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Pesquisa : B01.650.940.800.575.912.250.100.111 [Categoria DeCS]
Referências encontradas : 102 [refinar]
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  1 / 102 MEDLINE  
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[PMID]:28695925
[Au] Autor:Choi JH; Chung KS; Jin BR; Cheon SY; Nugroho A; Roh SS; An HJ
[Ad] Endereço:Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 220-702, Republic of Korea. hjan@sj.ac.kr.
[Ti] Título:Anti-inflammatory effects of an ethanol extract of Aster glehni via inhibition of NF-κB activation in mice with DSS-induced colitis.
[So] Source:Food Funct;8(7):2611-2620, 2017 Jul 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although Aster glehni has been reported to prevent diabetes mellitus, hypercholesterolemia, insomnia, and cardiovascular disease, the anti-inflammatory effect of Aster glehni in colonic tissue remains unclear. In this study, we investigated the anti-inflammatory effects and the underlying molecular mechanism of an ethanol extract of Aster glehni (AG) in mice with dextran sulfate sodium (DSS)-induced colitis. AG significantly attenuated DSS-induced DAI scores, which implied that it suppressed diarrhea, gross bleeding, and the infiltration of immune cells. AG administration also effectively prevented shortening of the colon length and enlargement of the spleen size. Histological examinations indicated that AG suppressed colonic damage and the thickness of the muscle layer induced by DSS. In addition, AG inhibited the production of pro-inflammatory cytokines, such as TNF-α, IL-1ß, and IL-6, and the protein expression of COX-2 and iNOS in mice with DSS-induced colitis. Administration with AG suppressed the activation of nuclear factor-κB (NF-κB) including the nuclear translocation of the p65 NF-κB subunit, phosphorylation and degradation of IκB-α. Taken together, these findings suggest that the anti-inflammatory effects of AG are mainly related to the inhibition of the expressions of inflammatory mediators via NF-κB inactivation, and support its possible therapeutic application in colitis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Aster/química
Colite/tratamento farmacológico
NF-kappa B/imunologia
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Colite/induzido quimicamente
Colite/genética
Colite/imunologia
Sulfato de Dextrana/efeitos adversos
Modelos Animais de Doenças
Seres Humanos
Interleucina-1beta/genética
Interleucina-1beta/imunologia
Interleucina-6/genética
Interleucina-6/imunologia
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Masculino
Camundongos
NF-kappa B/genética
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00369b


  2 / 102 MEDLINE  
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[PMID]:28638870
[Au] Autor:Yang J; Fa J; Li B
[Ad] Endereço:Women's Health Center, Women and Children's Hospital of LinYi, Linyi, Shandong, China, 276000.
[Ti] Título:APOPTOSIS INDUCTION OF EPIFRIEDELINOL ON HUMAN CERVICAL CANCER CELL LINE.
[So] Source:Afr J Tradit Complement Altern Med;14(4):80-86, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Present investigation evaluates the antitumor activity of epifriedelinol for the management of cervical cancer by inducing process of apoptosis. METHODS: Human Cervical Cancer Cell Line, C33A and HeLa were selected for study and treated with epifriedelinol at a concentration of (50-1000 µg/ml). Cytotoxicity of epifriedelinol was estimated by MTT assay and induction of apoptosis was assessed by estimating the activity of caspase 3, 8 and 9 enzyme, apoptosis assay and translocation of cytochrome c. Moreover an expression of several proteins that plays role in the apoptosis process was estimated by western blot method. RESULTS: Result of the study suggested that treatment with epifriedelinol significantly decrease the viability count of cancerous cell in a dose perndent manner and also enhances the formation of oligonucleosome in both the cell lines. However activity of caspase enzymes and translocation of cytochrome c were enhanced after treatment with epifriedelinol. It was also observed that epifriedelinol treatment alters the ratio of pro-apoptotic to anti-apoptotic proteins and enhances the expressions of inhibitor of apoptosis proteins (IAP). CONCLUSION: Result of our study proves the anticancer activity of epifriedelinol in cervical cancer by inducing apoptosis as treatment with it enhances the production of oligonucleosomes, translocation of cytochrome c and activity caspase enzymes.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Aster/química
Ácido Oleanólico/análogos & derivados
Extratos Vegetais/farmacologia
Neoplasias do Colo do Útero/fisiopatologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Ácido Oleanólico/química
Ácido Oleanólico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 5085-72-3 (friedelinol); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.10


  3 / 102 MEDLINE  
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[PMID]:28098516
[Au] Autor:Guo YR; Choung SY
[Ad] Endereço:1 Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University , Seoul, Republic of Korea.
[Ti] Título:Germacrone Attenuates Hyperlipidemia and Improves Lipid Metabolism in High-Fat Diet-Induced Obese C57BL/6J Mice.
[So] Source:J Med Food;20(1):46-55, 2017 Jan.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We previously showed that Aster spathulifolius Maxim extract (ASE) reduced body weight gain and serum and liver lipid levels and significantly suppressed serum insulin and leptin concentrations in high-fat diet (HFD)-induced obese rats. Germacrone (GM) was identified as a potent bioactive constituent of ASE. In this study, we hypothesized that GM can attenuate hyperlipidemia by alleviating fatty acid (FA) synthesis/uptake and improve lipid metabolism by stimulating FA ß-oxidation in HFD-induced obese C57BL/6J mice. To induce obesity, mice were fed an HFD for 6 weeks, while control mice were fed a commercial standard diet. The mice were allocated to six groups and fed either a normal diet, HFD, HFD with GM (5, 10, and 20 mg/kg), or HFD with 200 mg/kg Garcinia cambogia extract for 30 days. In the GM groups, body weight gain, visceral fat pad weight, fasting plasma glucose, serum insulin and leptin, and serum, as well as hepatic lipid, levels were attenuated. Transcriptional factors related to lipid metabolism, such as AMP-activated protein kinase α, sterol regulatory element-binding protein (SREBP) 1, SREBP 2, acetyl-CoA carboxylase, peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, FA synthase, and carnitine palmitoyltransferase 1, showed higher expression in the GM groups. In summary, GM may help attenuate hyperlipidemia by suppressing FA synthesis and uptake by inhibiting SREBP signaling pathway activation and improve lipid metabolism by stimulating FA ß-oxidation by activating the AMPKα signaling pathway in HFD-induced obesity.
[Mh] Termos MeSH primário: Aster/química
Hiperlipidemias/tratamento farmacológico
Metabolismo dos Lipídeos/efeitos dos fármacos
Obesidade/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Sesquiterpenos de Germacrano/administração & dosagem
[Mh] Termos MeSH secundário: Acetil-CoA Carboxilase/metabolismo
Animais
Dieta Hiperlipídica/efeitos adversos
Seres Humanos
Hiperlipidemias/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Obesidade/metabolismo
PPAR alfa/metabolismo
Extratos Vegetais/química
Ratos
Sesquiterpenos de Germacrano/química
Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PPAR alpha); 0 (Plant Extracts); 0 (Sesquiterpenes, Germacrane); 0 (Sterol Regulatory Element Binding Protein 1); 6902-91-6 (germacrone); EC 6.4.1.2 (Acetyl-CoA Carboxylase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.3811


  4 / 102 MEDLINE  
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[PMID]:27748562
[Au] Autor:Duarte B; Cabrita MT; Gameiro C; Matos AR; Godinho R; Marques JC; Caçador I
[Ad] Endereço:MARE - Marine and Environmental Sciences Centre, Faculty of Sciences of the University of Lisbon, Lisbon, Portugal.
[Ti] Título:Disentangling the photochemical salinity tolerance in Aster tripolium L.: connecting biophysical traits with changes in fatty acid composition.
[So] Source:Plant Biol (Stuttg);19(2):239-248, 2017 Mar.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A profound analysis of A. tripolium photochemical traits under salinity exposure is lacking in the literature, with very few references focusing on its fatty acid profile role in photophysiology. To address this, the deep photochemical processes were evaluated by Pulse Amplitude Modulated (PAM) Fluorometry coupled with a discrimination of its leaf fatty acid profile. Plants exposed to 125-250 mm NaCl showed higher photochemical light harvesting efficiencies and lower energy dissipation rates. under higher NaCl exposure, there is evident damage of the oxygen evolving complexes (OECs). On the other hand, Reaction Centre (RC) closure net rate and density increased, improving the energy fluxes entering the PS II, in spite of the high amounts of energy dissipated and the loss of PS II antennae connectivity. Energy dissipation was mainly achieved through the auroxanthin pathway. Total fatty acid content displayed a similar trend, being also higher under 125-250 mm NaCl with high levels of omega-3 and omega-6 fatty acids. The increase in oleic acid and palmitic acid allows the maintenance of the good functioning of the PS II. Also relevant was the high concentration of chloroplastic C16:1t in the individuals subjected to 125-250 mm NaCl, related with a higher electron transport activity and with the organization of the Light Harvesting Complexes (LHC) and thus reducing the activation of energy dissipation mechanisms. All these new insights shed some light not only on the photophysiology of this potential cash-crop, but also highlight its important saline agriculture applications of this species as forage and potential source of essential fatty acids.
[Mh] Termos MeSH primário: Aster/fisiologia
Ácidos Graxos/metabolismo
Fotossíntese
Complexo de Proteína do Fotossistema I/metabolismo
Complexo de Proteína do Fotossistema II/metabolismo
Cloreto de Sódio/farmacologia
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Aster/efeitos dos fármacos
Aster/efeitos da radiação
Escuridão
Luz
Fenótipo
Processos Fotoquímicos
Tolerância a Sal
Plantas Tolerantes a Sal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Photosystem I Protein Complex); 0 (Photosystem II Protein Complex); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12517


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[PMID]:28480359
[Au] Autor:Peng WJ; Xin RH; Luo YJ; Liang G; Ren LH; Liu Y; Wang GB; Zheng JF
[Ad] Endereço:Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Key Laboratory of New Animal Drug Project of Gansu Province, Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Key Laboratory of Veterinary Pharmaceutics Development, Ministry
[Ti] Título:EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF L. F.
[So] Source:Afr J Tradit Complement Altern Med;13(6):38-53, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: L. f. is used as a traditional Chinese drug to relieve cough and asthma symptoms and to eliminate phlegm. However, L. f. possesses toxicity, and little systematic research has been conducted on its toxic effects in the laboratory. METHODS AND MATERIALS: The acute group was administered 75% alcohol extract of L. f. in a single dose. A subchronic toxicity study was performed via daily oral administration of L. f. at a dose of 0.34 g/kg body weight in SD rats. The rats were divided into six groups: a petroleum ether extract (PEA) group, an ethyl acetate extract (EEA) group, an n-butyl alcohol extract (NEA) group, a remaining lower aqueous phases (REA) group, a 75% alcohol extract (AEA) group and a control group. Quantitative measurements of cytokines were obtained by fluorescence with a laser scanner using a Cy3 equivalent dye. RESULTS: The LD of the 75% alcohol extract of L. f. was 15.74 g/kg bw. In the subchronic toxicity study, no significant differences were observed among groups in relative organ weights, urine traits, liver antioxidase levels, or cytokine levels. However, significant sporadic differences were observed in body weight gains, haematology indices, biochemistry values, and histopathology features in PEA, EEA group. In addition, sporadic changes in other groups in measures such as WBC, MCHC, CK, ALP, AST, ALT, LDH, T-BIL, LDL-C, HDL-C, and TC were observed. CONCLUSION: The toxicity study showed that L. f. can produce toxic effects, mainly on the liver; much less on the heart. The LD was 15.74 g/kg BW in mice, and the subchronic toxicity study, used a dosage of 0.34 g/kg/d.BW, showed that the toxic components of L. f. were mainly concentrated in the petroleum ether fraction, followed by the ethyl acetate fraction, the n-butyl alcohol fraction, the lower aqueous phase and the 75% ethanol extracts. PEA, petroleum ether extract of L. f.; EEA, ethyl acetate extract of L. f.; NEA: n-butyl alcohol extract of L. f.; REA: lower aqueous phases of L. f.; AEA, 75% alcohol extract of L. f.; WBC, white blood cell; RBC, red blood cell, PLT, platelet; HCT, haematocrit; MCV, mean corpuscular volume; HGB, haemoglobin; MCH, mean corpuscular haemoglobin; MCHC, mean corpuscular haemoglobin concentration; CREA, creatinine; LDH, lactate dehydrogenase; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; T-BIL, total bilirubin; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; TP, total protein; ALB, albumin; Glu, glucose; TC, total cholesterol; TG, triglycerides; CK, creatine kinase; GSH, Glutathione; MDA, malondialdehyde; T-SOD, total superoxide dismutase; TNF, tumour necrosis factor; IFN, interferon; MCP, monocyte chemotactic protein C.
[Mh] Termos MeSH primário: Aster/toxicidade
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: 1-Butanol/toxicidade
Acetatos/toxicidade
Alcanos/toxicidade
Animais
Aster/química
Peso Corporal/efeitos dos fármacos
Citocinas/efeitos dos fármacos
Etanol/toxicidade
Feminino
Fígado/efeitos dos fármacos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Alkanes); 0 (Cytokines); 0 (Plant Extracts); 3K9958V90M (Ethanol); 76845O8NMZ (ethyl acetate); 8PJ61P6TS3 (1-Butanol); O3L624621X (naphtha)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.8


  6 / 102 MEDLINE  
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[PMID]:27590705
[Au] Autor:Seo S; Lee KG; Shin JS; Chung EK; Lee JY; Kim HJ; Lee KT
[Ad] Endereço:Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republi
[Ti] Título:6'-O-Caffeoyldihydrosyringin isolated from Aster glehni suppresses lipopolysaccharide-induced iNOS, COX-2, TNF-α, IL-1ß and IL-6 expression via NF-κB and AP-1 inactivation in RAW 264.7 macrophages.
[So] Source:Bioorg Med Chem Lett;26(19):4592-4598, 2016 10 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previously, we found that ethyl acetate extract fraction of Aster glehni exhibited anti-hyperuricemic effects in animal models and also five new caffeoylglucoside derivatives were isolated from this fraction. In this work, we evaluated the anti-inflammatory effects of these caffeoylglucoside derivatives and found that 6'-O-caffeoyldihydrosyringin (2, CDS) most potently inhibited the LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages. In addition, CDS was found to concentration-dependently reduce the production of NO, PGE2, and the pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1ß (IL-1ß) induced by LPS in macrophages. Consistent with these observations, CDS concentration-dependently inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) expression at the protein level and also iNOS, COX-2, TNF-α, and IL-6, IL-1ß expression at the mRNA level. Furthermore, CDS suppressed the LPS-induced transcriptional activities of nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) as well as the phosphorylation of p65 and c-Fos. Taken together, these results suggest that the anti-inflammatory effect of CDS is associated with the downregulation of iNOS, COX-2, TNF-α, IL-1ß, and IL-6 expression via the negative regulation of NF-κB and AP-1 activation in LPS-induced RAW 264.7 macrophages.
[Mh] Termos MeSH primário: Aster/química
Citocinas/metabolismo
Lipopolissacarídeos/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Lipopolysaccharides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE


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[PMID]:26993057
[Au] Autor:Hwang GY; Choung SY
[Ad] Endereço:Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul, Korea.
[Ti] Título:Anti-melanogenic effects of Aster spathulifolius extract in UVB-exposed C57BL/6J mice and B16F10 melanoma cells through the regulation of MAPK/ERK and AKT/GSK3ß signalling.
[So] Source:J Pharm Pharmacol;68(4):503-13, 2016 Apr.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Pharmacological studies of Aster spathulifolius Maxim(AS) have demonstrated its anti-allergy, anti-viral and anti-obesity effects, however, its anti-melanogenic effects is still unclear. In this study, the effects of AS extract (ASE) on the inhibition of melanin synthesis were investigated in vitro and in vivo. METHODS: To perform this study, the contents of melanin and tyrosinase activity were analysed in B16F10 melanoma cells. Western blotting was carried out to determine the underlyling mechanism. Additionally, we investigated the effect of this extract on hyperpigmentation in C57bL/6J mice induced by 3, 6 and 9 weeks of UVB irradiation. KEY FINDINGS: AS extract led to reduced melanin synthesis through the regulation of MITF and its downstream signals. Furthermore, ASE increased the phosphorylation of MAPK/ERK and Akt/GSK3ß signalling pathway components. In vivo study, hypopigmentation effects were also observed. The melanocyte activity and the distribution of melanin granules were decreased in UVB-irradiated mice treated with ASE. CONCLUSIONS: These results suggest that the ASE may be promising as an active anti-melanogenic component, and further investigations should be performed regarding its potential as a whitening agent in the field of cosmetics.
[Mh] Termos MeSH primário: Aster/química
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Glicogênio Sintase Quinase 3 beta/metabolismo
Hiperpigmentação/prevenção & controle
Melaninas/metabolismo
Melanoma Experimental/tratamento farmacológico
Extratos Vegetais/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Preparações Clareadoras de Pele/farmacologia
Neoplasias Cutâneas/tratamento farmacológico
Pele/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores
Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores
Hiperpigmentação/enzimologia
Melanócitos/efeitos dos fármacos
Melanócitos/enzimologia
Melanoma Experimental/enzimologia
Melanoma Experimental/patologia
Camundongos Endogâmicos C57BL
Fator de Transcrição Associado à Microftalmia/metabolismo
Monofenol Mono-Oxigenase/metabolismo
Fosforilação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Transdução de Sinais/efeitos dos fármacos
Pele/enzimologia
Preparações Clareadoras de Pele/isolamento & purificação
Neoplasias Cutâneas/enzimologia
Neoplasias Cutâneas/patologia
Pigmentação da Pele/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Melanins); 0 (Microphthalmia-Associated Transcription Factor); 0 (Mitf protein, mouse); 0 (Plant Extracts); 0 (Protein Kinase Inhibitors); 0 (Skin Lightening Preparations); EC 1.14.18.1 (Monophenol Monooxygenase); EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta); EC 2.7.11.1 (Gsk3b protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160320
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12524


  8 / 102 MEDLINE  
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[PMID]:26908215
[Au] Autor:Kim SJ; Bang CY; Guo YR; Choung SY
[Ad] Endereço:1 Department of Life and Nanopharmaceutical Science of Pharmacy, Kyung Hee University , Seoul, Korea.
[Ti] Título:Anti-Obesity Effects of Aster spathulifolius Extract in High-Fat Diet-Induced Obese Rats.
[So] Source:J Med Food;19(4):353-64, 2016 Apr.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the anti-obesity and antihyperlipidemic efficacy and molecular mechanisms of Aster spathulifolius Maxim extract (ASE) in rats with high-fat diet (HFD)-induced obesity. Rats were separately fed a normal diet or a HFD for 8 weeks, then they were treated with ASE (62.5, 125, or 250 mg/kg) for another 4.5 weeks. The ASE supplementation significantly lowered body weight gain, visceral fat pad weights, serum lipid levels, as well as hepatic lipid levels in HFD-induced obese rats. Histological analysis showed that the ASE-treated group showed lowered numbers of lipid droplets and smaller size of adipocytes compared to the HFD group. To understand the mechanism of action of ASE, the expression of genes and proteins involved in obesity were measured in liver and skeletal muscle. The expression of fatty acid oxidation and thermogenesis-related genes (e.g., PPAR-α, ACO, CPT1, UCP2, and UCP3) of HFD-induced obese rats were increased by ASE treatment. On the other hand, ASE treatment resulted in decreased expression of fat intake-related gene ACC2 and lipogenesis-related genes (e.g., SREBP-1c, ACC1, FAS, SCD1, GPATR, AGPAT, and DGAT). Furthermore, ASE treatment increased the level of phosphorylated AMPKα in obese rats. Similarly, the level of phosphorylated ACC, a target protein of AMPKα in ASE groups, was increased by ASE treatment compared with the HFD group. These results suggest that ASE attenuated visceral fat accumulation and improved hyperlipidemia in HFD-induced obese rats by increasing lipid metabolism through the regulation of AMPK activity and the expression of genes and proteins involved in lipolysis and lipogenesis.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/administração & dosagem
Aster/química
Obesidade/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Adipócitos/efeitos dos fármacos
Adipócitos/metabolismo
Animais
Dieta Hiperlipídica/efeitos adversos
Seres Humanos
Masculino
Obesidade/genética
Obesidade/metabolismo
PPAR alfa/genética
PPAR alfa/metabolismo
Ratos
Ratos Sprague-Dawley
Proteína de Ligação a Elemento Regulador de Esterol 1/genética
Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo
Proteína Desacopladora 1/genética
Proteína Desacopladora 1/metabolismo
Proteína Desacopladora 2/genética
Proteína Desacopladora 2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (PPAR alpha); 0 (Plant Extracts); 0 (Sterol Regulatory Element Binding Protein 1); 0 (Uncoupling Protein 1); 0 (Uncoupling Protein 2)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161217
[Lr] Data última revisão:
161217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2015.3566


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[PMID]:26874034
[Au] Autor:Chung MJ; Lee S; Park YI; Lee J; Kwon KH
[Ad] Endereço:Department of Food Science and Nutrition, Gwangju University, Gwangju 61743, Republic of Korea.
[Ti] Título:Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells.
[So] Source:Life Sci;148:173-82, 2016 Mar 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: We investigated the neuroprotective effects and action mechanism of three major compounds [daucosterol (Dau), pectolinarin (Pec), and astragalin (Ast)] isolated from edible plants against H2O2-induced cell death of human brain neuroblastoma SK-N-SH cells. MAIN METHODS: Cytotoxicity was determined by MTT and lactate dehydrogenase (LDH) assays. Apoptotic cell death was monitored by annexin V-FITC/PI double staining and by TUNEL assay. The formation of reactive oxygen species (ROS), expression of antioxidant enzymes and phosphorylation of mitogen-activated protein kinase (MAPK) were determined by 2,7-dichlorofluorescein diacetate (DCF-DA) assay, RT-PCR, and western blotting, respectively. KEY FINDINGS: The ethyl acetate fractions from Cirsium setidens (CSEA) and Aster scaber (ASEA) showed neuroprotective effects in SK-N-SH cells. The phytochemicals were isolated from CSEA and ASEA and identified by spectral analyses, as ß-sitosterol, Dau, Pec, Ast, or isoquercitrin. Pretreatment with Dau, Pec, or Ast showed protective effects against H2O2-induced cell death and inhibited ROS generation by oxidative stress. HO-1 mRNA and protein levels were increased by the presence of H2O2 and were further elevated by pretreatment with Dau and Ast. Dau pretreatment resulted in further increases of H2O2-induced enhancement in levels of CAT and SOD2. Pretreatment with Dau, Pec, and Ast inhibited phosphorylation of MAPK, such as extracellular protein regulated protein kinase, p38, and c-Jun N-terminal kinase by H2O2. SIGNIFICANCE: Dau exerts its neuroprotective effects by down regulation of MAPK pathways and upregulation of the HO-1, CAT and SOD2 antioxidant genes and is associated with reduced oxidative stress in SK-N-SH cells.
[Mh] Termos MeSH primário: Aster
Neoplasias Encefálicas/prevenção & controle
Cirsium
Flavonoides/uso terapêutico
Neuroblastoma/prevenção & controle
Fármacos Neuroprotetores/uso terapêutico
Fitosteróis/uso terapêutico
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Neuroblastoma/metabolismo
Neuroblastoma/patologia
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/isolamento & purificação
Fitosteróis/química
Fitosteróis/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Neuroprotective Agents); 0 (Phytosterols); 0 (Plant Extracts)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160314
[Lr] Data última revisão:
160314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160214
[St] Status:MEDLINE


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[PMID]:26686615
[Au] Autor:Szymanska S; Plociniczak T; Piotrowska-Seget Z; Zloch M; Ruppel S; Hrynkiewicz K
[Ad] Endereço:Department of Microbiology, Faculty of Biology and Environment Protection, N. Copernicus University, Lwowska 1, 87-100 Torun, Poland.
[Ti] Título:Metabolic potential and community structure of endophytic and rhizosphere bacteria associated with the roots of the halophyte Aster tripolium L.
[So] Source:Microbiol Res;182:68-79, 2016 Jan.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The submitted work assumes that the abundance and diversity of endophytic and rhizosphere microorganisms co-existing with the halophytic plant Aster tripolium L. growing in a salty meadow in the vicinity of a soda factory (central Poland) represent unique populations of cultivable bacterial strains. Endophytic and rhizosphere bacteria were (i) isolated and identified based on 16S rDNA sequences; (ii) screened for nifH and acdS genes; and (iii) analyzed based on selected metabolic properties. Moreover, total microbial biomass and community structures of the roots (endophytes), rhizosphere and soil were evaluated using a cultivation-independent technique (PLFA) to characterize plant-microbial interactions under natural salt conditions. The identification of the isolated strains showed domination by Gram-positive bacteria (mostly Bacillus spp.) both in the rhizosphere (90.9%) and roots (72.7%) of A. tripolium. Rhizosphere bacterial strains exhibited broader metabolic capacities, while endophytes exhibited higher specificities for metabolic activity. The PLFA analysis showed that the total bacterial biomass decreased in the following order (rhizosphere
[Mh] Termos MeSH primário: Aster/microbiologia
Bactérias/isolamento & purificação
Bactérias/metabolismo
Endófitos/isolamento & purificação
Endófitos/metabolismo
Raízes de Plantas/microbiologia
Microbiologia do Solo
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/genética
Biodiversidade
DNA Bacteriano/genética
DNA Ribossômico/genética
Endófitos/classificação
Endófitos/genética
Dados de Sequência Molecular
Filogenia
RNA Ribossômico 16S/genética
Rizosfera
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE



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