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[PMID]:29208442
[Au] Autor:Mehrtash H; Duncan K; Parascandola M; David A; Gritz ER; Gupta PC; Mehrotra R; Amer Nordin AS; Pearlman PC; Warnakulasuriya S; Wen CP; Zain RB; Trimble EL
[Ad] Endereço:National Cancer Institute, National Institutes of Health, Rockville, MA, USA. Electronic address: hedieh.mehrtash@nih.gov.
[Ti] Título:Defining a global research and policy agenda for betel quid and areca nut.
[So] Source:Lancet Oncol;18(12):e767-e775, 2017 Dec.
[Is] ISSN:1474-5488
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Betel quid and areca nut are known risk factors for many oral and oesophageal cancers, and their use is highly prevalent in the Asia-Pacific region. Additionally, betel quid and areca nut are associated with health effects on the cardiovascular, nervous, gastrointestinal, metabolic, respiratory, and reproductive systems. Unlike tobacco, for which the WHO Framework Convention on Tobacco Control provides evidence-based policies for reducing tobacco use, no global policy exists for the control of betel quid and areca nut use. Multidisciplinary research is needed to address this neglected global public health emergency and to mobilise efforts to control betel quid and areca nut use. In addition, future research is needed to advance our understanding of the basic biology, mechanisms, and epidemiology of betel quid and areca nut use, to advance possible prevention and cessation programmes for betel quid and areca nut users, and to design evidence-based screening and early diagnosis programmes to address the growing burden of cancers that are associated with use.
[Mh] Termos MeSH primário: Areca/efeitos adversos
Detecção Precoce de Câncer/normas
Neoplasias Esofágicas/prevenção & controle
Neoplasias Bucais/prevenção & controle
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Ásia/epidemiologia
Neoplasias Esofágicas/etiologia
Feminino
Saúde Global
Seres Humanos
Masculino
Neoplasias Bucais/etiologia
Formulação de Políticas
Projetos de Pesquisa/normas
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  2 / 1608 MEDLINE  
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[PMID]:28635656
[Au] Autor:Li L; Luo Z; Liu Y; Wang H; Liu A; Yu G; Li M; Yang R; Chen X; Zhu J; Zhao B
[Ad] Endereço:School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6, Zhonghuan South Road, Wangjing, Chaoyang District, Beijing 100102, China. lulu130901@126.com.
[Ti] Título:Screening and Identification of the Metabolites in Rat Plasma and Urine after Oral Administration of Areca catechu L. Nut Extract by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap-Orbitrap Tandem Mass Spectrometry.
[So] Source:Molecules;22(6), 2017 Jun 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:L. nut, a well-known toxic traditional herbal medicine, has been widely used to treat various diseases in China and many other Asian countries for centuries. However, to date the in vivo absorption and metabolism of its multiple bioactive or toxic components still remain unclear. In this study, liquid chromatography coupled with tandem mass spectrometry was used to analyze the major components and their metabolites in rat plasma and urine after oral administration of L. nut extract (ACNE). A total of 12 compounds, including 6 alkaloids, 3 tannins and 3 amino acids, were confirmed or tentatively identified from ACNE. In vivo, 40 constituents, including 8 prototypes and 32 metabolites were identified in rat plasma and urine samples. In summary, this study showed an insight into the metabolism of ACNE in vivo, which may provide helpful chemical information for better understanding of the toxicological and pharmacological profiles of ACNE.
[Mh] Termos MeSH primário: Areca/química
Catequina/química
Catequina/metabolismo
Nozes/química
Extratos Vegetais/química
Extratos Vegetais/metabolismo
[Mh] Termos MeSH secundário: Administração Oral
Alcaloides/sangue
Alcaloides/química
Alcaloides/urina
Aminoácidos/sangue
Aminoácidos/química
Aminoácidos/urina
Animais
Catequina/administração & dosagem
Cromatografia Líquida de Alta Pressão
Masculino
Extratos Vegetais/sangue
Extratos Vegetais/urina
Ratos
Ratos Sprague-Dawley
Espectrometria de Massas em Tandem
Taninos/sangue
Taninos/química
Taninos/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amino Acids); 0 (Plant Extracts); 0 (Tannins); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE


  3 / 1608 MEDLINE  
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[PMID]:28580560
[Au] Autor:Ma WF; Li CI; Gritz ER; Tamí-Maury I; Lam C; Lin CC
[Ad] Endereço:School of Nursing, China Medical University, and Adjunct Supervisor, Department of Nursing, China Medical University Hospital, Taichung, Taiwan, ROC, Taiwan, ROC.
[Ti] Título:[A Symbol of Connectedness Between the Self and the Tribal Home: Betel Quid in the Lives of Indigenous Taiwanese].
[So] Source:Hu Li Za Zhi;64(3):65-73, 2017 Jun.
[Is] ISSN:0047-262X
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:chi
[Ab] Resumo:BACKGROUND: Betel quid chewing plays a significant role in the development of oral cancer, yet the high prevalence of betel quid use remains a serious health problem in Taiwan, especially among indigenous Taiwanese. PURPOSE: The present study aimed to understand the reasons behind betel-quid chewing among indigenous Taiwanese people by examining the larger context of their culture and traditions. METHODS: This descriptive, qualitative study recruited ten regular betel quid indigenous chewers using purposive and snowball sampling. Four of the participants were interviewed individually and the remaining six comprised a focus group. Data were collected using in-depth interviews with semi-structured guidelines and analyzed using qualitative content analysis following the process of open coding, identifying codes, giving meaningful names to codes, putting similar codes in categories, and grouping categories into themes. RESULTS: Most of the participants associated betel quid with significant aspects of life, with betel quid symbolizing social belonging. In indigenous cultures, betel nut embodies the enduring companionship of lifelong friends. For the study participants, chewing betel quid was associated with symbolic meanings associated with the following five themes: betel quid chewing helps reinforce self-identity and sense of belonging; betel quid is considered a traditional symbol of love and marriage; betel quid reflects the celebration of simple abundance in indigenous life; betel quid represents an attitude toward life that accentuates the importance of learning to live in everlasting harmony with the environment and nature; and betel quid chewing is used to cure physical ailments and mitigate dental problems. CONCLUSIONS / IMPLICATIONS FOR PRACTICE: Beliefs related to chewing betel quid deeply impact the attitudes of indigenous people toward this behavior. Because chewing betel quid is an essential part of Taiwanese indigenous community life, the cultural and symbolic meanings of this practice must be taken into consideration when drafting related policies and developing cessation programs in order to help indigenous betel-quid chewers effectively reduce the risk of developing oral cancers.
[Mh] Termos MeSH primário: Areca
Grupos Populacionais
[Mh] Termos MeSH secundário: Areca/efeitos adversos
Seres Humanos
Pesquisa Qualitativa
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  4 / 1608 MEDLINE  
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[PMID]:28573260
[Au] Autor:Hu YJ; Chen J; Zhong WS; Ling TY; Jian XC; Lu RH; Tang ZG; Tao L
[Ti] Título:Trend Analysis of Betel Nut-associated Oral Cancer and Health Burden in China.
[So] Source:Chin J Dent Res;20(2):69-78, 2017.
[Is] ISSN:1462-6446
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To forecast the future trend of betel nut-associated oral cancer and the resulting burden on health based on historical oral cancer patient data in Hunan province, China. METHODS: Oral cancer patient data in five hospitals in Changsha (the capital city of Hunan province) were collected for the past 12 years. Three methods were used to analyse the data; Microsoft Excel Forecast Sheet, Excel Trendline, and the Logistic growth model. A combination of these three methods was used to forecast the future trend of betel nut-associated oral cancer and the resulting burden on health. RESULTS: Betel nut-associated oral cancer cases have been increasing rapidly in the past 12 years in Changsha. As of 2016, betel nuts had caused 8,222 cases of oral cancer in Changsha and close to 25,000 cases in Hunan, resulting in about ¥5 billion in accumulated financial loss. The combined trend analysis predicts that by 2030, betel nuts will cause more than 100,000 cases of oral cancer in Changsha and more than 300,000 cases in Hunan, and more than ¥64 billion in accumulated financial loss in medical expenses. CONCLUSION: The trend analysis of oral cancer patient data predicts that the growing betel nut industry in Hunan province will cause a humanitarian catastrophe with massive loss of human life and national resources. To prevent this catastrophe, China should ban betel nuts and provide early oral cancer screening for betel nut consumers as soon as possible.
[Mh] Termos MeSH primário: Areca/efeitos adversos
Mastigação
Neoplasias Bucais/epidemiologia
[Mh] Termos MeSH secundário: China/epidemiologia
Previsões
Seres Humanos
Modelos Logísticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.3290/j.cjdr.a38271


  5 / 1608 MEDLINE  
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[PMID]:28483252
[Au] Autor:Chitguppi C; Brar T
[Ad] Endereço:Jaypee Hospital, Noida 201301, India. Electronic address: dr.chandala.chitguppi@gmail.com.
[Ti] Título:Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood.
[So] Source:Int J Pediatr Otorhinolaryngol;97:55-60, 2017 Jun.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Oral submucous fibrosis in children is one of the devastating consequences of arecanut addiction in children. Arecanut is the fourth commonest psychoactive agents used worldwide. However, regrettably, unlike other addictions like tobacco and alcohol, its use in children has become socially acceptable atleast in a few countries. Consequently, children as young as two years have been noticed to be addicted to arecanuts. It has been a menace in most Asian countries and with increasing population migration, this has picked up even in the west. In order to understand the social factors leading to arecanut addiction in children and prognostic outcomes of paediatric oral submucous fibrosis, this review has been undertaken.
[Mh] Termos MeSH primário: Areca/efeitos adversos
Fibrose Oral Submucosa/etiologia
Psicotrópicos/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/complicações
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Pediatria
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE


  6 / 1608 MEDLINE  
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[PMID]:28339463
[Au] Autor:Tsai HT; Hsieh MJ; Lin CW; Su SC; Miao NF; Yang SF; Huang HC; Lai FC; Liu YF
[Ad] Endereço:Accelerated Bachelor of Science in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks.
[So] Source:PLoS One;12(3):e0163369, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. METHODOLOGY/PRINCIPAL FINDINGS: In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer. CONCLUSIONS: Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/efeitos adversos
Areca/efeitos adversos
Interação Gene-Ambiente
Neoplasias Bucais/etiologia
Polimorfismo de Nucleotídeo Único
Serpinas/genética
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Alelos
Estudos de Casos e Controles
Frequência do Gene
Predisposição Genética para Doença
Seres Humanos
Neoplasias Bucais/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SERPIN-B5); 0 (Serpins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0163369


  7 / 1608 MEDLINE  
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[PMID]:28272042
[Au] Autor:Dey MD; Ahmed M; Singh R; Boruah R; Mukhopadhyay R
[Ad] Endereço:Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, P.O. Napaam, Assam 784028, India E-mail: mrupak@tezu.ernet.in.
[Ti] Título:Utilization of two agrowastes for adsorption and removal of methylene blue: kinetics and isotherm studies.
[So] Source:Water Sci Technol;75(5-6):1138-1147, 2017 03.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fresh water streams contaminated with synthetic dye-containing effluents pose a threat to aquatic and human life either by preventing aquatic photosynthesis or by entering into the food chain. Adsorptive removal of such dyes with potent biosorbents is an important technique to reduce bioaccumulation and biomagnifications of the dyes in human life. We report use of betel nut (BN) husk and banana peel (BP), two most abundant ligno-cellulosic wastes, as efficient adsorbents for the removal of the basic dye methylene blue (MB). The adsorption by BN and BP was consistently high over wide ranges of pH and temperature, suggesting their dye removal potential in diverse conditions. Physico-chemical studies, e.g. scanning electron microscopy and Fourier transform-infrared spectroscopy studies, revealed changes in surface topology and functional moieties of BN and BP post adsorption, implying dye interaction with the biomass surface. The dye adsorption in both cases followed pseudo-second-order kinetics. While adsorption of MB by BN was better fitted with the Temkin isotherm model, adsorption with BP followed both Langmuir and Freundlich isotherm models. Our studies concluded that both adsorbents efficiently remove MB from its aqueous solution with BP proved to be marginally superior to BN.
[Mh] Termos MeSH primário: Agricultura
Azul de Metileno/isolamento & purificação
Temperatura Ambiente
Resíduos
[Mh] Termos MeSH secundário: Adsorção
Areca/ultraestrutura
Biomassa
Concentração de Íons de Hidrogênio
Cinética
Microscopia Eletrônica de Varredura
Modelos Teóricos
Musa/ultraestrutura
Espectroscopia de Infravermelho com Transformada de Fourier
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Waste Products); 0 (Water Pollutants, Chemical); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.589


  8 / 1608 MEDLINE  
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[PMID]:28257034
[Au] Autor:Xu Z; Huang CM; Shao Z; Zhao XP; Wang M; Yan TL; Zhou XC; Jiang EH; Liu K; Shang ZJ
[Ad] Endereço:The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, Wuhan University, Wuhan 430079, China. xuzhi_oms@whu.edu.cn.
[Ti] Título:Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 01.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Chewing areca nut is closely associated with oral squamous cell carcinoma (OSCC). The current study aimed to investigate potential associations between areca nut extract (ANE) and cisplatin toxicity in OSCC cells. OSCC cells (Cal-27 and Scc-9) viability and apoptosis were analyzed after treatment with ANE and/or cisplatin. The expressions of proteins associated with autophagy and the AMP-activated protein kinase (AMPK) signaling network were evaluated. We revealed that advanced OSCC patients with areca nut chewing habits presented higher LC3 expression and poorer prognosis. Reactive oxygen species (ROS)-mediated autophagy was induced after pro-longed treatment of ANE (six days, 3 µg). Cisplatin toxicity (IC , 48 h) was decreased in OSCC cells after ANE treatment (six days, 3 µg). Cisplatin toxicity could be enhanced by reversed autophagy by pretreatment of 3-methyladenine (3-MA), -acetyl-l-cysteine (NAC), or Compound C. Cleaved-Poly-(ADP-ribose) polymerase (cl-PARP) and cleaved-caspase 3 (cl-caspase 3) were downregulated in ANE-treated OSCC cells in the presence of cisplatin, which was also reversed by NAC and Compound C. Collectively, ANE could decrease cisplatin toxicity of OSCC by inducing autophagy, which involves the ROS and AMPK/mTOR signaling pathway.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Areca/química
Autofagia/efeitos dos fármacos
Cisplatino/farmacologia
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma de Células Escamosas/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Cisplatino/toxicidade
Resistência a Medicamentos Antineoplásicos
Seres Humanos
Proteínas Associadas aos Microtúbulos/genética
Proteínas Associadas aos Microtúbulos/metabolismo
Modelos Biológicos
Neoplasias Bucais/metabolismo
Serina-Treonina Quinases TOR/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Microtubule-Associated Proteins); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (light chain 3, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.31 (AMP-Activated Protein Kinases); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  9 / 1608 MEDLINE  
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[PMID]:28245263
[Au] Autor:Chen CH; Lu HI; Wang YM; Chen YH; Lo CM; Huang WT; Li SH
[Ad] Endereço:Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Department of Applied Chemistry, and Graduate Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, Taiwan.
[Ti] Título:Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.
[So] Source:PLoS One;12(2):e0172752, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Areca nut chewing is carcinogenic to humans. However, little is known about the impact of areca nut chewing on esophageal squamous cell carcinoma (ESCC). METHODS: We retrospectively reviewed 286 ESCC patients who received surgery or preoperative chemoradiotherapy followed by surgery at our institution. Background characteristics including areca nut chewing history were analyzed. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine ESCC model was used to test the impact of arecoline, a main constituent of areca nut, on ESCC. RESULTS: Compared to patients without areca nut chewing history, patients with areca nut chewing history had overall a younger age of onset (Mean age: 56.75 versus 52.68 yrs, P<0.001) and significantly worse overall survival than those without areca nut chewing history (P = 0.026). Among patients who received surgery, the overall survival rates were not significantly different between those with or without areca nut chewing history. Among patients who received preoperative chemoradiotherapy followed by surgery, those with areca nut chewing history had a significantly lower pathologic complete response rate (P = 0.002) and lower overall survival rate (P = 0.002) than those without. In the murine ESCC model, the incidence of esophageal invasive squamous cell carcinoma was 40% in mice exposed to concomitant 4-NQO and arecoline treatment for 8 weeks and 6% in mice exposed to 4-NQO only for 8 weeks (P = 0.037). CONCLUSIONS: Our results indicate that areca nut chewing history is significantly associated with younger age of onset, poor response to chemoradiotherapy, and shorter overall survival in ESCC patients. Arecoline, a main constituent of areca nut, accelerates esophageal tumorigenesis in the 4-NQO-induced murine ESCC model.
[Mh] Termos MeSH primário: Areca/efeitos adversos
Carcinoma de Células Escamosas/etiologia
Neoplasias Esofágicas/etiologia
Nozes/efeitos adversos
[Mh] Termos MeSH secundário: 4-Nitroquinolina-1-Óxido/toxicidade
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Antineoplásicos/uso terapêutico
Arecolina/efeitos adversos
Carcinoma de Células Escamosas/induzido quimicamente
Carcinoma de Células Escamosas/mortalidade
Carcinoma de Células Escamosas/patologia
Neoplasias Esofágicas/induzido quimicamente
Neoplasias Esofágicas/mortalidade
Neoplasias Esofágicas/patologia
Feminino
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 4ALN5933BH (Arecoline); 56-57-5 (4-Nitroquinoline-1-oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172752


  10 / 1608 MEDLINE  
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[PMID]:28225785
[Au] Autor:Hernandez BY; Zhu X; Goodman MT; Gatewood R; Mendiola P; Quinata K; Paulino YC
[Ad] Endereço:University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
[Ti] Título:Betel nut chewing, oral premalignant lesions, and the oral microbiome.
[So] Source:PLoS One;12(2):e0172196, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed. Oral swabbing and saliva samples were evaluated by 454 pyrosequencing of the V3- V5 region of the 16S rRNA bacterial gene and genotyped for HPV. One hundred twenty-two adults were enrolled including 64 current betel nut chewers, 37 former chewers, and 21 with no history of betel nut use. Oral premalignant lesions, including leukoplakia and submucous fibrosis, were observed in 10 chewers. Within-sample bacterial diversity was significantly lower in long-term (≥10 years) chewers vs. never chewers and in current chewers with oral lesions vs. individuals without lesions. Between-sample bacterial diversity based on Unifrac distances significantly differed by chewing status and oral lesion status. Current chewers had significantly elevated levels of Streptococcus infantis and higher and lower levels of distinct taxa of the Actinomyces and Streptococcus genera. Long-term chewers had reduced levels of Parascardovia and Streptococcus. Chewers with oral lesions had significantly elevated levels of Oribacterium, Actinomyces, and Streptococcus, including Streptococcus anginosus. In multivariate analyses, controlling for smoking, oral HPV, S.anginosus, and S. infantis levels, current betel nut chewing remained the only predictor of oral premalignant lesions. Our study provides evidence that betel nut chewing alters the oral bacterial microbiome including that of chewers who develop oral premalignant lesions. Nonetheless, whether microbial changes are involved in betel nut-induced oral carcinogenesis is only speculative. Further research is needed to discern the clinical significance of an altered oral microbiome and the mechanisms of oral cancer development in betel nut chewers.
[Mh] Termos MeSH primário: Areca
Microbiota
Doenças da Boca/microbiologia
Neoplasias Bucais/microbiologia
Lesões Pré-Cancerosas/microbiologia
Saliva/microbiologia
[Mh] Termos MeSH secundário: Actinomyces/isolamento & purificação
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Mastigação
Meia-Idade
Doenças da Boca/patologia
Neoplasias Bucais/patologia
Lesões Pré-Cancerosas/patologia
RNA Ribossômico 16S
Streptococcus/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172196



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