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Pesquisa : B01.650.940.800.575.912.250.084.500 [Categoria DeCS]
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[PMID]:29253815
[Au] Autor:Sabela MI; Makhanya T; Kanchi S; Shahbaaz M; Idress D; Bisetty K
[Ad] Endereço:Department of Chemistry, Durban University of Technology, P.O Box 1334, Durban 4000, South Africa. Electronic address: myalos@dut.ac.za.
[Ti] Título:One-pot biosynthesis of silver nanoparticles using Iboza Riparia and Ilex Mitis for cytotoxicity on human embryonic kidney cells.
[So] Source:J Photochem Photobiol B;178:560-567, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plant extracts continue gaining significant prominence in green synthesis of silver nanoparticles (AgNPs), due to their potential applications in nano-medicine and material engineering. This work reports on green synthesis of silver nanoparticles (AgNPs) from aqueous extracts of Iboza Riparia leaf and Ilex Mitis root bark with diterpenes (DTPs) and saponins (SPNs) as major components. After TEM, DLS, TGA/DSC, ATR, XRD and UV-Vis characterization, the relevant cytotoxicity studies were conducted with the MTT assay on human embryonic kidney cells (HEK293T) followed by antioxidant activity with ABTS. Overall, the AgNPs-DTPs (156nm) were found to be less toxic with 49.7% cell viability, while AgNPs-SPNs (50nm) and AgNPs-PVA (44nm) had cell viability of 40.8 and 28.0% respectively at 400µM. Based on the cytotoxicity and antioxidant activity, it is fair to report that these plant extracts have potential reducing and capping agents as they retain chemical properties on the surface of the nanoparticles.
[Mh] Termos MeSH primário: Ilex/química
Nanopartículas Metálicas/química
Prata/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Varredura Diferencial de Calorimetria
Sobrevivência Celular/efeitos dos fármacos
Diterpenos/química
Diterpenos/isolamento & purificação
Química Verde
Células HEK293
Seres Humanos
Ilex/metabolismo
Nanopartículas Metálicas/toxicidade
Tamanho da Partícula
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Saponinas/química
Saponinas/isolamento & purificação
Espectrofotometria Ultravioleta
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Diterpenes); 0 (Plant Extracts); 0 (Saponins); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  2 / 200 MEDLINE  
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[PMID]:28650494
[Au] Autor:Zhai X; Ren D; Luo Y; Hu Y; Yang X
[Ad] Endereço:Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China. dyren@snnu.edu.cn xbyang@snnu.edu.cn.
[Ti] Título:Chemical characteristics of an Ilex Kuding tea polysaccharide and its protective effects against high fructose-induced liver injury and vascular endothelial dysfunction in mice.
[So] Source:Food Funct;8(7):2536-2547, 2017 Jul 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the protective effects of Ilex Kuding tea polysaccharides (IKTP) on high fructose (HF)-induced liver injury and vascular endothelial dysfunction in mice. IKTP were identified as acidic heteropolysaccharides by FT-IR and HPLC. Healthy male Kunming mice fed 20% fructose in drinking water for 8 consecutive weeks significantly displayed dyslipidemia, hepatic steatosis, oxidative stress and vascular endothelial dysfunction. However, continuous administration of IKTP at 200, 400 and 800 mg per kg bw in HF-fed mice could prevent the damage caused by HF-diets, especially at dosages of 400 and 800 mg per kg bw (p < 0.01). IKTP significantly reduced the HF-induced elevation of the serum TC, TG, LDL-C, TXA and ET-1 levels, as well as AST and ALT activities, while markedly increased the HF-induced decline of HDL-C, PGI and eNOS levels in the serum compared to HF-fed mice. Meanwhile, the hepatic MDA level was lowered while SOD and GSH-Px activities were increased in IKTP-treated mice, compared to HF-fed mice. Histopathology of the liver and cardiovascular aortic by H&E or oil red O staining confirmed the liver steatosis and the vascular injury induced by HF-diets and the protective effects of IKTP. These findings suggest that HF causes oxidative damage, and IKTP alleviates liver injury and vascular endothelial dysfunction.
[Mh] Termos MeSH primário: Endotélio Vascular/efeitos dos fármacos
Fígado Gorduroso/prevenção & controle
Ilex/química
Extratos Vegetais/administração & dosagem
Polissacarídeos/administração & dosagem
Doenças Vasculares/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Endotélio Vascular/metabolismo
Fígado Gorduroso/etiologia
Fígado Gorduroso/metabolismo
Frutose/efeitos adversos
Glutationa Peroxidase/metabolismo
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Malondialdeído/metabolismo
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Superóxido Dismutase/metabolismo
Doenças Vasculares/etiologia
Doenças Vasculares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Polysaccharides); 30237-26-4 (Fructose); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00490g


  3 / 200 MEDLINE  
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[PMID]:28440893
[Au] Autor:Zhang Y; Xiong H; Bi J; Zhao G; Yang Y; Chen X; Li Y; Zhang C; Zhang G
[Ad] Endereço:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenhe District, Shenyang, People's Republic of China.
[Ti] Título:An HPLC method for simultaneous quantitative determination of seven secoiridoid glucosides separated from the roots of Ilex pubescens.
[So] Source:Biomed Chromatogr;31(11), 2017 Nov.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple and specific high-performance liquid chromatographic method has been developed and validated to simultaneously determine seven secoiridoid glucosides for the first time. Three of them were separated from the ethanolic extract of the roots of Ilex pubescens for the first time, namely nuezhenide A, ligusides B and oleonuezhenide. In quantitative analysis, all of the calibration curves showed good linear regression (r > 0.999) within the tested ranges, and the mean recoveries of three different concentrations ranged from 97.6 to 101.2%. The limit of detection and limit of quantification were <4.18 and 11.63 ng mL , respectively. The relative standard deviation for repeatability and the precision of seven analytes were <3.4 and 1.9%, respectively. The established method was successfully applied to simultaneous determination of seven secoiridoid glucosides in 11 batches of samples collected from different habitats in China.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Ilex/química
Glucosídeos Iridoides/análise
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Limite de Detecção
Modelos Lineares
Extratos Vegetais/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glucosides); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3995


  4 / 200 MEDLINE  
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[PMID]:28284430
[Au] Autor:Yuan Y; Pan S; Yang SL; Liu YL; Xu QM
[Ad] Endereço:Department of Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
[Ti] Título:Antioxidant and cardioprotective effects of Ilex cornuta on myocardial ischemia injury.
[So] Source:Chin J Nat Med;15(2):94-104, 2017 Feb.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxidant and cardioprotective effects of Ilex cornuta root with in vitro and in vivo models. The anti-oxidative effects of the extract of Ilex cornuta root (ICR) were measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging and MTT assays as well as immunoassay. Furthermore, a rat model of myocardial ischemia was established to investigate the cardioprotective effect of ICR in vivo. Eight compounds were isolated and identified from ICR and exhibited DPPH free-radical scavenging activities. They also could increase cell viability and inhibit morphological changes induced by H O or Na S O in H9c2 cardiomyocytes, followed by increasing the SOD activities and decreasing the MDA and ROS levels. In addition, it could suppress the apoptosis of cardiomyocytes. In the rat model of myocardial ischemia, ICR decreased myocardial infarct size and suppressed the activities of LDH and CK. Furthermore, ICR attenuated histopathological alterations of heart tissues and the MDA levels, while increasing SOD activities in serum. In conclusion, these results suggest that ICR has cardioprotective activity and could be developed as a new food supplement for the prevention of ischemic heart disease.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Fármacos Cardiovasculares/farmacologia
Ilex
Isquemia Miocárdica/patologia
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Antioxidantes/uso terapêutico
Apoptose
Fármacos Cardiovasculares/uso terapêutico
Sobrevivência Celular/efeitos dos fármacos
Peróxido de Hidrogênio/metabolismo
Malondialdeído/metabolismo
Infarto do Miocárdio
Isquemia Miocárdica/tratamento farmacológico
Isquemia Miocárdica/metabolismo
Miocárdio/citologia
Miocárdio/patologia
Miócitos Cardíacos/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Raízes de Plantas
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cardiovascular Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 4Y8F71G49Q (Malondialdehyde); BBX060AN9V (Hydrogen Peroxide); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  5 / 200 MEDLINE  
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[PMID]:28284425
[Au] Autor:Li SS; Liu YL; Xu QM; Mao CM; Yang SL
[Ad] Endereço:Children's Hospital of Soochow University, Suzhou 215003, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
[Ti] Título:Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H O -induced myocardial cell injury.
[So] Source:Chin J Nat Med;15(2):115-120, 2017 Feb.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3ß-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3ß-O-ß-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3ß-O-ß-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3ß-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H O -induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.
[Mh] Termos MeSH primário: Ilex/química
Miocárdio/patologia
Extratos Vegetais/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Compostos de Bifenilo/metabolismo
Fármacos Cardiovasculares/química
Fármacos Cardiovasculares/isolamento & purificação
Fármacos Cardiovasculares/farmacologia
Peróxido de Hidrogênio/metabolismo
Estrutura Molecular
Miocárdio/citologia
Miócitos Cardíacos/efeitos dos fármacos
Picratos/metabolismo
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Ratos
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Cardiovascular Agents); 0 (Picrates); 0 (Plant Extracts); 0 (Triterpenes); 0 (randialic acid B); BBX060AN9V (Hydrogen Peroxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  6 / 200 MEDLINE  
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[PMID]:28209193
[Au] Autor:Yimam M; Jiao P; Hong M; Brownell L; Lee YC; Hyun EJ; Kim HJ; Nam JB; Kim MR; Jia Q
[Ad] Endereço:Unigen, Inc., 3005 1st Avenue, Seattle, WA, 98121, USA. myimam@unigen.net.
[Ti] Título:UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss.
[So] Source:BMC Complement Altern Med;17(1):114, 2017 Feb 16.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity. METHOD: Adipogenesis activity of the composition was assessed in 3T3-L1 cells in vitro. Effects of UP601 on body weight and metabolic markers were evaluated. It was administered at oral doses of 300 mg/kg, 450 mg/kg and 600 mg/kg for 7 weeks. Orlistat (40 mg/kg/day) was used as a positive control. Body compositions of mice were assessed using dual energy X-ray absorptiometry (DEXA). Serum biomarkers were measured for liver function and lipid profiling. Relative organ weights were determined. Histopathological analysis was performed for non-alcoholic steatohepatitis (NASH) scoring. RESULTS: UP601 at 250 µg/ml resulted in 1.8-fold increase in lipolysis. Statistically significant changes in body weight (decreased by 9.1, 19.6 and 25.6% compared to the HFF group at week-7) were observed for mice treated with UP601 at 300, 450 and 600 mg/kg, respectively. Reductions of 9.1, 16.9, and 18.6% in total cholesterol; 45.0, 55.0, 63.6% in triglyceride; 34.8, 37.1 and 41.6% in LDL; 3.2, 21.6 (P = 0.03) and 33.7% (P = 0.005) in serum glucose were observed for UP601 at 300, 450 and 600 mg/kg, respectively. Body fat distribution was found reduced by 31.6 and 17.2% for the 450 mg/kg UP601 and orlistat, respectively, from the DEXA scan analysis. Up to an 89.1% reduction in mesenteric fat deposit was observed for UP601 in relative organ weight. Statistically significant improvements in NASH scores were observed for mice treated with UP601. CONCLUSION: UP601, a standardized botanical composition from Morus alba, Yerba mate and Magnolia officinalis could potentially be used for achieving healthy weight loss and maintenance.
[Mh] Termos MeSH primário: Ilex
Magnolia
Morus
Obesidade/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Perda de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipogenia/efeitos dos fármacos
Animais
Glicemia/metabolismo
Distribuição da Gordura Corporal
Dieta
Modelos Animais de Doenças
Hipoglicemiantes/farmacologia
Hipoglicemiantes/uso terapêutico
Hipolipemiantes/farmacologia
Hipolipemiantes/uso terapêutico
Lactonas/farmacologia
Lactonas/uso terapêutico
Lipídeos/sangue
Lipólise/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/patologia
Camundongos
Camundongos Endogâmicos C57BL
Hepatopatia Gordurosa não Alcoólica/prevenção & controle
Obesidade/sangue
Obesidade/etiologia
Obesidade/patologia
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Lactones); 0 (Lipids); 0 (Plant Extracts); 95M8R751W8 (orlistat)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170226
[Lr] Data última revisão:
170226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1627-1


  7 / 200 MEDLINE  
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[PMID]:28094185
[Au] Autor:Wen Q; Lu Y; Chao Z; Chen DF
[Ad] Endereço:Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
[Ti] Título:Anticomplement triterpenoids from the roots of Ilex asprella.
[So] Source:Bioorg Med Chem Lett;27(4):880-886, 2017 Feb 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five new (1-5) and twenty-eight known (6-33) triterpenoids were isolated from the roots of Ilex asprella. The structures of the new compounds were elucidated by the detailed spectral analysis. The ursane and oleanane triterpenoids were found to show anticomplement activity with some structure-activity relationships. Several triterpenoids (1-3, 6-7) exhibited potent anticomplement activity with the CH and AP values of 0.058-0.131mg/mL and 0.080-0.444mg/mL, respectively. It was found that caffeoyl group could enhance activity remarkably, followed by coumaroyl and feruloyl group. The 28-carboxyl group was also important to anticomplement activity for the triterpenoids. However, the triterpenoids with lactone ring (4, 9-14) exhibited weak activity and triterpenoid glycosides (5, 23-33) showed no inhibition. The targets of several bioactive triterpenoids in complement activation cascade were identified as well.
[Mh] Termos MeSH primário: Proteínas Inativadoras do Complemento/química
Ilex/química
Triterpenos/química
[Mh] Termos MeSH secundário: Animais
Proteínas Inativadoras do Complemento/isolamento & purificação
Proteínas Inativadoras do Complemento/farmacologia
Eritrócitos/citologia
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Hemólise/efeitos dos fármacos
Ilex/metabolismo
Espectroscopia de Ressonância Magnética
Conformação Molecular
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/química
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Ovinos
Relação Estrutura-Atividade
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complement Inactivator Proteins); 0 (Triterpenes); 0 (anticomplement); 0 (oleanane); 0 (ursane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170704
[Lr] Data última revisão:
170704
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


  8 / 200 MEDLINE  
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[PMID]:27912969
[Au] Autor:Wu P; Gao H; Liu JX; Liu L; Zhou H; Liu ZQ
[Ad] Endereço:International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China.
[Ti] Título:Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots.
[So] Source:Phytochemistry;134:122-132, 2017 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven triterpenoid saponins, named ilexsaponin I-O, along with twelve known ones, were isolated from the roots of Ilex pubescens. The structures of all compounds were elucidated by use of extensive spectroscopic methods (IR, HR-ESI-MS, and 1D and 2D NMR). Sugar residues obtained after acid hydrolysis were identified by TLC and HPLC. The in vitro anti-inflammatory effects of the triterpenoid saponins were also evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E (PGE ) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. Ilexsaponin I and ß-d-glucopyranosyl 3-ß-[ß-d-xylopyranosyl-(1 â†’ 2)-ß-d-glucopyranosyloxy]-olea-12-en-28-oate exerted more potent anti-inflammatory effects than the other compounds tested.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Inibidores de Ciclo-Oxigenase/isolamento & purificação
Inibidores de Ciclo-Oxigenase/farmacologia
Ilex/química
Saponinas/isolamento & purificação
Saponinas/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Inibidores de Ciclo-Oxigenase/química
Dinoprostona/antagonistas & inibidores
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Raízes de Plantas/química
Saponinas/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cyclooxygenase Inhibitors); 0 (Lipopolysaccharides); 0 (Saponins); 0 (Triterpenes); EC 1.14.13.39 (NOS2 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type II); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE


  9 / 200 MEDLINE  
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[PMID]:27447119
[Au] Autor:Liu WJ; Peng YY; Chen H; Liu XF; Liang JY; Sun JB
[Ad] Endereço:Department of Natural Medicinal Chemistry, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, P. R. China.
[Ti] Título:Triterpenoid Saponins with Potential Cytotoxic Activities from the Root Bark of Ilex rotunda Thunb.
[So] Source:Chem Biodivers;14(2), 2017 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A new 19-oxo-18,19-seco-ursane-type triterpeonoid saponin, laevigin E (8), together with 17 known compounds (1 - 7 and 9 - 18) were isolated from the root bark of Ilex rotunda Thunb. Their structures were determined by various spectroscopic analysis. Among them, compounds 6, 9, 11, and 18 were isolated from this species for the first time, while compounds 10 and 12 were firstly isolated from the family Aquifoliaceae. Biological activity assay showed that all triterpenoids exhibit moderate cytotoxic activities against MCF7, A549, HeLa and LN229 cell lines. The four triterpenoid saponins (3, 4, 6, and 8) exhibit slightly better activities compared to the four triterpenoid sapogenins (1, 2, 5, and 7). Compound 8 showed the best cytotoxicity against A549, HeLa and LN229 cell lines with IC of 17.83, 22.58 and 30.98 µm, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Ilex/química
Casca de Planta/química
Raízes de Plantas/química
Saponinas/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Células HeLa
Seres Humanos
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600209


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[PMID]:27977191
[Au] Autor:Xie M; Chen G; Hu B; Zhou L; Ou S; Zeng X; Sun Y
[Ad] Endereço:College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, China.
[Ti] Título:Hydrolysis of Dicaffeoylquinic Acids from Ilex kudingcha Happens in the Colon by Intestinal Microbiota.
[So] Source:J Agric Food Chem;64(51):9624-9630, 2016 Dec 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Monocaffeoylquinic acids (mono-CQAs) can be hydrolyzed or metabolized by pancreatin, intestinal brush border esterase, and microbiota in the colon. Data about the conversion of dicaffeoylquinic acids (diCQAs) in digestion are scarce. The diCQA-rich fraction including 3,4-, 3,5-, and 4,5-diCQAs was prepared from Ilex kudingcha, and the conversion in simulated gastricintestine was investigated. Artificial saliva, gastric and pancreatic fluids, Caco-2 monolayer cells, and anaerobic fermentation model were utilized to mimic digestions of the oral cavity, stomach, small intestine, and colon in vitro. The results revealed that diCQAs remained intact in simulated saliva, gastric, and pancreatic fluids and within Caco-2 cells. In anaerobic fermentation with human fecal slurry, diCQAs were hydrolyzed to mono-CQAs and caffeic acid, which were further metabolized to caffeic acid and dihydrocaffeic acid, respectively. The hydrolysis of diCQAs depended on the chemical structures, carbohydrates in the culture medium, and microbial compositions. Our research demonstrated that hydrolysis of diCQAs happened in the colon by intestinal microbiota.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Colo/microbiologia
Microbioma Gastrointestinal
Ilex/metabolismo
Extratos Vegetais/metabolismo
Ácido Quínico/análogos & derivados
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/isolamento & purificação
Células CACO-2
Colo/metabolismo
Seres Humanos
Hidrólise
Ilex/química
Estrutura Molecular
Extratos Vegetais/química
Ácido Quínico/química
Ácido Quínico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04710



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