Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.096.211 [Categoria DeCS]
Referências encontradas : 265 [refinar]
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[PMID]:28638881
[Au] Autor:Li YP; Wu S; Ran A; Xu DY; Wei JM; Zhao ZL
[Ad] Endereço:Department of Spine, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, 450002, China.
[Ti] Título: RETZ. ATTENUATES HYPERURICEMIA IN A METABOLIC ARTHRITIS RAT MODEL.
[So] Source:Afr J Tradit Complement Altern Med;14(4):180-187, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The leaves of Retz. has been documented in the folk medicine literature for its anti-arthritic activity. The target of the research envisaged was to elucidate the activity of extract on hyperuricemic condition in arthritis rat model. MATERIALS AND METHODS: Dried and powdered plant leaves were extracted using ether and chloroform. Potassium oxonate was injected intra-articularly to produce arthritis. The hyperuricemic effect, of was analyzed by studying levels of uric acid in serum as well as in urine of arthritis induced rats. Effects of plant extracts were also studied on BUN (blood urea nitrogen) levels and fraction of uric acid excreted. RESULTS: Results indicate that administration of presented substantial change in uric acid concentration, augmented by potassium oxonate administration in rats. The reduction in levels of uric acid levels was nearly same as allopurinol. The investigation also revealed that the primary plant extract has nephroprotective effect by enhancing the production of Prostaglandin E and Interleukin-1. Histological studies of rat kidney slices indicated the safety of the present plant extract. CONCLUSION: The crude extract of can be used to reduce hyperuricemia in metabolic arthritis produced in rat model, without inducing any potential damaging effects.
[Mh] Termos MeSH primário: Aristolochia/química
Artrite/tratamento farmacológico
Hiperuricemia/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Artrite/sangue
Artrite/complicações
Nitrogênio da Ureia Sanguínea
Creatinina/sangue
Dinoprostona/metabolismo
Seres Humanos
Hiperuricemia/sangue
Hiperuricemia/complicações
Interleucina-1/metabolismo
Masculino
Fitoterapia
Ratos
Ratos Sprague-Dawley
Ácido Úrico/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1); 0 (Plant Extracts); 268B43MJ25 (Uric Acid); AYI8EX34EU (Creatinine); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.21


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[PMID]:28245600
[Au] Autor:de Oliveira BM; Melo CR; Alves PB; Santos AA; Santos AC; Santana AD; Araújo AP; Nascimento PE; Blank AF; Bacci L
[Ad] Endereço:Departamento de Engenharia Agronômica, Universidade Federal de Sergipe, São Cristóvão 49100-000, Brazil. bruna_barreiros02@hotmail.com.
[Ti] Título:Essential Oil of Aristolochia trilobata: Synthesis, Routes of Exposure, Acute Toxicity, Binary Mixtures and Behavioral Effects on Leaf-Cutting Ants.
[So] Source:Molecules;22(3), 2017 Feb 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plants of the genus have been frequently reported as important medicinal plants. Despite their high bioactive potential, to date, there are no reports of their effects on leaf-cutting ants. Therefore, the present study aimed to evaluate the insecticidal activity of the essential oil of and its major components on and , two species of leaf-cutting ants. The bioassays were performed regarding routes of exposure, acute toxicity, binary mixtures of the major components and behavioral effects. Twenty-five components were identified in the essential oil of using a gas chromatographic system equipped with a mass spectrometer and a flame ionization detector. The components found in higher proportions were sulcatyl acetate, limonene, -cymene and linalool. The essential oil of and its individual major components were efficient against and workers when applied by fumigation. These components showed fast and efficient insecticidal activity on ants. The components acted synergistically and additively on and , respectively, and caused a strong repellency/irritability in the ants. Thus, our results demonstrate the great potential of the essential oil of and its major components for the development of new insecticides.
[Mh] Termos MeSH primário: Formigas/efeitos dos fármacos
Aristolochia/química
Inseticidas/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Animais
Formigas/fisiologia
Comportamento Animal/efeitos dos fármacos
Cromatografia Gasosa
Fumigação
Inseticidas/farmacologia
Óleos Voláteis/farmacologia
Folhas de Planta/química
Óleos Vegetais/química
Óleos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:28187732
[Au] Autor:Yuan J; Ren G; Liang J; Wang CZ; Yan Z; Huang Q; Li J; Chen Y; Tang Y; Liu X; Yuan CS
[Ad] Endereço:Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China. kings2008@163.com.
[Ti] Título:Comparative studies on the multi-component pharmacokinetics of Aristolochiae Fructus and honey-fried Aristolochiae Fructus extracts after oral administration in rats.
[So] Source:BMC Complement Altern Med;17(1):107, 2017 Feb 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aristolochiae Fructus (AF) and honey-fried Aristolochiae Fructus (HAF) have been used in China for a long time as anti-tussive and expectorant drugs. Few clinical cases have been reported to be associated with the toxicity of AF and HAF, although relatively high amounts of aristolochic acids (AAs) have been found in them. Our previous experiments have verified from the chemical changes and from traditional toxicology that honey-processing can significantly reduce the toxicity of AF. To further elucidate the detoxification mechanism of honey-processing, comparative pharmacokinetics of AAs in AF and HAF are performed in this study. METHODS: An HPLC-MS/MS (high-performance liquid chromatography-tandem mass spectrometry) method was developed and validated for the determination of AA I, AA II, AA C, AA D and 7-OH AA I in rat plasma. The multi-component pharmacokinetics of AAs in AF and HAF extracts were investigated after the oral administration of three doses to rats. The relative pharmacokinetic parameters were compared systematically. RESULTS: The five AAs shared a similar nonlinear PK (pharmacokinetic) process. They involve rapid absorption and elimination, and they were fit into a two-compartmental open model. Some significant pharmacokinetic differences were observed between the AF and HAF groups: the C and AUC values of AA I and AA II in the AF groups were much higher than those of the HAF groups. CONCLUSIONS: Honey-frying technology can reduce the toxicity of AF by significantly decreasing the absorption of AA I and AA II. The PK parameters obtained in this work could provide valuable references for the toxicity research and clinical use of Aristolochiaceae herbs, including AF and HAF. Process diagram of comparative pharmacokinetics study.
[Mh] Termos MeSH primário: Aristolochia/química
Ácidos Aristolóquicos/farmacocinética
Frutas/química
Mel
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Ácidos Aristolóquicos/sangue
Ácidos Aristolóquicos/química
Limite de Detecção
Modelos Lineares
Masculino
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1626-2


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[PMID]:28150858
[Au] Autor:Murugan Girija D; Y Ranga Rao S; Kalachaveedu M; Subbarayan R
[Ad] Endereço:Centre for Indian Systems of Medicine Quality Assurance and Standardization Sri Ramachandra University, Chennai, India.
[Ti] Título:Osteogenic differentiation of human gingival mesenchymal stem cells by Aristolochia bracteolata supplementation through enhanced Runx2 expression.
[So] Source:J Cell Physiol;232(7):1591-1595, 2017 Jul.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The phenotypic characteristics of human gingival derived mesenchymal stem cells (HGMSCs) on induction with total methanol extract of Aristolochia bracteolata have been evaluated. HGMSCs were cultured in control and two different induction medium: Control medium (basal medium), OM1 (Standard induction medium), and OM2 (100 µg/ml of A. bracteolata). Osteogenic differentiation of the cultured cells was assessed by studying the calcium deposition and osteoblastic gene expression. OM2 medium showed an enhanced osteogenic differentiation potential than OM1 as measured by increased calcium deposition and elevated expression of Runx2, osteopontin, osteonectin, osteocalcin, Collagen type I, and ALP levels in comparison with OM1 differentiated cells. We conclude that at 100 µg/ml A. bracteolata has induced HGMSC differentiation into osteogenic lineage consequent to enhanced Runx2 expression and related osteogenic genes.
[Mh] Termos MeSH primário: Aristolochia/química
Diferenciação Celular
Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo
Gengiva/citologia
Células Mesenquimais Estromais/citologia
Osteogênese
[Mh] Termos MeSH secundário: Adulto
Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/genética
Linhagem da Célula/efeitos dos fármacos
Linhagem da Célula/genética
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Células Mesenquimais Estromais/efeitos dos fármacos
Células Mesenquimais Estromais/metabolismo
Osteoblastos/citologia
Osteoblastos/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Osteogênese/genética
Extratos Vegetais/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Core Binding Factor Alpha 1 Subunit); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25835


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[PMID]:28137630
[Au] Autor:Wang X; Shi GR; Liu YF; Li L; Chen RY; Yu DQ
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
[Ti] Título:Aristolochic acid derivatives from the rhizome of Arisolochia championii.
[So] Source:Fitoterapia;118:63-68, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC values of 0.50, 7.37, 2.66, and 0.75µM, respectively.
[Mh] Termos MeSH primário: Aristolochia/química
Ácidos Aristolóquicos/química
Rizoma/química
[Mh] Termos MeSH secundário: Ácidos Aristolóquicos/isolamento & purificação
Linhagem Celular Tumoral
Seres Humanos
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:28107177
[Au] Autor:Quintans JS; Alves RD; Santos DA; Serafini MR; Alves PB; Costa EV; Zengin G; Quintans-Júnior LJ; Guimarães AG
[Ti] Título:Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2yl acetate, its main compound, in rodents.
[So] Source:Z Naturforsch C;72(3-4):93-97, 2017 Mar 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aristolochia trilobata L. is an aromatic plant, popularly known as "mil-homens", and its essential oil (EO) is generally used to treat colic, diarrhea and dysentery disorders. We evaluated the antinociceptive effect of A. trilobata stem EO and of its major compound, the (R)-(-)-6-methyl-5-hepten-2-yl acetate (sulcatyl acetate: SA), using acetic acid (0.85%)-induced writhing response and formalin-induced (20 µL of 1%) nociceptive behavior in mice. We also evaluated the EO and SA effect on motor coordination, using the rota-rod apparatus. EO (25, 50 and 100 mg/kg) or SA (25 and 50 mg/kg) reduced nociceptive behavior in the writhing test (p<0.001). EO (100 mg/kg) and SA (25 and 50 mg/kg) decreased the nociception on the first phase of the formalin test (p<0.05). On the second phase, EO (25: p<0.01; 50: p<0.05 and 100 mg/kg: p<0.001) and SA (25 and 50 mg/kg; p<0.001) reduced the nociceptive response induced by formalin. EO and SA were not able to cause changes in the motor coordination of animals. Together, our results suggest that EO has an analgesic profile and SA seems to be one of the active compounds in this effect.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Aristolochia/química
Heptanol/farmacologia
Óleos Voláteis/isolamento & purificação
Caules de Planta/química
[Mh] Termos MeSH secundário: Acetatos/antagonistas & inibidores
Acetatos/farmacologia
Analgésicos/isolamento & purificação
Animais
Heptanol/análogos & derivados
Heptanol/isolamento & purificação
Masculino
Camundongos
Óleos Voláteis/química
Medição da Dor
Extratos Vegetais/química
Desempenho Psicomotor/efeitos dos fármacos
Teste de Desempenho do Rota-Rod
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Analgesics); 0 (Oils, Volatile); 0 (Plant Extracts); 8JQ5607IO5 (Heptanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:28019104
[Au] Autor:Wang X; Shi GR; Liu YF; Chen RY; Yu DQ
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Four new compounds from the rhizome of Aristolochia championii.
[So] Source:J Asian Nat Prod Res;19(2):114-120, 2017 Feb.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new flavonoid glycosides (1-3) and one new aristololactam N-glycoside (4) were isolated from the rhizome of Aristolochia championii. The structures of compounds 1-4 were elucidated on the basis of their spectroscopic data and chemical evidence (UV, IR, HR-ESI-MS, 1D and 2D NMR). Their structures were determined as 8-(5-formyl-2-furanmethyl)-isorhamentin 3-O-robinobioside (1), 8-(5-methyl-2-furanoyl)-isorhamentin 3-O-robinobioside (2), 8-formylisorhamentin 3-O-robinobioside (3), and N-ß-D-glucopyranosylaristololactam V (4), respectively.
[Mh] Termos MeSH primário: Aristolochia/química
Flavonoides/isolamento & purificação
Glicosídeos/isolamento & purificação
Rizoma/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Flavonoides/química
Glicosídeos/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-(5-formyl-2-furanmethyl)-isorhamentin 3-O-robinobioside); 0 (8-(5-methyl-2-furanoyl)-isorhamentin 3-O-robinobioside); 0 (8-formylisorhamentin 3-O-robinobioside); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Glycosides); 0 (N-beta-D-glucopyranosylaristololactam)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1268129


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[PMID]:27704335
[Au] Autor:Chen SR; Zhang WP; Bao JM; Cheng ZB; Yin S
[Ad] Endereço:Laboratory of Pharmacology and Toxicology, Guangzhou Higher Education Mega Center, School of Pharmaceutical Sciences, Sun Yat-Sen University, 132 East Waihuan Road, Guangzhou, 510006, Guangdong, People's Republic of China. chshaor@mail.sysu.edu.cn.
[Ti] Título:Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx.
[So] Source:Arch Pharm Res;40(1):122-130, 2017 Jan.
[Is] ISSN:0253-6269
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Aristoyunnolin H is a novel aristophyllene sesquiterpenoid isolated from the traditional Chinese medicine Aristolochia yunnanensis Franch. The present research was designed to explore the anti-fibrotic effects of aristoyunnolin H in adult rat cardiac fibroblasts (CFs) stimulated with angiotensin II (Ang II). Western blot analysis data showed that aristoyunnolin H reduced the upregulation of fibronectin (FN), connective tissue growth factor and collagen I(Col I) production induced by Ang II in CFs. By studying the dynamic intracellular changes of Ca , we further found that while aristoyunnolin H relieved the calcium influx, it has no effect on intracellular calcium store release. Meanwhile, aristoyunnolin H also inhibited the Ang II-stimulated phosphorylation of Ca /calmodulin-dependent protein kinase II. In conclusion, aristoyunnolin H may attenuate extracellular matrix secretion in vitro by inhibiting Ang II-induced calcium signaling.
[Mh] Termos MeSH primário: Sinalização do Cálcio/fisiologia
Cálcio/metabolismo
Matriz Extracelular/secreção
Fibroblastos/secreção
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Aristolochia
Sinalização do Cálcio/efeitos dos fármacos
Células Cultivadas
Relação Dose-Resposta a Droga
Matriz Extracelular/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Masculino
Miocárdio/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sesquiterpenes); 0 (aristoyunnolin H); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.1007/s12272-016-0843-4


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[PMID]:27628622
[Au] Autor:Al-Barham MB; Al-Jaber HI; Al-Qudah MA; Abu Zarga MH
[Ad] Endereço:a Faculty of Science, Department of Chemistry , The University of Jordan , Amman , Jordan.
[Ti] Título:New aristolochic acid and other chemical constituents of Aristolochia maurorum growing wild in Jordan.
[So] Source:Nat Prod Res;31(3):245-252, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Investigation of the chemical constituents of Aristolochia maurorum growing wild in Jordan resulted in the isolation and characterisation of one new compound in addition to 19 known compounds. The new compound was identified as aristolochic acid II alanine amide (14). The other known compounds were the following: palmitic acid (1), ß-sitosterol (2), E-ethyl-p-coumarate (3), Z-ethyl-p-coumarate (4), aristolochic acid IV methyl ester (5), aristolactam I (6), loliolide (7), (+)-dehydrovomifoliol (8), glycerol-1-palmitate (9), aristolochic acid I (10), E-p-coumaric acid (11), E-N-coumaroyltyramine (12), ß-sitosteryl glucoside (13), aristolochic acid IV (15), aristolochic acid III (16), esculetin (17), uracil (18), shepherdine (19) and adenosine (20). The isolated compounds were characterised by different spectroscopic methods including NMR (1D and 2D), UV, IR and HRESIMS.
[Mh] Termos MeSH primário: Aristolochia/química
Ácidos Aristolóquicos/isolamento & purificação
[Mh] Termos MeSH secundário: Amidas/isolamento & purificação
Anti-Infecciosos/isolamento & purificação
Ácidos Cumáricos/isolamento & purificação
Glucosídeos/isolamento & purificação
Jordânia
Propionatos
Tiramina/análogos & derivados
Tiramina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Anti-Infective Agents); 0 (Aristolochic Acids); 0 (Coumaric Acids); 0 (Glucosides); 0 (N-coumaroyltyramine); 0 (Propionates); 0 (ethyl coumarate); 13395-02-3 (aristolactam I); 94218WFP5T (aristolochic acid I); BB72D5PU2Y (aristolochic acid II); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid); X8ZC7V0OX3 (Tyramine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE


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[PMID]:27507740
[Au] Autor:Suárez-Baron H; Pérez-Mesa P; Ambrose BA; González F; Pabón-Mora N
[Ad] Endereço:Instituto de Biología, Universidad de Antioquia, Medellín, Colombia.
[Ti] Título:Deep into the Aristolochia Flower: Expression of C, D, and E-Class Genes in Aristolochia fimbriata (Aristolochiaceae).
[So] Source:J Exp Zool B Mol Dev Evol;328(1-2):55-71, 2017 Jan.
[Is] ISSN:1552-5015
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aristolochia fimbriata (Aristolochiaceae) is a member of an early diverging lineage of flowering plants and a promising candidate for evo-devo studies. Aristolochia flowers exhibit a unique floral synorganization that consists of a monosymmetric and petaloid calyx formed by three congenitally fused sepals, and a gynostemium formed by the congenital fusion between stamens and the stigmatic region of the carpels. This floral ground plan atypical in the magnoliids can be used to evaluate the role of floral organ identity MADS-box genes during early flower evolution. In this study, we present in situ hybridization experiments for the homologs of the canonical C-, D-, and E-class genes. Spatiotemporal expression of the C-class gene AfimAG is restricted to stamens, ovary, and ovules, suggesting a conserved stamen and carpel identity function, consistent with that reported in core-eudicots and monocots. The D-class gene AfimSTK is detected in the anthers, the stigmas, the ovary, the ovules, the fruit, and the seeds, suggesting conserved roles in ovule and seed identity and unique roles in stamens, ovary, and fruit development. In addition, AfimSTK expression patterns in areas of organ abscission and dehiscence zones suggest putative roles linked to senescence processes. We found that both E-class genes are expressed in the anthers and the ovary; however, AfimSEP2 exhibits higher expression compared to AfimSEP1. These findings provide a comprehensive picture of the ancestral expression patterns of the canonical MADS-box floral organ identity genes and the foundations for further comparative analyses in other magnoliids.
[Mh] Termos MeSH primário: Aristolochia/metabolismo
Flores/metabolismo
Regulação da Expressão Gênica de Plantas/fisiologia
Proteínas de Domínio MADS/metabolismo
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Aristolochia/anatomia & histologia
Aristolochia/genética
Flores/anatomia & histologia
Flores/genética
Duplicação Gênica
Genoma de Planta
Proteínas de Domínio MADS/genética
Filogenia
Proteínas de Plantas/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MADS Domain Proteins); 0 (Plant Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE
[do] DOI:10.1002/jez.b.22686



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