Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.100.046 [Categoria DeCS] Referências encontradas : 87 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28397757 [Au] Autor: Dong LM; Zhang M; Xu QL; Zhang Q; Luo B; Luo QW; Liu WB; Tan JW [Ad] Endereço: Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. donglimei1990@163.com. [Ti] Título: Two New Thymol Derivatives from the Roots of Ageratina adenophora. [So] Source: Molecules;22(4), 2017 Apr 08. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol ( ) and 7-acetoxy-8-methoxy-9-isobutyryloxythymol ( ), were isolated from fresh roots of , together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol ( ), 9-oxoageraphorone ( ), (-)-isochaminic acid ( ) and (1α,6α)-10-hydroxycar-3-ene-2-one ( ). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the roots of for the first time. All the compounds were tested for their in vitro antibacterial activity toward three Gram-positive and two Gram-negative bacterial strains. Thymol derivatives - only selectively showed slight in vitro bacteriostatic activity toward three Gram-positive bacteria. The two known carene-type monoterpenes and were found to show moderate in vitro antibacterial activity against all five tested bacterial strains, with MIC values from 15.6 to 62.5 µg/mL. In addition, compounds and were further revealed to show in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC values ranging from 18.36 to 41.87 µM. However, their cytotoxic activities were inferior to those of reference compound adriamycin. [Mh] Termos MeSH primário: Ageratina/química Extratos Vegetais/química Raízes de Plantas/química Timol/análogos & derivados Timol/química [Mh] Termos MeSH secundário: Antibacterianos/química Antibacterianos/farmacologia Antineoplásicos Fitogênicos/química Antineoplásicos Fitogênicos/farmacologia Bactérias/efeitos dos fármacos Linhagem Celular Tumoral Sobrevivência Celular/efeitos dos fármacos Seres Humanos Concentração Inibidora 50 Espectroscopia de Ressonância Magnética Testes de Sensibilidade Microbiana Estrutura Molecular [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 3J50XA376E (Thymol) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170531 [Lr] Data última revisão: 170531 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170412 [St] Status: MEDLINE

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[PMID]: 28299831 [Au] Autor: Romero-Cerecero O; Islas-Garduño AL; Zamilpa A; Tortoriello J [Ad] Endereço: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Xochitepec, Morelos, Mexico. [Ti] Título: Effectiveness of Ageratina pichinchensis Extract in Patients with Vulvovaginal Candidiasis. A Randomized, Double-Blind, and Controlled Pilot Study. [So] Source: Phytother Res;31(6):885-890, 2017 Jun. [Is] ISSN: 1099-1573 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Previous clinical studies have demonstrated the antifungal effectiveness of Ageratina pichinchensis extracts when topically administered to patients with dermatomycosis. The objective of this study was to evaluate the effectiveness and tolerability of a 7% standardized extract of A. pichinchensis (intravaginal) in patients with vulvovaginal candidiasis. The extract was standardized in terms of its encecalin content and administered during 6 days to patients with Candida albicans-associated vulvovaginitis. The positive control group was treated with Clotrimazole (100 mg). On day 7 of the study, a partial evaluation was carried out; it demonstrated that 94.1% of patients treated with Clotrimazole and 100% of those treated with the A. pichinchensis extract referred a decrease or absence of signs and symptoms consistent with vulvovaginal candidiasis. In the final evaluation, 2 weeks after concluding administration, 86.6% of patients in the control group and 81.2% (p = 0.65) of those treated with the A. pichinchensis extract demonstrated therapeutic success. Statistical analysis evidenced no significant differences between the two treatment groups. With the results obtained, it is possible to conclude that the standardized extract from A. pichinchensis, intravaginally administered, showed therapeutic and mycological effectiveness, as well as tolerability, in patients with vulvovaginal candidiasis, without noting statistical differences in patients treated with Clotrimazole. Copyright © 2017 John Wiley & Sons, Ltd. [Mh] Termos MeSH primário: Ageratina/química Antifúngicos/uso terapêutico Candidíase Vulvovaginal/tratamento farmacológico Extratos Vegetais/uso terapêutico [Mh] Termos MeSH secundário: Adulto Candida albicans/efeitos dos fármacos Clotrimazol/uso terapêutico Método Duplo-Cego Feminino Seres Humanos Fitoterapia/métodos Projetos Piloto Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Antifungal Agents); 0 (Plant Extracts); G07GZ97H65 (Clotrimazole) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170925 [Lr] Data última revisão: 170925 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170317 [St] Status: MEDLINE [do] DOI: 10.1002/ptr.5802

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[PMID]: 28239038 [Au] Autor: Kong Y; Kong J; Wang D; Huang H; Geng K; Wang Y; Xia Y [Ad] Endereço: Key Laboratory of Special Biological Resource Development and Utilization of Universities of Yunnan Province, Kunming University. [Ti] Título: Effect of Ageratina adenophora invasion on the composition and diversity of soil microbiome. [So] Source: J Gen Appl Microbiol;63(2):114-121, 2017 May 12. [Is] ISSN: 1349-8037 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: In the present study, high throughput 16S rRNA gene sequencing was used to investigate soil invaded by the aggressive weed Ageratina adenophora to determine its effect on the species composition, distribution, and biodiversity of the bacterial communities. Soil samples from 12 micro-sites containing a monoculture of A. adenophora plants, mixtures of A. adenophora and different native plant species, and native species alone were studied. We found that the invasion of this weed resulted in a selection of bacteria belonging to phyla Acidobacteria and Verrucomicrobia and the lack of bacteria belonging to phyla Actinobacteria and Planctomycetes, but did not affect significantly the percentage abundances of members of other phyla. A similar bacterial population selection was also observed at genus or subgroup levels. The NO -N level was an important factor affecting soil bacterial communities and contributed to the dominance of A. adenophora. However, the numbers of total bacterial species, and the diversity and structure of soil bacterial microbiome did not (P > 0.05) change significantly following invasion by this weed. [Mh] Termos MeSH primário: Ageratina/microbiologia Microbiota Microbiologia do Solo [Mh] Termos MeSH secundário: Actinobacteria/classificação Actinobacteria/genética Actinobacteria/isolamento & purificação Ageratina/crescimento & desenvolvimento China Sequenciamento de Nucleotídeos em Larga Escala Planctomycetales/classificação Planctomycetales/genética Planctomycetales/isolamento & purificação Plantas Daninhas/crescimento & desenvolvimento Plantas Daninhas/microbiologia RNA Ribossômico 16S/isolamento & purificação Análise de Sequência de DNA Solo/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (RNA, Ribosomal, 16S); 0 (Soil) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170228 [St] Status: MEDLINE [do] DOI: 10.2323/jgam.2016.08.002

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[PMID]: 28042867 [Au] Autor: Liu B; Cao L; Zhang L; Yuan X; Zhao B [Ad] Endereço: Division of Biorefinery Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. lbyone@163.com. [Ti] Título: Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum. [So] Source: Molecules;22(1), 2016 Dec 31. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: is widely distributed throughout the world's tropical and temperate regions. It has become a harmful weed of crops and natural environments. Its leaves contain bioactive compounds such as chlorogenic acid and may be used as feed additives. In this study, chlorogenic acid was extracted and separated from leaves of . Three chlorogenic acid products were prepared with different purities of 6.11%, 22.17%, and 96.03%. Phytochemical analysis demonstrated that the main toxins of sesquiterpenes were almost completely removed in sample preparation procedure. The three products were evaluated for safety via in vitro and in vivo toxicological studies. All the products exhibited no cytotoxic effects at a dose of 400 µg/mL in an in vitro cell viability assay. When administered in vivo at a single dose up to 1.5 g/kg bw, all three products caused no signs or symptoms of toxicity in mice. These results encourage further exploration of extracts from in feed additive application. [Mh] Termos MeSH primário: Ageratina/química Ácido Clorogênico/análogos & derivados Ácido Clorogênico/farmacologia Hepatócitos/efeitos dos fármacos Compostos Fitoquímicos/farmacologia [Mh] Termos MeSH secundário: Animais Linhagem Celular Tumoral Sobrevivência Celular/efeitos dos fármacos Ácido Clorogênico/química Feminino Células Hep G2 Seres Humanos Masculino Camundongos Camundongos Endogâmicos ICR Compostos Fitoquímicos/química Extratos Vegetais/farmacologia Folhas de Planta/química Sesquiterpenos/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Phytochemicals); 0 (Plant Extracts); 0 (Sesquiterpenes); 318ADP12RI (Chlorogenic Acid) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170609 [Lr] Data última revisão: 170609 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170103 [St] Status: MEDLINE

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[PMID]: 28040821 [Au] Autor: Halteh P; Scher RK; Lipner SR [Ad] Endereço: Weill Cornell Medical College, Qatar, Ar-Rayyan. [Ti] Título: Over-the-counter and natural remedies for onychomycosis: do they really work? [So] Source: Cutis;98(5):E16-E25, 2016 Nov. [Is] ISSN: 2326-6929 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Onychomycosis is a fungal infection of the nail unit that may lead to dystrophy and disfigurement over time. It accounts for up to 50% of all nail conditions, with toenails affected more commonly than fingernails. Onychomycosis may affect quality of life and increase the prevalence and severity of foot ulcers in patients with diabetes. Available oral agents approved by the US Food and Drug Administration (FDA) for the treatment of onychomycosis include terbinafine and itraconazole, which have demonstrated good efficacy but are associated with the risk of systemic side effects and drug-drug interactions. Topical medications that are FDA approved for onychomycosis include ciclopirox, efinaconazole, and tavaborole. These therapies generally have incomplete efficacy compared to systemic agents as well as long treatment courses and possible local side effects such as erythema and/or blisters. Given the need for safe, effective, and cost-effective options for onychomycosis therapy, there has been a renewed interest in natural and over-the-counter (OTC) alternatives. This review will synthesize the laboratory data, known antifungal mechanisms, and clinical studies assessing the efficacy of OTC and natural products for onychomycosis treatment. [Mh] Termos MeSH primário: Medicina Tradicional Medicamentos sem Prescrição/uso terapêutico Onicomicose/tratamento farmacológico [Mh] Termos MeSH secundário: Administração Tópica Ageratina Antitussígenos/uso terapêutico Coniferophyta Seres Humanos Extratos Vegetais/uso terapêutico Óleos Vegetais/uso terapêutico Resinas Vegetais/uso terapêutico Óleo de Girassol Óleo de Melaleuca/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antitussive Agents); 0 (Nonprescription Drugs); 0 (Plant Extracts); 0 (Plant Oils); 0 (Resins, Plant); 0 (Sunflower Oil); 68647-73-4 (Tea Tree Oil) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170102 [St] Status: MEDLINE

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[PMID]: 27911906 [Au] Autor: Song D; Pan K; Tariq A; Azizullah A; Sun F; Li Z; Xiong Q [Ad] Endereço: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China. [Ti] Título: Adsorptive Removal of Toxic Chromium from Waste-Water Using Wheat Straw and Eupatorium adenophorum. [So] Source: PLoS One;11(12):e0167037, 2016. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Environmental pollution with heavy metals is a serious issue worldwide posing threats to humans, animals and plants and to the stability of overall ecosystem. Chromium (Cr) is one of most hazardous heavy metals with a high carcinogenic and recalcitrant nature. Aim of the present study was to select low-cost biosorbent using wheat straw and Eupatorium adenophorum through simple carbonization process, capable of removing Cr (VI) efficiently from wastewater. From studied plants a low cost adsorbent was prepared for removing Cr (VI) from aqueous solution following very simple carbonization method excluding activation process. Several factors such as pH, contact time, sorbent dosage and temperature were investigated for attaining ideal condition. For analysis of adsorption equilibrium isotherm data, Langmuir, Freundlich and Temkin models were used while pseudo-first-order, pseudo-second-order, external diffusion and intra-particle diffusion models were used for the analysis of kinetic data. The obtained results revealed that 99.9% of Cr (VI) removal was observed in the solution with a pH of 1.0. Among all the tested models Langmuir model fitted more closely according to the data obtained. Increase in adsorption capacity was observed with increasing temperature revealing endothermic nature of Cr (VI). The maximum Cr (VI) adsorption potential of E. adenophorum and wheat straw was 89.22 mg per 1 gram adsorbent at 308K. Kinetic data of absorption precisely followed pseudo-second-order model. Present study revealed highest potential of E. adenophorum and wheat straw for producing low cost adsorbent and to remove Cr (VI) from contaminated water. [Mh] Termos MeSH primário: Ageratina/crescimento & desenvolvimento Compostos de Cromo/metabolismo Modelos Biológicos Águas Residuais/microbiologia Microbiologia da Água Poluentes Químicos da Água/metabolismo [Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio Triticum Purificação da Água/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chromium Compounds); 0 (Waste Water); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170630 [Lr] Data última revisão: 170630 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161203 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0167037

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[PMID]: 27726359 [Au] Autor: Pardo-Novoa JC; Arreaga-González HM; Gómez-Hurtado MA; Rodríguez-García G; Cerda-García-Rojas CM; Joseph-Nathan P; Del Río RE [Ad] Endereço: Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria , Morelia, Michoacán 58030, Mexico. [Ti] Título: Absolute Configuration of Menthene Derivatives by Vibrational Circular Dichroism. [So] Source: J Nat Prod;79(10):2570-2579, 2016 Oct 28. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The aerial parts of Ageratina glabrata afforded (-)-(3S,4R,5R,6S)-3,5,6-trihydroxy-1-menthene 3-O-ß-d-glucopyranoside (1) and (-)-(3S,4S,6R)-3,6-dihydroxy-1-menthene 3-O-ß-d-glucopyranoside (3). Acid hydrolysis of 1 yielded (+)-(1R,4S,5R,6R)-1,5,6-trihydroxy-2-menthene (5) and (+)-(1S,4S,5R,6R)-1,5,6-trihydroxy-2-menthene (6), while hydrolysis of 3 yielded (+)-(3S,4S,6R)-3,6-dihydroxy-1-menthene (10), (+)-(1R,4S,6R)-1,6-dihydroxy-2-menthene (11), and (+)-(1S,4S,6R)-1,6-dihydroxy-2-menthene (12). The structures of the new compounds 1, 2, 5-9, and 11 were defined by 1D and 2D NMR experiments, while the absolute configurations of the series of compounds were determined by comparison of the experimental vibrational circular dichroism (VCD) spectra of the 1,6-acetonide 5-acetate derived from 6 and of the 1,6-acetonide derived from 12 with their DFT-calculated spectra. In addition, Flack and Hooft X-ray parameters of 10 permitted the same conclusion. The results further led to the absolute configuration reassignment of 10 isolated from Brickellia rosmarinifolia, Mikania saltensis, Ligularia muliensis, L. sagitta, and Lindera strychnifolia, as well as of 11 from Cacalia tangutica, as ent-11. [Mh] Termos MeSH primário: Ageratina/química Dicroísmo Circular/métodos Terpenos/química [Mh] Termos MeSH secundário: Asteraceae México Estrutura Molecular Ressonância Magnética Nuclear Biomolecular Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Terpenes); 11028-39-0 (1-menthene) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170616 [Lr] Data última revisão: 170616 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161012 [St] Status: MEDLINE

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[PMID]: 27626392 [Au] Autor: Bustos-Brito C; Vázquez-Heredia VJ; Calzada F; Yépez-Mulia L; Calderón JS; Hernández-Ortega S; Esquivel B; García-Hernández N; Quijano L [Ad] Endereço: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, D.F. 04510, Mexico. bustosbritocelia@comunidad.unam.mx. [Ti] Título: Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate. [So] Source: Molecules;21(9), 2016 Sep 12. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Chemical investigation of the leaves from Ageratina glabrata yielded four new thymol derivatives, namely: 10-benzoyloxy-8,9-dehydro-6-hydroxythymol isobutyrate (4), 10-benzoyloxy-8,9-dehydrothymol (5), 10-benzoyloxythymol (6) and 10-benzoyloxy-6,8-dihydroxy-9-isobutyryl-oxythymol (7). In addition, (8S)-10-benzoyloxy-8,9-epoxy-6-hydroxythymol isobutyrate (1), together with other two already known thymol derivatives identified as 10-benzoyloxy-8,9-epoxy-6-methoxythymol isobutyrate (2) and 10-benzoyloxy-8,9-epoxythymol isobutyrate (3) were also obtained. In this paper, we report the structures and complete assignments of the ¹H and (13)C-NMR data of compounds 1-7, and the absolute configuration for compound 1, unambiguously established by single crystal X-ray diffraction, and evaluation of the Flack parameter. The in vitro antiprotozoal assay showed that compound 1 and its derivative 1a were the most potent antiamoebic and antigiardial compounds. Both compounds showed selectivity and good antiamoebic activity comparable to emetine and metronidazole, respectively, two antiprotozoal drugs used as positive controls. In relation to anti-propulsive effect, compound 1 and 1a showed inhibitory activity, with activities comparable to quercetin and compound 9, two natural antipropulsive compounds used as positive controls. These data suggest that compound 1 may play an important role in antidiarrheal properties of Ageratina glabrata. [Mh] Termos MeSH primário: Ageratina/química Antidiarreicos Isobutiratos Folhas de Planta/química Timol [Mh] Termos MeSH secundário: Antidiarreicos/química Antidiarreicos/isolamento & purificação Seres Humanos Isobutiratos/química Isobutiratos/isolamento & purificação Espectroscopia de Ressonância Magnética Timol/análogos & derivados Timol/química Timol/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antidiarrheals); 0 (Isobutyrates); 3J50XA376E (Thymol) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170417 [Lr] Data última revisão: 170417 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160915 [St] Status: MEDLINE

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[PMID]: 27490569 [Au] Autor: Li YH; Han WJ; Gui XW; Wei T; Tang SY; Jin JM [Ad] Endereço: Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100048, China. lyhlf11@sina.com. [Ti] Título: Putative Nonribosomal Peptide Synthetase and Cytochrome P450 Genes Responsible for Tentoxin Biosynthesis in Alternaria alternata ZJ33. [So] Source: Toxins (Basel);8(8), 2016 08 02. [Is] ISSN: 2072-6651 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Tentoxin, a cyclic tetrapeptide produced by several Alternaria species, inhibits the F1-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants. In this study, we report two clustered genes, encoding a putative non-ribosome peptide synthetase (NRPS) TES and a cytochrome P450 protein TES1, that are required for tentoxin biosynthesis in Alternaria alternata strain ZJ33, which was isolated from blighted leaves of Eupatorium adenophorum. Using a pair of primers designed according to the consensus sequences of the adenylation domain of NRPSs, two fragments containing putative adenylation domains were amplified from A. alternata ZJ33, and subsequent PCR analyses demonstrated that these fragments belonged to the same NRPS coding sequence. With no introns, TES consists of a single 15,486 base pair open reading frame encoding a predicted 5161 amino acid protein. Meanwhile, the TES1 gene is predicted to contain five introns and encode a 506 amino acid protein. The TES protein is predicted to be comprised of four peptide synthase modules with two additional N-methylation domains, and the number and arrangement of the modules in TES were consistent with the number and arrangement of the amino acid residues of tentoxin, respectively. Notably, both TES and TES1 null mutants generated via homologous recombination failed to produce tentoxin. This study provides the first evidence concerning the biosynthesis of tentoxin in A. alternata. [Mh] Termos MeSH primário: Ageratina/microbiologia Alternaria/enzimologia Proteínas de Bactérias/metabolismo Sistema Enzimático do Citocromo P-450/metabolismo Biossíntese de Peptídeos Independentes de Ácido Nucleico Peptídeo Sintases/metabolismo Peptídeos Cíclicos/biossíntese [Mh] Termos MeSH secundário: Alternaria/genética Sistema Enzimático do Citocromo P-450/genética Regulação Bacteriana da Expressão Gênica Regulação Enzimológica da Expressão Gênica Peptídeo Sintases/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Bacterial Proteins); 0 (Peptides, Cyclic); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 6.3.2.- (Peptide Synthases); EC 6.3.2.- (non-ribosomal peptide synthase); FW4EQ02E0Z (tentoxin) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171122 [Lr] Data última revisão: 171122 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160805 [St] Status: MEDLINE

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[PMID]: 27448114 [Au] Autor: Bustos-Brito C; Esquivel B; Calzada F; Yepez-Mulia L; Calderón JS; Porras-Ramirez J; Quijano L [Ad] Endereço: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, D.F., 04510, México. bustosbritocelia@yahoo.com.mx. [Ti] Título: Further Thymol Derivatives from Ageratina cylindrica. [So] Source: Chem Biodivers;13(10):1281-1289, 2016 Oct. [Is] ISSN: 1612-1880 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: From the leaves of Ageratina cylindrica, in addition to the described [(2S)-2-{4-formyl-5-hydroxy-2-[(2-methylpropanoyl)oxy]phenyl}oxiran-2-yl]methyl benzoate (cylindrinol A, 8), seven new thymol derivatives were isolated and named cylindrinols B - H (1 - 7). The structures of these compounds were established as (2-{4-(hydroxymethyl)-2-[(2-methylpropanoyl)oxy]phenyl}oxiran-2-yl)methyl benzoate (1), (2-{4-formyl-2-[(2-methylpropanoyl)oxy]phenyl}oxiran-2-yl)methyl benzoate (2), (2-{4-[(acetyloxy)methyl]-2-[(2-methylpropanoyl)oxy]phenyl}oxiran-2-yl)methyl benzoate (3), [2-(2-[(2-methylpropanoyl)oxy]-4-{[(2-methylpropanoyl)oxy]methyl}phenyl)oxiran-2-yl]methyl benzoate (4), [2-(5-hydroxy-2-[(2-methylpropanoyl)oxy]-4-{[(2-methylpropanoyl)oxy]methyl}phenyl)oxiran-2-yl]methyl benzoate (5), 2-{4-(hydroxymethyl)-2-[(2-methylpropanoyl)oxy]phenyl}prop-2-en-1-yl benzoate (6), and 2-hydroxy-2-[2-hydroxy-4-(hydroxymethyl)-phenyl]-3-[(2-methylpropanoyl)oxy]propyl benzoate (7), by spectroscopic means. Compounds 1 showed moderate antiprotozoal activity on both protozoa. Compounds 4 and 5 showed selectivity on Giardia lamblia trophozoites. All isolated compounds were less active than two antiprotozoal drugs, metronidazole and emetine, used as positive controls. Compound 5 exhibited a high inhibitory effect on hyperpropulsive movement of the small intestine in rats; its effect was best than loperamide, antidiarrheal drug used as a positive control. [Mh] Termos MeSH primário: Ageratina/química Antiprotozoários/química Antiprotozoários/farmacologia Giardia lamblia/efeitos dos fármacos Intestino Delgado/efeitos dos fármacos Timol/análogos & derivados Timol/isolamento & purificação [Mh] Termos MeSH secundário: Animais Antiprotozoários/isolamento & purificação Relação Dose-Resposta a Droga Intestino Delgado/fisiologia Testes de Sensibilidade Parasitária Folhas de Planta/química Ratos Relação Estrutura-Atividade Timol/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiprotozoal Agents); 3J50XA376E (Thymol) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170118 [Lr] Data última revisão: 170118 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160723 [St] Status: MEDLINE [do] DOI: 10.1002/cbdv.201600038

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