Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.087.374 [Categoria DeCS]
Referências encontradas : 424 [refinar]
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[PMID]:28676388
[Au] Autor:Zhang L; Li BB; Li HZ; Meng X; Lin X; Jiang YY; Ahn JS; Cui L
[Ad] Endereço:College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, Jilin Province 132013, People's Republic of China.
[Ti] Título:Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B).
[So] Source:Fitoterapia;121:58-63, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new compounds, erythro-7'E-4-hydroxy-3,3'-dimethoxy-8,5'-oxyneoligna-7'-ene-7,9-diol-9'-al (1), (7S,8S)-4-hydroxy-3,1',3'-trimethoxy-4',7-epoxy-8,5'-neolign-9-ol (5), (7S,8S,7'E)-5-hydroxy-3,3'-dimethoxy-4',7-epoxy-8,5'-neolign-7'-ene-9,9'-diol (6) and (7S,8S,7'E)-5-hydroxy-3,3',9'-trimethoxy-4'-7-epoxy-8,5'-neolign-7'-ene-9-ol (7). Along with four known compounds (2-4, 8) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the compounds were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, compounds 1-4 and 6-8 were found to exhibit selective inhibitory activity on PTP1B with IC values ranging from 17.2±1.6 to 32.7±1.2µM.
[Mh] Termos MeSH primário: Eleutherococcus/química
Lignanas/farmacologia
Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Lignanas/isolamento & purificação
Estrutura Molecular
Caules de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


  2 / 424 MEDLINE  
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[PMID]:28441735
[Au] Autor:Nishina A; Itagaki M; Suzuki Y; Koketsu M; Ninomiya M; Sato D; Suzuki T; Hayakawa S; Kuroda M; Kimura H
[Ad] Endereço:College of Science and Technology, Nihon University, 1-5-1 Kandasurugadai, Chiyoda, Tokyo 101-0062, Japan. nishina.atsuyoshi@nihon-u.ac.jp.
[Ti] Título:Effects of Flavonoids and Triterpene Analogues from Leaves of Eleutherococcus sieboldianus (Makino) Koidz. 'Himeukogi' in 3T3-L1 Preadipocytes.
[So] Source:Molecules;22(4), 2017 Apr 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:(Makino) Koidz. is a local product from the area in and around Yonezawa City in Yamagata Prefecture, Japan. It has been used as a medicinal plant for a long time. We isolated and identified four types of flavonoid glycosides [astragalin ( ), isoquercetin ( ), rhamnocitrin 3- -glucoside ( ), and nicotiflorin ( )], a triterpene [methyl hederagenin ( )], and three types of triterpene glycosides [δ-hederin ( ), echinocystic acid 3- -arabinoside ( ), and cauloside B ( )] from the methanol extract of , which regulates lipid accumulation in 3T3-L1 preadipocytes. Among the compounds isolated, and up- and down-regulated lipid accumulation and insulin induced adipocyte differentiation in 3T3-L1 preadipocytes. Compound induced up-regulation of lipid accumulation and decreased adipocyte size, while down-regulated lipid accumulations without decreasing cell size. Additionally, increased adipogenic proteins [peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and fatty-acid-binding protein 4 (FABP4)]. In contrast, decreased the levels of all adipogenic proteins and glucose transporter type 4 (GLUT4), but increased adiponectin.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/farmacologia
Eleutherococcus/química
Flavonoides/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/efeitos dos fármacos
Adipócitos/metabolismo
Adipogenia/efeitos dos fármacos
Animais
Sobrevivência Celular/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos
Metabolismo dos Lipídeos/efeitos dos fármacos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Triterpenes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28399215
[Au] Autor:Zhai C; Wang M; Raman V; Rehman JU; Meng Y; Zhao J; Avula B; Wang YH; Khan Z; Khan IA
[Ad] Endereço:National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677 ( zhaicm163@163.com; meiwang@olemiss.edu; vraman@olemiss.edu; jurehman@olemiss.edu; ymeng@olemiss.edu; jianping@olemiss.edu; bavula@olemiss.edu; wangyh@olemiss.edu; ikhan@olemiss.edu ).
[Ti] Título:Eleutherococcus senticosus (Araliaceae) Leaf Morpho-Anatomy, Essential Oil Composition, and Its Biological Activity Against Aedes aegypti (Diptera: Culicidae).
[So] Source:J Med Entomol;54(3):658-669, 2017 May 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The roots of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., a well-known medicinal plant from Eastern Asia, are used worldwide for their known beneficial medicinal properties. Recently, the leaves have been used as an alternative to the roots. The present study was aimed at exploring the leaf essential oil as a potential source of compounds for mosquito management. Gas chromatography/mass spectrometry analysis of the leaf essential oil revealed 87 compounds, constituting 95.2% of the oil. α-Bisabolol (26.46%), ß-caryophyllene (7.45%), germacrene D (6.87%), ß-bisabolene (4.95%), and α-humulene (3.50%) were five of the major constituents. The essential oil was subjected to biting deterrence and repellent activity against mosquito Aedes aegypti. The biting deterrence of the oil produced a proportion not biting (PNB) value of 0.62 at 10 µg/cm2 as compared with 0.86 of control DEET (N,N-diethyl-3-methylbenzamide) at a standard dose of 25 nmol/cm2. Among individually selected compounds present in the oil (α-bisabolol, ß-caryophyllene, α-humulene, and caryophyllene oxide), only α-bisabolol produced a PNB value of 0.80, equivalent to DEET at 25 nmol/cm2, whereas the others were not repellent. The artificial mixture (AMES-1) of these four selected compounds produced a relatively high PNB value of 0.80. The repellent activity measured by minimum effective dosage (MED) for α-bisabolol and α-humulene produced MED values of 0.094 and 0.104 mg/cm2, respectively, as compared with 0.023 mg/cm2 of DEET. The leaf essential oil, the artificial mixture (AMES-1), and other binary and tertiary combinations of major compounds showed no repellent activity. In addition, morpho-anatomical features of the leaf are provided for correct identification of the species.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Eleutherococcus/química
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Aedes/crescimento & desenvolvimento
Animais
Eleutherococcus/anatomia & histologia
Eleutherococcus/metabolismo
Comportamento Alimentar/efeitos dos fármacos
Feminino
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Óleos Voláteis/análise
Folhas de Planta/anatomia & histologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides); 0 (Oils, Volatile)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjw221


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[PMID]:28274455
[Au] Autor:Ge YW; Zhu S; Yoshimatsu K; Komatsu K
[Ad] Endereço:Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
[Ti] Título:MS/MS similarity networking accelerated target profiling of triterpene saponins in Eleutherococcus senticosus leaves.
[So] Source:Food Chem;227:444-452, 2017 Jul 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The targeted mass information of compounds accelerated their discovery in a large volume of untargeted MS data. An MS/MS similarity networking is advanced in clustering the structural analogues, which benefits the collection of mass information of similar compounds. The triterpene saponins extracted from Eleutherococcus senticosus leaves (ESL), a kind of functional tea, have shown promise in the relief of Alzheimer's disease. In this work, a target-precursor list (TPL) generated using MS/MS similarity networking was employed to rapidly trace 106 triterpene saponins from the aqueous extracts of ESL, of which 49 were tentatively identified as potentially new triterpene saponins. Moreover, a compound database of triterpene saponins was established and successfully applied to uncover their distribution features in ESL samples collected from different areas.
[Mh] Termos MeSH primário: Eleutherococcus/química
Extratos Vegetais/química
Saponinas/química
Espectrometria de Massas em Tandem/métodos
Triterpenos/química
[Mh] Termos MeSH secundário: Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28214940
[Au] Autor:Shi WJ; Ying GG; Huang GY; Liang YQ; Hu LX; Zhao JL; Zhang JN
[Ad] Endereço:State Key Laboratory of Organic Geochemistry, CAS Research Centre of PRD Environmental Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, 510640, Guangzhou, China.
[Ti] Título:Transcriptional and Biochemical Alterations in Zebrafish Eleuthero-Embryos (Danio rerio) After Exposure to Synthetic Progestogen Dydrogesterone.
[So] Source:Bull Environ Contam Toxicol;99(1):39-45, 2017 Jul.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Little information has so far been known on the effects of synthetic progestogen dydrogesterone (DDG) in organisms like fish. This study aimed to investigate the effects of DDG on the transcriptional and biochemical alterations in zebrafish eleuthero-embryos. Zebrafish eleuthero-embryos were analyzed for the transcriptional alterations by real-time quantitative PCR (RT-qPCR) and biochemical changes by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FITR) after 144 h exposure to DDG. The results of qPCR analysis showed that DDG exposure significantly suppressed the transcriptions of target genes involved in hypothalamic-pituitary-thyroid (HPT) axis, while it induced the expression of target genes mRNA belonging to hypothalamic-pituitary-gonad (HPG) axis. In addition, ATR-FTIR spectroscopy analysis showed that the biochemical alterations of protein, nucleic acid and lipid were observed following DDG treatment. The finding from this study suggests that DDG exposure could have potential multiple effects in fish.
[Mh] Termos MeSH primário: Didrogesterona/toxicidade
Embrião não Mamífero/efeitos dos fármacos
Disruptores Endócrinos/toxicidade
Poluentes Químicos da Água/toxicidade
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Eleutherococcus
Sistema Endócrino
Congêneres da Progesterona
Poluentes Químicos da Água/metabolismo
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Progesterone Congeners); 0 (Water Pollutants, Chemical); 90I02KLE8K (Dydrogesterone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-017-2046-1


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[PMID]:28183150
[Au] Autor:Kong Z; Jie H; Zhou C; Yang L; Tan Z; Yang W
[Ad] Endereço:Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.
[Ti] Título:Effects of dietary supplementation of Acanthopanax senticosus on gastrointestinal tract development in calves.
[So] Source:Anim Sci J;88(9):1321-1326, 2017 Sep.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Twenty-four newborn Holstein dairy male calves (with initial body weight of 38 ± 3.0 kg) were used in a randomized block design experiment to determine effects of dietary supplementation of Acanthopanax senticosus (AS) on gastrointestinal tract development. Calves were fed milk (10%/body weight) three times at 06.00, 12.00 and 18.00 hours daily with one to four treatments during the experimental periods (4 to 28 days): no supplementation of AS (control group, CG); 1.0 g/L•time of micro-powder AS (MP); 1.0 g/L•time of superfine powder AS (SP); or 1.0 g/L•time of coarse powder AS (CP). On days 7, 14, 21 and 28, 20 mL blood samples were collected at 06.00 hours before the morning feeding. At the end of the trial (28 days), all calves were euthanized, and tissue samples were taken and placed in 4% buffered formaldehyde for analyses. In the rumen of MP treatment, compared with the CG treatment, wall thickness and papillae diameter was both significantly lower (P<0.05), while crypt depth was significantly greater (P<0.05). In the duodenum, villi diameter of AS supplemented treatments was significantly lower than that of CG treatment (P<0.05). Results indicate that calves during sucking period supplemented with AS as MP style could promote gastrointestinal development.
[Mh] Termos MeSH primário: Ração Animal
Bovinos/crescimento & desenvolvimento
Dieta/veterinária
Suplementos Nutricionais
Eleutherococcus
Trato Gastrointestinal/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Animais Lactentes
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12764


  7 / 424 MEDLINE  
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[PMID]:28182104
[Au] Autor:Zaluski D; Olech M; Verpoorte R; Khan I; Kuzniewski R; Nowak R
[Ad] Endereço:Department of Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 Marie Curie-Sklodowska Street, 85-094 Bydgoszcz, Poland.
[Ti] Título:Phytoconstituents and Nutritional Properties of the Fruits of and : A Study of Non-European Species Cultivated in Poland.
[So] Source:Oxid Med Cell Longev;2017:8374295, 2017.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:fruits have been consumed in Russia and Asia throughout the centuries. Currently, there is an increasing interest in these products by the community of Western Europe. Many people suffer from micronutrient deficiencies, known as malnutrition, which consequently influences body condition. The aim of this study was to investigate pharmaconutrition, proximate, mineral, and fatty acid composition, total phenolics content, and total flavonoids content of and fruits cultivated in Poland. and contain a high amount of protein and fibres (16.70% and 12.28%; 61.41% and 45.63%, resp.). The fruits were generally high in K (21 g/kg) and low in sodium (0.001 g/kg). In terms of fatty acid composition, both species had a high amount of monounsaturated fatty acids (54.84-57.95%) and polyunsaturated fatty acids (36.22-37.0%). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound, ranging from 260 to 810 g/100 g DE. Among flavonoids, hyperoside was found to be in the highest amount (120-780 g/100 g DE). Considering a rich chemical composition of the fruits, a better understanding of their health benefits is important in order to increase their utility and to enrich dietary sources of health promoting compounds. Because of a high amount of protein and a low calorific value, the fruits should be considered food for vegans or vegetarians.
[Mh] Termos MeSH primário: Eleutherococcus/química
Frutas/química
[Mh] Termos MeSH secundário: Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1155/2017/8374295


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[PMID]:28164395
[Au] Autor:Lee S; Park HJ; Jeon SJ; Kim E; Lee HE; Kim H; Kwon Y; Zhang J; Jung IH; Ryu JH
[Ad] Endereço:Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 02447, Korea.
[Ti] Título:Cognitive Ameliorating Effect of Acanthopanax koreanum Against Scopolamine-Induced Memory Impairment in Mice.
[So] Source:Phytother Res;31(3):425-432, 2017 Mar.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acanthopanax koreanum Nakai (Araliaceae) is one of the most widely cultivated medicinal plants in Jeju Island, Korea, and the roots and stem bark of A. koreanum have been traditionally used as a tonic agent for general weakness. However, the use of A. koreanum for general weakness observed in the elderly, including those with declined cognitive function, has not been intensively investigated. This study was performed to investigate the effect of the ethanol extract of A. koreanum (EEAK) on cholinergic blockade-induced memory impairment in mice. To evaluate the ameliorating effects of EEAK against scopolamine-induced memory impairment, mice were orally administered EEAK (25, 50, 100, or 200 mg/kg), and several behavioral tasks, including a passive avoidance task, the Y-maze, and a novel object recognition task, were employed. Besides, western blot analysis was conducted to examine whether EEAK affected memory-associated signaling molecules, such as protein kinase B (Akt), Ca /calmodulin-dependent protein kinase II (CaMKII), and cAMP response element-binding protein (CREB). The administration of EEAK (100 or 200 mg/kg, p.o.) significantly ameliorated the scopolamine-induced cognitive impairment in the passive avoidance task, the Y-maze, and the novel object recognition task. The phosphorylation levels of both Akt and CaMKII were significantly increased by approximately two-fold compared with the control group because of the administration of EEAK (100 or 200 mg/kg) (p < 0.05). Moreover, the phosphorylation level of CREB was also significantly increased compared with the control group by the administration of EEAK (200 mg/kg) (p < 0.05). The present study suggests that EEAK ameliorates the cognitive dysfunction induced by the cholinergic blockade, in part, via several memory-associated signaling molecules and may hold therapeutic potential against cognitive dysfunction, such as that presented in neurodegenerative diseases, for example, Alzheimer's disease. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Eleutherococcus/química
Transtornos da Memória/induzido quimicamente
Transtornos da Memória/tratamento farmacológico
Extratos Vegetais/farmacologia
Hidrobrometo de Escopolamina/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Transtornos Cognitivos/induzido quimicamente
Transtornos Cognitivos/tratamento farmacológico
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Etanol/química
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Transtornos da Memória/psicologia
Camundongos
Camundongos Endogâmicos ICR
Extratos Vegetais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclic AMP Response Element-Binding Protein); 0 (Plant Extracts); 3K9958V90M (Ethanol); 451IFR0GXB (Scopolamine Hydrobromide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5764


  9 / 424 MEDLINE  
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[PMID]:28065780
[Au] Autor:Zhang SN; Li XZ; Yang XY
[Ad] Endereço:Department of Pharmacy, Guiyang University of Chinese Medicine, Guiyang 550025, PR China.
[Ti] Título:Drug-likeness prediction of chemical constituents isolated from Chinese materia medica Ciwujia.
[So] Source:J Ethnopharmacol;198:131-138, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Ciwujia (CWJ), one of the most commonly used Chinese materia medicas (CMMs), is derived from the roots, rhizomes, and stems of Acanthopanax senticosus harms (AS). CWJ has been used for the treatment of various central nervous system (CNS) and peripheral system diseases. Drug-likeness prediction can help to analyze the absorption, distribution, metabolism, and excretion (ADME) processes of the compounds in CWJ, as well as their potential therapeutic and toxic effects, which is of significance in the confirmation of the active material bases of CWJ. MATERIALS AND METHODS: The ADME properties of the compounds were calculated through web based PreADMET program and ACD/I-Lab 2.0. The potential therapeutic and toxicity targets of these compounds were screened by the ChemQuery tool in DrugBank and T3DB. RESULTS: 14/39 compounds had moderate or good oral bioavailability (OB). 29/39 compounds bound weakly to the plasma proteins. 18/39 compounds might pass across the blood-brain barrier (BBB). Most of these compounds showed low renal excretion ability. 25/39 compounds had 99 structurally similar drugs and 158 potential therapeutic targets. Additionally, 17/39 compounds had 53 structurally similar toxins and 126 potential toxicity targets. CONCLUSION: Our study suggests that these compounds have a certain drug-likeness potentials, which are also likely to be the material bases of CWJ. These results may provide a reference for the safe use of CWJ and the expansion of its application scope.
[Mh] Termos MeSH primário: Eleutherococcus/química
Materia Medica/análise
[Mh] Termos MeSH secundário: Barreira Hematoencefálica
Biologia Computacional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Materia Medica)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


  10 / 424 MEDLINE  
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[PMID]:28049349
[Au] Autor:Song Y; Yang CJ; Wang ZB; Zhao N; Feng XS; Meng FH
[Ad] Endereço:a School of Pharmacy , China Medical University , Shenyang , P.R. China.
[Ti] Título:Chemical constituents of Eleutherococcus sessiliflorus extract and its sedative-hypnotic effect.
[So] Source:Nat Prod Res;31(17):1995-2000, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the chemical constituents and bioactivities of the roots of Eleutherococcus sessiliflorus (E. sessiliflorus). The compounds were isolated through various chromatography techniques and elucidated by mass spectrometric (MS), 1D- and 2D-NMR analyses. The sedative-hypnotic effect of E. sessiliflorus ethanol extract and its fractions (acetic ether, n-butanol and water fraction) were also investigated. In the chemical constituent study, one new compound, 3-ethyl-5-hydroxy-3-(hydroxymethyl) pentyl-3-(3,4-dihydroxyphenyl) acrylate and fourteen known compounds were isolated and identified. The chromatographic fingerprint of E. sessiliflorus was established by UPLC-PDA-MS/MS analysis. In bioactivity study, it was found that the water fraction of E. sessiliflorus extract could prolong pentobarbital-induced sleeping time more than that of the other fractions of E. sessiliflorus extract in mice, which provided a basis for future study on sedative-hypnotic effect of the chemical constituents in E. sessiliflorus.
[Mh] Termos MeSH primário: Eleutherococcus/química
Hipnóticos e Sedativos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: 1-Butanol/química
Animais
Etanol
Hipnóticos e Sedativos/química
Masculino
Camundongos
Pentobarbital/farmacologia
Extratos Vegetais/análise
Raízes de Plantas/química
Sono/efeitos dos fármacos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 0 (Plant Extracts); 3K9958V90M (Ethanol); 8PJ61P6TS3 (1-Butanol); I4744080IR (Pentobarbital)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1272106



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