Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.037 [Categoria DeCS]
Referências encontradas : 229 [refinar]
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[PMID]:28645294
[Au] Autor:Telerman A; Ofir R; Kashman Y; Elmann A
[Ad] Endereço:Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, POB 15159, 7528809, Rishon Lezion, Israel.
[Ti] Título:3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling.
[So] Source:BMC Complement Altern Med;17(1):332, 2017 Jun 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alzheimer's disease is a neurodegenerative disease, characterized by progressive decline in memory and cognitive functions, that results from loss of neurons in the brain. Amyloid beta (Aß) protein and oxidative stress are major contributors to Alzheimer's disease, therefore, protecting neuronal cells against Aß-induced toxicity and oxidative stress might form an effective approach for treatment of this disease. 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF) is a flavonoid we have purified from the plant Achillea fragrantissima; and the present study examined, for the first time, the effects of this compound on Aß-toxicity to neuronal cells. METHODS: Various chromatographic techniques were used to isolate TTF from the plant Achillea fragrantissima, and an N2a neuroblastoma cell line was used to study its activities. The cellular levels of total and phosphorylated stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and of total and phosphorylated extracellular signal-regulated kinase (ERK 1/2) were determined by enzyme-linked immunosorbent assay (ELISA). Intracellular reactive oxygen species (ROS) levels were measured by using 2',7'-dichlorofluorescein diacetate (DCF-DA). Cytotoxicity and cell viability were assessed by using lactate dehydrogenase (LDH) activity in cell-conditioned media, or by crystal violet cell staining, respectively. RESULTS: TTF prevented the Aß-induced death of neurons and attenuated the intracellular accumulation of ROS following treatment of these cells with Aß. TTF also inhibited the Aß-induced phosphorylation of the signaling proteins SAPK/JNK and ERK 1/2, which belong to the mitogen-activated protein kinase (MAPK) family. CONCLUSION: TTF should be studied further as a potential therapeutic means for the treatment of Alzheimer's disease.
[Mh] Termos MeSH primário: Achillea/química
Doença de Alzheimer/metabolismo
Peptídeos beta-Amiloides/toxicidade
Antioxidantes/farmacologia
Flavonas/farmacologia
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Doença de Alzheimer/tratamento farmacológico
Doença de Alzheimer/fisiopatologia
Peptídeos beta-Amiloides/metabolismo
Antioxidantes/química
Apoptose/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular
Flavonas/química
Seres Humanos
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Neurônios/citologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Fármacos Neuroprotetores/química
Estresse Oxidativo/efeitos dos fármacos
Fosforilação
Extratos Vegetais/química
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Antioxidants); 0 (Flavones); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1840-y


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[PMID]:28618131
[Au] Autor:Ali SI; Gopalakrishnan B; Venkatesalu V
[Ad] Endereço:Department of Botany, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India.
[Ti] Título:Pharmacognosy, Phytochemistry and Pharmacological Properties of Achillea millefolium L.: A Review.
[So] Source:Phytother Res;31(8):1140-1161, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names. Monoterpenes are the most representative metabolites constituting 90% of the essential oils in relation to the sesquiterpenes, and a wide range of chemical compounds have also been reported. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of A. millefoilum with antiinflammatory, antiulcer, anticancer activities etc. lending support to the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological activities, A. millefoilum will be a better option for new drug discovery. The present review will comprehensively summarize the pharmacognosy, phytochemistry and ethnopharmacology of A. millefoilum reported to date, with emphasis on more in vitro, clinical and pathological studies needed to investigate the unexploited potential of this plant. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Achillea/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Etnofarmacologia
Seres Humanos
Medicina Tradicional
Farmacognosia
Compostos Fitoquímicos/farmacologia
Fitoterapia
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5840


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[PMID]:28424880
[Au] Autor:Isbister KM; Lamb EG; Stewart KJ
[Ad] Endereço:Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, S7N 5A8, SK, Canada.
[Ti] Título:Herbicide Toxicity Testing with Non-Target Boreal Plants: The Sensitivity of Achillea millefolium L. and Chamerion angustifolium L. to Triclopyr and Imazapyr.
[So] Source:Environ Manage;60(1):136-156, 2017 Jul.
[Is] ISSN:1432-1009
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Terrestrial plant toxicity tests were conducted to determine the sensitivity of two boreal plants, yarrow (Achillea millefolium L.) and fireweed (Chamerion angustifolium L.), to the herbicides imazapyr and triclopyr. Both plants are common non-target species on northern powerline rights-of-way where the impacts of proposed herbicide applications are of concern. In the vegetative vigour test, triclopyr foliar spray caused extensive damage to A. millefolium at <50% of the maximum field application rate (inhibition concentration (IC) = 1443.8 g a.i. ha ) and was lethal to C. angustifolium at the lowest dose tested (1210.9 g a.i. ha ). Both species demonstrated extremely high sensitivity to imazapyr foliar spray: IC = 8.29 g a.i. ha and 4.82 g a.i. ha (<1.5% of the maximum field rate). The seedling emergence and seedling growth tests were conducted in the organic horizon of five boreal soils. Few differences in herbicide bioavailability between soils were detected. Triclopyr limited growth of A. millefolium, C. angustifolium and standard test species Calamagrostis canadensis at low levels (most IC estimates between 2-20 µg g ). For imazapyr, IC estimates could not be calculated as there was >75% inhibition of endpoints at the lowest doses of ~2 µg g . A foliar application of triclopyr or imazapyr for woody species control would likely cause significant damage to boreal non-target plants. The high sensitivity of both species to herbicide residues in soil indicates long term impacts are dependent on herbicide degradation rates in northern conditions. A. millefolium performed well and is recommended for use in toxicity testing relevant to boreal regions.
[Mh] Termos MeSH primário: Achillea/efeitos dos fármacos
Glicolatos/toxicidade
Herbicidas/toxicidade
Imidazóis/toxicidade
Niacina/análogos & derivados
Onagraceae/efeitos dos fármacos
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Achillea/crescimento & desenvolvimento
Clima Frio
Niacina/toxicidade
Onagraceae/crescimento & desenvolvimento
Projetos Piloto
Plântulas/efeitos dos fármacos
Plântulas/crescimento & desenvolvimento
Solo/química
Especificidade da Espécie
Testes de Toxicidade
Yukon
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycolates); 0 (Herbicides); 0 (Imidazoles); 0 (Soil); 0 (Soil Pollutants); 2679MF687A (Niacin); 787MX0M5A6 (imazapyr); MV06PHJ6I0 (triclopyr)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1007/s00267-017-0867-7


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[PMID]:28343034
[Au] Autor:Zengin G; Bulut G; Mollica A; Haznedaroglu MZ; Dogan A; Aktumsek A
[Ad] Endereço:Selcuk University, Science Faculty, Department of Biology, Campus, 42250, Konya, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr.
[Ti] Título:Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches.
[So] Source:Food Chem Toxicol;107(Pt B):597-608, 2017 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. Enzyme inhibitory effects were tested against cholinesterases, tyrosinase, amylase, glucosidase and lipase. Total phenolic contents were ranged from 20.52 mgGAE/g extract (B. croceum methanol extract) to 41.13 mgGAE/g extract (A. phrygia methanol extract). Generally, methanol and water extracts showed the strongest antioxidant abilities, while the ethyl acetate extracts had the most promising enzyme inhibitory effects. HPLC analysis revealed the abundance of some phenolics including rutin, quercetin, sinapic acid and chlorogenic acid, respectively. These components were also assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health-promoting ingredients.
[Mh] Termos MeSH primário: Achillea/química
Bupleurum/química
Fenóis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Cromatografia Líquida de Alta Pressão
Simulação por Computador
Modelos Moleculares
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE


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[PMID]:28179115
[Au] Autor:Mohammadhosseini M; Sarker SD; Akbarzadeh A
[Ad] Endereço:Department of Chemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran. Electronic address: majidmohammadhosseini@yahoo.com.
[Ti] Título:Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review.
[So] Source:J Ethnopharmacol;199:257-315, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they have been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines. They are also known as effective remedies that promote breast-feedings and regulate women menstruation. This review presents an overview on the ethnopharmacological knowledge of the Achillea genus and provides a deeper insight into medicinal and pharmaceutical applications of different Achillea species. MATERIALS AND METHODS: Relevant data were obtained through systematic electronic searches from various scientific databases including the Institute of scientific information (ISI)-Web of Science, Google Scholar, Scopus, Pubmed, other relevant texts and local books. RESULTS: A variety of ethnopharmacological properties of the Achillea have been documented, and a broad spectrum of medicinal applications, and phytochemicals of the essential oils and extracts of this genus have been identified. CONCLUSIONS: General correlations between the ethnopharmacological uses and medicinal properties identified through systematic research have been observed. Some of the medicinal properties could also be linked to the phytochemicals present in this genus. The findings of the studied reports in this review article represent therapeutic characteristics of Achillea species and account for their significant impact on the current and future modern medicine.
[Mh] Termos MeSH primário: Achillea
Etnofarmacologia/métodos
Óleos Voláteis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/isolamento & purificação
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Fármacos Gastrointestinais/química
Fármacos Gastrointestinais/isolamento & purificação
Seres Humanos
Óleos Voláteis/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Gastrointestinal Agents); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE


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[PMID]:28174780
[Au] Autor:Zengin G; Aktumsek A; Ceylan R; Uysal S; Mocan A; Guler GO; Mahomoodally MF; Glamoclija J; Ciric A; Sokovic M
[Ad] Endereço:Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey. gokhanzengin@selcuk.edu.tr.
[Ti] Título:Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia).
[So] Source:Food Funct;8(3):1152-1165, 2017 Mar 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles. Moreover, the total phenolic and flavonoid contents were determined and LC-MS analysis was performed for the chemical profile of the investigated extracts. The LC-MS analysis revealed the presence of several caffeoylquinic acids in these extracts. Generally, the methanol and water extracts exhibited stronger antioxidant abilities, which correlated with the higher levels of phenolic compounds when compared to the ethyl acetate extracts. In addition, the best antimicrobial activities were obtained for the ethyl acetate and methanolic extracts. However, the ethyl acetate extract had remarkable enzyme inhibitory potential. On the basis of our results, Achillea species may be promoted as promising sources of natural agents and used for the development of nutraceuticals or functional food ingredients.
[Mh] Termos MeSH primário: Achillea/química
Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Inibidores Enzimáticos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Achillea/classificação
Amilases/antagonistas & inibidores
Amilases/química
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Alimento Funcional/análise
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/química
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase); EC 3.2.1.- (Amylases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01847e


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[PMID]:28163113
[Au] Autor:Tadic V; Arsic I; Zvezdanovic J; Zugic A; Cvetkovic D; Pavkov S
[Ad] Endereço:Institute for Medicinal Plant Research "Dr Josif Pancic", Tadeusa Koscuska 1, 11000 Belgrade, Serbia. Electronic address: vtadic@mocbilja.rs.
[Ti] Título:The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application.
[So] Source:J Ethnopharmacol;199:138-148, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in traditional medicine. AIM OF THE STUDY: To evaluate oil yarrow extracts traditional use in treatment of topical/dermatological skin impairments, sodium lauryl sulfate test was applied, and in vivo measuring of the biophysical parameters (erythema index, skin capacitance and the pH of the skin) in the artificially irritated skin was performed. As traditionally olive and sunflower oil have been used equally for extracts production, the experiment was carried out to investigate whether any of the oil extractants has the advantage over the other, and if the method of extraction might influence the desired activity. The observed activity has been connected to the chemical profile of the investigated extracts and their antioxidative properties. MATERIALS AND METHODS: In vivo measurements were performed using the appropriate probes for measuring skin capacitance, pH of the skin and erythema index (EI). The designed experiment enabled the evaluation of the anti-inflammatory effects of a seven-day application of oil yarrow extracts known in traditional medicine, on artificially irritated skin of volunteers. The chemical profile for the investigated samples was achieved applying the HPLC and UHPLC-MS methods. Also, ferric reducing antioxidant power (FRAP) test was performed to assess the antioxidant properties of the investigated samples. RESULTS: The application of tested oil extracts on artificially irritated skin in vivo demonstrated the ability to re-establish their optimal pH and hydration of skin to the values measured prior to the irritation. Considering the EI transition, the investigated samples succeeded in re-establishing the baseline values, with no significant difference after three- and seven-day application. CONCLUSIONS: The data obtained in the study showed that the oil yarrow extracts had an evident anti-inflammatory property. Namely, the investigated extracts demonstrated significant anti-inflammatory effect in an in vivo double blind randomized study, using a sodium lauryl sulfate test. The skin parameters assessed in the study (skin capacitance, pH and EI) were restored to the basal values after three- and seven-day treatment with the tested extracts. The shown effects were attributed to yarrow oil extracts composition. The yarrow oil extracts might be used as promising base in the phytopreparations designed for dermatological application as anti-inflammatory agents with a positive impact on the skin pH and its moisture content.
[Mh] Termos MeSH primário: Achillea
Anti-Inflamatórios/administração & dosagem
Azeite de Oliva/administração & dosagem
Extratos Vegetais/administração & dosagem
Óleos Vegetais/administração & dosagem
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Anti-Inflamatórios/isolamento & purificação
Asteraceae
Método Duplo-Cego
Seres Humanos
Azeite de Oliva/isolamento & purificação
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Pele/patologia
Testes de Irritação da Pele/métodos
Dodecilsulfato de Sódio/efeitos adversos
Óleo de Girassol
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Olive Oil); 0 (Plant Extracts); 0 (Plant Oils); 0 (Sunflower Oil); 368GB5141J (Sodium Dodecyl Sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE


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[PMID]:28101823
[Au] Autor:García-Risco MR; Mouhid L; Salas-Pérez L; López-Padilla A; Santoyo S; Jaime L; Ramírez de Molina A; Reglero G; Fornari T
[Ad] Endereço:Institute of Food Science Research (CIAL), Madrid, Spain.
[Ti] Título:Biological Activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) Plant Extracts.
[So] Source:Plant Foods Hum Nutr;72(1):96-102, 2017 Mar.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) extracts were obtained by applying two sequential extraction processes: supercritical fluid extraction with carbon dioxide, followed by ultrasonic assisted extraction using green solvents (ethanol and ethanol:water 50:50). The extracts were analyzed in terms of the total content of phenolic compounds and the content of flavonoids; the volatile oil composition of supercritical extracts was analyzed by gas chromatography and the antioxidant capacity and cell toxicity was determined. Lamiaceae plant extracts presented higher content of phenolics (and flavonoids) than Asteraceae extracts. Regardless of the species studied, the supercritical extracts presented the lowest antioxidant activity and the ethanol:water extracts offered the largest, following the order Origanum majorana > Melissa officinalis ≈ Achillea millefolium > Calendula officinalis. However, concerning the effect on cell toxicity, Asteraceae (especially Achillea millefolium) supercritical extracts were significantly more efficient despite being the less active as an antioxidant agent. These results indicate that the effect on cell viability is not related to the antioxidant activity of the extracts.
[Mh] Termos MeSH primário: Achillea/química
Antioxidantes/farmacologia
Calendula/química
Melissa/química
Origanum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Sobrevivência Celular/efeitos dos fármacos
Cromatografia com Fluido Supercrítico
Flavonoides/análise
Flavonoides/farmacologia
Óleos Voláteis/análise
Óleos Voláteis/farmacologia
Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Oils, Volatile); 0 (Phenols); 0 (Plant Extracts); 0 (Solvents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0596-8


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[PMID]:28167484
[Au] Autor:Galavi HR; Saravani R; Shahraki A; Ashtiani M
[Ad] Endereço:Student Scientific Research Center, Zahedan University of Medical Sciences, Zahedan, Iran / Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
[Ti] Título:Anti-proliferative and apoptosis inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract on human breast adenocarcinoma cell lines MCF-7 and MDA-Mb-468.
[So] Source:Pak J Pharm Sci;29(6 Suppl):2397-2403, 2016 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Achillea wilhelmsii C. Koch contains a variety of components such as flavonoid. The previous studies showed that flavonoid has anti-cancer properties. The aim of the present study was to determine the anti-proliferative and apoptosis-inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract (HAWE) on MCF-7 and MDA-Mb-468 human breast carcinoma cell lines. The anti-proliferative activity of HAWE was evaluated using MTT, flowcytometry by annexin V/PI double staining, and caspase-3 activity. The results of MTT showed that the ED50 of MCF-7 and MDA-Mb-468 was 25µg/ml of HAWE, 48h after treatment. Flowcytometry by annexin V/PI showed that HAWE induced late apoptosis in MCF-7 and early apoptosis in MDA-Mb-468. In addition, the caspase-3 colorimetric method showed that caspase-3 increased in the MDA-Mb-468 after treatment with HAWE. This study found that the hydroalcoholic extract of Achillea wilhelmsii C. Koch induced apoptosis in both the MCF-7 and MDA-Mb-468 human breast carcinoma cell lines.
[Mh] Termos MeSH primário: Achillea/química
Adenocarcinoma/tratamento farmacológico
Álcoois/química
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Proliferação Celular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Solventes/química
[Mh] Termos MeSH secundário: Adenocarcinoma/metabolismo
Adenocarcinoma/patologia
Anexina A5/metabolismo
Antineoplásicos Fitogênicos/isolamento & purificação
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Caspase 3/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Fitoterapia
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Annexin A5); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Solvents); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE


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[PMID]:27731806
[Au] Autor:Qureshi MN; Stecher G; Bonn GK
[Ad] Endereço:Department of Chemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan.
[Ti] Título:Quantification of polyphenolic compounds and flavonoids in Achillea millefolium and Equisetum arvense.
[So] Source:Pak J Pharm Sci;29(5):1519-1523, 2016 Sep.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Flavonoids have been of considerable importance and interest because of their medicinal activity. Responding to their numerous health benefits, a comparative study on the quantitative determination of total polyphenolic compounds and flavonoids was carried out in Achillea millefolium and Equisetum arvense. Total polyphenolic compounds were quantified by Folin-Ciocalteau method using different solvents in order to prove their extraction efficiency. Focus within total polyphenolic quantification study was placed on the traditional reflux and solvents used were: water, 100% acetone, 100% ethanol, 80% ethanol, 50% methanol and 70% methanol. In order to make flavonoids free from glycosidic moiety for quantification, hydrolysis was performed in 50% MeOH at 90°C using 6 M HCl concentration. Reverse phase high performance liquid chromatography (RP-HPLC) in gradient elution mode at 50°C using Hypersil BDS (RP-18) column was employed for the separation of flavonoids. Mobile phase used consisted of different combinations of water-methanol-tetrahydrofuran-phosphoric acid. Flavonoids quantified were luteolin, quercetin, apigenin, isorhamnetin and kaempferol.
[Mh] Termos MeSH primário: Achillea/química
Equisetum/química
Flavonoides/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Polifenóis/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cromatografia de Fase Reversa
Flavonoides/química
Estrutura Molecular
Fitoterapia
Extratos Vegetais/química
Plantas Medicinais
Polifenóis/química
Solventes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Solvents)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE



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