Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.056 [Categoria DeCS]
Referências encontradas : 59 [refinar]
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[PMID]:27633406
[Au] Autor:Faqueti LG; Brieudes V; Halabalaki M; Skaltsounis AL; Nascimento LF; Barros WM; Santos AR; Biavatti MW
[Ad] Endereço:Department of Pharmaceutical Sciences, CCS, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.
[Ti] Título:Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides.
[So] Source:J Ethnopharmacol;194:369-377, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Ageratum conyzoides L. is a plant widely used in traditional medicine in tropical and subtropical regions of the world due to its anti-inflammatory, antinociceptive and antibacterial properties. AIM OF THE STUDY: To characterize the standardized extract of polymethoxyflavones (SEPAc) from the plant and evaluate its antinociceptive and anti-inflammatory effects. MATERIALS AND METHODS: The SEPAc purified from the ethanol extract of the plant leaves was characterized by high resolution mass spectrometry and the methoxyflavones were quantified by a validated UPLC-PDA method. The antinociceptive and anti-inflammatory activities of the SEPAc were evaluated after oral administration on the acute nocifensive behavior of mice induced by formalin, prostaglandin E2 (PGE2) and proinflammatory cytokines (interleukin-1beta (IL-1ß)) and tumor necrosis factor-alpha (TNF-α) in mice. RESULTS: Qualitative analyses revealed the presence of seven methoxyflavones in the SEPAc, also a simple UPLC-PDA method was developed and validated for the quantification of 5,6,7,3',4',5'-hexametoxyflavone; nobiletin; 5'-methoxynobiletin and eupalestin, major compounds in the extract. The SEPAc exhibited antinociceptive and anti-inflammatory activities in both formalin phases, with significant inhibition of the paw edema formation and significant reduction of the nocifensive response induced by an intraplantar injection of PGE2 and intrathecal injection of interleukin-1ß. CONCLUSIONS: The SEPAc exhibited significant antinociceptive and anti-inflammatory effects. These results provided scientific suggestion of its potential as a source of new medicines to treat inflammatory diseases, such rheumatoid arthritis.
[Mh] Termos MeSH primário: Ageratum/química
Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Flavonas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Camundongos
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Flavones); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE


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[PMID]:27596330
[Au] Autor:Vigil de Mello SV; da Rosa JS; Facchin BM; Luz AB; Vicente G; Faqueti LG; Rosa DW; Biavatti MW; Fröde TS
[Ad] Endereço:Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
[Ti] Título:Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity.
[So] Source:J Ethnopharmacol;194:337-347, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Ageratum conyzoides Linn (Asteraceae), a tropical plant that is very common in West Africa and some parts of Asia and South America, has been used to treat inflammatory disorders. In Brazil, teas made from A. conyzoides L. are used as anti-inflammatory, analgesic and anti-diarrheic agents. Therefore, it is necessary to study the mechanism of anti-inflammatory action of A. conyzoides L. to support its medicinal use for treating inflammatory conditions. These studies will also support the development of effective pharmacological agents with potent anti-inflammatory properties. AIM OF THE STUDY: To evaluate the anti-inflammatory effects of the crude extract (CE), its derived fractions: ethanol (EtOH-F), hexane (HEX-F), ethyl acetate (EtOAc-F) and dichloromethane (DCM-F) and isolated compounds, such as 5'-methoxy nobiletin (MeONOB), 1,2-benzopyrone and eupalestin, which are obtained from the aerial parts of A. conyzoides L. MATERIALS AND METHODS: These evaluations were performed using an animal model of inflammation induced by carrageenan. The following inflammatory parameters were analysed: leukocyte influx, protein concentration of the exudate, myeloperoxidase (MPO), adenosine deaminase (ADA) and nitric oxide metabolites (NOx) concentrations, interleukin 10 (IL-10), interleukin 17A (IL-17A), interleukin 6 (IL-6), tumor necrosis factor (TNF), interferon gamma (IFN-γ) and phosphorylation of p65 subunit of NF-κB (p-p65 NF-κB), p38 mitogen-activated protein kinases (p-p38 MAPK) were also analysed. RESULTS: CE, its EtOH-F, HEX-F, EtOAc-F and DCM-F and the isolated compounds, including MeONOB, 1,2-benzopyrone and eupalestin, significantly reduced leukocyte influx, protein concentration of the exudate, MPO, ADA, and NOx concentrations (p<0.05). CE, EtOH-F and isolated compounds significantly reduced IL-17A, IL-6, TNF and IFN-γ levels (p<0.05). CE, EtOH-F and isolated compound 1,2-benzopyrone also increased IL-10 levels (p<0.05). Isolated compounds, MeONOB, 1,2-benzopyrone and eupalestin, reduced p-p65 NF-κB and p-p38 MAPK (p<0.01). CONCLUSIONS: This study demonstrates that A. conyzoides L. exerts its important anti-inflammatory properties by inhibiting leukocyte influx and protein concentration of the exudate, as well as reducing the levels of several pro-inflammatory mediators. The anti-inflammatory action of A. conyzoides L. may be because of the inhibition of p65 NF-κB and MAPK activation by the isolated compounds.
[Mh] Termos MeSH primário: Ageratum/química
Anti-Inflamatórios/farmacologia
Carragenina/toxicidade
Inflamação/prevenção & controle
Extratos Vegetais/farmacologia
Cavidade Pleural/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Inflamação/induzido quimicamente
Masculino
Camundongos
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 9000-07-1 (Carrageenan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27097086
[Au] Autor:Maia VC; Araújo L
[Ad] Endereço:Departamento de Entomologia, Museu Nacional, Rio de Janeiro RJ , Brazil, Departamento de Entomologia, Museu Nacional, Quinta da Boa Vista, s/n, São Cristóvão, CEP 20940-040, Rio de Janeiro, RJ, Brazil.
[Ti] Título:Clinodiplosis agerati (Diptera, Cecidomyiidae), a new galling species associated with Ageratum conyzoides (Asteraceae) from Brazil.
[So] Source:Braz J Biol;76(3):782-6, 2016 Apr 19.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Clinodiplosis agerati, a new galling species that induces stem galls on Ageratum conyzoides (Asteraceae) is described and illustrated (larva, pupa, male, female and gall) based on material collected in Minas Gerais, Brazil. The new species is compared with the other Neotropical species. This is the first record of the Clinodiplosis in Ageratum.
[Mh] Termos MeSH primário: Ageratum/parasitologia
Dípteros/classificação
Dípteros/fisiologia
Interações Hospedeiro-Parasita/fisiologia
Tumores de Planta/parasitologia
[Mh] Termos MeSH secundário: Animais
Brasil
Feminino
Larva
Masculino
Pupa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE


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[PMID]:26946375
[Au] Autor:Tanvir R; Sajid I; Hasnain S; Kulik A; Grond S
[Ad] Endereço:Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, 54590, Lahore, Punjab, Pakistan; Institut fur Organische Chemie, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18A, 72076, Tübingen, Germany. Electronic address: rabiatanvir@hotmail.com.
[Ti] Título:Rare actinomycetes Nocardia caishijiensis and Pseudonocardia carboxydivorans as endophytes, their bioactivity and metabolites evaluation.
[So] Source:Microbiol Res;185:22-35, 2016 Apr.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Two strains identified as Nocardia caishijiensis (SORS 64b) and Pseudonocardia carboxydivorans (AGLS 2) were isolated as endophytes from Sonchus oleraceus and Ageratum conyzoides respectively. The analysis of their extracts revealed them to be strongly bioactive. The N. caishijiensis extract gave an LC50 of 570 µg/ml(-1) in the brine shrimp cytotoxicity assay and an EC50 of 0.552 µg/ml(-1) in the DPPH antioxidant assay. Antimicrobial activity was observed against Methicillin resistant Staphlococcus aureus (MRSA) and Escherichia coli ATCC 25922 (14 mm), Klebsiella pneumoniae ATCC 706003 (13 mm), S. aureus ATCC 25923 (11 mm) and Candida tropicalis (20 mm). For the extract of P. carboxydivorans the EC50 was 0.670 µg/ml(-1) and it was observed to be more bioactive against Bacillus subtilis DSM 10 ATCC 6051 (21 mm), C. tropicalis (20 mm), S. aureus ATCC 25923 (17 mm), MRSA (17 mm), E. coli K12 (W1130) (16 mm) and Chlorella vulgaris (10 mm). The genotoxicity testing revealed a 20 mm zone of inhibition against the polA mutant strain E. coli K-12 AB 3027 suggesting damage to the DNA and polA genes. The TLC and bioautography screening revealed a diversity of active bands of medium polar and nonpolar compounds. Metabolite analysis by HPLC-DAD via UV/vis spectral screening suggested the possibility of stenothricin and bagremycin A in the mycelium extract of N. caishijiensis respectively. In the broth and mycelium extract of P. carboxydivorans borrelidin was suggested along with α-pyrone. The HPLC-MS revealed bioactive long chained amide derivatives such as 7-Octadecenamide, 9, 12 octadecandienamide. This study reports the rare actinomycetes N. caishijiensis and P. carboxydivorans as endophytes and evaluates their bioactive metabolites.
[Mh] Termos MeSH primário: Actinobacteria/fisiologia
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Endófitos/fisiologia
Nocardia/fisiologia
[Mh] Termos MeSH secundário: Actinobacteria/química
Actinobacteria/isolamento & purificação
Actinobacteria/metabolismo
Ageratum/microbiologia
Aminobenzoatos/química
Animais
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Asteraceae/microbiologia
Bacillus subtilis/efeitos dos fármacos
Sequência de Bases
DNA Bacteriano/efeitos dos fármacos
Endófitos/química
Endófitos/isolamento & purificação
Endófitos/metabolismo
Escherichia coli/efeitos dos fármacos
Klebsiella pneumoniae/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Nocardia/química
Nocardia/isolamento & purificação
Nocardia/metabolismo
Filogenia
RNA Ribossômico 16S/genética
Análise de Sequência
Sonchus/microbiologia
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aminobenzoates); 0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S); 0 (bagremycin A)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160307
[St] Status:MEDLINE


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[PMID]:25525626
[Au] Autor:Parveen S; Godara R; Katoch R; Yadav A; Verma PK; Katoch M; Singh NK
[Ad] Endereço:Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, R.S. Pura, Jammu 181 102, India.
[Ti] Título:In vitro evaluation of ethanolic extracts of Ageratum conyzoides and Artemisia absinthium against cattle tick, Rhipicephalus microplus.
[So] Source:ScientificWorldJournal;2014:858973, 2014.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In vitro efficacy of ethanolic extracts obtained from the aerial parts of Ageratum conyzoides and Artemisia absinthium was assessed on Rhipicephalus microplus using adult immersion test (AIT). Five concentrations of the extract (1.25%, 2.5%, 5%, 10%, and 20%) with three replications for each concentration were used in the bioassay. In AIT, the maximum mortality was recorded as 40% and 66.7% at 20% concentration for A. conyzoides and A. absinthium, respectively. Acaricidal activity was found to be higher in the extract of A. absinthium with LC50 and LC95 values of 11.2% and 61.7%, respectively. Egg mass weight of the live ticks treated with different concentrations of the extracts was significantly (P<0.05) lower than that of control ticks; consequently, the reproductive index and oviposition values of the treated ticks were reduced significantly (P<0.05). The A. conyzoides inhibited 90% hatching of eggs at the 20% concentration, whereas A. absinthium showed 100% inhibition at 5%, 10%, and 20% concentrations. The results show that A. absinthium has better acaricidal properties than A. conyzoides and could be useful in controlling R. microplus.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Ageratum/química
Artemisia absinthium/química
Etanol/química
Extratos Vegetais/farmacologia
Rhipicephalus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Bovinos
Relação Dose-Resposta a Droga
Oviposição/efeitos dos fármacos
Óvulo/efeitos dos fármacos
Fitoterapia
Análise de Regressão
Reprodução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151028
[Lr] Data última revisão:
151028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141220
[St] Status:MEDLINE
[do] DOI:10.1155/2014/858973


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[PMID]:25268755
[Au] Autor:Wang WC; Wu CY; Lai YC; Lin NS; Hsu YH; Hu CC
[Ad] Endereço:Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan.
[Ti] Título:Characterization of the cryptic AV3 promoter of ageratum yellow vein virus in prokaryotic and eukaryotic systems.
[So] Source:PLoS One;9(9):e108608, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A cryptic prokaryotic promoter, designated AV3 promoter, has been previously identified in certain begomovirus genus, including ageratum yellow vein virus isolate NT (AYVV-NT). In this study, we demonstrated that the core nucleotides in the putative -10 and -35 boxes are necessary but not sufficient for promoter activity in Escherichia coli, and showed that AYVV-NT AV3 promoter could specifically interact with single-stranded DNA-binding protein and sigma 70 of E. coli involved in transcription. Several AYVV-NT-encoded proteins were found to increase the activity of AV3 promoter. The transcription start sites downstream to AV3 promoter were mapped to nucleotide positions 803 or 805 in E. coli, and 856 in Nicotiana benthamiana. The eukaryotic activity of AV3 promoter and the translatability of a short downstream open reading frame were further confirmed by using a green fluorescent protein reporter construct in yeast (Saccharomyces cerevisiae) cells. These results suggested that AV3 promoter might be a remnant of evolution that retained cryptic activity at present.
[Mh] Termos MeSH primário: Ageratum/virologia
Begomovirus/genética
Fases de Leitura Aberta
Regiões Promotoras Genéticas
Tabaco/virologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Agrobacterium/genética
Sequência de Bases
Begomovirus/metabolismo
Evolução Biológica
Escherichia coli/genética
Escherichia coli/virologia
Genoma Viral
Dados de Sequência Molecular
Doenças das Plantas/virologia
Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/virologia
Transcrição Genética
Proteínas Virais/química
Proteínas Virais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141001
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0108608


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[PMID]:25048610
[Au] Autor:Diallo A; Eklu-Gadegbeku K; Amegbor K; Agbonon A; Aklikokou K; Creppy E; Gbeassor M
[Ad] Endereço:Department of Toxicology, Faculty of Health Sciences, University of Lome, P.O. Box 216 Lomé 05, Lomé, Togo. Electronic address: aboudoulatif@gmail.com.
[Ti] Título:In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae).
[So] Source:J Ethnopharmacol;155(2):1214-8, 2014 Sep 11.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: In African traditional medicine, Ageratum conyzoides has been used as purgative, febrifuge, anti-ulcer and wound dressing. To date there is no safety information about long term use of Ageratum conyzoides which contains pyrrolizidine alkaloids, a class of hepatotoxic and carcinogenic phytochemicals. This study aims to evaluate the 90 days subchronic toxicity and in vitro toxicity of Ageratum conyzoides. MATERIALS AND METHODS: Three groups of 8 rats (4 males and 4 females) received distilled water (control), 500 and 1000 mg/kg of the extract daily for 90 consecutive days by oral gavage. The animals were observed daily for abnormal clinical signs and death. Body weight, relative organ weight, haematological and biochemical parameters of blood as well as heart, kidney, liver and spleen tissues histology were evaluated. RESULTS: After 90 days administration, Ageratum conyzoides increased significantly (p<0.05) the relative weight of the liver, the spleen and kidney as compared to control group. Ageratum conyzoides increased also significantly (p<0.05) ALP, ALT, AST and blood glucose. Furthermore, an increase in the number of platelets associated with a normocytic and normochromic anaemia was observed. The cytotoxicity, determined by the MTT test and neutral red assay, has shown that the cytotoxicity of hydroalcoholic extract of Ageratum conyzoides and its total alkaloids was very close. CONCLUSIONS: Our results have shown that Ageratum conyzoides at 500 and 1000 mg/kg can induce liver, kidney and haematological disorders. These toxics effects can be attributed to its total alkaloids especially to pyrrolizidine alkaloids which are present in this plant.
[Mh] Termos MeSH primário: Ageratum
Etanol/química
Extratos Vegetais/toxicidade
Solventes/química
[Mh] Termos MeSH secundário: Administração Oral
Ageratum/química
Anemia/sangue
Anemia/induzido quimicamente
Anemia/diagnóstico
Animais
Biomarcadores/sangue
Plaquetas/efeitos dos fármacos
Plaquetas/metabolismo
Plaquetas/patologia
Células CACO-2
Sobrevivência Celular/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/sangue
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Feminino
Seres Humanos
Concentração Inibidora 50
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Nefropatias/sangue
Nefropatias/induzido quimicamente
Nefropatias/diagnóstico
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Plantas Medicinais
Ratos Wistar
Medição de Risco
Fatores de Tempo
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140723
[St] Status:MEDLINE


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[PMID]:25008895
[Au] Autor:Leke WN; Kvarnheden A
[Ad] Endereço:International Institute of Tropical Agriculture (IITA), PMB 5320, Oyo road, Ibadan, Nigeria, w.leke@cgiar.org.
[Ti] Título:Mixed infection by two West African tomato-infecting begomoviruses and ageratum leaf curl Cameroon betasatellite in tomato in Cameroon.
[So] Source:Arch Virol;159(11):3145-8, 2014 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Begomovirus isolates ToF3B2 and ToF3B17 and betasatellite isolate SatBToF3 were obtained from the same infected tomato plant showing begomovirus disease symptoms in Fontem, Cameroon. The full-length nucleotide sequences of ToF3B2, ToF3B17 and SatBToF3 were cloned and sequenced and were determined to be 2,797 nt, 2,794 and 1,373 nt long respectively. When compared with other begomovirus and betasatellite sequences, ToF3B2 was 93.5 % identical to Tomato leaf curl Togo virus, ToF3B17 was 95 % identical to Tomato leaf curl Cameroon virus and SatBToF3 was 92 % identical to Ageratum leaf curl Cameroon betasatellite (ALCCMB), respectively. The identification of ALCCMB in Ageratum and now in tomato strongly suggests Ageratum may be an alternative host to these viruses and that ALCCMB is non host specific and may cause severe diseases when transmitted to other crops.
[Mh] Termos MeSH primário: Begomovirus/genética
Begomovirus/isolamento & purificação
Lycopersicon esculentum/virologia
Doenças das Plantas/virologia
Vírus Satélites/isolamento & purificação
[Mh] Termos MeSH secundário: Ageratum/virologia
Sequência de Bases
Begomovirus/classificação
Begomovirus/fisiologia
Camarões
Coinfecção/virologia
Genoma Viral
Especificidade de Hospedeiro
Dados de Sequência Molecular
Filogenia
Vírus Satélites/classificação
Vírus Satélites/genética
Vírus Satélites/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1412
[Cu] Atualização por classe:141017
[Lr] Data última revisão:
141017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140711
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-014-2159-3


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[PMID]:24579495
[Au] Autor:Ogunlade B; Yama OE; Saalu LC; Clement AB
[Ad] Endereço:Department of Anatomy, College of Medicine of the University of Lagos, Nigeria.
[Ti] Título:Ageratum conyzoides attenuates alcohol induced liver toxicity in male Wistar rats.
[So] Source:Nig Q J Hosp Med;23(1):48-53, 2013 Jan-Mar.
[Is] ISSN:0189-2657
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ageratum conyzoides (AC) is unique for its antioxidant activity and protective role to tissues. However this property is yet to be demonstrated in animals administered toxic alcohol concentrations. OBJECTIVE: To determine the effect of AC extract on the oxidative stress, liver enzymes and histology. METHODS: Twenty four male rats (190-230 g) were divided into three groups of eight rats. Group A (control) administered distilled water. Group B (ethanol group) received 10 g/kg body weight of ethanol. Group C (ethanol + AC group) were treated with ethanol (as above) and AC (250 mg/kg body weight) concurrently. Total experimental duration was 35 days at the end of which animals were euthanized by cervical dislocation. Liver and blood samples were taken and processed for: microscopic studies, estimation of activities of liver enzymes [alanine aminotransferase (AST), aspartate aminotransferase (ALT) and alkaline phosphatase (ALP)], Malondialdehyde (MDA) and antioxidants [Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and Catalase (CAT)] respectively. RESULTS: Compared to control, the rats treated with ethanol had significantly increased liver enzymes and MDA levels but these were decreased in ethanol + AC group compared to the ethanol group. The histologies of concurrent ethanol + AC treated group were similar to control groups. CONCLUSION: AC protects the liver against alcohol induced damage.
[Mh] Termos MeSH primário: Ageratum
Hepatopatias Alcoólicas/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/enzimologia
Hepatopatias Alcoólicas/patologia
Testes de Função Hepática
Masculino
Malondialdeído/metabolismo
Tamanho do Órgão/efeitos dos fármacos
Folhas de Planta
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140303
[Lr] Data última revisão:
140303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140304
[St] Status:MEDLINE


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[PMID]:23577800
[Au] Autor:Hossain H; Karmakar UK; Biswas SK; Shahid-Ud-Daula AF; Jahan IA; Adnan T; Chowdhury A
[Ad] Endereço:Bangladesh Council of Scientific and Industrial Research Laboratories, Dhaka, Bangladesh.
[Ti] Título:Antinociceptive and antioxidant potential of the crude ethanol extract of the leaves of Ageratum conyzoides grown in Bangladesh.
[So] Source:Pharm Biol;51(7):893-8, 2013 Jul.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Ageratum conyzoides Linn. (Asteraceae) is an annual herbaceous plant with a long history of traditional medicinal and agricultural uses; it is usually grown in the northeast part of Bangladesh. OBJECTIVE: The ethanol extract of the plant leaves was evaluated for preliminary phytochemical screening with its antinociceptive and antioxidant activities. MATERIALS AND METHODS: The preliminary phytochemical analysis was performed on the basis of standard procedures. The analgesic activity of the extract was investigated using the acetic acid-induced writhing method in mice. Five complementary tests such as DPPH free radical scavenging, nitric oxide (NO) scavenging, reducing power, Fe(++) ion chelating ability and total phenolic content were used for determining antioxidant activities. RESULTS: The results of preliminary phytochemical analysis showed the presence of alkaloids, reducing sugars, saponins, gums, steroids, tannins and flavonoids. The extract possessed a significant dose-dependent DPPH free radical scavenging activity with an IC50 value of 18.91 µg/ml compared to ascorbic acid (IC50: 2.937 µg/ml) and butylated hydroxyanisole (IC50: 5.10 µg/ml). The IC50 value of the extract for NO scavenging (41.81 µg/ml) was also found to be significant compared to the IC50 value of ascorbic acid (37.93 µg/ml). Moreover, the extract showed reducing power activity and Fe(++) ion chelating ability. The total phenolic amount was also calculated as quite high (378.37 mg/g of gallic acid equivalents) in the crude ethanol extract. DISCUSSION AND CONCLUSION: Therefore, the obtained results tend to suggest the antinociceptive and antioxidant activities of the ethanol extract of the plant leaves and justify its use in folkloric remedies.
[Mh] Termos MeSH primário: Ageratum/química
Analgésicos/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Analgésicos/isolamento & purificação
Animais
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Ácido Ascórbico/administração & dosagem
Ácido Ascórbico/farmacologia
Bangladesh
Hidroxianisol Butilado/administração & dosagem
Hidroxianisol Butilado/farmacologia
Relação Dose-Resposta a Droga
Etanol/química
Feminino
Depuradores de Radicais Livres/administração & dosagem
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Concentração Inibidora 50
Masculino
Medicina Tradicional
Camundongos
Óxido Nítrico/metabolismo
Fenóis/isolamento & purificação
Fenóis/farmacologia
Extratos Vegetais/administração & dosagem
Folhas de Planta
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Plant Extracts); 25013-16-5 (Butylated Hydroxyanisole); 31C4KY9ESH (Nitric Oxide); 3K9958V90M (Ethanol); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:130621
[Lr] Data última revisão:
130621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130413
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.770535



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