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Pesquisa : B01.650.940.800.575.912.250.096 [Categoria DeCS]
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[PMID]:27608953
[Au] Autor:Yu J; Ma CM; Wang X; Shang MY; Hattori M; Xu F; Jing Y; Dong SW; Xu YQ; Zhang CY; Cai SQ
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
[Ti] Título:Analysis of aristolochic acids, aristololactams and their analogues using liquid chromatography tandem mass spectrometry.
[So] Source:Chin J Nat Med;14(8):626-40, 2016 Aug.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:More than 80 aristolochic acids (AAs) and aristololactams (ALs) have been found in plants of the Aristolochiaceae family, but relatively few have been fully studied. The present study aimed at developing and validating a liquid chromatography tandem mass spectrometry (LC/MS(n)) for the analysis of these compounds. We characterized the fragmentation behaviors of 31 AAs, ALs, and their analogues via high performance liquid chromatography coupled with electrospray ionization mass spectrometry. We summarized their fragmentation rules and used these rules to identify the constituents contained in Aristolochia contorta, Ar. debilis, Ar. manshurensis, Ar. fangchi, Ar. cinnabarina, and Ar. mollissima. The AAs and ALs showed very different MS behaviors. In MS(1) of AAs, the characteristic pseudomolecular ions were [M + NH4](+), [M + H](+), and [M + H - H2O](+). However, only [M + H](+) was found in the MS(1) of ALs, which was simpler than that of AAs. Distinct MS(n)fragmentation patterns were found for AAs and ALs, showing the same skeleton among the different substituent groups. The distribution of the 31 constituents in the 6 species of Aristolochia genus was reported for the first time. 25 Analogues of AAs and ALs were detected in this genus. A hierarchical schemes and a calculating formula of the molecular formula of these nitrophenanthrene carboxylic acids and their lactams were proposed. In conclusion, this method could be applied to identification of similar unknown constituents in other plants.
[Mh] Termos MeSH primário: Aristolochiaceae/química
Ácidos Aristolóquicos/química
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Estrutura Molecular
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


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[PMID]:27150151
[Au] Autor:Futamura-Masuda M; Yokota-Honda M; Anraku T; Nakanishi K; Murata K; Shinada T; Matsuda H
[Ad] Endereço:Faculty of Pharmacy, Kindai University.
[Ti] Título:Effect of Asiasarum Root Extract and Its Constituents on Interleukin-1ß-Stimulated Matrix Metalloproteinase-1 Secretion from Human Gingival Fibroblasts.
[So] Source:Biol Pharm Bull;39(5):823-31, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Asiasarum root (roots and rhizome of Asiasarum sieboldii or A. heterotropoides var. mandshuricum) has been frequently used in traditional Chinese medicinal formulas for the management of oral malodor syndrome caused by periodontal disease. However, there are no scientific reports concerning these effects and the mechanism of action. The objective of this study was to examine the inhibitory effects of Asiasarum root and its constituents on oral malodor syndrome and periodontal disease. A 50% ethanolic extract of Asiasarum root (AR-ext) showed L-methionine γ-lyase (METase) inhibitory activity at a concentration of 200 µg/mL, and inhibited interleukin (IL)-1ß-stimulated matrix metalloproteinase (MMP)-1 secretion from human gingival fibroblasts (HGFs) at a concentration of 10 and 50 µg/mL without cytotoxic effects. Activity-guided fractionation of the AR-ext suggested that METase inhibitory activity was attributable to a mixture of linoleic and oleic acid, because these unsaturated fatty acids showed weak METase inhibitory activities. Similar fractionation using MMP-1 secretion inhibitory activity led to the isolation of two unsaturated fatty acid amides, (2E,4E,8Z,10E)-N-(2-methylpropyl)dodeca-2,4,8,10-tetraenamide (1) and (2E,4E,8Z,10Z)-N-(2-methylpropyl)dodeca-2,4,8,10-tetraenamide (2), as active constituents with inhibitory activity on MMP-1 secretion from HGFs. To elucidate the inhibition mechanism on MMP-1 secretion, the effect of 2 on mitogen-activated protein kinase (MAPK) phosphorylation was examined. Western blotting analysis revealed that 2 (10 µM) reduced the phosphorylation of p38 and c-Jun-N-terminal kinase. These results suggested that 2 suppresses intracellular MMP-1 expression and MMP-1 secretion from IL-1ß-stimulated HGFs by down-regulation of MAPK phosphorylation.
[Mh] Termos MeSH primário: Aristolochiaceae
Liases de Carbono-Enxofre/antagonistas & inibidores
Fibroblastos/efeitos dos fármacos
Gengiva/citologia
Metaloproteinase 1 da Matriz/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Liases de Carbono-Enxofre/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Fibroblastos/metabolismo
Halitose
Seres Humanos
Interleucina-1beta/farmacologia
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Raízes de Plantas
Porphyromonas gingivalis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Plant Extracts); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1); EC 4.4.- (Carbon-Sulfur Lyases); EC 4.4.1.11 (L-methionine gamma-lyase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b15-01000


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[PMID]:26270958
[Au] Autor:Wu L; Sun W; Wang B; Zhao H; Li Y; Cai S; Xiang L; Zhu Y; Yao H; Song J; Cheng YC; Chen S
[Ad] Endereço:1] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China [2] College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
[Ti] Título:An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids.
[So] Source:Sci Rep;5:11318, 2015 Aug 13.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Traditional herbal medicines adulterated and contaminated with plant materials from the Aristolochiaceae family, which contain aristolochic acids (AAs), cause aristolochic acid nephropathy. Approximately 256 traditional Chinese patent medicines, containing Aristolochiaceous materials, are still being sold in Chinese markets today. In order to protect consumers from health risks due to AAs, the hidden assassins, efficient methods to differentiate Aristolochiaceous herbs from their putative substitutes need to be established. In this study, 158 Aristolochiaceous samples representing 46 species and four genera as well as 131 non-Aristolochiaceous samples representing 33 species, 20 genera and 12 families were analyzed using DNA barcodes based on the ITS2 and psbA-trnH sequences. Aristolochiaceous materials and their non-Aristolochiaceous substitutes were successfully identified using BLAST1, the nearest distance method and the neighbor-joining (NJ) tree. In addition, based on sequence information of ITS2, we developed a Real-Time PCR assay which successfully identified herbal material from the Aristolochiaceae family. Using Ultra High Performance Liquid Chromatography-Mass Spectrometer (UHPLC-HR-MS), we demonstrated that most representatives from the Aristolochiaceae family contain toxic AAs. Therefore, integrated DNA barcodes, Real-Time PCR assays using TaqMan probes and UHPLC-HR-MS system provides an efficient and reliable authentication system to protect consumers from health risks due to the hidden assassins (AAs).
[Mh] Termos MeSH primário: Aristolochiaceae/genética
Ácidos Aristolóquicos/análise
Código de Barras de DNA Taxonômico/métodos
Contaminação de Medicamentos/prevenção & controle
Medicamentos de Ervas Chinesas/análise
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Aristolochiaceae/classificação
Aristolochiaceae/metabolismo
Ácidos Aristolóquicos/genética
Medicamentos de Ervas Chinesas/química
Medicina Tradicional/métodos
Integração de Sistemas
Tecnologia Farmacêutica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Drugs, Chinese Herbal); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150814
[St] Status:MEDLINE
[do] DOI:10.1038/srep11318


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[PMID]:26183576
[Au] Autor:Ma L; Qin Y; Shen Z; Bi H; Hu H; Huang M; Zhou H; Yu L; Jiang H; Zeng S
[Ad] Endereço:Laboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
[Ti] Título:Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2.
[So] Source:J Ethnopharmacol;172:430-5, 2015 Aug 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Aristolochic acid nephropathy is a severe kidney disease caused by the administration of aristolochic acid, which is widely existed in plants of the Aristolochiaceae family. Aristolochic acid I (AAI) is the main toxic component in aristolochic acid. AIM OF THE STUDY: The roles of intestinal efflux drug transporters in the transport of AAI are unclear. This study investigates the interaction between AAI and main intestinal efflux transporters. MATERIALS AND METHODS: Firstly, bidirectional transport of AAI in Caco-2 cell monolayers was investigated. Then, MDCK-MDR1 (gene of P-glycoprotein (P-gp)), MDCK-MRP2 and LLC-PK1-BCRP cell lines were used for further investigation. RESULTS: In this study, we observed that the efflux ratio of AAI in Caco-2 cell monolayers was 5.8, which indicated that efflux transporters might be involved in the transport of AAI. AAI did not inhibit Rho123 efflux by P-gp and calcein efflux by MRP2, and intracellular accumulation of AAI in P-gp or MRP2 overexpressing cells was not different from their parental cells. These results indicated that AAI was not a substrate of P-gp or MRP2. In contrast, intracellular accumulation of AAI in LLC-PK1-BCRP cells was significantly lower than in their parental cells. The presence of GF120918, a BCRP inhibitor, significantly increased AAI accumulation in BCRP overexpressing cells but not in their parental cells. In addition, bidirectional transport assay of AAI in LLC-PK1-BCRP monolayers showed that the net efflux ratios of AAI were 13.8, 8.0 and 7.0 at 20, 40 and 80 µM AAI, respectively, and decreased to 3.0, 1.9 and 2.0 by the addition of 10 µM GF120918. CONCLUSIONS: These results indicated that AAI was a substrate of BCRP but not P-gp or MRP2.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/metabolismo
Aristolochiaceae/química
Ácidos Aristolóquicos/farmacocinética
Intestinos/metabolismo
Proteínas de Neoplasias/metabolismo
[Mh] Termos MeSH secundário: Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo
Animais
Ácidos Aristolóquicos/isolamento & purificação
Transporte Biológico
Células CACO-2
Cães
Seres Humanos
Células LLC-PK1
Células Madin Darby de Rim Canino
Proteínas Associadas à Resistência a Múltiplos Medicamentos/metabolismo
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ABCG2 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family G, Member 2); 0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Aristolochic Acids); 0 (Multidrug Resistance-Associated Proteins); 0 (Neoplasm Proteins); 4AF605U6JN (multidrug resistance-associated protein 2); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE


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[PMID]:25676509
[Au] Autor:Ma Y; Jia Q; Wang P; Cheng X; Kang Y
[Ad] Endereço:Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi'an 710021, P. R. China, (phone/fax: +86-29-86168312); Shaanxi Research Institute of Agricultural Products Processing Technology, Shaanxi University of Science & Technology, Xi'an 710021, P. R. China. mym63@sina.com.
[Ti] Título:Aza-polycyclic aromatic hydrocarbons from Saruma henryi.
[So] Source:Chem Biodivers;12(2):284-8, 2015 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A new azafluoranthene alkaloid, named sarumine (1), along with six known N-containing derivatives of phenanthrenes, 2-7, were isolated from the whole herb of Saruma henryi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Moreover, antimicrobial activities of all compounds were evaluated.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Aristolochiaceae/química
Compostos Aza/química
Hidrocarbonetos Aromáticos Policíclicos/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Aristolochiaceae/metabolismo
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Conformação Molecular
Hidrocarbonetos Aromáticos Policíclicos/isolamento & purificação
Hidrocarbonetos Aromáticos Policíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Aza Compounds); 0 (Polycyclic Aromatic Hydrocarbons)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150214
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201400059


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[PMID]:25599730
[Au] Autor:Ardalan MR; Khodaie L; Nasri H; Jouyban A
[Ad] Endereço:Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ardalan34@yahoo.com.
[Ti] Título:Herbs and hazards: risk of aristolochic acid nephropathy in Iran.
[So] Source:Iran J Kidney Dis;9(1):14-7, 2015 Jan.
[Is] ISSN:1735-8604
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:Herbs are usually considered as inherently harmless products. Nonetheless, various renal injuries have been reported in association with several herbs. The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid is found in Chinese slim herbs. Balkan endemic nephropathy is nowadays considered as an aristolochic acid nephropathy. Plants of Aristolochiaceae (also known as birthwort, dutchman's pipe, and somersworth) is named zaravand or chopoghak in Persian and it grows in different mountainous and rural areas of Iran. The fruit and the steam of the Aristolochiacae are named zaravand gerd (nokhod alvand) and zaravand dearaz, respectively, and have different usage in Iranian teadirional such as treatment of headache, back pain, and anxiety. Some patients with end-stage renal disease and bilateral small kidneys have a history of exposure to some herbal remedies. We need to consider the possibility of environmental toxins and even Aristolochia nephrotoxicity as a potential danger in Iran.
[Mh] Termos MeSH primário: Aristolochiaceae
Ácidos Aristolóquicos/efeitos adversos
Nefropatia dos Bálcãs/induzido quimicamente
Extratos Vegetais/efeitos adversos
[Mh] Termos MeSH secundário: Aristolochiaceae/química
Nefropatia dos Bálcãs/diagnóstico
Seres Humanos
Irã (Geográfico)
Fitoterapia
Plantas Medicinais
Medição de Risco
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Plant Extracts); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150121
[St] Status:MEDLINE


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[PMID]:25427624
[Au] Autor:Li XW; Yokota S; Wang D; Wang X; Shoyama Y; Cai SQ
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P.R. China.
[Ti] Título:Localization of aristolochic acid in mouse kidney tissues by immunohistochemistry using an anti-AA-I and AA-II monoclonal antibody.
[So] Source:Am J Chin Med;42(6):1453-69, 2014.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Aristolochic acids (AAs) are found in herbal medicines of Aristolochiaceae plants, including Aristolochia and Asarum species. AAs are associated with a rapidly progressive interstitial nephritis, which is called aristolochic acid nephropathy (AAN). However, the in-situ localization of AAs in the target organ, the kidney, has not been investigated yet. In the present study, the accumulation of aristolochic acid I (AA-I) in mouse kidney was revealed by immunoperoxidase light microscopy as well as colloidal gold immunoelectron microscopy (IEM) based on an anti-AA-I and AA-II monoclonal antibody (mAb). Male BALB/c mice were treated with 1.25 or 2.50 mg kg(-1) of AA-I per day for 5 days. Paraffin sections and ultra-thin sections of kidney tissue were respectively prepared. Under light microscopy, the apical surface of proximal tubules was strongly stained for AA-I, whereas no obvious immunostaining was found in the distal tubules and glomerulus, which remained relatively intact. Under electron microscopy, epithelial cells of the proximal tubules, distal tubules and collecting tubules were broken to various degrees. Gold labeling in the proximal and distal tubules was stronger than that in the collecting tubules. In renal tubules, immunogold signals of AA-I tended to accumulate in the mitochondria and peroxisomes, though the signals could be observed all over the cell. Gold signals were also found in the erythrocytes of glomeruli. The MAb against AA-I and AA-II provides a clue for the identification of proteins or factors which might interact with AA-I and thus induce targeted damage of kidney.
[Mh] Termos MeSH primário: Anticorpos Monoclonais
Ácidos Aristolóquicos/análise
Ácidos Aristolóquicos/toxicidade
Imuno-Histoquímica/métodos
Rim/metabolismo
[Mh] Termos MeSH secundário: Animais
Aristolochiaceae/química
Ácidos Aristolóquicos/imunologia
Ácidos Aristolóquicos/farmacocinética
Túbulos Renais Proximais/metabolismo
Masculino
Camundongos Endogâmicos BALB C
Microscopia Imunoeletrônica
Mitocôndrias/metabolismo
Peroxissomos/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Aristolochic Acids); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141128
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X14500918


  8 / 41 MEDLINE  
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[PMID]:24694829
[Au] Autor:Wagner ST; Hesse L; Isnard S; Samain MS; Bolin J; Maass E; Neinhuis C; Rowe NP; Wanke S
[Ad] Endereço:Institut für Botanik, Technische Universität Dresden, D-01062 Dresden, Germany sarah.wagner@tu-dresden.de.
[Ti] Título:Major trends in stem anatomy and growth forms in the perianth-bearing Piperales, with special focus on Aristolochia.
[So] Source:Ann Bot;113(7):1139-54, 2014 Jun.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The order Piperales has the highest diversity of growth forms among the earliest angiosperm lineages, including trees, shrubs, climbers and herbs. However, within the perianth-bearing Piperales (Asarum, Saruma, Lactoris, Hydnora, Prosopanche, Thottea and Aristolochia), climbing species only occur in the most species-rich genus Aristolochia. This study traces anatomical and morphological traits among these lineages, to detect trends in growth form evolution and developmental processes. METHODS: Transverse stem sections of different developmental stages of representatives of Asarum, Saruma, Lactoris, Hydnora, Thottea and Aristolochia were compared and anatomical traits were linked to growth form evolution. Biomechanical properties of representative climbers were determined in three-point bending tests and are discussed based on the anatomical observations. Growth form evolution of the perianth-bearing Piperales was reconstructed by ancestral character state reconstruction using Mesquite. KEY RESULTS: While species of Asarum and Saruma are exclusively herbaceous, species of the remaining genera show a higher diversity of growth habit and anatomy. This growth form diversity is accompanied by a more complex stem anatomy and appropriate biomechanical properties. The ancestral growth form of the perianth-bearing Piperales is reconstructed with either a shrub-like or herbaceous character state, while the following three backbone nodes in the reconstruction show a shrub-like character state. Accordingly, the climbing habit most probably evolved in the ancestor of Aristolochia. CONCLUSIONS: Since the ancestor of the perianth-bearing Piperales has been reconstructed with a herb- or shrub-like habit, it is proposed that the climbing habit is a derived growth form, which evolved with the diversification of Aristolochia, and might have been a key feature for its diversification. Observed anatomical synapomorphies, such as the perivascular fibres in Lactoris, Thottea and Aristolochia, support the phylogenetic relationship of several lineages within the perianth-bearing Piperales. In addition, the hypothesis that the vegetative organs of the holoparasitic Hydnoraceae are most probably rhizomes is confirmed.
[Mh] Termos MeSH primário: Aristolochiaceae/anatomia & histologia
Aristolochiaceae/crescimento & desenvolvimento
Caules de Planta/anatomia & histologia
Caules de Planta/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Evolução Biológica
Fenômenos Biomecânicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140404
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcu044


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[PMID]:24583199
[Au] Autor:Ren G; Huang Q; Wu J; Yuan J; Yang G; Yan Z; Yao S
[Ad] Endereço:Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
[Ti] Título:Cloud point extraction-HPLC method for the determination and pharmacokinetic study of aristolochic acids in rat plasma after oral administration of Aristolochiae Fructus.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;953-954:73-9, 2014 Mar 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Based on cloud-point extraction (CPE), a high performance liquid chromatography method (HPLC) was developed and validated for the determination of aristolochic acids (AAs) in rat plasma after oral administration of Aristolochiae Fructus (AF). Non-ionic surfactant Genapol X-080, an environmentally friendly solvent, was used for the micelle-mediated extraction. Various influencing factors on CPE process were investigated and optimized. AAs were extracted from rat plasma after adding 1ml of 4.5% (v/v) surfactant in the presence of 0.2mol/l HCl and 20mg NaCl, and the incubation temperature and time were 50°C and 10min, respectively. Base-line separation was obtained for the AAs in rat plasma with the optimized chromatography conditions. The detection limits (LOD) reached downward 10ng/ml. The intra-day and inter-day precisions were less than 7.8%, the accuracies were within ±5.5%, and the average recovery factors were in the range of 94.5-105.4%. In comparison with liquid-liquid extraction, the CPE method has a considerable LOD and higher recoveries. The proposed CPE-HPLC method was specific, sensitive and reliable, and could be an effective tool for the determination of AAs in biological matrixes. With the method the pharmacokinetics of AAs were investigated successfully after oral administration of AF by rats.
[Mh] Termos MeSH primário: Aristolochiaceae/química
Ácidos Aristolóquicos/sangue
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/administração & dosagem
Frutas/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Concentração de Íons de Hidrogênio
Modelos Lineares
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140317
[Lr] Data última revisão:
140317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140304
[St] Status:MEDLINE


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[PMID]:23954541
[Au] Autor:Joshi BD; Srivastava A; Gupta V; Tandon P; Jain S
[Ad] Endereço:Department of Physics, University of Lucknow, Lucknow 226007, India; Department of Physics, Siddhanath Sc. Campus, Tribhuvan University, Nepal.
[Ti] Título:Spectroscopic and quantum chemical study of an alkaloid aristolochic acid I.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;116:258-69, 2013 Dec.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aristolochic acids (AAs) (Aristolochiaceae) are used in the traditional Chinese herb medicine. We have presented the geometry optimization, electrostatic potential surface, frontier orbital energy gap and vibrational wavenumbers of aristolochic acid I (AA I) using ab initio Hartree-Fock (HF) and density functional theory (DFT/B3LYP) method employing 6-311G(d,p) basis set. A complete vibrational assignment has been done on the basis of calculations on monomer and dimer of AA I. The UV-vis absorption spectrum has been recorded in ethanol solvent and compared with the calculated one in the gas phase as well as in solvent environment (integral-equation formalism polarizable continuum model; IEF-PCM) using TD-DFT/6-31G basis set. A short outline of the NBO analysis segment with their structural meaning has been presented. The variation of thermodynamic properties with temperature was calculated theoretically and the thermal response of the compound has been recorded with the help of differential scanning calorimetry (DSC) in N2 environment.
[Mh] Termos MeSH primário: Alcaloides/química
Aristolochiaceae/química
Ácidos Aristolóquicos/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Teoria Quântica
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Aristolochic Acids); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130820
[St] Status:MEDLINE



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