Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.488 [Categoria DeCS]
Referências encontradas : 7 [refinar]
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  1 / 7 MEDLINE  
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[PMID]:26669116
[Au] Autor:Zhang C; Mei Z; Cheng J; He Y; Khan MA; Luo P; Imani S; Fu J
[Ti] Título:Development of SCAR Markers Based on Improved RAPD Amplification Fragments and Molecular Cloning for Authentication of Herbal Medicines Angelica sinensis, Angelica acutiloba and Levisticum officinale.
[So] Source:Nat Prod Commun;10(10):1743-7, 2015 Oct.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Molecular cloning from DNA fragments of improved RAPD amplification of Angelica sinensis, Angelica acutiloba and Levisticum officinale, provided novel sequence-characterized amplified region (SCAR) markers A13, A23, A1-34 and A1-0 whose sequences were deposited in the GenBank database with the accession numbers KP641315, KP641316, KP641317 and KP641318, respectively. By optional PCR amplification, the SCAR markers A13 and A23 are Levisticum officinale-specific, whereas the SCAR marker A1-34 is Angelica acutiloba-specific, and the SCAR marker A1-0 is Angelica sinensis-specific. These diagnostic SCAR markers may be useful for genetic authentications, for ecological conservation of all three medicinal plants and as a helpful tool for the genetic authentication of adulterant samples.
[Mh] Termos MeSH primário: Angelica/genética
Marcadores Genéticos
Levisticum/genética
Preparações de Plantas/química
[Mh] Termos MeSH secundário: Angelica/química
Sequência de Bases
China
Clonagem Molecular
DNA de Plantas/genética
Demografia
Levisticum/química
Técnica de Amplificação ao Acaso de DNA Polimórfico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Genetic Markers); 0 (Plant Preparations)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151216
[Lr] Data última revisão:
151216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151217
[St] Status:MEDLINE


  2 / 7 MEDLINE  
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[PMID]:24961287
[Au] Autor:Yuan QJ; Zhang B; Jiang D; Zhang WJ; Lin TY; Wang NH; Chiou SJ; Huang LQ
[Ad] Endereço:State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
[Ti] Título:Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes.
[So] Source:Mol Ecol Resour;15(2):358-71, 2015 Mar.
[Is] ISSN:1755-0998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes.
[Mh] Termos MeSH primário: Angelica/classificação
Angelica/genética
Código de Barras de DNA Taxonômico/métodos
Materia Medica/isolamento & purificação
Filogenia
Plantas Medicinais/classificação
Plantas Medicinais/genética
[Mh] Termos MeSH secundário: China
Análise por Conglomerados
DNA de Plantas/química
DNA de Plantas/genética
DNA Espaçador Ribossômico/química
DNA Espaçador Ribossômico/genética
Levisticum/classificação
Levisticum/genética
Dados de Sequência Molecular
Análise de Sequência de DNA
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant); 0 (DNA, Ribosomal Spacer); 0 (Materia Medica)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140626
[St] Status:MEDLINE
[do] DOI:10.1111/1755-0998.12296


  3 / 7 MEDLINE  
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[PMID]:24338945
[Au] Autor:Zawirska-Wojtasiak R; Wojtowicz E; Przygonski K; Olkowicz M
[Ad] Endereço:Department of Food Science and Nutrition, Poznan University of Life Sciences, PL-60-637, Poznan, Poland.
[Ti] Título:Chlorogenic acid in raw materials for the production of chicory coffee.
[So] Source:J Sci Food Agric;94(10):2118-23, 2014 Aug.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chicory coffee is produced from traditional raw materials. Other materials are added to improve its aroma. The aim of this study was to test new raw materials with a high content of chlorogenic acid (CGA) as the criterion for their selection. This acid is degraded in the course of roasting and is a source of phenolic compounds affecting coffee aroma. For this reason, contents of CGAs were analyzed in traditional and new materials before and after roasting and compared with the chemicals formed in the roasted pure standard of chlorogenic acid (5-CQA). RESULTS: It was shown that the novel raw materials contained considerable amounts of 5-CQA, frequently higher than in traditional chicory. The roasting process caused significant losses of 5-CQA in the tested raw materials, amounting to 55-91%. In turn, the analysis of volatile compounds in roasted materials showed the presence of certain phenolic and heterocyclic compounds that were also formed as degradation products of the pure 5-CQA chemical standard. CONCLUSION: Novel raw materials, mainly chokeberry, artichoke and lovage, are rich sources of CGAs, particularly 5-CQA. Their application in the production of chicory coffee may result in an increased content of primarily phenolic compounds in its aroma.
[Mh] Termos MeSH primário: Bebidas
Chicória/química
Ácido Clorogênico/análise
Cynara scolymus/química
Temperatura Alta
Levisticum/química
Photinia/química
[Mh] Termos MeSH secundário: Café
Culinária/métodos
Seres Humanos
Odorantes
Fenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coffee); 0 (Phenols); 318ADP12RI (Chlorogenic Acid)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131217
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.6532


  4 / 7 MEDLINE  
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[PMID]:23948036
[Au] Autor:Lapeere H; Boone B; Verhaeghe E; Ongenae K; Lambert J
[Ad] Endereço:Department of Dermatology, Ghent University Hospital, Ghent, 9000, Belgium. hilde.lapeere@ugent.be
[Ti] Título:Contact dermatitis caused by lovage (Levisticum officinalis) essential oil.
[So] Source:Contact Dermatitis;69(3):181-2, 2013 Sep.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite de Contato/etiologia
Levisticum/imunologia
Óleos Voláteis
[Mh] Termos MeSH secundário: Dermatite de Contato/tratamento farmacológico
Feminino
Seres Humanos
Testes do Emplastro
Esteroides/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Steroids)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:130816
[Lr] Data última revisão:
130816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130817
[St] Status:MEDLINE
[do] DOI:10.1111/cod.12082


  5 / 7 MEDLINE  
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[PMID]:21273597
[Au] Autor:Sertel S; Eichhorn T; Plinkert PK; Efferth T
[Ad] Endereço:Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
[Ti] Título:Chemical Composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells.
[So] Source:Anticancer Res;31(1):185-91, 2011 Jan.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC). MATERIALS AND METHODS: Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses. RESULTS: Lovage essential oil extract had an IC50 value of 292.6 µg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling. CONCLUSION: Levisticum officinale essential oil inhibits human HNSCC cell growth.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Proliferação Celular/efeitos dos fármacos
Neoplasias de Cabeça e Pescoço/patologia
Levisticum/química
Folhas de Planta/química
Óleos Vegetais/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Biomarcadores Tumorais/genética
Biomarcadores Tumorais/metabolismo
Carcinoma de Células Escamosas/tratamento farmacológico
Carcinoma de Células Escamosas/genética
Cromatografia Gasosa
Perfilação da Expressão Gênica
Neoplasias de Cabeça e Pescoço/tratamento farmacológico
Neoplasias de Cabeça e Pescoço/genética
Seres Humanos
Análise de Sequência com Séries de Oligonucleotídeos
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Plant Oils)
[Em] Mês de entrada:1103
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110129
[St] Status:MEDLINE


  6 / 7 MEDLINE  
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[PMID]:19156598
[Au] Autor:Nunes IS; Faria JM; Figueiredo AC; Pedro LG; Trindade H; Barroso JG
[Ad] Endereço:Universidade de Lisboa, Faculdade de Ciências de Lisboa, Departamento de Biologia Vegetal, Instituto de Biotecnologia e Bioengenharia, Centro de Biotecnologia Vegetal, Lisbon, Portugal.
[Ti] Título:Menthol and geraniol biotransformation and glycosylation capacity of Levisticum officinale hairy roots.
[So] Source:Planta Med;75(4):387-91, 2009 Mar.
[Is] ISSN:0032-0943
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The biotransformation capacity of Levisticum officinale W.D.J. Koch hairy root cultures was studied by evaluating the effect of the addition of 25 mg/L menthol or geraniol on morphology, growth, and volatiles production. L. officinale hairy root cultures were maintained for 7 weeks in SH medium, in darkness at 24 degrees C and 80 r.p.m., and the substrates were added 15 days after inoculation. Growth was evaluated by measuring fresh and dry weight and by using the dissimilation method. Volatiles composition was analyzed by GC and GC-MS. Hairy roots morphology and growth were not influenced by substrate addition. No new volatiles were detected after menthol addition and, as was also the case with the control cultures, volatiles of these hairy roots were dominated by (Z)-falcarinol (1-45%), N-octanal (3-8%), palmitic acid (3-10%), and (Z)-ligustilide (2-9%). The addition of geraniol induced the production of six new volatiles: nerol/citronellol/neral (traces-15%), alpha-terpineol (0.2-3%), linalool (0.1-1.2%), and geranyl acetate (traces-2%). The relative amounts of the substrates and some of their biotransformation products decreased during the course of the experiment. Following the addition of beta-glycosidase to the remaining distillation water, analysis of the extracted volatiles showed that lovage hairy roots were able to convert both substrates and their biotransformation products into glycosidic forms. GC:gas chromatography GC-MS:gas chromatography-mass spectrometry SH:Schenk and Hildebrandt (1972) culture medium.
[Mh] Termos MeSH primário: Levisticum/metabolismo
Mentol/metabolismo
Raízes de Plantas/metabolismo
Terpenos/metabolismo
[Mh] Termos MeSH secundário: Glicosilação
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Terpenes); 1490-04-6 (Menthol); L837108USY (geraniol)
[Em] Mês de entrada:0905
[Cu] Atualização por classe:121115
[Lr] Data última revisão:
121115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090122
[St] Status:MEDLINE
[do] DOI:10.1055/s-0028-1112217


  7 / 7 MEDLINE  
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[PMID]:18273553
[Au] Autor:Costa MM; Figueiredo AC; Barroso JG; Pedro LG; Deans SG; Scheffer JJ
[Ad] Endereço:Universidade de Lisboa, Faculdade de Ciências de Lisboa, Dep. de Biologia Vegetal, Centro de Biotecnologia Vegetal, 1749-016, Lisbon, Portugal.
[Ti] Título:Nitrogen stress induction on Levisticum officinale hairy roots grown in darkness and under photoperiod conditions: effect on growth and volatile components.
[So] Source:Biotechnol Lett;30(7):1265-70, 2008 Jul.
[Is] ISSN:0141-5492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Six-year-old Levisticum officinale (lovage) hairy root cultures were used to study the effect of eight different NH(4) (+):NO(3) (-) ratios on their growth and volatile components. All cultures were kept at 24 degrees C on orbital shakers at 80 rpm, in darkness or in a 16 h light/8 h dark photoperiod. Growth was evaluated by dry and fresh weight determination. The volatiles were isolated by distillation-extraction and analysed by GC and GC-MS. Greater growth was attained in darkness with 10:90 (control, SH medium), 50:50 and 25:75 NH(4) (+):NO(3) (-) ratios, and also with SH control medium under the photoperiod condition, with a 10, 14, 12.5 and 12.5 fold increase of biomass in terms of dry weight, respectively, at the end of 42 days of growth. UPGMA cluster analysis of the mixtures of volatiles isolated from the hairy roots grown with different NH(4) (+):NO(3) (-) ratios confirmed their chemical variability. Although no particular grouping was detected in relation to the NH(4) (+):NO(3) (-) ratios or light conditions studied, most of the mixtures of volatiles isolated from the hairy roots were either dominated by n-octanal, (Z)-falcarinol or both components in about the same relative amounts.
[Mh] Termos MeSH primário: Escuridão
Levisticum/metabolismo
Nitrogênio/metabolismo
Óleos Voláteis/metabolismo
Fotoperíodo
Raízes de Plantas/metabolismo
[Mh] Termos MeSH secundário: Amônia/farmacologia
Levisticum/química
Levisticum/citologia
Nitratos/farmacologia
Óleos Voláteis/análise
Raízes de Plantas/química
Raízes de Plantas/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nitrates); 0 (Oils, Volatile); 7664-41-7 (Ammonia); N762921K75 (Nitrogen)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080215
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-008-9664-y



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