Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.568 [Categoria DeCS]
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[PMID]:28160865
[Au] Autor:Ahn H; Lee GS
[Ad] Endereço:College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
[Ti] Título:Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation.
[So] Source:Phytomedicine;24:77-86, 2017 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Water dropwort (Oenanthe javanica), an umbelliferous plant, has been reported as hypolipidemic, antiplatelet, antitumor, or immune-stimulating agents and it has been suggested to cure cardiovascular disease and cancer. PURPOSE: Present study aimed to evaluate the effect of the extracts of water dropwort (EWD) and its pharmacological molecules, hyperoside and isorhamnetin, on inflammatory response, especially inflammasome activation. STUDY DESIGN/METHODS: The anti-inflammasome properties of EWD, isorhamnetin, and hyperoside were elucidated by human and mouse macrophages. RESULTS: EWD attenuated secretion of interleukin (IL)-1ß and formation of Asc pyroptosome resulting from NLRP3, NLRC4, and AIM2 inflammasome activation without interruption of cytokine transcription. Isorhamnetin selectively inhibited NLRP3 and AIM2 inflammasome activation and down-regulated expression of pro-inflammatory cytokines. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. In addition, EWD, isorhamnetin, and hyperoside inhibited caspase-1. CONCLUSION: Isorhamnetin and hyperoside, a key molecule of water dropwort, have been suggested as candidates to attenuate inflammasome inhibition.
[Mh] Termos MeSH primário: Inflamassomos/efeitos dos fármacos
Inflamação/tratamento farmacológico
Oenanthe/química
Extratos Vegetais/uso terapêutico
Quercetina/análogos & derivados
Quercetina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammasomes); 0 (Plant Extracts); 8O1CR18L82 (hyperoside); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:27765362
[Au] Autor:Chen CM; Chen IC; Chen YL; Lin TH; Chen WL; Chao CY; Wu YR; Lu YT; Lee CY; Chien HC; Chen TS; Lee-Chen GJ; Lee CM
[Ad] Endereço:Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei 10507, Taiwan.
[Ti] Título:Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP damage via inducing FBXO7 expression.
[So] Source:Phytomedicine;23(12):1422-1433, 2016 Nov 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The F-box protein 7 (FBXO7) mutations have been identified in families with early-onset parkinsonism and pyramidal tract signs, and designated as PARK15. In addition, FBXO7 mutations were found in typical and young onset Parkinson's disease (PD). Evidence has also shown that FBXO7 plays an important role in the development of dopaminergic neurons and increased stability and overexpression of FBXO7 may be beneficial to PD. PURPOSE: We screened extracts of medicinal herbs to enhance FBXO7 expression for neuroprotection in MPP -treated cells. METHODS: Promoter reporter assay in HEK-293 cells was used to examine the cis/trans elements controlling FBXO7 expression and to screen extracts of medicinal herbs enhancing FBXO7 expression. MTT assay was performed to assess cell viability of MPP -treated HEK-293/SH-SY5Y cells. In addition, proteasome activity, mitochondrial membrane potential and FBXO7/TRAF2/GATA2 protein expression were evaluated. RESULTS: We demonstrated that -202--57 region of the FBXO7 promoter is likely to contain sequences that are bound by positive trans protein factors to activate FBXO7 expression and GATA2 is the main trans protein factor enhancing FBXO7 expression. Extracts of medicinal herbs Oenanthe javanica (Blume) DC. (Umbelliferae), Casuarina equisetifolia L. (Casuarinaceae), and Sorghum bicolor (L.) Moench (Gramineae) improved cell viability of both MPP -treated HEK-293 and SH-SY5Y cells, rescued proteasome activity in MPP -treated HEK-293 cells, and restored mitochondrial membrane potential in MPP -treated SH-SY5Y cells. These protection effects of herbal extracts are acting through enhancing FBXO7 and decreasing TRAF2 expression, which is probably mediated by GATA2 induction. CONCLUSION: Collectively, our study provides new targets, FBXO7 and its regulator GATA2, for the development of potential treatments of PD.
[Mh] Termos MeSH primário: 1-Metil-4-fenilpiridínio/toxicidade
Proteínas F-Box/metabolismo
Fármacos Neuroprotetores/farmacologia
Oenanthe
Doença de Parkinson/metabolismo
Extratos Vegetais/farmacologia
Sorghum
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Proteínas F-Box/genética
Fator de Transcrição GATA2/metabolismo
Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Células HEK293
Herbicidas/toxicidade
Seres Humanos
Magnoliopsida
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mutação
Fármacos Neuroprotetores/uso terapêutico
Doença de Parkinson/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Regiões Promotoras Genéticas
Complexo de Endopeptidases do Proteassoma/metabolismo
Fator 2 Associado a Receptor de TNF/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (F-Box Proteins); 0 (GATA2 Transcription Factor); 0 (GATA2 protein, human); 0 (Herbicides); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (TNF Receptor-Associated Factor 2); EC 3.4.25.1 (Proteasome Endopeptidase Complex); R865A5OY8J (1-Methyl-4-phenylpyridinium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27173234
[Au] Autor:Fu S; Li LN; Long ZC; Ke WD; Ye AH; Guo YH; Chen JM
[Ad] Endereço:Laboratory of Plant Systematics and Evolutionary Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
[Ti] Título:Evaluation of the taxonomic status of water dropwort (Oenanthe, Apiaceae) accessions from East Asia based on nuclear rDNA internal transcribed spacer sequences.
[So] Source:Genet Mol Res;15(2), 2016 Apr 25.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Oenanthe L. is a taxonomically complex genus, several species of which have long been used as vegetables and traditional medicines in East Asia. In order to clarify the taxonomic status of Oenanthe accessions and provide baseline data for the sustainable use of its genetic resources, we examined sequence variations in the internal transcribed spacer (ITS) region of Oenanthe accessions collected from a wide geographical area in China and its neighboring countries. For comparison, ITS sequences in GenBank for almost all currently reported species of Oenanthe were also included in our analyses. Both phylogenetic tree construction methods (Bayesian inference and maximum likelihood) revealed that the accessions tended to cluster into two groups, which were closely related to O. mildbraedii and O. sarmentosa. However, these two species have never been recorded in China or its neighboring countries. Therefore, it seems probable that in our sampled locations, Oenanthe accessions have been given an incorrect name, such as O. javanica. Future studies should carefully check the morphological characteristics of other Oenanthe species and sequence their ITS regions in order to clarify the taxonomic status of the genus.
[Mh] Termos MeSH primário: DNA Espaçador Ribossômico/genética
Oenanthe/genética
Filogenia
[Mh] Termos MeSH secundário: Animais
China
Classificação
Variação Genética
Oenanthe/classificação
Análise de Sequência de DNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15027363


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[PMID]:27164268
[Au] Autor:Cordeiro C; Favas PJC; Pratas J; Sarkar SK; Venkatachalam P
[Ad] Endereço:MARE, Marine and Environmental Sciences Centre, Faculty of Sciences and Technology, University of Coimbra, 3004-517, Coimbra, Portugal.
[Ti] Título:Uranium accumulation in aquatic macrophytes in an uraniferous region: Relevance to natural attenuation.
[So] Source:Chemosphere;156:76-87, 2016 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytoremediation potential of uranium (U) was investigated by submerged, free-floating and rooted emergent native aquatic macrophytes inhabiting along the streams of Horta da Vilariça, a uraniferous geochemical region of NE Portugal. The work has been undertaken with the following objectives: (i) to relate the U concentrations in water-sediment-plant system; and (ii) to identify the potentialities of aquatic plants to remediate U-contaminated waters based on accumulation pattern. A total of 25 plant species culminating 233 samples was collected from 15 study points along with surface water and contiguous sediments. Concentrations of U showed wide range of variations both in waters (0.61-5.56 µg L(-1), mean value 1.98 µg L(-1)) and sediments (124-23,910 µg kg(-1), mean value 3929 µg kg(-1)) and this is also reflected in plant species examined. The plant species exhibited the ability to accumulate U several orders of magnitude higher than the surrounding water. Maximum U concentrations was recorded in the bryophyte Scorpiurium deflexifolium (49,639 µg kg(-1)) followed by Fontinalis antipyretica (35,771 µg kg(-1)), shoots of Rorippa sylvestris (33,837 µg kg(-1)), roots of Oenanthe crocata (17,807 µg kg(-1)) as well as in Nasturtium officinale (10,995 µg kg(-1)). Scorpiurium deflexifolium displayed a high bioconcentration factor (BF) of ∼2.5 × 10(4) (mean value). The species Fontinalis antipyretica, Nasturtium officinale (roots) and Rorippa sylvestris (shoots) exhibited the mean BFs of 1.7 × 10(4), 5 × 10(3) and 4.8 × 10(3) respectively. Maximum translocation factor (TF) was very much pronounced in the rooted perennial herb Rorippa sylvestris showing extreme ability to transport U for the shoots and seems to be promising candidate to be used as bioindicator species.
[Mh] Termos MeSH primário: Urânio/metabolismo
Poluentes Radioativos da Água/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Briófitas/metabolismo
Bryopsida/metabolismo
Monitoramento Ambiental
Nasturtium/metabolismo
Oenanthe/metabolismo
Raízes de Plantas/metabolismo
Brotos de Planta/metabolismo
Portugal
Rios/química
Rorippa/metabolismo
Urânio/análise
Poluentes Radioativos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Radioactive); 4OC371KSTK (Uranium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE


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[PMID]:27075296
[Au] Autor:Ogita T; Vallejo Manaois R; Wakagi M; Oki T; Takano Ishikawa Y; Watanabe J
[Ad] Endereço:a National Food Research Institute, National Agriculture and Food Research Organization , Tsukuba , Ibaraki , Japan ;
[Ti] Título:Identification and evaluation of antioxidants in Japanese parsley.
[So] Source:Int J Food Sci Nutr;67(4):431-40, 2016 Jun.
[Is] ISSN:1465-3478
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two cultivars of Japanese parsley were harvested in different seasons; their antioxidant capacities were evaluated by oxygen radical absorbance capacity (ORAC) methods, and the contents of hydrophilic and lipophilic antioxidants were compared. Japanese parsley possessed potent antioxidant capacities both in hydrophilic and lipophilic extracts when evaluated by ORAC methods. LC/MS/MS analyses revealed that chlorogenic acid and four kinds of quercetin glycosides were major antioxidants in the hydrophilic extract. Lutein was the main contributor to the antioxidant capacity of the lipophilic extract. Antioxidant capacities of the hydrophilic extracts of both cultivars tended to be higher in winter because of the increase in the contents of chlorogenic acid and quercetin glycosides. An obvious trend in the lipophilic antioxidant capacities or lutein contents was not observed irrespective of the cultivar.
[Mh] Termos MeSH primário: Antioxidantes/análise
Ácido Clorogênico/análise
Glicosídeos/análise
Luteína/análise
Oenanthe/química
Componentes Aéreos da Planta/química
Quercetina/análise
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Ácido Clorogênico/química
Ácido Clorogênico/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Depuradores de Radicais Livres/análise
Depuradores de Radicais Livres/química
Glicosídeos/química
Glicosídeos/isolamento & purificação
Interações Hidrofóbicas e Hidrofílicas
Japão
Luteína/química
Luteína/isolamento & purificação
Oenanthe/crescimento & desenvolvimento
Quercetina/química
Quercetina/isolamento & purificação
Estações do Ano
Solventes/química
Especificidade da Espécie
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
alfa-Tocoferol/análise
alfa-Tocoferol/química
alfa-Tocoferol/isolamento & purificação
gama-Tocoferol/análise
gama-Tocoferol/química
gama-Tocoferol/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Glycosides); 0 (Solvents); 318ADP12RI (Chlorogenic Acid); 8EF1Z1238F (gamma-Tocopherol); 9IKM0I5T1E (Quercetin); H4N855PNZ1 (alpha-Tocopherol); X72A60C9MT (Lutein)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.3109/09637486.2016.1170770


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[PMID]:27055891
[Au] Autor:Gao JM; Sun XQ; Jiang WC; Wei YM; Guo JS; Liu YY; Zhang K
[Ad] Endereço:Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing, 400045, China. gao-junmin@126.com.
[Ti] Título:Heavy metals in sediments, soils, and aquatic plants from a secondary anabranch of the three gorges reservoir region, China.
[So] Source:Environ Sci Pollut Res Int;23(11):10415-25, 2016 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We investigated the occurrence of cadmium (Cd), copper (Cu), chromium (Cr), nickel (Ni), lead (Pb), Znic (Zn), iron (Fe), manganese (Mn), and magnesium (Mg) in sediments, as well as in related soils and aquatic plants in the Liangtan River, a typical secondary anabranch of the Yangtze River in the Three Gorges Reservoir Region (TGRR) of China. We found that sediments accumulated more metals than soils and aquatic plants. Concentrations of the nine metals in sediments and soils followed the same sequence, while their concentrations in aquatic plants followed a different sequence. Potential adverse effects of contaminated sediments on benthic fauna were evaluated, and the results showed that the toxic effect on benthic organisms followed the sequence Zn > Ni > Cr > Cu > Cd > Pb. The potential ecological risk index analysis indicated that Cd in sediments had considerable ecological risk, whereas Cr, Cu, Zn, Ni, and Pb had low ecological risk. The potential ecological risk index (RI) of the heavy metals in sediments of the Liangtan River was 174.9, indicating moderate ecological risk. The transfer factor trend of metals for aquatic plants showed that Cd and Ni had the most and least accumulation, respectively. For Cu, Cd, Mg, Pb, and Cr, a significant positive correlation of the metal concentrations was observed between sediments and soils, but no correlations (excluding Cr) were detected between sediments and aquatic plants. Our study indicated that anthropogenic input may be the primary source of metal contamination in the Liangtan River, and that Zn and Cd pollution in the Liangtan River should be further explored.
[Mh] Termos MeSH primário: Eichhornia/química
Metais Pesados/análise
Oenanthe/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: China
Cromo/análise
Ecologia
Monitoramento Ambiental
Sedimentos Geológicos/química
Metais Pesados/toxicidade
Medição de Risco
Rios
Solo/química
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil); 0 (Water Pollutants, Chemical); 0R0008Q3JB (Chromium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6587-3


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[PMID]:26976768
[Au] Autor:Ai G; Huang ZM; Liu QC; Han YQ; Chen X
[Ad] Endereço:Hospital of Institute of Aviation Medicine of Air Force, Beijing 100142, China; Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China. Electronic address: guoair@163.com.
[Ti] Título:The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine.
[So] Source:J Ethnopharmacol;186:53-60, 2016 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGY RELEVANCE: Water dropwort [Oenanthe javanica (O. javanica)] is an aquatic perennial herb cultivated in East Asian countries. It has been popularly used in traditional Chinese medicine which is beneficial for the treatment of many diseases, including jaundice and various types of chronic and acute hepatitis. In the present study, we investigated the hepatoprotective effect of total phenolics from O. javanica (TPOJ) against D-galactosamine (D-GalN) induced liver injury in mice. MATERIAL AND METHODS: The hepatoprotective activity of TPOJ (125, 250 and 500mg/kg) was investigated on D-GalN (800mg/kg)-induced liver damages in mice. Blood and liver were collected for biochemical and microscopic analysis. RT-PCR was used to determine the changes in hepatic nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Protein levels of iNOS, COX-2, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were determined by western blotting. RESULTS: In the animal studies, TPOJ could improve the survival of acute liver failure model significantly and prevente the D-GalN-induced elevation of the serum enzymatic markers and nonenzymatic markers levels significantly. Meanwhile, TPOJ-treatment decreased the malondialdehyde (MDA) level and elevated the content of glutathione (GSH) in the liver as compared to those in the D-GalN group. Hepatic activities and protein expressions of antioxidative enzymes, including SOD, GPx, and CAT were enhanced dose dependently with TPOJ. At the same time, application of TPOJ effectively suppressed the D-GalN-induced proinflammatory mRNA and protein expression of iNOS and COX-2. Subsequently, the serum levels of proinflammatory mediators, nitric oxide (NO) and prostaglandin E2 (PGE2) were reduced. Additionally, histological analyses also showed that TPOJ reduced the extent of liver lesions induced by D-GalN. CONCLUSION: Our investigation demonstrated the hepatoprotective activity of TPOJ and revealed that TPOJ attributed its significance in the traditional use for treating liver diseases.
[Mh] Termos MeSH primário: Galactosamina/toxicidade
Falência Hepática Aguda/induzido quimicamente
Falência Hepática Aguda/tratamento farmacológico
Oenanthe/química
Fenóis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Masculino
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Fenóis/administração & dosagem
Fenóis/química
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Silimarina/administração & dosagem
Silimarina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts); 0 (Silymarin); 7535-00-4 (Galactosamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE


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[PMID]:26486611
[Au] Autor:Favre-Bac L; Mony C; Ernoult A; Burel F; Arnaud JF
[Ad] Endereço:UMR CNRS 6553 ECOBIO, Université de Rennes 1, Campus de Beaulieu, Rennes Cedex, France.
[Ti] Título:Ditch network sustains functional connectivity and influences patterns of gene flow in an intensive agricultural landscape.
[So] Source:Heredity (Edinb);116(2):200-12, 2016 Feb.
[Is] ISSN:1365-2540
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In intensive agricultural landscapes, plant species previously relying on semi-natural habitats may persist as metapopulations within landscape linear elements. Maintenance of populations' connectivity through pollen and seed dispersal is a key factor in species persistence in the face of substantial habitat loss. The goals of this study were to investigate the potential corridor role of ditches and to identify the landscape components that significantly impact patterns of gene flow among remnant populations. Using microsatellite loci, we explored the spatial genetic structure of two hydrochorous wetland plants exhibiting contrasting local abundance and different habitat requirements: the rare and regionally protected Oenanthe aquatica and the more commonly distributed Lycopus europaeus, in an 83 km(2) agricultural lowland located in northern France. Both species exhibited a significant spatial genetic structure, along with substantial levels of genetic differentiation, especially for L. europaeus, which also expressed high levels of inbreeding. Isolation-by-distance analysis revealed enhanced gene flow along ditches, indicating their key role in effective seed and pollen dispersal. Our data also suggested that the configuration of the ditch network and the landscape elements significantly affected population genetic structure, with (i) species-specific scale effects on the genetic neighborhood and (ii) detrimental impact of human ditch management on genetic diversity, especially for O. aquatica. Altogether, these findings highlighted the key role of ditches in the maintenance of plant biodiversity in intensive agricultural landscapes with few remnant wetland habitats.
[Mh] Termos MeSH primário: Ecossistema
Fluxo Gênico
Genética Populacional
Lycopus/genética
Oenanthe/genética
[Mh] Termos MeSH secundário: Agricultura
França
Variação Genética
Genótipo
Geografia
Desequilíbrio de Ligação
Repetições de Microssatélites
Análise Espacial
Zonas Úmidas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151022
[St] Status:MEDLINE
[do] DOI:10.1038/hdy.2015.90


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[PMID]:26537044
[Au] Autor:Choi IW; Kim HY; Quan JH; Ryu JG; Sun R; Lee YH
[Ad] Endereço:Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 35015, Korea.
[Ti] Título:Monitoring of Fasciola Species Contamination in Water Dropwort by cox1 Mitochondrial and ITS-2 rDNA Sequencing Analysis.
[So] Source:Korean J Parasitol;53(5):641-5, 2015 Oct.
[Is] ISSN:1738-0006
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Fascioliasis, a food-borne trematode zoonosis, is a disease primarily in cattle and sheep and occasionally in humans. Water dropwort (Oenanthe javanica), an aquatic perennial herb, is a common second intermediate host of Fasciola, and the fresh stems and leaves are widely used as a seasoning in the Korean diet. However, no information regarding Fasciola species contamination in water dropwort is available. Here, we collected 500 samples of water dropwort in 3 areas in Korea during February and March 2015, and the water dropwort contamination of Fasciola species was monitored by DNA sequencing analysis of the Fasciola hepatica and Fasciola gigantica specific mitochondrial cytochrome c oxidase subunit 1 (cox1) and nuclear ribosomal internal transcribed spacer 2 (ITS-2). Among the 500 samples assessed, the presence of F. hepatica cox1 and 1TS-2 markers were detected in 2 samples, and F. hepatica contamination was confirmed by sequencing analysis. The nucleotide sequences of cox1 PCR products from the 2 F. hepatica-contaminated samples were 96.5% identical to the F. hepatica cox1 sequences in GenBank, whereas F. gigantica cox1 sequences were 46.8% similar with the sequence detected from the cox1 positive samples. However, F. gigantica cox1 and ITS-2 markers were not detected by PCR in the 500 samples of water dropwort. Collectively, in this survey of the water dropwort contamination with Fasciola species, very low prevalence of F. hepatica contamination was detected in the samples.
[Mh] Termos MeSH primário: DNA Espaçador Ribossômico/genética
Complexo IV da Cadeia de Transporte de Elétrons/genética
Fasciola hepatica/genética
Fasciola hepatica/isolamento & purificação
Oenanthe/parasitologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Análise por Conglomerados
DNA de Helmintos/química
DNA de Helmintos/genética
DNA Espaçador Ribossômico/química
Coreia (Geográfico)
Dados de Sequência Molecular
Filogenia
Análise de Sequência de DNA
Homologia de Sequência do Ácido Nucleico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Helminth); 0 (DNA, Ribosomal Spacer); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151107
[Lr] Data última revisão:
151107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151106
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2015.53.5.641


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[PMID]:26521793
[Au] Autor:Park JH; Cho JH; Kim IH; Ahn JH; Lee JC; Chen BH; Shin BN; Tae HJ; Yoo KY; Hong S; Kang IJ; Won MH; Kim JD
[Ti] Título:Oenanthe Javanica Extract Protects Against Experimentally Induced Ischemic Neuronal Damage via its Antioxidant Effects.
[So] Source:Chin Med J (Engl);128(21):2932-7, 2015 Nov 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Water dropwort (Oenanthe javanica) as a popular traditional medicine in Asia shows various biological properties including antioxidant activity. In this study, we firstly examined the neuroprotective effect of Oenanthe javanica extract (OJE) in the hippocampal cornus ammonis 1 region (CA1 region) of the gerbil subjected to transient cerebral ischemia. METHODS: Gerbils were established by the occlusion of common carotid arteries for 5 min. The neuroprotective effect of OJE was estimated by cresyl violet staining. In addition, 4 antioxidants (copper, zinc superoxide dismutase [SOD], manganese SOD, catalase, and glutathione peroxidase) immunoreactivities were investigated by immunohistochemistry. RESULTS: Pyramidal neurons in the CA1 region showed neuronal death at 5 days postischemia; at this point in time, all antioxidants immunoreactivities disappeared in CA1 pyramidal neurons and showed in many nonpyramidal cells. Treatment with 200 mg/kg, not 100 mg/kg, OJE protected CA1 pyramidal neurons from ischemic damage. In addition, 200 mg/kg OJE treatment increased or maintained antioxidants immunoreactivities. Especially, among the antioxidants, glutathione peroxidase immunoreactivity was effectively increased in the CA1 pyramidal neurons of the OJE-treated sham-operated and ischemia-operated groups. CONCLUSION: Our present results indicate that treatment with OJE can protect neurons from transient ischemic damage and that the neuroprotective effect may be closely associated with increased or maintained intracellular antioxidant enzymes by OJE.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Antioxidantes/uso terapêutico
Ataque Isquêmico Transitório/prevenção & controle
Oenanthe/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Gerbillinae
Glutationa Peroxidase/metabolismo
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); EC 1.11.1.9 (Glutathione Peroxidase)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.168063



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