Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.411 [Categoria DeCS]
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[PMID]:28637122
[Au] Autor:Wang ZG; Mi J; Wang XR; Huo YY; Peng YJ; Zhang HM; Gao Y; Zhang HL
[Ad] Endereço:a Department of Pharmaceutical Analysis , Heilongjiang University of Chinese Medicine , Harbin , China.
[Ti] Título:A new cinnamic acid glycoside from roots of Heracleum dissectum.
[So] Source:Nat Prod Res;32(2):133-140, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them compound 2-9 was isolated from the plant for the first time. Their structures were elucidated and identified on the basis of their physicochemical properties and by extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. The results of triglyceride accumulation screening in 3T3-L1 cells showed that compounds 1, 5 and 9 exhibited significantly accelerating activities of adipogenesis in adipocytes.
[Mh] Termos MeSH primário: Cinamatos/isolamento & purificação
Glicosídeos/isolamento & purificação
Heracleum/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/efeitos dos fármacos
Adipogenia/efeitos dos fármacos
Animais
Glicosídeos Cardíacos
Cinamatos/química
Glicosídeos/química
Camundongos
Fenóis/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiac Glycosides); 0 (Cinnamates); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1340285


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[PMID]:28926580
[Au] Autor:Medrzycki P; Jarzyna I; Obidzinski A; Tokarska-Guzik B; Sotek Z; Pabjanek P; Pytlarczyk A; Sachajdakiewicz I
[Ad] Endereço:Laboratory of Applied Plant Ecology, Faculty of Ecology, University of Ecology and Management in Warsaw, Warsaw, Poland.
[Ti] Título:Simple yet effective: Historical proximity variables improve the species distribution models for invasive giant hogweed (Heracleum mantegazzianum s.l.) in Poland.
[So] Source:PLoS One;12(9):e0184677, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Species distribution models are scarcely applicable to invasive species because of their breaking of the models' assumptions. So far, few mechanistic, semi-mechanistic or statistical solutions like dispersal constraints or propagule limitation have been applied. We evaluated a novel quasi-semi-mechanistic approach for regional scale models, using historical proximity variables (HPV) representing a state of the population in a given moment in the past. Our aim was to test the effects of addition of HPV sets of different minimal recentness, information capacity and the total number of variables on the quality of the species distribution model for Heracleum mantegazzianum on 116000 km2 in Poland. As environmental predictors, we used fragments of 103 1×1 km, world- wide, free-access rasters from WorldGrids.org. Single and ensemble models were computed using BIOMOD2 package 3.1.47 working in R environment 3.1.0. The addition of HPV improved the quality of single and ensemble models from poor to good and excellent. The quality was the highest for the variants with HPVs based on the distance from the most recent past occurrences. It was mostly affected by the algorithm type, but all HPV traits (minimal recentness, information capacity, model type or the number of the time periods) were significantly important determinants. The addition of HPVs improved the quality of current projections, raising the occurrence probability in regions where the species had occurred before. We conclude that HPV addition enables semi-realistic estimation of the rate of spread and can be applied to the short-term forecasting of invasive or declining species, which also break equal-dispersal probability assumptions.
[Mh] Termos MeSH primário: Heracleum/fisiologia
Espécies Introduzidas
Modelos Teóricos
[Mh] Termos MeSH secundário: Demografia
Ecossistema
Heracleum/crescimento & desenvolvimento
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184677


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[PMID]:28556437
[Au] Autor:Zhang HL; Wu XY; Mi J; Peng YJ; Wang ZG; Liu Y; Wu XL; Gao Y
[Ad] Endereço:School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, P. R. China.
[Ti] Título:A New Anti-Inflammatory Alkaloid from Roots of Heracleum dissectum.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Using various chromatographic methods, a new piperidinone alkaloid, (3S)-3-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}piperidin-2-one (1), together with 10 known compounds, bergapten (2), xanthotoxol (3), isopimpinellin (4), isobergapten (5), heratomol-6-O-ß-d-glucopyranoside (6), scopoletin (7), apterin (8), 3-methoxy-4-ß-d-glucopyranosyloxypropiophenone, (praeroside; 9), tachioside (10) and coniferin (11), were isolated from roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti-inflammatory activity in vitro. As the results, compound 1 and 8 showed significantly inhibitory activity on nitric oxide production in RAW264.7 cells.
[Mh] Termos MeSH primário: Alcaloides/química
Anti-Inflamatórios/química
Heracleum/química
Piperidonas/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Camundongos
Modelos Moleculares
Óxido Nítrico/imunologia
Piperidonas/isolamento & purificação
Piperidonas/farmacologia
Extratos Vegetais/química
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Piperidones); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); WLN0GQQ6EK (2-piperidone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700184


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[PMID]:27507512
[Au] Autor:Zhang H; Su Y; Wang X; Mi J; Huo Y; Wang Z; Liu Y; Gao Y
[Ad] Endereço:School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
[Ti] Título:Antidiabetic activity and chemical constituents of the aerial parts of Heracleum dissectum Ledeb.
[So] Source:Food Chem;214:572-579, 2017 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Heracleum dissectum Ledeb. has long been used as a wild edible vegetable by local people in China. The purpose of this study is to investigate the antidiabetic potential of aerial part of H. dissectum methanol extract (HdME) and the chemical constituents. Ten compounds including eight coumarins were isolated and four of them were found from H. dissectum for the first time. HdME potently inhibited the elevation of plasma glucose after its oral administration to glucose-loaded mice, and its petroleum ether (PE) fraction exerted the greatest inhibitory activities. Meanwhile, HdME (125 and 250mg/kg) also significantly decreased the blood glucose level in STZ-induced diabetic mice, but had no effect in normoglycemic mice. Additionally, HdME showed weak inhibitory effects on α-glucosidase activity and DPPH free radicals scavenging. In conclusion, HdME has antidiabetic action and PE fraction is the active part where coumarins possibly play an important role in antidiabetic activity.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Heracleum/química
Hipoglicemiantes/química
Componentes Aéreos da Planta/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


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[PMID]:27827938
[Au] Autor:Alam MB; Seo BJ; Zhao P; Lee SH
[Ad] Endereço:Department of Food Science & Biotechnology, Kyungpook National University, Daegu 41566, Korea. mbalam@knu.ac.kr.
[Ti] Título:Anti-Melanogenic Activities of Heracleum moellendorffii via ERK1/2-Mediated MITF Downregulation.
[So] Source:Int J Mol Sci;17(11), 2016 Nov 04.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this study, the anti-melanogenic effects of Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in melan-a cells were investigated. Mushroom tyrosinase (TYR) activity and melanin content as well as cellular tyrosinase activity were measured in the cells. mRNA and protein expression of microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TYRP-1) and -2 were also examined. The results demonstrate that treatment with HmHe significantly inhibits mushroom tyrosinase activity. Furthermore, HmHe also markedly inhibits melanin production and intracellular tyrosinase activity. By suppressing the expression of TYR, TYRP-1, TYRP-2, and MITF, HmHe treatment antagonized melanin production in melan-a cells. Additionally, HmHe interfered with the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, with reversal of HmHe-induced melanogenesis inhibition after treatment with specific inhibitor U0126. In summary, HmHe can be said to stimulate ERK1/2 phosphorylation and subsequent degradation of MITF, resulting in suppression of melanogenic enzymes and melanin production, possibly due to the presence of polyphenolic compounds.
[Mh] Termos MeSH primário: Heracleum/química
Indóis/antagonistas & inibidores
Melaninas/antagonistas & inibidores
Melanócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Agaricales/química
Animais
Butadienos/farmacologia
Linhagem Celular
Inibidores Enzimáticos/farmacologia
Proteínas Fúngicas/antagonistas & inibidores
Proteínas Fúngicas/metabolismo
Regulação da Expressão Gênica
Indóis/metabolismo
Oxirredutases Intramoleculares/antagonistas & inibidores
Oxirredutases Intramoleculares/genética
Oxirredutases Intramoleculares/metabolismo
Melaninas/biossíntese
Melanócitos/citologia
Melanócitos/metabolismo
Glicoproteínas de Membrana/antagonistas & inibidores
Glicoproteínas de Membrana/genética
Glicoproteínas de Membrana/metabolismo
Camundongos
Fator de Transcrição Associado à Microftalmia/genética
Fator de Transcrição Associado à Microftalmia/metabolismo
Proteína Quinase 1 Ativada por Mitógeno/antagonistas & inibidores
Proteína Quinase 1 Ativada por Mitógeno/genética
Proteína Quinase 1 Ativada por Mitógeno/metabolismo
Proteína Quinase 3 Ativada por Mitógeno/antagonistas & inibidores
Proteína Quinase 3 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/metabolismo
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/metabolismo
Nitrilos/farmacologia
Oxirredutases/antagonistas & inibidores
Oxirredutases/genética
Oxirredutases/metabolismo
Fosforilação/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/isolamento & purificação
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Enzyme Inhibitors); 0 (Fungal Proteins); 0 (Indoles); 0 (Melanins); 0 (Membrane Glycoproteins); 0 (Microphthalmia-Associated Transcription Factor); 0 (Mitf protein, mouse); 0 (Nitriles); 0 (Plant Extracts); 0 (Protective Agents); 0 (U 0126); 0 (melanogen); EC 1.- (Oxidoreductases); EC 1.14.18.- (Tyrp1 protein, mouse); EC 1.14.18.1 (Monophenol Monooxygenase); EC 2.7.11.24 (Mapk1 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.3.12 (dopachrome isomerase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27755521
[Au] Autor:Zdrojewicz Z; Stebnicki M; Stebnicki M
[Ad] Endereço:Medical University of Wroclaw, Poland: Faculty of Postgraduate Medical Training, Department and Clinic of Endocrinology, Diabetology and Isotope Therapy.
[Ti] Título:[Sosnowsky's hogweed - toxicology and threat to health].
[Ti] Título:Barszcz Sosnowskiego ­ toksykologia a zagrozenie dla zdrowia..
[So] Source:Pol Merkur Lekarski;41(243):165-168, 2016 Sep 29.
[Is] ISSN:1426-9686
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:Sosnowsky's hogweed (Heracleum sosnowskyi Manden.) is a genus of plants in the family Apiaceae which also includes Giant Hogweed (Heracleum mantegazzianum Sommier and Levier). They are both found in Central Europe, mainly in neglected green areas or riversides. Sosnowsky's hogweed was brought to Poland from the Soviet Union in the 1950s to be used in animal feed production. Intended goals couldn't be achieved and the plant spread throughout grounds distant to the primarily cultivated lands. Sosnowsky's hogweed is especially hazardous in direct contact with human skin. It results from the content of photoallergic substances called furanocoumarins in its essential oil. Clinically it is presented as burns, mainly of 2nd and 3rd degree. They mostly occur on the face, upper and lower limbs. Typical symptoms include pain, redness, swelling and heat in the area of exposure. Their extent depends on burn's depth and area and also on time of exposure to plant's toxins. In this article we present Sosnowsky's hogweed's activity and its influence on human health.
[Mh] Termos MeSH primário: Furocumarinas/toxicidade
Heracleum/química
Fármacos Fotossensibilizantes/toxicidade
Queimadura Solar/etiologia
[Mh] Termos MeSH secundário: Furocumarinas/efeitos adversos
Heracleum/toxicidade
Seres Humanos
Fármacos Fotossensibilizantes/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Furocoumarins); 0 (Photosensitizing Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27751916
[Au] Autor:Hoseinifar SH; Zoheiri F; Lazado CC
[Ad] Endereço:Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
[Ti] Título:Dietary phytoimmunostimulant Persian hogweed (Heracleum persicum) has more remarkable impacts on skin mucus than on serum in common carp (Cyprinus carpio).
[So] Source:Fish Shellfish Immunol;59:77-82, 2016 Dec.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Immunostimulation through the use of sustainable and eco-friendly dietary additives is one of the current prophylactic strategies in fish husbandry. Plant-based immunostimulants are highly considered for this intent, both for their scientific and practical advantages. Persian hogweed (Heracleum persicum) is a flower-bearing herb that possesses interesting pharmacological importance due to its bioactive compounds. It is commonly used as spice, food additive, dietary supplement and traditional remedy. The present study evaluated the potential of H. persicum as a dietary phytoimmunostimulant in common carp (Cyprinus carpio). The powder form of H. persicum was incorporated in the basal diet at three different inclusion levels: 2.5, 5 and 10 g kg . The basal diet (0 g kg of H. persicum) served as control. Experimental diets were administered to the fish for a period of 8 weeks. At the termination of the feeding experiment, impacts on fish immunity and performance were evaluated. Inclusion of H. persicum in the diet significantly elevated several immunological factors such as immunoglobulins, lysozyme, protease and alternative complement activities in carp. Interestingly, the changes were more pronounced in the skin mucus than in the serum. Performance was significantly improved in the fish groups that received the candidate phytoimmunostimulant. Specifically, final weight, weight gain, specific growth rate and feed conversion ratio were significantly improved in the fish that received dietary H. persicum at inclusion levels 5 g kg and higher. This study demonstrated the potential of Persian hogweed as a candidate dietary phytoimmunostimulant in carp, impacting mainly the skin mucosal defenses. The study supports the current trend in the exploration of sustainable plant-based dietary supplements that are capable of boosting the immunological defenses of farmed fish.
[Mh] Termos MeSH primário: Carpas/imunologia
Suplementos Nutricionais
Heracleum/química
Imunidade Inata
Extratos Vegetais
Pele/imunologia
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Ração Animal/análise
Animais
Dieta/veterinária
Membrana Mucosa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27504617
[Au] Autor:Govindarajan M; Benelli G
[Ad] Endereço:Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. Electronic address: drgovind1979@gmail.com.
[Ti] Título:Eco-friendly larvicides from Indian plants: Effectiveness of lavandulyl acetate and bicyclogermacrene on malaria, dengue and Japanese encephalitis mosquito vectors.
[So] Source:Ecotoxicol Environ Saf;133:395-402, 2016 Nov.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mosquitoes (Diptera: Culicidae) are a key threat for millions of people and animals worldwide, since they act as vectors for devastating pathogens and parasites, including malaria, dengue, Japanese encephalitis, filiariasis and Zika virus. Mosquito young instars are usually targeted using organophosphates, insect growth regulators and microbial agents. Indoor residual spraying and insecticide-treated bed nets are also employed. However, these chemicals have negative effects on human health and the environment and induce resistance in a number of vectors. In this scenario, newer and safer tools have been recently implemented to enhance mosquito control. The concrete potential of screening plant species as sources of metabolites for entomological and parasitological purposes is worthy of attention, as recently elucidated by the Y. Tu's example. Here we investigated the toxicity of Heracleum sprengelianum (Apiaceae) leaf essential oil and its major compounds toward third instar larvae of the malaria vector Anopheles subpictus, the arbovirus vector Aedes albopictus and the Japanese encephalitis vector Culex tritaeniorhynchus. GC-MS analysis showed that EO major components were lavandulyl acetate (17.8%) and bicyclogermacrene (12.9%). The EO was toxic to A. subpictus, A. albopictus, and C. tritaeniorhynchus, with LC50 of 33.4, 37.5 and 40.9µg/ml, respectively. Lavandulyl acetate was more toxic to mosquito larvae if compared to bicyclogermacrene. Their LC50 were 4.17 and 10.3µg/ml for A. subpictus, 4.60 and 11.1µg/ml for A. albopictus, 5.11 and 12.5µg/ml for C. tritaeniorhynchus. Notably, the EO and its major compounds were safer to three non-target mosquito predators, Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 ranging from 206 to 4219µg/ml. Overall, this study highlights that H. sprengelianum EO is a promising source of eco-friendly larvicides against three important mosquito vectors with moderate toxicity against non-target aquatic organisms.
[Mh] Termos MeSH primário: Culicidae/efeitos dos fármacos
Dengue
Encefalite Japonesa
Inseticidas/toxicidade
Malária
Mosquitos Vetores
Óleos Voláteis/toxicidade
[Mh] Termos MeSH secundário: Acetatos/toxicidade
Aedes/efeitos dos fármacos
Animais
Anopheles/efeitos dos fármacos
Dengue/prevenção & controle
Dengue/transmissão
Encefalite Japonesa/prevenção & controle
Encefalite Japonesa/transmissão
Meio Ambiente
Heracleum/química
Seres Humanos
Índia
Inseticidas/análise
Larva/efeitos dos fármacos
Malária/prevenção & controle
Malária/transmissão
Monoterpenos/toxicidade
Controle de Mosquitos
Óleos Voláteis/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Sesquiterpenos de Germacrano/toxicidade
Infecção pelo Zika virus/prevenção & controle
Infecção pelo Zika virus/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Insecticides); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes, Germacrane); 0 (lavandulyl acetate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


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[PMID]:27396211
[Au] Autor:Usjak L; Petrovic S; Drobac M; Sokovic M; Stanojkovic T; Ciric A; Niketic M
[Ti] Título:Chemical Composition and Bioactivity of the Essential Oils of Heracleum pyrenaicum subsp. pollinianum and Heracleum orphanidis.
[So] Source:Nat Prod Commun;11(4):529-34, 2016 Apr.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this research was to analyze the chemical composition, antimicrobial and cytotoxic activity of Heracleun pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti (HPP) and H. orphanidis Boiss. (HO) essential oils. The composition of the oils was analyzed by GC and GC-MS. ß-Pinene (35.1%) was the most abundant compound in HPP root oil, while (Z)-falcarinol (80.0%) dominated in HO root oil. (E)-Nerolidol (28.5%) was the main constituent in HPP leaf oil. HPP fruit oil, as well as HO leaf and fruit oils mainly contained aliphatic esters, mostly octyl acetate (50.5-84.5%). Antimicrobial screening was performed by microdilution method against eight bacterial and eight fungal strains. The strongest antibacterial activity was shown by both root oils (MICs 0.02-0.60 mg/mL and MBCs 0.04-2.50 mg/mL for HPP, and MICs 0.02-1.25 mg/mL and MBCs 0.04-2.50 mg/mL for HO), while the best antifungal potential was exhibited by HPP fruit oil (MICs 0.30-0.60 mg/mL and MFCs 0.60-1.25 mg/mL) and HO leaf oil (MICs 0.15-0.63 mg/mL and MFCs 0.30-1.25 mg/mL). The tested root and fruit oils exhibited strong cytotoxic effect, which was determined by MTT test against HeLa (IC50 7.53-21.07 µg/mL) and LS174 (IC50 24.16-58.86 µg/mL) cell lines.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Antineoplásicos Fitogênicos/análise
Heracleum/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Ensaios de Seleção de Medicamentos Antitumorais
Células HeLa
Seres Humanos
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Oils, Volatile)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160711
[Lr] Data última revisão:
160711
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


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[PMID]:26991469
[Au] Autor:Usjak LJ; Petrovic SD; Drobac MM; Sokovic MD; Stanojkovic TP; Ciric AD; Grozdanic NÐ; Niketic MS
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, RS-11221, Belgrade.
[Ti] Título:Chemical Composition, Antimicrobial and Cytotoxic Activity of Heracleum verticillatum Pancic and H. ternatum Velen. (Apiaceae) Essential Oils.
[So] Source:Chem Biodivers;13(4):466-76, 2016 Apr.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this work, the chemical composition, antimicrobial and cytotoxic activity of Heracleum verticillatum Pancic and H. ternatum Velen. root, leaf, and fruit essential oils were investigated. The composition was analyzed by GC and GC/MS. Heracleum verticillatum and H. ternatum root oils were dominated by monoterpenes, mostly ß-pinene (23.5% and 47.3%, respectively). Heracleum verticillatum leaf oil was characterized by monoterpenes, mainly limonene (20.3%), and sesquiterpenes, mostly (E)-caryophyllene (19.1%), while H. ternatum leaf oil by the high percentage of phenylpropanoids, with (Z)-isoelemicin (35.1%) being dominant constituent. Both fruit oils contained the majority of aliphatic esters, mostly octyl acetate (42.3% in H. verticillatum oil and 49.0% in H. ternatum oil). The antimicrobial activity of the oils was determined by microdilution method against eight bacterial and eight fungal strains. The strongest effect was exhibited by H. verticillatum root oil, particularly against Staphylococcus aureus, Salmonella typhimurium (MICs = 0.14 mg/ml, MBCs = 0.28 mg/ml), and Trichoderma viride (MIC = 0.05 mg/ml, MFC = 0.11 mg/ml). Cytotoxic effect was determined by MTT test against malignant HeLa, LS174, and A549 cells (IC50 = 5.9 - 146.0 µg/ml), and against normal MRC-5 cells (IC50 > 120.1 µg/ml). The best effect was exhibited by H. verticillatum root oil on A549 cells (IC50 = 5.9 µg/ml), and H. ternatum root oil against LS174 cells (IC50 = 6.7 µg/ml).
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Apiaceae/química
Heracleum/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents, Phytogenic)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500151



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