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[PMID]:28173794
[Au] Autor:Njateng GS; Du Z; Gatsing D; Mouokeu RS; Liu Y; Zang HX; Gu J; Luo X; Kuiate JR
[Ad] Endereço:Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Antibacterial and antioxidant properties of crude extract, fractions and compounds from the stem bark of Polyscias fulva Hiern (Araliaceae).
[So] Source:BMC Complement Altern Med;17(1):99, 2017 Feb 07.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In our previous work, the dichloromethane-methanol (1:1 v/v) extract, fractions and isolated compounds from Polyscias fulva stem bark showed interesting antifungal activity. As a continuity of that work, this study aimed to bring out complementary informations about the antimicrobial properties of P. fulva stem bark that may be useful in the standardization of phytomedicine from this plant. METHODS: The antibacterial activities of the crude extract, fractions (n-hexane, ethyl acetate, n-butanol and residual) and isolated compounds from Polyscias fulva stem bark were assayed by broth microdilution techniques. Their antioxidant activity were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), pyrogallol (superoxide anion) and ß-carotene - linoleic acid assays. RESULTS: The crude extract presented antibacterial activities against S. typhi (ATCC 6539), E. aerogenes (ATCC 13045), P. aeruginosa (PA01) and E. coli (ATCC 10536) with MIC values of 2000 to 8000 µg/ml. The fractionation led the ethyle acetate and n-butanol fractions relatively more active (MIC = 500 to 1000 µg/ml) as compared to the crude extract. ß-sitosterol and 3-O-α-L- arabinopyranosyl-hederagenin were the most active compounds on the tested bacteria with MIC values ranging from 6.25 to 100 µg/ml. The most sensitive was P. aeruginosa (PA01) on which all the tested compounds were active with MICs ranging from 6.25 to 400 µg/ml. Among all the tested substances, the crude extract (RSa50 = 84.86 µg/ml) and the methyl atrarate (RSa50 = 14.77 µg/ml), showed the highest scavenging activities against DPPH free radicals and those arising from the oxidation of the linoleic acid respectively. CONCLUSION: From this study, the results obtained reveal that the stem bark of P. fulva possesses antibacterial and antioxidant activities. It may then be useful in the development of an antimicrobial phytomedicine with a large spectrum of actvity endowed with antioxidant properties which can be standardised based on the isolated compounds.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Araliaceae
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Seres Humanos
Picratos/química
Casca de Planta
Caules de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1572-z


  2 / 162 MEDLINE  
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[PMID]:27676700
[Au] Autor:Li M; Liu F; Jin YR; Wang XZ; Wu Q; Liu Y; Li XW
[Ad] Endereço:College of Chemistry, Jilin University, Changchun, P. R. China.
[Ti] Título:Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity.
[So] Source:Planta Med;83(3-04):351-357, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Five new triterpenoid saponins ( - ) and four known triterpenoid saponins, ginsenoside Re ( ), majonoside R ( ), 24( )-majonoside R ( ), and ginsenoside Rf ( ), were isolated from the rhizomes of . The structures of new compounds were elucidated as (20 ,24 ,25 *)-6-O-[ -D-glucopyranosyl-(1 → 2)- -D-glucopyranosyl]-dammar-20,24-epoxy-3 ,6 ,12 ,25,26-pentaol ( ), (20 ,24 ,25 )-6-O-[ -D-glucopyranosyl-(1 → 2)- -D-glucopyranosyl]-dammar-20,24-epoxy-3 ,6 ,12 ,25,26-pentaol ( ), (20 )-6-O-[ -D-glucopyranosyl-(1 → 2)- -D-glucopyranosyl]-dammar-20,25-epoxy-3 ,6 ,12 ,24 -tetraol ( ), 6-O-[ -D-glucopyranosyl-(1 → 2)- -D-glucopyranosyl]-dammar-3 ,6 ,12 ,20 ,24 ,25-hexaol ( ), and 6-O-[ -D-glucop-yranosyl-(1 → 2)- -D-glucopyranosyl]-dammar-25(26)-ene-3 ,6 ,12 ,20 ,24 -pentaol ( ) on the basis of extensive spectral analysis and chemical methods. Ginsenoside Re was isolated from the plant for the first time. The similarities of the nine compounds lie in the fact that their aglycones are conjoined with the same glucopyranose moieties, the same linkage of the glycosyl chains, and the same glycosylation sites, while they have a varied C-17 side chain. Compounds and exhibited moderate antiplatelet aggregation activities induced by adenosine diphosphate with IC values of 23.24 and 18.43 µM, respectively. Compound displayed moderate inhibition of arachidonic acid-induced platelet aggregation with an IC value of 30.11 µM.
[Mh] Termos MeSH primário: Araliaceae/química
Inibidores da Agregação de Plaquetas/química
Inibidores da Agregação de Plaquetas/farmacologia
Rizoma/química
Saponinas/química
Saponinas/farmacologia
Triterpenos/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Ácido Araquidônico/antagonistas & inibidores
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Ginsenosídeos/química
Hidrólise
Concentração Inibidora 50
Panax/química
Extratos Vegetais/química
Plantas Medicinais
Inibidores da Agregação de Plaquetas/isolamento & purificação
Saponinas/isolamento & purificação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Ginsenosides); 0 (Plant Extracts); 0 (Platelet Aggregation Inhibitors); 0 (Saponins); 0 (Triterpenes); 27YG812J1I (Arachidonic Acid); JOS8BON5YW (ginsenoside Rf)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-117554


  3 / 162 MEDLINE  
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[PMID]:27919924
[Au] Autor:Karpunina PV; Oskolski AA; Nuraliev MS; Lowry PP; Degtjareva GV; Samigullin TH; Valiejo-Roman CM; Sokoloff DD
[Ad] Endereço:Biological Faculty, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.
[Ti] Título:Gradual vs. abrupt reduction of carpels in syncarpous gynoecia: A case study from Polyscias subg. Arthrophyllum (Araliaceae: Apiales).
[So] Source:Am J Bot;103(12):2028-2057, 2016 Dec.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Revealing the relative roles of gradual and abrupt transformations of morphological characters is an important topic of evolutionary biology. Gynoecia apparently consisting of one carpel have evolved from pluricarpellate syncarpous gynoecia in several angiosperm clades. The process of reduction can involve intermediate stages, with one fertile and one or more sterile carpels (pseudomonomery). The possible origin of monomery directly via an abrupt change of gynoecium merism has been a matter of dispute. We explore the nature of gynoecium reduction in a clade of Araliaceae. METHODS: The anatomy and development of unilocular gynoecia are investigated using light and scanning electron microscopy in two members of Polyscias subg. Arthrophyllum. Gynoecium diversity in the genus is discussed in a phylogenetic framework. KEY RESULTS: Unilocular gynoecia with one fertile ovule have evolved at least four times in Polyscias, including one newly discovered case. The two unilocular taxa investigated are unicarpellate, without any traces of reduced sterile carpels. Carpel orientation is unstable, and the ovary roof and style contain numerous vascular bundles without clearly recognizable dorsals or ventrals. In contrast to pluricarpellate Araliaceae and Apiaceae, the cross zone is apparently oblique in the unicarpellate species. CONCLUSIONS: No support was found for gradual gynoecium reduction via pseudomonomery. The abrupt origin of monomery via direct change of gynoecium merism and the unstable carpel orientation observed are related to the general lability of the flower groundplan in Polyscias. The apparent occurrence of the unusual oblique cross zone in unicarpellate Araliaceae can be explained by developmental constraints.
[Mh] Termos MeSH primário: Araliaceae/ultraestrutura
Flores/ultraestrutura
[Mh] Termos MeSH secundário: Araliaceae/genética
Araliaceae/crescimento & desenvolvimento
Evolução Biológica
Flores/genética
Flores/crescimento & desenvolvimento
Microscopia
Microscopia Eletrônica de Varredura
Óvulo Vegetal/genética
Óvulo Vegetal/crescimento & desenvolvimento
Óvulo Vegetal/ultraestrutura
Filogenia
Sementes/genética
Sementes/crescimento & desenvolvimento
Sementes/ultraestrutura
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600269


  4 / 162 MEDLINE  
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[PMID]:27829466
[Au] Autor:Kim W; Yim HS; Yoo DY; Jung HY; Kim JW; Choi JH; Yoon YS; Kim DW; Hwang IK
[Ad] Endereço:Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, South Korea.
[Ti] Título:Dendropanax morbifera Léveille extract ameliorates cadmium-induced impairment in memory and hippocampal neurogenesis in rats.
[So] Source:BMC Complement Altern Med;16(1):452, 2016 Nov 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cadmium leads to learning and memory impairment. Dendropanax morbifera Léveille stem extract (DMS) reduces cadmium-induced oxidative stress in the hippocampus. We investigated the effects of DMS on cadmium-induced impairments in memory in rats. METHODS: Cadmium (2 mg/kg), with or without DMS (100 mg/kg), was orally administered to 7-week-old Sprague-Dawley rats for 28 days. Galantamine (5 mg/kg), an acetylcholinesterase inhibitor, was intraperitoneally administered as a positive control. A novel-object recognition test was conducted 2 h after the final administration. Cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin, respectively. Acetylcholinesterase activity in the synaptosomes of the hippocampus was also measured based on the formation of 5,5'-dithio-bis-acid nitrobenzoic acid. RESULTS: An increase in the preferential exploration time of new objects was observed in both vehicle-treated and cadmium-treated rats. In addition, DMS administration increased cell proliferation and neuroblast differentiation in the dentate gyrus of vehicle-treated and cadmium-treated rats. Acetylcholinesterase activity in the hippocampal synaptosomes was also significantly higher in the DMS-treated group than in the vehicle-treated group. The effect of DMS on cadmium-induced memory impairment and cell proliferation in the hippocampus was comparable to that of galantamine. CONCLUSIONS: These results suggest that DMS ameliorates cadmium-induced memory impairment via increase in cell proliferation, neuroblast differentiation, and acetylcholinesterase activity in the hippocampus. The consumption of DMS may reduce cadmium-induced neurotoxicity in animals or humans.
[Mh] Termos MeSH primário: Araliaceae/química
Cádmio/toxicidade
Hipocampo/efeitos dos fármacos
Transtornos da Memória/tratamento farmacológico
Neurogênese/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Hipocampo/citologia
Hipocampo/metabolismo
Seres Humanos
Masculino
Memória/efeitos dos fármacos
Transtornos da Memória/etiologia
Transtornos da Memória/metabolismo
Transtornos da Memória/fisiopatologia
Neurônios/citologia
Neurônios/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


  5 / 162 MEDLINE  
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[PMID]:27767392
[Au] Autor:Ferreira NH; de Andrade KJ; Leandro LF; Acésio NO; Mendes SA; Cintra LS; Januário AH; Tavares DC
[Ad] Endereço:a University of Franca , Franca , São Paulo , Brazil.
[Ti] Título:Testing of Schefflera vinosa extract in mammalian cells in vitro and in vivo for potential toxicity, genetic damage, and role of oxidation.
[So] Source:J Toxicol Environ Health A;79(24):1201-1210, 2016.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to examine the cytotoxic and genotoxic potential of a hydroethanolic extract of Schefflera vinosa (SV), a plant with schistosomicidal activity, as well as its influence on DNA damage induced by different mutagens, methyl methane sulfonate (MMS) and hydrogen peroxide (H O ), in V79 cells and Swiss mice. Schefflera vinosa extract produced cytotoxicity at concentrations of 312.5 µg/ml or higher using the XTT cell proliferation assay kit. Treatment of V79 cell cultures with the highest SV concentration tested (150 µg/ml) significantly increased the frequency of micronuclei (MN) compared to controls. All SV concentrations significantly reduced the frequency of MN induced by hydrogen peroxide in V79 cell cultures. Further, SV was able to scavenge free radicals in the DPPH assay. In the in vivo test system, treatment with the highest dose tested (1,000 mg/kg body weight) induced a significant rise in frequency of DNA damage using the comet assay. However, animals treated with different doses of SV demonstrated absence of genotoxicity in the bone marrow MN test. For assessment of modulatory effects, the lower concentration of SV (250 mg/kg body weight) administered to MMS-treated mice significantly reduced frequency of DNA damage compared to the positive control (MMS alone). In contrast, the highest concentration tested (1,000 mg/kg body weight) significantly increased the rate of MN induced by MMS. The lack of genotoxic damage at biologically relevant SV concentrations, as well as the SV-mediated antigenotoxic and antioxidant activities, indicate the potential therapeutic usefulness of this plant extract. These activities may be attributed, at least in part, to the flavonoid quercitrin, its major component.
[Mh] Termos MeSH primário: Araliaceae/química
Citotoxinas/toxicidade
Dano ao DNA/efeitos dos fármacos
Mutagênicos/toxicidade
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Células CHO
Ensaio Cometa
Cricetinae
Cricetulus
Relação Dose-Resposta a Droga
Peróxido de Hidrogênio/farmacologia
Masculino
Metanossulfonato de Metila/farmacologia
Camundongos
Testes para Micronúcleos
Mutagênicos/farmacologia
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Mutagens); 0 (Plant Extracts); AT5C31J09G (Methyl Methanesulfonate); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


  6 / 162 MEDLINE  
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[PMID]:27592831
[Au] Autor:Nakamura M; Ra JH; Kim JS
[Ad] Endereço:Majors in Plant Resource and Environment, College of Agriculture & Life Science, SARI, Jeju National University.
[Ti] Título:The Comparative Analysis of Antioxidant and Biological Activity for the Dendropanax morbifera LEV. Leaves Extracted by Different Ethanol Concentrations.
[So] Source:Yakugaku Zasshi;136(9):1285-96, 2016.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The different concentrations of ethanol (20-100%) and distilled water extract for Dendropanax morbifera LEV. leaves were evaluated to induce antioxidant and biological activity employed by variety of assays. The 20%, 80%, and 100% ethanol extract demonstrated the relatively higher activity, whereas distilled water, 40%, and 60% ethanol extracts exhibited the lower antioxidant and biological activity. Especially, 80% ethanol extract showed the remarkably higher radical scavenging activity, reducing power, total phenol and flavonoid content, α-glucosidase, and tyrosinase inhibitory activity, and alcohol dehydrogenases (ADH) and aldehyde dehydrogenase (ALDH) activity. Also, 100% ethanol extract exhibited relatively greater activity, but there did not show significant radical scavenging activity. Furthermore, there were 50% and 30% promotion effect for ADH activity assay and 80% and 40% promotion effect for ALDH activity assay in 80% and 100% ethanol extract, respectively. In addition, in the minimum inhibitory concentration (MIC), all extracts except for distilled water extract inhibited Bacillus cereus, Staphylococcus aureus subsp. aureus, Escherichia coli. For Pichia jadinii, whole extracts effectively inhibited yeast multiplication at concentration of 125 µg/mL for 100% ethanol extract and 250 µg/mL for the rest of extract. These result indicated that D. morbifera LEV. leaves extracted by 80% ethanol would be the ideal extracting solution to maximize inherent antioxidant and biological activity agent.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Araliaceae/química
Extratos Vegetais/análise
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Álcool Desidrogenase/metabolismo
Aldeído Desidrogenase/metabolismo
Relação Dose-Resposta a Droga
Etanol
Flavonoides/análise
Depuradores de Radicais Livres
Inibidores de Glicosídeo Hidrolases
Monofenol Mono-Oxigenase/antagonistas & inibidores
Folhas de Planta/química
Polifenóis/análise
Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Glycoside Hydrolase Inhibitors); 0 (Plant Extracts); 0 (Polyphenols); 059QF0KO0R (Water); 3K9958V90M (Ethanol); EC 1.1.1.1 (Alcohol Dehydrogenase); EC 1.14.18.1 (Monophenol Monooxygenase); EC 1.2.1.3 (Aldehyde Dehydrogenase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00018


  7 / 162 MEDLINE  
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[PMID]:27570451
[Au] Autor:Wang C; Mathiyalagan R; Kim YJ; Castro-Aceituno V; Singh P; Ahn S; Wang D; Yang DC
[Ad] Endereço:Department of Oriental Medicine Biotechnology and Ginseng Bank.
[Ti] Título:Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities.
[So] Source:Int J Nanomedicine;11:3691-701, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Dendropanax morbifera Léveille is an oriental medicinal plant that is traditionally used in folk medicine and grows in a specific region of South Korea. We aimed to enhance the utilization of D. morbifera medicinal plants for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). D. morbifera leaf extract acted as both a reducing and a stabilizing agent that rapidly synthesized Dendropanax AgNPs (D-AgNPs) and Dendropanax AuNPs (D-AuNPs). The D-AgNPs and D-AuNPs were characterized by ultraviolet-visible spectroscopy, energy dispersive X-ray analysis, elemental mapping, field emission transmission electron microscopy, X-ray diffraction, and dynamic light scattering. The characterizations revealed that the D-AgNPs and D-AuNPs were in polygon and hexagon shapes with average sizes of 100-150 nm and 10-20 nm, respectively. The important outcomes were the synthesis of AgNPs and AuNPs within 1 hour and 3 minutes, respectively, avoiding the subsequent processing for removal of any toxic components or for stabilizing the nanoparticles. Additionally, D-AgNPs and D-AuNPs were examined for cytotoxicity in a human keratinocyte cell line and in A549 human lung cancer cell line. The results indicated that D-AgNPs exhibited less cytotoxicity in the human keratinocyte cell line at 100 µg/mL after 48 hours. On the other hand, D-AgNPs showed potent cytotoxicity in the lung cancer cells at the same concentration after 48 hours, whereas D-AuNPs did not exhibit cytotoxicity in both cell lines at the same concentration. However, both D-AgNPs and D-AuNPs at 50 µg/mL enhanced the cytotoxicity of ginsenoside compound K at 25 µM after 48 hours of treatment compared with CK alone. We believe that this rapid green synthesis of D-AgNPs and D-AuNPs is a valuable addition to the applications of D. morbifera medicinal plant. D-AuNPs can be used as carriers for drug delivery and in cancer therapy due to their lack of normal cell cytotoxicity.
[Mh] Termos MeSH primário: Araliaceae/química
Ouro/farmacologia
Química Verde/métodos
Nanopartículas Metálicas/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Prata/farmacologia
[Mh] Termos MeSH secundário: Células A549
Morte Celular/efeitos dos fármacos
Seres Humanos
Neoplasias Pulmonares/patologia
Nanopartículas Metálicas/ultraestrutura
Espectrometria por Raios X
Espectrofotometria Ultravioleta
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3M4G523W1G (Silver); 7440-57-5 (Gold)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S97181


  8 / 162 MEDLINE  
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[PMID]:27425217
[Au] Autor:Xu JL; Gu LH; Wang ZT; Bligh A; Han ZZ; Liu SJ
[Ad] Endereço:a Key Laboratory of Standardization of Chinese Medicines, Ministry of Education , Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
[Ti] Título:Seventeen steroids from the pith of Tetrapanax papyriferus.
[So] Source:J Asian Nat Prod Res;18(12):1131-1137, 2016 Dec.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new steroidal ketones (1, 2), together with 10 known steroids (3-12) and five known steroidal saponins (13-17), have been obtained from the pitch of Tetrapanax papyrierus. The structures of 1 and 2 were elucidated as 3ß-hydroxystigmast-8, 22-diene-7,11-dione and 3ß-hydroxystigmast-8-ene-7,11-dione by IR, HR-ESI-MS, 1D and 2D NMR techniques. Except for 4, 14, 15, 16, 13 compounds reported in this paper were isolated from Tetrapanax papyriferus for the first time.
[Mh] Termos MeSH primário: Araliaceae/química
Saponinas/isolamento & purificação
Estigmasterol/análogos & derivados
Estigmasterol/isolamento & purificação
[Mh] Termos MeSH secundário: Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Rizoma/química
Saponinas/química
Estereoisomerismo
Estigmasterol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Saponins); 99WUK5D0Y8 (Stigmasterol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE


  9 / 162 MEDLINE  
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[PMID]:27251158
[Au] Autor:Castro Aceituno V; Ahn S; Simu SY; Wang C; Mathiyalagan R; Yang DC
[Ad] Endereço:Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 446-701, Republic of Korea.
[Ti] Título:Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells.
[So] Source:In Vitro Cell Dev Biol Anim;52(10):1012-1019, 2016 Dec.
[Is] ISSN:1543-706X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Green synthesized silver nanoparticles have significant potential in the pharmaceutical field because of their biological functions such as antioxidant and anticancer activities. Novel silver nanoparticles synthesized from Dendropanax morbifera Léveille leaves (D-AgNPs) exhibit antimicrobial activity and reduce the viability of cancer cells without affecting the viability of RAW 264.7 macrophage-like cells. In this study, we evaluated the anticancer effect of D-AgNPs by measuring the levels of reactive oxygen species (ROS) production and toxicity against A549 and HepG2 cell lines. The effect of D-AgNPs on cell migration, induction of apoptosis, and modification of gene and/or protein expression of cancer-related markers was determined using A549 cells. D-AgNPs exhibited cytotoxicity in A549 and HepG2 cell at different concentrations and enhanced the production of ROS in both cell lines. An increase in cell apoptosis and a reduction in cell migration in A549 cells were also observed after D-AgNP treatment. Furthermore, the effect of D-AgNPs in A549 cells was shown to be related to modification of the EGFR/p38 MAPK pathway. Our data provide the first evidence supporting the potential of D-AgNPs as a possible anticancer agent, particularly for the treatment of non-small cell lung carcinoma.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Araliaceae/química
Movimento Celular/efeitos dos fármacos
Neoplasias Pulmonares/patologia
Nanopartículas Metálicas/química
Espécies Reativas de Oxigênio/metabolismo
Prata/farmacologia
[Mh] Termos MeSH secundário: Células A549
Sobrevivência Celular/efeitos dos fármacos
Regulação para Baixo/efeitos dos fármacos
Fator de Crescimento Epidérmico/farmacologia
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células Hep G2
Seres Humanos
Neoplasias Pulmonares/enzimologia
Fosforilação/efeitos dos fármacos
Receptor do Fator de Crescimento Epidérmico/genética
Receptor do Fator de Crescimento Epidérmico/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 3M4G523W1G (Silver); 62229-50-9 (Epidermal Growth Factor); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE


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[PMID]:27150144
[Au] Autor:Akram M; Kim KA; Kim ES; Syed AS; Kim CY; Lee JS; Bae ON
[Ad] Endereço:College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University.
[Ti] Título:Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway.
[So] Source:Biol Pharm Bull;39(5):728-36, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms. In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-κB (NF-κB) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases.
[Mh] Termos MeSH primário: Analgésicos
Anti-Inflamatórios
Araliaceae
Heme Oxigenase-1/metabolismo
Proteínas de Membrana/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Extratos Vegetais
[Mh] Termos MeSH secundário: Ácido Acético
Analgésicos/farmacologia
Analgésicos/uso terapêutico
Animais
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Clorofórmio/química
Citocinas/metabolismo
Dinoprostona/metabolismo
Orelha/patologia
Edema/induzido quimicamente
Edema/tratamento farmacológico
MAP Quinase Quinase 4/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos ICR
NF-kappa B/metabolismo
Nitritos/metabolismo
Dor/induzido quimicamente
Dor/tratamento farmacológico
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Folhas de Planta
Células RAW 264.7
Solventes/química
Acetato de Tetradecanoilforbol
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nitrites); 0 (Plant Extracts); 0 (Solvents); 7V31YC746X (Chloroform); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 2.7.12.2 (MAP Kinase Kinase 4); K7Q1JQR04M (Dinoprostone); NI40JAQ945 (Tetradecanoylphorbol Acetate); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b15-00823



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