Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.087.450 [Categoria DeCS]
Referências encontradas : 37 [refinar]
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[PMID]:27667518
[Au] Autor:Sun W; He YS; Xu LH; Zhang BY; Qi LW; Yang J; Li P; Wen XD
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus.
[So] Source:Chin J Nat Med;14(9):714-720, 2016 Sep.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Polyynes, such as facarindiol (FAD) and oplopandiol (OPD), are responsible for anticancer activities of Oplopanax elatus (O. elatus). A novel approach to pharmacokinetics determination of the two natural polyynes in rats was developed and validated using a liquid chromatography-electrospray ionization-mass spectrometry (LC-MS) method. Biosamples were prepared by liquid-liquid extraction using ethyl acetate/n-hexane (V : V = 9 : 1) and the analytes were eluted on an Agilent ZORBAX Eclipse Plus C18 threaded column (4.6 mm × 50 mm, 1.8 µm) with the mobile phase of acetonitrile-0.1% aqueous formic acid at a flow-rate of 0.5 mL·min(-1) within a total run time of 11 min. All analytes were simultaneously monitored in a single-quadrupole mass spectrometer in the selected ion monitoring (SIM) mode using electrospray source in positive mode. The method was demonstrated to be rapid, sensitive, and reliable, and it was successfully applied to the pharmacokinetic studies of the two polyynes in rat plasma after oral administration of polyynes extract of O. elatus.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Di-Inos/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Álcoois Graxos/farmacocinética
Naftóis/farmacocinética
Oplopanax/química
Poliacetilenos/farmacocinética
Espectrometria de Massas por Ionização por Electrospray/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Di-Inos/administração & dosagem
Medicamentos de Ervas Chinesas/administração & dosagem
Álcoois Graxos/administração & dosagem
Masculino
Naftóis/administração & dosagem
Poliacetilenos/administração & dosagem
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diynes); 0 (Drugs, Chinese Herbal); 0 (Fatty Alcohols); 0 (Naphthols); 13902-62-0 (oplodiol); 25067-58-7 (Polyacetylenes); 55297-87-5 (falcarindiol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170923
[Lr] Data última revisão:
170923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:26221768
[Au] Autor:Cheung SS; Tai J; Hasman D; Ou D; Warnock GL
[Ad] Endereço:a Department of Surgery , University of British Columbia , Vancouver , British Columbia , Canada 
[Ti] Título:Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound.
[So] Source:Nutr Cancer;67(6):954-64, 2015.
[Is] ISSN:1532-7914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Devil's club Oplopanax horridus (DC) is a close relative of ginseng; its inner root and stem bark extract showed antiproliferation activity on human leukemia, ovarian, breast and colon cancer cells. We study here the effects of DC 70% ethanol extract alone, or in combination with cisplatin, gemcitabine, and paclitaxel on pancreatic endocrine HP62 and pancreatic ductal carcinoma PANC-1 and BxPC-3 cells. Antiproliferation activity assay, cell cycle analysis by flow cytometry, apoptosis-related markers by antibody array, and RT-PCR assay were used for this study. DC extract inhibited proliferation of HP62 with IC50 (50% inhibition concentration) at 0.037±0.002% (v/v), PANC-1 at 0.0058 ± 0.0004% and BxPC-3 at 0.021 ± 0.003%. DC at 0.0033% combined with 1 nM of paclitaxel showed inhibition synergy on PANC-1 cells with a combination index of 0.44. Apoptosis focused antibody array profile indicated upregulation of cytochrome C, claspin, cIAP-2 and HTRA2/Omi apoptosis-related markers in DC-treated HP62 and PANC-1. Our data suggest that DC acts through targeting the intrinsic mitochondrial apoptosis pathway in the pancreatic cancer cells. The high antiproliferation potency of DC on PANC-1 is potentially useful as an adjunct therapy for treating pancreatic cancer, which is known for developing resistance to conventional chemotherapeutics.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Oplopanax/química
Poliacetilenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Cisplatino/farmacologia
Desoxicitidina/análogos & derivados
Desoxicitidina/farmacologia
Seres Humanos
Concentração Inibidora 50
Paclitaxel/farmacologia
Neoplasias Pancreáticas/tratamento farmacológico
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0W860991D6 (Deoxycytidine); 25067-58-7 (Polyacetylenes); B76N6SBZ8R (gemcitabine); P88XT4IS4D (Paclitaxel); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150819
[Lr] Data última revisão:
150819
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150730
[St] Status:MEDLINE
[do] DOI:10.1080/01635581.2015.1055367


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[PMID]:25443364
[Au] Autor:Shikov AN; Pozharitskaya ON; Makarov VG; Yang WZ; Guo DA
[Ad] Endereço:Saint-Petersburg Institute of Pharmacy, 188663, Kuzmolovo P 245, Russia. Electronic address: spb.pharmacy@gmail.com.
[Ti] Título:Oplopanax elatus (Nakai) Nakai: chemistry, traditional use and pharmacology.
[So] Source:Chin J Nat Med;12(10):721-9, 2014 Oct.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Oplopanax elatus (Nakai) Nakai, a member of the ancient angiosperm plant family Araliaceae, is used for the treatment of different disorders in the medicine systems of China, Russia, and Korea, and was designated in Russia as a classical adaptogen. Despite extensive studies of classical adaptogens, there are comparatively few reports concerning the chemical composition and pharmacological effects of O. elatus in English. The plant is a potential source of saponins, flavonoids, anthraquinones, terpenes, and other active compounds. Experimental studies and clinical applications have indicated that O. elatus possesses a number of pharmacological activities, including adaptogenic, anti-convulsant, anti-diabetic, anti-fungal, anti-inflammatory, anti-oxidant, blood pressure modulating, and reproductive function effects. In this review, the chemistry, safety, and therapeutic potential of O. elatus are summarized and highlighted to encourage the further development of this plant.
[Mh] Termos MeSH primário: Oplopanax/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Medicina Tradicional
Fitoterapia
Extratos Vegetais/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25438081
[Au] Autor:Shao L; Bao MH; Ouyang DS; Wang CZ; Yuan CS; Zhou HH; Huang WH
[Ad] Endereço:Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. Shaoli82@aliyun.com.
[Ti] Título:Unstable simple volatiles and gas chromatography-tandem mass spectrometry analysis of essential oil from the roots bark of Oplopanax horridus extracted by supercritical fluid extraction.
[So] Source:Molecules;19(12):19708-17, 2014 Nov 27.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Volatile oil from the root bark of Oplopanax horridus is regarded to be responsible for the clinical uses of the title plant as a respiratory stimulant and expectorant. Therefore, a supercritical fluid extraction method was first employed to extract the volatile oil from the roots bark of O. horridus, which was subsequently analyzed by GC/MS. Forty-eight volatile compounds were identified by GC/MS analysis, including (S,E)-nerolidol (52.5%), τ-cadinol (21.6%) and S-falcarinol (3.6%). Accordingly, the volatile oil (100 g) was subjected to chromatographic separation and purification. As a result, the three compounds, (E)-nerolidol (2 g), τ-cadinol (62 mg) and S-falcarinol (21 mg), were isolated and purified from the volatile oil, the structures of which were unambiguously elucidated by detailed spectroscopic analysis including 1D- and 2D-NMR techniques.
[Mh] Termos MeSH primário: Cromatografia com Fluido Supercrítico/métodos
Cromatografia Gasosa-Espectrometria de Massas/métodos
Óleos Voláteis/isolamento & purificação
Oplopanax/química
Casca de Planta/química
Raízes de Plantas/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Óleos Voláteis/química
Pressão
Reprodutibilidade dos Testes
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141202
[St] Status:MEDLINE
[do] DOI:10.3390/molecules191219708


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[PMID]:25340187
[Au] Autor:McGill CM; Alba-Rodriguez EJ; Li S; Benson CJ; Ondrasik RM; Fisher LN; Claxton DF; Barth BM
[Ti] Título:Extracts of Devil's club (Oplopanax horridus) exert therapeutic efficacy in experimental models of acute myeloid leukemia.
[So] Source:Phytother Res;28(9):1308-14, 2014 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acute myeloid leukemia (AML) is a group of hematological malignancies defined by expanded clonal populations of immature progenitors (blasts) of myeloid phenotype in blood and bone marrow. Given a typical poor prognostic outlook, there is great need for novel agents with anti-AML activity. Devil's club (Oplopanax horridus) is one of the most significant medicinal plants used among the indigenous people of Southeast Alaska and the coastal Pacific Northwest, with different linguistic groups utilizing various parts of the plant to treat many different conditions including cancer. Studies identifying medically relevant components in Devil's club are limited. For this research study, samples were extracted in 70% ethanol before in vitro analysis, to assess effects on AML cell line viability as well as to study regulation of tyrosine phosphorylation and cysteine oxidation. The root extract displayed better in vitro anti-AML efficacy in addition to a noted anti-tyrosine kinase activity independent of an antioxidant effect. In vivo therapeutic studies using an immunocompetent murine model of AML further demonstrated that Devil's club root extract improved the murine survival while decreasing immunosuppressive regulatory T cells and improving CD8+ T-cell functionality. This study defines for the first time an anti-AML efficacy for extracts of Devil's club.
[Mh] Termos MeSH primário: Leucemia Mieloide Aguda/tratamento farmacológico
Oplopanax/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD8-Positivos/citologia
Linhagem Celular Tumoral
Modelos Animais de Doenças
Feminino
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Fitoterapia
Plantas Medicinais/química
Transdução de Sinais
Linfócitos T Reguladores/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:141022
[Lr] Data última revisão:
141022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141024
[St] Status:MEDLINE


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[PMID]:25282894
[Au] Autor:Huang WH; Luo W; Wang CZ; Yuan CS; Nie MK; Shi SY; Zhou HH; Ouyang DS
[Ti] Título:[Phenolic constituents from Oplopanax horridus].
[So] Source:Zhongguo Zhong Yao Za Zhi;39(10):1852-7, 2014 May.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The chemical constituents were isolated and purified by various chromatographic techniques indluding silica gel, reverse phase silica gel, sephadex LH-20 and pre-HPLC and identified by their physicochemical properties and spectral data. Sixteen phenolic compounds had been isolated and n-butanol extracts which were fractionated from the ethanol extract of Oplopanax horridus roots bark. Their structures were identified as below, including 7 phenylpropanoid compounds, ferulic acid (1), 3-acetylcaffeic acid (2), caffeic acid (3), homovanillyl alcohol 4-O-beta-D-glucopyranoside (4), 3-hydroxyphenethyl alcohol 4-O-beta-D-glucopyranoside (5), 3, 5-dimethoxycinnamyl alcohol 4-O-beta-D-glucopyranoside (6), and 3-dimethoxycinnamyl alcohol 4-O-beta-D-glucopyranoside (7). Three coumarins, scopoletin (8), esculetin (9) and 3'-angeloyl-4'-acetyl-cis-knellactone (10). And 6 lignan compounds, (+)-isolaricires-inol-9'-O-beta-D-glucopyranoside (11), 3, 3'-dimethoxy-4, 9, 9'-trihydroxy-4', 7-epoxy-5', 8-lignan-4, 9-bis-O-beta-D-glucopyranoside (12), (+)-5, 5'-dimethoxylariciresinol 4'-O-beta-D-glucopyranoside (13), (-)-5,5'-dimethoxylariciresinol 4'-O-beta-D-glucopyranoside (14), (-)-pinoresinol 4'-O-beta-D-glucopyranoside (15), and (+)-5, 5'-dimethoxylariciresinol 9'-O-beta-D-glucopyranoside (16). All compounds were isolated and identified for the first time from this plant All the constituents except compounds 4, 6, 12 and 13 were obtained for the first time from the genus Oplopanax.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Oplopanax/química
Fenóis/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/isolamento & purificação
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Fenóis/isolamento & purificação
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Phenols)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:141006
[Lr] Data última revisão:
141006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141007
[St] Status:MEDLINE


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[PMID]:25070635
[Au] Autor:Yang ZM; Zhao J; Lao KM; Chen XJ; Leong F; Wang CZ; Yuan CS; Li SP
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
[Ti] Título:Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography.
[So] Source:Electrophoresis;35(20):2959-64, 2014 Oct.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A PEG-modified reversed migration MEEKC method was developed for simultaneous determination of six polyynes, including oplopandiol, falcarindiol, oplopandiol acetate, (11S, 16S, 9Z)-9,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate, oplopantriol B, and oplopantriol A, in Oplopanax horridus and Oplopanax elatus. The running buffer containing 0.8% v/v ethyl acetate, 3.8% w/v SDS, 6.6% v/v n-butanol in 20 mM phosphate buffer (pH 2.5), followed by mixing with propan-2-ol at 30% v/v and PEG-1000 at 15% w/v, was applied in the analysis. The proposed method was successfully applied to determine the six polyynes in five samples of Oplopanax horridus and one of O. elatus. The result showed that the types and amounts of polyynes present were obviously different when comparing the two herbs. Besides, the developed PEG-modified reversed MEEKC method might be suitable for the analysis of hydrophobic analytes in herbal medicines.
[Mh] Termos MeSH primário: Cromatografia Capilar Eletrocinética Micelar/métodos
Oplopanax/química
Poliacetilenos/análise
Polietilenoglicóis/química
[Mh] Termos MeSH secundário: Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
25067-58-7 (Polyacetylenes); 30IQX730WE (Polyethylene Glycols)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140730
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201400159


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[PMID]:25045937
[Au] Autor:Zhang Z; Yu C; Zhang CF; Wu XH; Wen XD; Anderson S; Du W; Huang WH; Li SP; Wang CZ; Yuan CS
[Ad] Endereço:Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA. zzhang2@bsd.uchicago.edu.
[Ti] Título:Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on colorectal cancer.
[So] Source:Nutrients;6(7):2668-80, 2014 Jul 18.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oplopanax horridus is a North American botanical that has received limited investigations. We previously isolated over a dozen of the constituents from O. horridus, and among them oplopantriol A (OPT A) is a novel compound. In this study, we firstly evaluated the in vivo chemoprevention activities of OPT A using the xenograft colon cancer mouse model. Our data showed that this compound significantly suppressed tumor growth with dose-related effects (p < 0.01). Next, we characterized the compound's growth inhibitory effects in human colorectal cancer cell lines HCT-116 and SW-480. With OPT A treatment, these malignant cells were significantly inhibited in both a concentration- and time-dependent manner (both p < 0.01). The IC50 was approximately 5 µM for HCT-116 and 7 µM for SW-480 cells. OPT A significantly induced apoptosis and arrested the cell cycle at the G2/M phase. From further mechanism explorations, our data showed that OPT A significantly upregulated the expression of a cluster of genes, especially the tumor necrosis factor receptor family and caspase family, suggesting that the tumor necrosis factor-related apoptotic pathway plays a key role in OPT A induced apoptosis.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Oplopanax/química
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Proliferação Celular
Neoplasias Colorretais/tratamento farmacológico
Modelos Animais de Doenças
Feminino
Células HCT116
Seres Humanos
Camundongos
Camundongos Nus
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140722
[St] Status:MEDLINE
[do] DOI:10.3390/nu6072668


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[PMID]:24922275
[Au] Autor:Tai J; Cheung SS; Hasman D
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Canada.
[Ti] Título:Human ovarian cancer multicellular spheroids: a model for testing antiproliferation activity of Devil's club (Oplopanax horridus) and anticancer agents.
[So] Source:Planta Med;80(8-9):662-70, 2014 Jun.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study was conducted to employ an ovarian cancer Ovcar 10 three-dimensional model to assess the antiproliferation activity of the medicinal plant Devil's club, Oplopanax horridus, and its active compound, alone and in combination, with chemotherapeutic agents compared to Ovcar 10 two-dimensional cells grown as monolayer cells. Ovcar 10 three-dimensional spheroids were prepared with a rotary cell culture system. Cell counting kit-8 assessed the antiproliferation activity. Apoptosis-related gene expression in three-dimensional spheroids and two- dimensional cells was analyzed with an apoptosis antibody array. Flow cytometry was used to analyze the cell cycle. Ovcar 10 cells formed compact three-dimensional spheroids after 5 days of culture in a rotary culture system. Ovcar 10 three-dimensional spheroids were significantly more resistant to killing by Devil's club extract, its active compound alone, gemcitabine, and paclitaxel, but not cisplatin compared to two-dimensional cells, with IC50 levels closer to that observed in vivo. Devil's club extract and its active compound alone significantly enhanced the antiproliferation activity of cisplatin and gemcitabine at some concentrations, but did not affect the activity of paclitaxel. A number of apoptosis-related genes were differentially expressed in three-dimensional spheroids, two-dimensional cells, and cells treated with Devil's club extract compared to untreated controls. In three-dimensional spheroids, the proportion of cells in the G2/M phase was slightly increased and the S phase was slightly decreased compared to two-dimensional cells. Ovcar 10 cells in three-dimensional spheroids altered the expression of multiple apoptosis-related genes, which may have contributed to the increased resistance of the cells to some drugs.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Oplopanax/química
Neoplasias Ovarianas/tratamento farmacológico
Extratos Vegetais/farmacologia
Esferoides Celulares/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Cisplatino/farmacologia
Desoxicitidina/análogos & derivados
Desoxicitidina/farmacologia
Feminino
Seres Humanos
Neoplasias Ovarianas/patologia
Paclitaxel/farmacologia
Casca de Planta/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Proteoma
Células Tumorais Cultivadas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Proteome); 0W860991D6 (Deoxycytidine); B76N6SBZ8R (gemcitabine); P88XT4IS4D (Paclitaxel); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140613
[St] Status:MEDLINE
[do] DOI:10.1055/s-0034-1368506


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[PMID]:24830715
[Au] Autor:Huang WH; Shao L; Wang CZ; Yuan CS; Zhou HH
[Ad] Endereço:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. endeavor34852@aliyun.com.
[Ti] Título:Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives.
[So] Source:Molecules;19(5):6142-62, 2014 May 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Six polyynes OH-1~6, some of which are occur naturally in acetylated form, had been isolated and identified from the root bark of Oplopanax horridus (Devil's Club), a natural dietary supplement and medicinal plant in North America. During the evaluation of the polyynes' potential anticancer activities, sixteen more acetylated derivatives OHR-1~16 have synthesized and their anti-proliferation activity on MCF-7, MDA-MB-231, A549, HepG2 and LO2 cells assayed to elucidate their structure-activity relationships. The results showed that OH-1 ((3S, 8S)-falcarindiol) had the most potent anticancer activity, with IC50 values of 15.3, 23.5, 7.7 and 4.7 µM on MCF-7, A549, HepG2 and MDA-MB-231 cells, respectively. For the primary structure-activity relationship, the anticancer activities of polyynes become weaker if their hydroxyl groups are acetylated, the terminal double bonds transformed into single bonds or they contain one more methylene group in the main skeleton chain.
[Mh] Termos MeSH primário: Neoplasias/tratamento farmacológico
Oplopanax/química
Extratos Vegetais/administração & dosagem
Poliacetilenos/administração & dosagem
[Mh] Termos MeSH secundário: Acetilação/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
América do Norte
Casca de Planta/química
Extratos Vegetais/química
Raízes de Plantas/química
Poliacetilenos/química
Poliacetilenos/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 25067-58-7 (Polyacetylenes)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:150615
[Lr] Data última revisão:
150615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140517
[St] Status:MEDLINE
[do] DOI:10.3390/molecules19056142



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