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Pesquisa : B01.650.940.800.575.912.250.075.511 [Categoria DeCS]
Referências encontradas : 240 [refinar]
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[PMID]:28276766
[Au] Autor:Wei W; Xu W; Yang XW
[Ad] Endereço:a State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center , Peking University , Beijing 100191 , China.
[Ti] Título:Two new phthalide dimers from the rhizomes of Ligusticum chuanxiong.
[So] Source:J Asian Nat Prod Res;19(7):704-711, 2017 Jul.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two pairs of diastereoisomers, namely (3'Z)-(3S,8S,3a'S,6'R)-4,5-dehydro-3.3a',8.6'-diligustilide (1) and (3'Z)-(3S,8R,3a'S,6'R)-4,5-dehydro-3.3a',8.6'-diligustilide (3), chuanxiongdiolide R3 (2), and chuanxiongdiolide R1 (4), were isolated from the 95% ethanolic aqueous extract of the rhizomes of Ligusticum chuanxiong. Among these Phthalide dimers, compounds 1 and 2 were new ones. The structures of the new isolates were elucidated based on spectroscopic data analyses, and their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra.
[Mh] Termos MeSH primário: Benzofuranos/isolamento & purificação
Ligusticum/química
Rizoma/química
[Mh] Termos MeSH secundário: Benzofuranos/química
Dicroísmo Circular
Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((3'Z)-(3S,8S,3a'S,6'R)-4,5-dehydro-3.3a',8.6'-diligustilide); 0 (Benzofurans); 0 (Drugs, Chinese Herbal); 8VV922U86J (phthalide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1275584


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[PMID]:28216596
[Au] Autor:Zou YF; Fu YP; Chen XF; Austarheim I; Inngjerdingen KT; Huang C; Eticha LD; Song X; Li L; Feng B; He CL; Yin ZQ; Paulsen BS
[Ad] Endereço:Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China. yuanfengzou@sicau.edu.cn.
[Ti] Título:Purification and Partial Structural Characterization of a Complement Fixating Polysaccharide from Rhizomes of Ligusticum chuanxiong.
[So] Source:Molecules;22(2), 2017 Feb 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Rhizome of is an effective medical plant, which has been extensively applied for centuries in migraine and cardiovascular diseases treatment in China. Polysaccharides from this plant have been shown to have interesting bioactivities, but previous studies have only been performed on the neutral polysaccharides. In this study, LCP-I-I, a pectic polysaccharide fraction, was obtained from the 100 °C water extracts of rhizomes and purified by diethylaminethyl (DEAE) sepharose anion exchange chromatography and gel filtration. Monosaccharide analysis and linkage determination in addition to Fourier transform infrared (FT-IR) spectrometer and Nuclear magnetic resonance (NMR) spectrum, indicated that LCP-I-I is a typical pectic polysaccharide, with homo-galacturonan and rhamnogalacturonan type I regions and arabinogalactan type I and type II (AG-I/AG-II) side chains. LCP-I-I exhibited potent complement fixation activity, ICH of 26.3 ± 2.2 µg/mL, and thus has potential as a natural immunomodulator.
[Mh] Termos MeSH primário: Ativação do Complemento
Medicamentos de Ervas Chinesas/química
Ligusticum/química
Pectinas/química
[Mh] Termos MeSH secundário: Cromatografia DEAE-Celulose
Cromatografia Gasosa
Testes de Fixação de Complemento
Galactanos/química
Cromatografia Gasosa-Espectrometria de Massas
Espectroscopia de Ressonância Magnética
Peso Molecular
Monossacarídeos/química
Plantas Medicinais/química
Rizoma/química
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Galactans); 0 (Monosaccharides); 0 (Pectins); 0 (chuanxiong rhizome preparation); 0 (rhamnogalacturonan I); SL4SX1O487 (arabinogalactan)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28040510
[Au] Autor:Wang JY; Chen WM; Wen CS; Hung SC; Chen PW; Chiu JH
[Ad] Endereço:Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. Electronic address: jywang7@vghtpe.gov.tw.
[Ti] Título:Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells.
[So] Source:J Ethnopharmacol;198:64-72, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Postmenopausal osteoporosis is the most common bone disease worldwide. Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking. AIM OF THIS STUDY: This study was designed to investigate the effects of Du-Huo-Ji-Sheng-Tang (DHJST), a Chinese herbal medicine and its active component Ligusticum chuanxiong on osteogenic differentiation and the aging process of human mesenchymal cells (hMSCs). MATERIALS & METHODS: hMSCs were used as in vitro model and osteogenesis was induced by administration of either osteogenesis inducing medium (OIM) or dexamethasone-depleted OIM (DDOIM) for 1-week or 2 weeks and the results were evaluated by measuring the formation of mineralization nodules. The effects of the compound recipe DHJST and its active component L. chuanxiong on hMSCs osteogenesis-related gene expression was determined by real-time PCR that targeted bone morphogenetic protein-2 (BMP2), RUNX2, ALP, COL-1, osteopontin (OPN), and osteocalcin (OCN). Antibodies against BMP-related signaling pathway proteins, such as BMP-2, ERK, SMAD 1/5/8, and RUNX2, were also detected at the protein level by Western blotting. Finally, the cumulative growth curve and senescence of the hMSCs were evaluated in order to assess the aging process. RESULTS: L. chuanxiong increased osteogenic activity in hMSCs and up-regulated BMP-2 and RUNX2 gene expression via the activation of SMAD 1/5/8 and ERK signaling. Furthermore DHJST also showed a trend towards promoting the same effects in the same system. In the absence of dexamethasone, DHJST did activate SMAD 1/5/8 and ERK signaling and hence increased RUNX2 protein expression in hMSCs. In addition, both DHJST and L. chuanxiong delayed the hMSCs aging process by decreasing cell senescence. CONCLUSIONS: We concluded that DHJST and its active component L. chuanxiong are able to promote osteogenic activity and decrease hMSCs senescence as cells age.
[Mh] Termos MeSH primário: Senescência Celular/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Ligusticum
Células Mesenquimais Estromais/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteína Morfogenética Óssea 2/genética
Diferenciação Celular/efeitos dos fármacos
Células Cultivadas
Subunidade alfa 1 de Fator de Ligação ao Core/genética
Seres Humanos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Células Mesenquimais Estromais/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BMP2 protein, human); 0 (Bone Morphogenetic Protein 2); 0 (Core Binding Factor Alpha 1 Subunit); 0 (Drugs, Chinese Herbal); 0 (RUNX2 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


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[PMID]:27752792
[Au] Autor:Yu JH; Li YY; Xiang M; Zhu JQ; Huang XH; Wang WJ; Tan R; Zhou JY; Liao H
[Ad] Endereço:School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China.
[Ti] Título:Molecular cloning and characterization of α-amylase/subtilisin inhibitor from rhizome of Ligusticum chuanxiong.
[So] Source:Biotechnol Lett;39(1):141-148, 2017 Jan.
[Is] ISSN:1573-6776
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To clone and characterize a novel bi-functional α-amylase/subtilisin inhibitor (LASI) from the rhizome of Ligusticum chuanxiong, a traditional Chinese medicine. RESULTS: The LASI showed strong homology with members of the Kunitz trypsin inhibitor family. Its putative amino acid sequence has a 40 % identity with that of the α-amylase/subtilisin inhibitor from rice. LASI gene without signal peptide was expressed in E. coli Rosetta. After purification, the recombinant LASI protein was inhibitory against not only α-amylase from porcine pancreas, Helicoverpa armigera, Spodoptera litura and Plutella xylostella, but also subtilisin A, but not against trypsin or chymotrypsin. In addition, the expression level of LASI in rhizome was higher than that in leaf and LASI expression was enhanced by salt, chilling and drought treatment. CONCLUSIONS: This is the first member of the Kunitz-protease inhibitor family identified in traditional Chinese medicine and it might be involved in the plant defense responses against lepidopterous pests, microorganisms and abiotic stresses.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/metabolismo
Ligusticum/metabolismo
Rizoma/metabolismo
Subtilisina/antagonistas & inibidores
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Clonagem Molecular
Inibidores Enzimáticos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); EC 3.2.1.1 (alpha-Amylases); EC 3.4.21.62 (Subtilisin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-016-2227-8


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[PMID]:27919258
[Au] Autor:Ma Q; Ma C; Wu F; Xiong YK; Feng Y; Liang S
[Ad] Endereço:Engineering Research Center of Modern Preparation of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Room 5117, No. 1200 Cai Lun Road, Pudong District, Shanghai, 201203, People's Republic of China.
[Ti] Título:Preparation and structural determination of four metabolites of senkyunolide I in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass and nuclear magnetic resonance spectra.
[So] Source:BMC Complement Altern Med;16(1):504, 2016 Dec 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Senkyunolide I (SEI) is one of the most important bioactive phthalides of Ligusticum chuanxiong Hort. (Umbelliferae), a Traditional Chinese Medicine. Our previous studies suggested that it might be developed as a potential treatment for migraine. METHODS: In this paper, we aimed to isolate and characterize the main metabolites of SEI after gavage feeding in rats. Their structures were identified precisely on the basis of nuclear magnetic resonance (NMR) spectroscopy and UPLC/Q-TOF-MS spectrometry. We also established the main metabolic pathways of SEI in rats. RESULTS: Four metabolites (M1-M4) were isolated, for the first time, from bile samples of rats by preparative high-performance liquid chromatography. Their structures were determined as SEI-6S-O-ß-D-glucuronide (M1), SEI-7S-O-ß-D-glucuronide (M2), SEI-7S-S-glutathione (M3) and SEI-7R-S-glutathione (M4) on the basis of the molecular mass of the analytes, using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and 1D and 2D NMR. CONCLUSIONS: The results demonstrated that glucuronide and glutathione conjugation were the major pathways of SEI metabolism in vivo, and the configuration at the 7th-position could be inverted during glutathione conjugation.
[Mh] Termos MeSH primário: Benzofuranos/química
Medicamentos de Ervas Chinesas/química
Ligusticum/química
[Mh] Termos MeSH secundário: Animais
Benzofuranos/metabolismo
Cromatografia Líquida de Alta Pressão
Imagem por Ressonância Magnética
Masculino
Estrutura Molecular
Ratos
Ratos Sprague-Dawley
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Drugs, Chinese Herbal); 12PJ07292V (senkyunolide I)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


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[PMID]:27915331
[Au] Autor:Liu X; Li X; Ji S; Cui X; Li M
[Ad] Endereço:Department of Pharmacy, No.401 Hospital of PLA, Qingdao, China.
[Ti] Título:Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia.
[So] Source:Cell Physiol Biochem;40(3-4):770-780, 2016.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. METHODS: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC. RESULTS: The bioactive components of LCH were ligustrazine, ferulic acid, cnidilide and ligustilide. Ligustrazine and ferulic acid could significantly reduce serum lactic acid in canine model of acute myocardial ischemia, while ligustilide could significantly reduce the elevation of serum free fatty acid. CONCLUSIONS: The spectrum-effect relationship study shows that the effective components of LCH are ligustrazine, ferulic acid, cnidilide and ligustilide, which have protective effect on myocardial ischemia.
[Mh] Termos MeSH primário: Cardiotônicos/análise
Cardiotônicos/uso terapêutico
Ligusticum/química
Isquemia Miocárdica/tratamento farmacológico
[Mh] Termos MeSH secundário: 4-Butirolactona/análogos & derivados
4-Butirolactona/farmacologia
4-Butirolactona/uso terapêutico
Animais
Cardiotônicos/farmacologia
Cromatografia Líquida de Alta Pressão
Ácidos Cumáricos/farmacologia
Ácidos Cumáricos/uso terapêutico
Modelos Animais de Doenças
Cães
Infarto do Miocárdio/sangue
Infarto do Miocárdio/complicações
Infarto do Miocárdio/tratamento farmacológico
Infarto do Miocárdio/patologia
Isquemia Miocárdica/sangue
Isquemia Miocárdica/complicações
Isquemia Miocárdica/patologia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Padrões de Referência
Rizoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Coumaric Acids); 0 (Plant Extracts); 4431-01-0 (ligustilide); AVM951ZWST (ferulic acid); OL659KIY4X (4-Butyrolactone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27819731
[Au] Autor:Wu JS; Zhang PM; Sun LJ; Liu XZ
[Ad] Endereço:Department of Urology, the Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
[Ti] Título:Liguisticum wallichii inhibits renal carcinoma progression by downregulating UBE3A and through suppression of NF-κB signaling.
[So] Source:Genet Mol Res;15(4), 2016 Nov 03.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Renal carcinoma accounts for a fifth of the morbidity among malignant tumors in China. Ubiquitin-protein ligase E3A (UBE3A) plays an important role in the occurrence and development of gene mutation-induced diseases. This study was designed to investigate the mechanism of Liguistium wallichii in treating renal carcinoma. Hematoxylin and eosin staining was applied to detect the pathological changes in a rat renal carcinoma model. The experimental group received L. wallichii treatment at 100 mg/kg every 48 h for 4 weeks, while the control group only received normal saline. The proliferation index Ki67 was measured by immunohistochemistry. Primary renal carcinoma cells were isolated and UBE3A expression was measured by quantitative polymerase chain reaction. The related signaling pathway was screened by the Pathway Finder Array. pP65 nuclear import was detected by immunofluorescence. A total of 60 rats were used for the renal carcinoma model, of which 58 rats were successfully established and equally divided into two groups: L. wallichii and normal saline. Ki67 expression decreased in the L. wallichii group and was upregulated in the normal saline group. Histological analysis showed significant renal cell nucleus division in the normal saline group. The UBE3A level decreased after L. wallichii treatment compared to the level in the normal saline group. The Pathway Finder Array revealed that the NF-κB signaling pathway was activated, and pP65 presented obvious nuclear import in the normal saline group. In conclusion, L. wallichii inhibits renal carcinoma progression by downregulating UBE3A and suppressing the NF-κB signaling pathway.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/patologia
Progressão da Doença
Regulação para Baixo
Neoplasias Renais/patologia
Ligusticum/química
NF-kappa B/metabolismo
Ubiquitina-Proteína Ligases/genética
[Mh] Termos MeSH secundário: Animais
Carcinoma de Células Renais/tratamento farmacológico
Carcinoma de Células Renais/genética
Modelos Animais de Doenças
Regulação para Baixo/efeitos dos fármacos
Antígeno Ki-67/metabolismo
Neoplasias Renais/tratamento farmacológico
Neoplasias Renais/genética
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Transdução de Sinais/efeitos dos fármacos
Ubiquitina-Proteína Ligases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0 (NF-kappa B); 0 (Plant Extracts); EC 2.3.2.26 (UBE3A protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE
[do] DOI:10.4238/gmr15049023


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[PMID]:27754334
[Au] Autor:Zhang C; Liu R; He J; Ma Z; Zhang X
[Ad] Endereço:Research and Development Center of Biorational Pesticide, Northwest Agriculture & Forestry University, Yangling 712100, Shaanxi, China. zhangchao1990@nwsuaf.edu.cn.
[Ti] Título:Chemical Compositions of Ligusticum chuanxiong Oil and Lemongrass Oil and Their Joint Action against Aphis citricola Van Der Goot (Hemiptera: Aphididae).
[So] Source:Molecules;21(10), 2016 Oct 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In order to develop novel botanical insecticides, the joint action of oil (LCO) and lemongrass oil (LO) against van der Goot was determined systematically indoors and outdoors. The chemical profiles of LCO and LO as determined by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the main compounds from LCO were ( )-ligustilide (44.58%) and senkyunolide A (26.92%), and that of LO were geranial (42.16%) and neral (32.58%), respectively. The mixture of LCO and LO showed significant synergy against , with a common-toxicity coefficient (CTC) value of 221.46 at the optimal ratio of LCO to LO (4:1, : ). Based on the results of solvents and emulsifiers screening, oil·Lemongrass oil 20% emulsifiable concentrate (20% LCO·LO EC) was developed, and its stability was confirmed with tests of cold and thermal storage. Field trials indicated that the insecticidal activity of the diluted 20% LCO·LO EC (1000 fold dilution) was comparable to conventional pesticide (20% imidacloprid EC) on seven days after application. Thus, the mixture of LCO and LO has the potential to be further developed as a botanical pesticide.
[Mh] Termos MeSH primário: Afídeos/efeitos dos fármacos
Cymbopogon/química
Ligusticum/química
Óleos Vegetais/química
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Sinergismo Farmacológico
Emulsificantes/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Inseticidas/química
Inseticidas/farmacologia
Estrutura Molecular
Solventes/análise
Terpenos/química
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Insecticides); 0 (Plant Oils); 0 (Solvents); 0 (Terpenes); 5BIA40E9ED (lemongrass oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27729283
[Au] Autor:Donkor PO; Chen Y; Ding L; Qiu F
[Ad] Endereço:School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; University of Ghana School of Pharmacy, P.O. Box KB 52, Korle-Bu, Ghana.
[Ti] Título:Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics.
[So] Source:J Ethnopharmacol;194:530-548, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Ligusticum species (Umbelliferae) have been widely used in traditional Chinese medicine, Korean folk medicine and Native American medicine for their medicinal and nutritional value. Decoctions of the rhizomes are used in treatment and prophylaxis of migraine, anemia and cardiovascular conditions including stroke. AIM OF STUDY: This review is intended to fully compile the constituents of locally and traditionally used Ligusticum species, present their bioactivities and highlight potential leads for future drug design, and thus, provide a reference for further research and application of these species. Emphasis is also placed on current trends in the pharmacokinetic studies of the major constituents. METHODS: The literature discussed is derived from readily accessible papers spanning the early 1990s to the end of 2015. Information was collected from journals, books and online searches (Google Scholar, PubMed, ScienceDirect, SciFinder, Springerlink and CNKI). RESULTS: The major phytoconstituents, 154 of which are presented in this review, include alkaloids, phthalides and phenolic acids. The crude extracts and isolated constituents have exhibited a wide range of in vitro and in vivo pharmacologic effects, including cardioprotective, antioxidant, anti-inflammatory and neuroprotective activities. The bioactive alkaloid tetramethylpyrazine (TMP) has attracted the most attention for its potent effect on calcium channels, anti-platelet as well as anti-inflammatory effects. Pharmacokinetic studies of major constituents have also been summarized. CONCLUSION: The pthalides, organic acids and alkaloids of Ligusticum species have emerged as a good source of traditional medicines for the management of cardio- and cerebrovascular conditions, inflammation and neurogenerative disorders. The species discussed in this review have demonstrated wide pharmacological actions and have great potential to yield multipotent drugs if challenges such as poor bioavailability, solubility and toxicological profiles are addressed. Apart from the rhizomes, pharmacological activities of other botanical parts also need to be studied further. Expansion of research to cover other species in the Ligusticum genus would provide more opportunities for the discovery of new bioactive principles.
[Mh] Termos MeSH primário: Ligusticum/química
Medicina Tradicional
Compostos Fitoquímicos/uso terapêutico
[Mh] Termos MeSH secundário: Farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


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[PMID]:27632784
[Au] Autor:Wu C; Zhao L; Rong Y; Zhu G; Liang S; Wang S
[Ad] Endereço:Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
[Ti] Título:The pharmacokinetic screening of multiple components of the Nao Mai Tong formula in rat plasma by liquid chromatography tandem mass spectrometry combined with pattern recognition method and its application to comparative pharmacokinetics.
[So] Source:J Pharm Biomed Anal;131:345-354, 2016 Nov 30.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Nao Mai Tong formula (NMT) is composed of Rhubarb, Ginseng, Ligusticum wallichii and Pueraria in a ratio of 3:3:2:2 (w/w) and is a well-known traditional Chinese prescription that has been clinically employed for treating ischemia cerebrovascular disease. The goal of this study was to investigate the pharmacokinetics of multiple components (chryohol-8-O-ß-D-glucoyroide, physcion-8-O-ß-D-glucopyranoside, aloe-emodin, rhein, emodin, chrysophanol, ginsenoside Rg , ginsenoside Rb , ginsenoside Rb ginsenoside Rc, senkyunolide I, ligustilide puerarin, daidzein, 3'-methoxy puerarin) after the oral administration of the NMT formula in rats. A rapid and sensitive UHPLC-Quadrupole-Orbitrap-MS with a sequential positive and negative ionization mode was developed to determine the 15 absorbed ingredients. After extraction from blood, the analytes and internal standards were subjected to ultra-high performance liquid chromatography with Agela Venusil MPC (2.1mm×100mm, 3µm, Agela, USA). The mobile phase consisted of methanol and ammonium acetate (3mmolL ) under gradient elution conditions. This validated method was successfully applied to a comparative pharmacokinetic study of fifteen components in rat plasma after oral administration of the NMT formula or single herb extracts to normal and stroke-afflicted rats. A principal component analysis (PCA) was utilized to evaluate the differences in the pharmacokinetic behavior (time-course) of the absorbed components of NMT, and the absorbed components were assigned to 3 separate clusters. A comparison of the body dynamics of each group indicated that cluster B (ginsenoside Rg , ginsenoside Rb , ginsenoside Rb ginsenoside Rc) might be the most important constituents controlling the pharmacological effects of NMT. The comparative pharmacokinetic study showed that the different groups had different pharmacokinetic characteristics. The pharmacokinetics-based UHPLC Quadrupole-Orbitrap-MS using a full-scan mode combined with a pattern recognition approach can provide a reliable and suitable means of screening and identifying potentially bioactive components that contribute to the pharmacological effects of Traditional Chinese Medicine (TCM).
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacocinética
Ligusticum
Panax
Pueraria
Rheum
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cromatografia Líquida de Alta Pressão/métodos
Composição de Medicamentos
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/química
Ligusticum/metabolismo
Panax/metabolismo
Pueraria/metabolismo
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Rheum/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE



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