Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.093.480 [Categoria DeCS]
Referências encontradas : 70 [refinar]
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[PMID]:29442002
[Au] Autor:Vrbovská H; Babincová M
[Ti] Título:Comparative analysis of synthetic and nutraceutical antioxidants as possible neuroprotective agents.
[So] Source:Pharmazie;71(12):724-726, 2016 12 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Damage caused by oxidative stress in cases of neurodegenerative diseases such as Alzheimer's or Parkinson's has been proven to be irreversible. However, diet supplementation of antioxidants can be beneficial to the total antioxidant status of the human body. Given that oxidative stress is a principal cause of neurodegenerative disease, effective natural antioxidants could provide therapeutic options for these disorders. Therefore we investigated the antioxidant properties of two natural extracts and five synthetic compounds in lipid rich environment of liposomes with oxidation induced by Fenton's reagent. Antioxidant activity has been quantified using the Klein peroxidation index and oxygen uptake. Both natural extracts from Acai berry and Ginseng as well as all synthetic compounds - N-acetyl-L-cysteine, tocopherol, huperzines, caffeic acid and lipoic acid displayed good antioxidants properties, which confirm their suitability as neuroprotective agents.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Suplementos Nutricionais
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Euterpe/química
Peróxido de Hidrogênio
Ferro
Peroxidação de Lipídeos/efeitos dos fármacos
Lipídeos/química
Lipossomos
Estresse Oxidativo/efeitos dos fármacos
Consumo de Oxigênio
Panax/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fenton's reagent); 0 (Lipids); 0 (Liposomes); 0 (Neuroprotective Agents); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6730


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[PMID]:28551224
[Au] Autor:Alqurashi RM; Alarifi SN; Walton GE; Costabile AF; Rowland IR; Commane DM
[Ad] Endereço:Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, United Kingdom. Electronic address: r.m.m.alqurashi@pgr.reading.ac.uk.
[Ti] Título:In vitro approaches to assess the effects of açai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota.
[So] Source:Food Chem;234:190-198, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A considerable proportion of dietary plant-polyphenols reach the colon intact; determining the effects of these compounds on colon-health is of interest. We hypothesise that both fibre and plant polyphenols present in açai (Euterpe oleracea) provide prebiotic and anti-genotoxic benefits in the colon. We investigated this hypothesis using a simulated in vitro gastrointestinal digestion of açai pulp, and a subsequent pH-controlled, anaerobic, batch-culture fermentation model reflective of the distal region of the human large intestine. Following in vitro digestion, 49.8% of the total initial polyphenols were available. In mixed-culture fermentations with faecal inoculate, the digested açai pulp precipitated reductions in the numbers of both the Bacteroides-Prevotella spp. and the Clostridium-histolyticum groups, and increased the short-chain fatty acids produced compared to the negative control. The samples retained significant anti-oxidant and anti-genotoxic potential through digestion and fermentation. Dietary intervention studies are needed to prove that consuming açai is beneficial to gut health.
[Mh] Termos MeSH primário: Digestão
Euterpe/química
Microbiota
Polifenóis/química
[Mh] Termos MeSH secundário: Fermentação
Seres Humanos
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Polyphenols)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28527426
[Au] Autor:Petruk G; Illiano A; Del Giudice R; Raiola A; Amoresano A; Rigano MM; Piccoli R; Monti DM
[Ad] Endereço:Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte Sant'Angelo, via Cinthia 4, 80126 Naples, Italy.
[Ti] Título:Malvidin and cyanidin derivatives from açai fruit (Euterpe oleracea Mart.) counteract UV-A-induced oxidative stress in immortalized fibroblasts.
[So] Source:J Photochem Photobiol B;172:42-51, 2017 Jul.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:UV-A radiations are known to induce cellular oxidative stress, leading to premature skin aging. Consumption of açai fruit (Euterpe oleracea Martius) is known to have many health benefits due to its high level of antioxidants. Herein, we analyzed the ability of phenolic compounds extracted from this fruit to attenuate UV-A-induced oxidative stress in immortalized fibroblast. A methanol/water açai extract was fractionated by HPLC and each fraction tested for anti-oxidant stress activity. Immortalized fibroblasts were pre-incubated with açai fractions and then exposed to UV-A radiations. Açai extract was found to be able to strongly protect cells from oxidative stress. In particular, reactive oxygen species (ROS) production, GSH depletion, lipid peroxidation and no increase in the phosphorylation levels of proteins involved in the oxidative stress pathway was observed in cells pre-incubated with the extract and then irradiated by UV-A. Mass spectrometry analyses of HPLC fractionated extract led us to the identification of malvidin and cyanidin derivatives as the most active molecules able to counteract the negative effects induced by UV-A irradiation. Our results indicate, for the first time, that açai fruit is a valuable natural source for malvidin and cyanidin to be used as anti-stress molecules and represent good candidates for dietary intervention in the prevention of age related skin damage.
[Mh] Termos MeSH primário: Antocianinas/farmacologia
Euterpe/química
Estresse Oxidativo/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Células 3T3
Animais
Antocianinas/química
Antocianinas/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Cromatografia de Fase Reversa
Euterpe/metabolismo
Frutas/química
Frutas/metabolismo
Espectrometria de Massas
Camundongos
Estresse Oxidativo/efeitos da radiação
Fosforilação/efeitos dos fármacos
Fosforilação/efeitos da radiação
Extratos Vegetais/química
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 10463-84-0 (malvidin); 7732ZHU564 (cyanidin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE


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[PMID]:28490147
[Au] Autor:Peron DV; Fraga S; Antelo F
[Ad] Endereço:Escola de Química e Alimentos, Programa de Pós Graduação em Engenharia Química, Universidade Federal do Rio Grande (FURG), Avenida Itália km 8, 96203-900 Rio Grande/RS, Brazil.
[Ti] Título:Thermal degradation kinetics of anthocyanins extracted from juçara (Euterpe edulis Martius) and "Italia" grapes (Vitis vinifera L.), and the effect of heating on the antioxidant capacity.
[So] Source:Food Chem;232:836-840, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of temperature on the degradation of anthocyanins in juçara and "Italia" grape extracts was determined between 50 and 90°C. For both species, thermal degradation followed a first-order kinetic model. The decimal reduction time decreased with increasing temperature, and dependence on the thermodegradable factor was lower at higher temperatures. The anthocyanins from juçara degraded more slowly than those extracted from "Italia" grapes. The activation enthalpy and free energy of inactivation indicated an endothermic reaction, not spontaneous degradation, whereas the activation entropy suggested that the transition state has less structural freedom than that of the reactants. The antioxidant capacity of the extracts was reduced when subjected to 90°C heat treatment, however, significant quantities of this bioactive compound still remained.
[Mh] Termos MeSH primário: Antocianinas/química
Euterpe/química
Vitis/química
[Mh] Termos MeSH secundário: Frutas
Calefação
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28317748
[Au] Autor:Schulz M; Biluca FC; Gonzaga LV; Borges GD; Vitali L; Micke GA; de Gois JS; de Almeida TS; Borges DL; Miller PR; Costa AC; Fett R
[Ad] Endereço:Department of Food Science and Technology, Federal University of Santa Catarina, Florianopolis 88034-001, Brazil. Electronic address: schulzmay@gmail.com.
[Ti] Título:Bioaccessibility of bioactive compounds and antioxidant potential of juçara fruits (Euterpe edulis Martius) subjected to in vitro gastrointestinal digestion.
[So] Source:Food Chem;228:447-454, 2017 Aug 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An in vitro method involving simulated gastrointestinal digestion was used to assess the bioaccessibility of fifteen minerals, twenty-two phenolic compounds and the antioxidant capacity in juçara fruit during seven ripening stages. For minerals and phenolics, respectively, initial contents were up to 1325.9 and 22.9mg100g , whereas after in vitro digestion, the maximum values were 556.7 and 14.43mg100g (dry matter). Antioxidant capacity, determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) and ferric reducing antioxidant power (FRAP), after in vitro digestion decreased 51-78% when compared to the crude extract. Bioaccessible fractions of quercetin, protocatechuic and p-coumaric acids presented positive and significant correlation with results of DPPH and FRAP. Furthermore, our study demonstrated that the ripening stages of juçara fruit influenced the bioaccessibility of compounds and antioxidant capacity, which presented higher levels in purple fruits collected 42-69days after the appearance of the red berries on bunches.
[Mh] Termos MeSH primário: Euterpe/química
Frutas/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Digestão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28188416
[Au] Autor:Lins DBDS; Gardon FR; Meyer JFDCA; Santos RFD
[Ad] Endereço:Department of Water, Energy and Environmental Resources, University of Campinas, Av. Albert Einstein, 951, Campinas, 13083-970, SP, Brazil.
[Ti] Título:Keystone Species, Forest and Landscape: A Model to Select Protected Areas.
[So] Source:Environ Manage;59(6):1017-1033, 2017 Jun.
[Is] ISSN:1432-1009
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The selection of forest fragments for conservation is usually based on spatial parameters as forest size and canopy integrity. This strategy assumes that chosen fragments present high conservation status, ensuring biodiversity and ecological functions. We argue that a well-preserved forest fragment that remains connected by the landscape structure, does not necessarily hold attributes that ensure the presence of keystone species. We also discuss that the presence of keystone species does not always mean that it has the best conditions for its occurrence and maintenance. We developed a model to select areas in forest landscapes to be prioritized for protection based on suitability curves that unify and compare spatial indicators of three categories: forest fragment quality, landscape quality, and environmental conditions for the occurrence of a keystone species. We use a case study to compare different suitability degrees for Euterpe edulis presence, considered an important functional element in Atlantic Forest (São Paulo, Brazil) landscapes and a forest resource for local people. The results show that the identification of medium or advanced stage fragments as singular indicator of forest quality does not guarantee the existence or maintenance of this keystone species. Even in some well-preserved forest fragments, connected to others and with palm presence, the reverse J-shaped distribution of the population size structure is not sustained and these forests continue to be threatened due to human disturbances.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
Euterpe/crescimento & desenvolvimento
Florestas
Modelos Teóricos
[Mh] Termos MeSH secundário: Biodiversidade
Brasil
Ecologia
Seres Humanos
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1007/s00267-017-0832-5


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[PMID]:28106205
[Au] Autor:Costa MG; Ooki GN; Vieira AD; Bedani R; Saad SM
[Ad] Endereço:Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, B16, 05508-000 São Paulo, SP, Brazil. susaad@usp.br.
[Ti] Título:Synbiotic Amazonian palm berry (açai, Euterpe oleracea Mart.) ice cream improved Lactobacillus rhamnosus GG survival to simulated gastrointestinal stress.
[So] Source:Food Funct;8(2):731-740, 2017 Feb 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of açai pulp ice cream and of its supplementation with inulin (I), whey protein concentrate (WC), and/or whey protein isolate (WI) on the viability and resistance to simulated gastrointestinal stress of the probiotic Lactobacillus (Lb.) rhamnosus GG strain throughout storage at -18 °C for up to 112 days was evaluated and morphological changes during stress were monitored. Lb. rhamnosus GG viability was stable in all formulations for up to 112 days of storage, preserving populations around 9 log CFU g . Compared to the fresh culture, Lb. rhamnosus GG showed higher survival under simulated gastrointestinal conditions when incorporated into açai ice cream, indicating that the presence of the food matrix contributed to the microorganism survival. A reduction of at least 5 log cycles of Lb. rhamnosus GG was observed in all formulations after the gastrointestinal simulation in all storage periods assessed. The addition of I, WC, and/or WI did not show any significant effect on the probiotic survival under simulated gastrointestinal stress (p < 0.05). Compared to the fresh culture, fewer morphological changes were observed when the probiotic was added to ice cream. Thus, the açai pulp ice cream was shown to be a suitable matrix for Lb. rhamnosus GG, improving its survival under in vitro simulated gastrointestinal conditions.
[Mh] Termos MeSH primário: Euterpe/metabolismo
Trato Gastrointestinal/microbiologia
Sorvetes/microbiologia
Lactobacillus rhamnosus/crescimento & desenvolvimento
Probióticos/metabolismo
Simbióticos/análise
[Mh] Termos MeSH secundário: Aditivos Alimentares/análise
Armazenamento de Alimentos
Frutas/metabolismo
Seres Humanos
Sorvetes/análise
Viabilidade Microbiana
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo00778c


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[PMID]:28041564
[Au] Autor:Torma PD; Brasil AV; Carvalho AV; Jablonski A; Rabelo TK; Moreira JC; Gelain DP; Flôres SH; Augusti PR; Rios AO
[Ad] Endereço:Instituto de Ciência e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, Prédio 43.212, Campus do Vale, Porto Alegre, RS CEP 91501-970, Brazil.
[Ti] Título:Hydroethanolic extracts from different genotypes of açaí (Euterpe oleracea) presented antioxidant potential and protected human neuron-like cells (SH-SY5Y).
[So] Source:Food Chem;222:94-104, 2017 May 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fruit breeding programs have resulted in bioactive compounds increase and health effects. Thus, this study aimed to evaluate the antioxidant activity and neuroprotective effects of the hydroethanolic extracts from six açaí (Euterpe oleracea) genotypes using ABTS, deoxyribose, and glutathione oxidation assays, as well as, SH-SY5Y cells insulted with H O . L22P13 genotype showed the highest total content of anthocyanins, while L06P13 showed a high content of total carotenoids. However, the genotypes showed no difference in the antioxidant activity by ABTS and deoxyribose assays. The hydroethanolic extracts from different genotypes of açaí showed a protective effect (13-62%) on SH-SY5Y cells insulted by H O at a concentration of 50µg/mL by DCFH-DA assay. Except L04P16, no genotypes showed cytotoxicity in the SRB assay. These results indicate that açaí genotypes have antioxidant effect against reactive species generated in SH-SY5Y cells, suggesting a neuroprotective effect of the hydroethanolic extracts from these fruits.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Euterpe
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Euterpe/química
Frutas
Genótipo
Seres Humanos
Neurônios/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:28024281
[Au] Autor:Monge-Fuentes V; Muehlmann LA; Longo JP; Silva JR; Fascineli ML; de Souza P; Faria F; Degterev IA; Rodriguez A; Carneiro FP; Lucci CM; Escobar P; Amorim RF; Azevedo RB
[Ad] Endereço:Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brazil.
[Ti] Título:Photodynamic therapy mediated by acai oil (Euterpe oleracea Martius) in nanoemulsion: A potential treatment for melanoma.
[So] Source:J Photochem Photobiol B;166:301-310, 2017 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Melanoma is the most aggressive and lethal form of skin cancer, responsible for >80% of deaths. Standard treatments for late-stage melanoma usually present poor results, leading to life-threatening side effects and low overall survival. Thus, it is necessary to rethink treatment strategies and design new tools for the treatment of this disease. On that ground, we hereby report the use of acai oil in nanoemulsion (NanoA) as a novel photosensitizer for photodynamic therapy (PDT) used to treat melanoma in in vitro and in vivo experimental models. NIH/3T3 normal cells and B16F10 melanoma cell lines were treated with PDT and presented 85% cell death for melanoma cells, while maintaining high viability in normal cells. Flow cytometry indicated that cell death occurred by late apoptosis/necrosis. Tumor bearing C57BL/6 mice treated five times with PDT using acai oil in nanoemulsion showed tumor volume reduction of 82% in comparison to control/tumor group. Necrotic tissue per tumor area reached its highest value in PDT-treated mice, supporting PDT efficacy. Overall, acai oil in nanoemulsion was an effective photosensitizer, representing a promising source of new photosensitizing molecules for PDT treatment of melanoma, a tumor with an inherent tendency to be refractory for this type of therapy.
[Mh] Termos MeSH primário: Emulsões
Euterpe/química
Melanoma/tratamento farmacológico
Fotoquimioterapia
Óleos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Camundongos
Camundongos Endogâmicos C57BL
Células NIH 3T3
Nanotecnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Plant Oils)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:27979133
[Au] Autor:Cantu-Jungles TM; Iacomini M; Cipriani TR; Cordeiro LMC
[Ad] Endereço:Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil.
[Ti] Título:Isolation and characterization of a xylan with industrial and biomedical applications from edible açaí berries (Euterpe oleraceae).
[So] Source:Food Chem;221:1595-1597, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical features of xylan largely determine its physical and biological properties and its use in the industry. In this work, we describe the occurrence, purification and partial characterization of a xylan in edible açaí berries (Euterpe oleraceae), using a fairly simple and inexpensive method of purification from alkaline açaí extract. A mainly linear (1→4)-ß-d-xylan was found as the majority (70%) of alkali extract and 4.2% of the dry matter açaí pulp. This represents the biggest source of xylan found so far in a fruit pulp and could be suitable for applications in the industry and biomedical field.
[Mh] Termos MeSH primário: Euterpe/química
Frutas/química
Xilanos/análise
[Mh] Termos MeSH secundário: Manipulação de Alimentos
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Xylans)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE



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