chem Biodivers;14(2), 2017 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Chemical composition and antioxidant activity of four fennel populations (England, Spain, Poland and Iran) were investigated during six developmental stages including two vegetative and four reproductive phases. In reproductive phase, the essential oil content of fruits decreased and the maximum content (5.9%) was obtained in immediate fruits. The essential oils were analyzed using GC/MS. trans-Anethole was the main component of the leaves and the fruits oil. In leaves, it ranged from 41.28% in England at late vegetative stage to 56.6% in Poland population at early vegetative stage. Other major compounds of leaves were limonene, α-pinene and (Z)-ß-ocimene. In reproductive phases the trans-anethole increased dramatically. It varied from 85.25% in immature fruits from Poland to 90.7% in pre-mature stage from Spain. The highest phenolic content in the extracts at different growth stages obtained 189 mg TAE/g DW at full mature stage of seed in Iran population. The flavonoid of leaves extract ranged from 3 to 7.5 mg QUE/g DW, while in fruits extract varied from 3 to 10.3 mg QUE/g DW. Antioxidant activity of the extracts was evaluated using 1,1-diphenyl-2-picrylhydrazy (DPPH) and ß-carotene model systems. Immature and full mature growth stages of fennel population from Spain indicated the highest activity in quenching of DPPH radical (74.2% and 74.5, respectively). Antioxidant activities of the extracts had high positive correlation with their phenolic contents in all fruit maturity stages. Finally, it might probably be suggested that in fennel the hot and humid condition can lead to increase trans-anethole, while the hot and dry one can produce higher amount of phenolics and flavonoids.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Foeniculum/química
Óleos Voláteis/farmacologia
Fenóis/farmacologia
Desenvolvimento Vegetal/efeitos dos fármacos
Extratos Vegetais/farmacologia
Reprodução/efeitos dos fármacos
[Mh] Termos MeSH secundário: Foeniculum/classificação
Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600246


  9 / 203 MEDLINE  
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[PMID]:27802299
[Au] Autor:Sheweita SA; El-Hosseiny LS; Nashashibi MA
[Ad] Endereço:Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
[Ti] Título:Protective Effects of Essential Oils as Natural Antioxidants against Hepatotoxicity Induced by Cyclophosphamide in Mice.
[So] Source:PLoS One;11(11):e0165667, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein which is the proximate toxic metabolite. Many different natural antioxidants were found to alleviate the toxic effects of various toxic agents via different mechanisms. Therefore, the present study aimed at investigating the role of essential oils extracted from fennel, cumin and clove as natural antioxidants in the alleviation of hepatotoxicity induced by CP through assessment of hepatotoxicity biomarkers (AST, ALT, ALP), histopathology of liver tissues as well as other biochemical parameters involved in the metabolism of CP. The data of the present study showed that treatment of male mice with cyclophosphamide (2.5 mg/Kg BW) as repeated dose for 28 consecutive days was found to induce hepatotoxicity through the elevation in the activities of AST, ALT, and ALP. Combined administration of any of these oils with CP to mice partially normalized the altered hepatic biochemical markers caused by CP, whereas administration of fennel, clove or cumin essential oils alone couldn't change liver function indices. Moreover, CP caused histological changes in livers of mice including swelling and dilation in sinusoidal space, inflammation in portal tract and hepatocytes, as well as, hyperplasia in Kuppfer cells. However, co-administration of any of the essential oils with CP alleviated to some extent the changes caused by CP but not as the normal liver. CP was also found to induce free radical levels (measured as thiobarbituric acid reactive substances) and inhibited the activities of superoxide dismutase, glutathione reductase, and catalase as well as activities and protein expressions of both glutathione S-transferase (GSTπ) and glutathione peroxidase. Essential oils restored changes in activities of antioxidant enzymes (SOD, CAT, GR, GST, and GPx) caused by CP to their normal levels compared to control group. In addition, treatment of mice with CP was found to induce the protein expression of CYP 3A4, 2B1/2, 2C6, 2C23. Moreover, the present study showed that essential oils reduced the expression of CYPs 2E1, 3A4 but could not restore the expression of CYP 2C6 and 2C23 compared to CP-treated mice. Interestingly, pretreatment of mice with essential oil of clove was found to restore activities of DMN-dI, AHH, and ECOD which were induced by CP to their normal control levels. It is concluded that EOs showed a marked hepatoprotective effect against hepatotoxicity induced by CP. In addition, co-administration of CP with any of these oils might be used as a new strategy for cancer treatment to alleviate the hepatotoxicity induced by CP.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/patologia
Ciclofosfamida
Fígado/efeitos dos fármacos
Fígado/patologia
Óleos Voláteis/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Cuminum/química
Sistema Enzimático do Citocromo P-450/metabolismo
Foeniculum/química
Fígado/metabolismo
Masculino
Camundongos
Óleos Voláteis/química
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Óleos Vegetais/química
Óleos Vegetais/isolamento & purificação
Óleos Vegetais/farmacologia
Óleos Vegetais/uso terapêutico
Syzygium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils); 8N3DW7272P (Cyclophosphamide); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0165667


  10 / 203 MEDLINE  
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[PMID]:27765346
[Au] Autor:Sun Z; Park SY; Hwang E; Park B; Seo SA; Cho JG; Zhang M; Yi TH
[Ad] Endereço:Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, 1732 Deokyoungdaero, Giheung-gu, Yongin-si, Gyeonggi-do, 446-701, Republic of Korea.
[Ti] Título:Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways.
[So] Source:Phytomedicine;23(12):1273-1284, 2016 Nov 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. METHODS: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-ß1 (TGF-ß1) were measured by kits. Additionally, the level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), p-ERK and p38 were evaluated by western blotting. In vivo, H&E and Masson's trichrome staining were employed. The expression of MMP-1, procollagen type I, TGF-ß1 and elastin were measured by western blot. RESULTS: FV significantly increased the production of collagen, elastin and TGF-ß1 levels, while blocked matrix metalloproteinases (MMPs) production in UVB irradiation induced hairless mice, which were consistent with the result in NHDFs. Furthermore, FV dose-dependently decreased the production of ROS and LDH by promoting the nuclear amount of Nrf2 and enhancing the expression of cytoprotective antioxidants such as GSH. FV also significantly quenched UVB-induced phosphorylation of ERK and p38 in NHDFs. CONCLUSION: Our results indicate that FV is a potential botanical agent for the treatment of skin damage induced by UV irradiation.
[Mh] Termos MeSH primário: Foeniculum/química
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Fator 2 Relacionado a NF-E2/agonistas
Extratos Vegetais/farmacologia
Protetores contra Radiação/farmacologia
Envelhecimento da Pele/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Dieta
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Fibroblastos/efeitos da radiação
Expressão Gênica/efeitos dos fármacos
Expressão Gênica/efeitos da radiação
Seres Humanos
Fosforilação/efeitos dos fármacos
Sementes/química
Pele/citologia
Pele/efeitos dos fármacos
Pele/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Plant Extracts); 0 (Radiation-Protective Agents); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE



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