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Pesquisa : B01.650.940.800.575.912.250.100.100.099 [Categoria DeCS]
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[PMID]:28472675
[Au] Autor:Radulovic NS; Gencic MS; Stojanovic NM; Randjelovic PJ; Stojanovic-Radic ZZ; Stojiljkovic NI
[Ad] Endereço:Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia. Electronic address: nikoradulovic@yahoo.com.
[Ti] Título:Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.
[So] Source:Food Chem Toxicol;105:355-369, 2017 Jul.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurotoxic thujones (α- and ß-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.) containing these monoterpene ketones. The data from three in vivo neuropharmacological tests on rats (open field, light-dark, and diazepam-induced sleep), and toxicity assays (brine shrimp, and antimicrobial activity against a panel of microorganisms), together with the data from detailed chemical analyses, were subjected to a multivariate statistical treatment to reveal the possible correlation(s) between the content of essential-oil constituents and the observed effects. The results strongly imply that the toxic and behaviour-modulating activity of the oils (hundreds of constituents) should not be associated exclusively with thujones. The statistical analyses pinpointed to a number of essential-oil constituents other than thujones that demonstrated a clear correlation with either the toxicity, antimicrobial effect or the activity on CNS. Thus, in addition to the thujone content, the amount and toxicity of other constituents should be taken into consideration when making risk assessment and determining the regulatory status of plants in food and medicines.
[Mh] Termos MeSH primário: Artemisia absinthium/química
Óleos Voláteis/toxicidade
Óleos Vegetais/toxicidade
Salvia officinalis/química
Tanacetum/química
Thuja/química
[Mh] Termos MeSH secundário: Animais
Artemisia absinthium/toxicidade
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Óleos Voláteis/análise
Óleos Vegetais/análise
Ratos
Ratos Wistar
Salvia officinalis/toxicidade
Tanacetum/toxicidade
Thuja/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:27630101
[Au] Autor:Govindarajan M; Benelli G
[Ad] Endereço:Department of Zoology, Unit of Vector Control, Phytochemistry and Nanotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India. drgovind1979@gmail.com.
[Ti] Título:Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms.
[So] Source:Parasitol Res;115(12):4649-4661, 2016 Dec.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The eco-friendly control of mosquito vectors is a crucial challenge of public health importance. Here we evaluated the larvicidal potential of Artemisia absinthium essential oil (EO) and its three major chemical constituents against six mosquito vectors: Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. The EO was obtained by leaf hydro-distillation. Its chemical composition was analyzed using gas chromatography-mass spectrometry. Major components were (E)-ß-farnesene (31.6 %), (Z)-en-yn-dicycloether (11.12 %), and (Z)-ß-ocimene (27.8 %). The EO was toxic effect against larval populations of An. stephensi, An. subpictus, Ae. aegypti, Ae. albopictus, Cx. quinquefasciatus, and Cx. tritaeniorhynchus, with LC values of 41.85, 52.02, 46.33, 57.57, 50.57, and 62.16 µg/ml. (E)-ß-farnesene, (Z)-en-yn-dicycloether, and (Z)-ß-ocimene were highly effective on An. stephensi (LC = 8.13, 16.24 and 25.84 µg/ml) followed by An. subpictus (LC = 10.18, 20.99, and 30.86 µg/ml), Ae. aegypti (LC = 8.83,17.66, and 28.35 µg/ml), Ae. albopictus (LC = 11.38,23.47, and 33.72 µg/ml), Cx. quinquefasciatus (LC = 9.66, 19.76, and 31.52 µg/ml), and Cx. tritaeniorhynchus (LC = 12.51,25.88, and 37.13 µg/ml). Notably, the EO and its major compounds were safer to the non-target organisms Chironomous circumdatus, Anisops bouvieri and Gambusia affinis, with LC values ranging from 207.22 to 4385 µg/ml. Overall, our results highlight that (E)-ß-farnesene, (Z)-en-yn-dicycloether, and (Z)-ß-ocimene from the A. absinthium EO represent promising eco-friendly larvicides against six key mosquito vectors with moderate toxicity against non-target organisms.
[Mh] Termos MeSH primário: Artemisia absinthium/química
Inseticidas/isolamento & purificação
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Alcenos
Animais
Anopheles/efeitos dos fármacos
Organismos Aquáticos
Culex/efeitos dos fármacos
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Larva/efeitos dos fármacos
Controle de Mosquitos/métodos
Mosquitos Vetores/efeitos dos fármacos
Óleos Voláteis
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Sesquiterpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 13877-91-3 (beta-ocimene); 18794-84-8 (beta-farnesene); 8008-93-3 (absinthium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE


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[PMID]:27515537
[Au] Autor:Ali M; Abbasi BH; Ahmad N; Ali SS; Ali S; Ali GS
[Ad] Endereço:Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
[Ti] Título:Sucrose-enhanced biosynthesis of medicinally important antioxidant secondary metabolites in cell suspension cultures of Artemisia absinthium L.
[So] Source:Bioprocess Biosyst Eng;39(12):1945-1954, 2016 Dec.
[Is] ISSN:1615-7605
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Natural products are gaining tremendous importance in pharmaceutical industry and attention has been focused on the applications of in vitro technologies to enhance yield and productivity of such products. In this study, we investigated the accumulation of biomass and antioxidant secondary metabolites in response to different carbohydrate sources (sucrose, maltose, fructose and glucose) and sucrose concentrations (1, 3, 5, 7 and 9 %). Moreover, the effects of 3 % repeated sucrose feeding (day-12, -18 and -24) were also investigated. The results showed the superiority of disaccharides over monosaccharides for maximum biomass and secondary metabolites accumulation. Comparable profiles for maximum biomass were observed in response to sucrose and maltose and initial sucrose concentrations of 3 and 5 %. Maximum total phenolic and total flavonoid contents were displayed by cultures treated with sucrose and maltose; however, initial sucrose concentrations of 5 and 7 % were optimum for both classes of metabolites, respectively. Following 3 % extra sucrose feeding, cultures fed on day-24 (late-log phase) showed higher biomass, total phenolic and total flavonoid contents as compared to control cultures. Highest antioxidant activity was exhibited by maltose-treated cultures. Moreover, sucrose-treated cultures displayed positive correlation of antioxidant activity with total phenolics and total flavonoids production. This work describes the stimulatory role of disaccharides and sucrose feeding strategy for higher accumulation of phenolics and flavonoids, which could be potentially scaled up to bioreactor level for the bulk production of these metabolites in suspension cultures of A. absinthium.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Artemisia absinthium/metabolismo
Flavonoides/biossíntese
Células Vegetais/metabolismo
Sacarose/farmacologia
[Mh] Termos MeSH secundário: Artemisia absinthium/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 57-50-1 (Sucrose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170216
[Lr] Data última revisão:
170216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE


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[PMID]:27451252
[Au] Autor:Bach B; Cleroux M; Saillen M; Schönenberger P; Burgos S; Ducruet J; Vallat A
[Ad] Endereço:CHANGINS, Viticulture and Oenology, University of Applied Sciences and Arts Western Switzerland, Route de Duillier 50, 1260 Nyon, Switzerland. Electronic address: benoit.bach@changins.ch.
[Ti] Título:A new chemical tool for absinthe producers, quantification of α/ß-thujone and the bitter components in Artemisia absinthium.
[So] Source:Food Chem;213:813-817, 2016 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The concentrations of α/ß-thujone and the bitter components of Artemisia absinthium were quantified from alcoholic wormwood extracts during four phenological stages of their harvest period. A solid-phase micro-extraction method coupled to gas chromatography-mass spectrometry was used to determine the concentration of the two isomeric forms of thujone. In parallel, the combination of ultra-high pressure liquid chromatography and high resolution mass spectrometry allowed to quantify the compounds absinthin, artemisetin and dihydro-epi-deoxyarteannuin B. This present study aimed at helping absinthe producers to determine the best harvesting period.
[Mh] Termos MeSH primário: Absinto (Extrato)/análise
Artemisia absinthium/química
Monoterpenos/análise
Paladar
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Manipulação de Alimentos
Qualidade dos Alimentos
Cromatografia Gasosa-Espectrometria de Massas
Espectrometria de Massas
Extratos Vegetais/análise
Reprodutibilidade dos Testes
Sesquiterpenos de Guaiano/análise
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Plant Extracts); 0 (Sesquiterpenes, Guaiane); 0 (absinthin); 8ZI5R3T54Q (beta-thujone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27313817
[Au] Autor:El Makrini NI; Hassam B
[Ad] Endereço:Department of Dermatology, Ibn Sina Hospital, Rabat, Morocco.
[Ti] Título:Artemisia absinthium: burning plant!
[So] Source:Pan Afr Med J;23:10, 2016.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Mh] Termos MeSH primário: Artemisia absinthium/química
Dermatite de Contato/etiologia
Preparações de Plantas/efeitos adversos
[Mh] Termos MeSH secundário: Dermatite de Contato/patologia
Feminino
Seres Humanos
Meia-Idade
Preparações de Plantas/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2016.23.10.8605


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[PMID]:27033043
[Au] Autor:Desaulniers AT; Lamberson WR; Safranski TJ
[Ad] Endereço:Division of Animal Sciences, University of Missouri-Columbia, Columbia, MO, USA.
[Ti] Título:Prenatal heat stress reduces male anogenital distance at birth and adult testis size, which are rescued by concurrent maternal Artemisia absinthium consumption.
[So] Source:J Therm Biol;57:84-91, 2016 Apr.
[Is] ISSN:0306-4565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Boars from sows with elevated plasma cortisol during pregnancy have shorter anogenital distance (AGD), a trait associated with subfertility. Since gestating sows often experience summer heat stress (HS), a mouse model was used to evaluate the effect of prenatal HS on AGD and fertility; efficacy of the heat stress-mitigating supplement Artemisia absinthium (AB) was also evaluated. Dams were treated from d 8-18 of gestation, residing in ambient temperatures from 0700 to 1900h. From 1900 to 0700h females were exposed to 34.13±0.27°C (HS) with access to water (HSW; n=9), HS with access to a 1% w/v decoction of AB (HSA; n=9), 20.81±0.20°C (thermal neutral; TN) with water (TNW; n=10) or TN with AB (TNA; n=10). Daily liquid consumption was measured from d 6-18, and tail temperature was recorded at 0700 and 1900h from d 8-18. Progeny weight and AGD were recorded at birth and weaning. At maturity, males were mated to non-littermate females from each treatment; these females were euthanized after 16 d of TN gestation. Reproductive traits were compared among all male/female treatment combinations; testes were weighed. Average liquid intake differed among treatments with HS and AB animals drinking more (P<0.0004). A treatment by time interaction for tail temperature (P<0.001) was observed; HS increased tail temperature of HSA and HSW animals similarly compared to TNA and TNW. Treatment affected (P<0.01) male birth AGD (HSW shortest; P<0.07). At maturity, HSW males also had the smallest testes (P<0.02). However, we observed no differences in fertility (P>0.10). These data indicate that in utero HS decreases both male birth AGD and adult testis size, effects which maternal AB consumption mitigates.
[Mh] Termos MeSH primário: Artemisia absinthium/química
Resposta ao Choque Térmico
Extratos Vegetais/farmacologia
Efeitos Tardios da Exposição Pré-Natal/tratamento farmacológico
Testículo/embriologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos
Extratos Vegetais/uso terapêutico
Gravidez
Efeitos Tardios da Exposição Pré-Natal/etiologia
Testículo/anormalidades
Testículo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


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[PMID]:27005506
[Au] Autor:Ali A; Rahman K; Jahan N; Jamil A; Rashid A; Shah SM
[Ad] Endereço:College of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Pakistan / Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:Protection of DNA during oxidative stress and cytotoxic potential of Artemisia absinthium.
[So] Source:Pak J Pharm Sci;29(1 Suppl):295-9, 2016 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Medicinal plants are rich in secondary metabolites (alkoloids, glycosides, coumarins, flavonides, steroids, etc.) and considered to be more effective and a safer alternative source to manage a variety of diseases related to liver, heart and kidney disordered. This study determines in vitro antioxidant and in vivo toxicological profile including hemolytic, brine shrimp lethality and mutagenicity of aerial parts of Artemisia absinthium. DNA protection assay was performed on pUC19 plasmid vector using H(2)O(2) as oxidative agent. Total phenolic and flavonoid content were determined using colorimetric methods. Toxicity of the plant was evaluated by brine shrimp lethality, hemolytic and mutagenic activity. DNA protection assay of the plant showed concentration dependent protective effect and at concentration 10µL/mL revealed complete protective effect against H(2)O(2) induced DNA damage. Highest phenolic and flavonoid content was found to be 167.3 (mg GAE 100g DW(-1)) and 14 (mg CE 100g DW(-1)) respectively. Results showed that A. absinthium is potent against standard toxicological procedures, that indicates the presence of bioactive components in the plant and possess antioxidant activity that protects DNA against H(2)O(2) induced oxidative damage. Thus the results showed/support that A. absinthium provides significant health benefits.
[Mh] Termos MeSH primário: Artemisia absinthium/química
DNA/química
Estresse Oxidativo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Artemia
Compostos de Bifenilo
Colorimetria
Dano ao DNA
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/química
Flavonoides/farmacologia
Flavonoides/toxicidade
Hemólise/efeitos dos fármacos
Seres Humanos
Técnicas In Vitro
Testes de Mutagenicidade
Fenóis/química
Fenóis/farmacologia
Fenóis/toxicidade
Picratos
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Plasmídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 9007-49-2 (DNA); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE


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[PMID]:26478321
[Au] Autor:Ali M; Kim B; Belfield KD; Norman D; Brennan M; Ali GS
[Ad] Endereço:Mid-Florida Research and Education Center and Department of Plant Pathology, University of Florida/Institute of Food and Agricultural Sciences, 2725 Binion Rd., Apopka, FL 32703, United States.
[Ti] Título:Green synthesis and characterization of silver nanoparticles using Artemisia absinthium aqueous extract--A comprehensive study.
[So] Source:Mater Sci Eng C Mater Biol Appl;58:359-65, 2016 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Unlike chemical synthesis, biological synthesis of nanoparticles is gaining tremendous interest, and plant extracts are preferred over other biological sources due to their ample availability and wide array of reducing metabolites. In this project, we investigated the reducing potential of aqueous extract of Artemisia absinthium L. for synthesizing silver nanoparticles (AgNPs). Optimal synthesis of AgNPs with desirable physical and biological properties was investigated using ultra violet-visible spectroscopy (UV-vis), dynamic light scattering (DLS), transmission electron microscopy (TEM) and energy-dispersive X-ray analysis (EDX). To determine their appropriate concentrations for AgNP synthesis, two-fold dilutions of silver nitrate (20 to 0.62 mM) and aqueous plant extract (100 to 0.79 mg ml(-1)) were reacted. The results showed that silver nitrate (2mM) and plant extract (10 mg ml(-1)) mixed in different ratios significantly affected size, stability and yield of AgNPs. Extract to AgNO3 ratio of 6:4v/v resulted in the highest conversion efficiency of AgNO3 to AgNPs, with the particles in average size range of less than 100 nm. Furthermore, the direct imaging of synthesized AgNPs by TEM revealed polydispersed particles in the size range of 5 to 20 nm. Similarly, nanoparticles with the characteristic peak of silver were observed with EDX. This study presents a comprehensive investigation of the differential behavior of plant extract and AgNO3 to synthesize biologically stable AgNPs.
[Mh] Termos MeSH primário: Artemisia absinthium/química
Química Verde/métodos
Nanopartículas Metálicas/química
Extratos Vegetais/química
Prata/química
[Mh] Termos MeSH secundário: Cinética
Nanopartículas Metálicas/ultraestrutura
Tamanho da Partícula
Espectrometria por Raios X
Espectrofotometria Ultravioleta
Eletricidade Estática
Titulometria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151019
[Lr] Data última revisão:
151019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151020
[St] Status:MEDLINE


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[PMID]:26665406
[Au] Autor:Li Y; Zheng M; Zhai X; Huang Y; Khalid A; Malik A; Shah P; Karim S; Azhar S; Hou X
[Ti] Título:EFFECT OF-GYMNEMA SYLVESTRE, CITRULLUS COLOCYNTHIS AND ARTEMISIA ABSINTHIUM ON BLOOD GLUCOSE AND LIPID PROFILE IN DIABETIC HUMAN.
[So] Source:Acta Pol Pharm;72(5):981-5, 2015 Sep-Oct.
[Is] ISSN:0001-6837
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to manage diabetes with medicinal plants (Gymnema sylvestre, Artemisia absinthium and Citillus colocynthis) in human patients with type II diabetes. Thirty two patients of type II diabetes from both sexes of 30-60 years age were registered for this study and distributed them into four groups, each having 8 patients. Capsules of each, Gymnema sylvestre, Artemisia absinthium and Citrullus colocynthis were given to patients twice a day for 30 days in 1 g per day dosage and investigated for glucose, triglyceride (TGL) and cholesterol level. Gymnema sylvestre reduced 37% glucose, 5% TGL, 13% cholesterol and 19% low desity lipoproteins (LDL) level in diabetic individuals. Citrullus colocynth reduced glucose, cholesterol and TGL and HDL-cholesterol level by 35, 6, 6, and 5%, respectively. Artemisia absinthium reduced 3% high desity lipoproteins (HDL) and 6% LDL level. From results, it can be concluded that the powdered Gymnema sylvestre, Citrulus colocynthis, and Artemisia absinthium possess good anti-diabetic features, however these herbal products had no significant effect on lipid profiles of the diabetic human.
[Mh] Termos MeSH primário: Artemisia absinthium
Glicemia/análise
Citrullus colocynthis
Diabetes Mellitus Tipo 2/tratamento farmacológico
Gymnema sylvestre
Fitoterapia
[Mh] Termos MeSH secundário: Adulto
Diabetes Mellitus Tipo 2/sangue
Feminino
Seres Humanos
Lipoproteínas HDL/sangue
Lipoproteínas LDL/sangue
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151210
[Lr] Data última revisão:
151210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE


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[PMID]:26576073
[Au] Autor:Algieri F; Rodriguez-Nogales A; Rodriguez-Cabezas ME; Risco S; Ocete MA; Galvez J
[Ad] Endereço:CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n, Armilla, 18016 Granada, Spain.
[Ti] Título:Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review.
[So] Source:Mediators Inflamm;2015:179616, 2015.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crohn's disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.
[Mh] Termos MeSH primário: Doenças Inflamatórias Intestinais/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Aloe
Andrographis
Artemisia absinthium
Boswellia
Cannabis
Curcuma
Seres Humanos
Doenças Inflamatórias Intestinais/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.1155/2015/179616



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