Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.133 [Categoria DeCS]
Referências encontradas : 160 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 16 ir para página                         

  1 / 160 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28886028
[Au] Autor:Abdala-Roberts L; Pratt R; Pratt JD; Mooney KA
[Ad] Endereço:Departamento de Ecología Tropical, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
[Ti] Título:Traits underlying community consequences of plant intra-specific diversity.
[So] Source:PLoS One;12(9):e0183493, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A plant's performance and interactions with other trophic levels are recorgnized to be contingent upon plant diversity and underlying associational dynamics, but far less is known about the plant traits driving such phenomena. We manipulated diversity in plant traits using pairs of plant and a substitutive design to elucidate the mechanisms underlying diversity effects operating at a fine spatial scale. Specifically, we measured the effects of diversity in sex (sexual monocultures vs. male and female genotypes together) and growth rate (growth rate monocultures vs. fast- and slow-growing genotypes together) on growth of the shrub Baccharis salicifolia and on above- and belowground consumers associated with this plant. We compared effects on associate abundance (# associates per plant) vs. density (# associates per kg plant biomass) to elucidate the mechanisms underlying diversity effects; effects on abundance but not density suggest diversity effects are mediated by resource abundance (i.e. plant biomass) alone, whereas effects on density suggest diversity effects are mediated by plant-based heterogeneity or quality. Sexual diversity increased root growth but reduced the density (but not abundance) of the dietary generalist aphid Aphis gossypii and its associated aphid-tending ants, suggesting sex mixtures were of lower quality to this herbivore (e.g. via reduced plant quality), and that this effect indirectly influenced ants. Sexual diversity had no effect on the abundance or density of parasitoids attacking A. gossypii, the dietary specialist aphid Uroleucon macolai, or mycorrhizae. In contrast, growth rate diversity did not influence plant growth or any associates except for the dietary specialist aphid U. macolai, which increased in both abundance and density at high diversity, suggesting growth rate mixtures were of higher quality to this herbivore. These results highlight that plant associational and diversity effects on consumers are contingent upon the source of plant trait variation, and that the nature of such dynamics may vary both within and among trophic levels.
[Mh] Termos MeSH primário: Biodiversidade
Plantas/classificação
[Mh] Termos MeSH secundário: Animais
Afídeos/patogenicidade
Baccharis/parasitologia
Baccharis/fisiologia
Biomassa
Genótipo
Herbivoria/fisiologia
Plantas/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183493


  2 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Lima, Sonia Oliveira
Texto completo SciELO Brasil
[PMID]:28538800
[Au] Autor:Lima SO; Figueiredo MBGA; Santana VR; Santana DPA; Nogueira MS; Porto ES; Andrade RLB; Santos JM; Albuquerque RLC; Cardoso JC
[Ad] Endereço:PhD, Full Professor, Department of Morphology and Structural Biology, Research and Technology Institute, Universidade Tiradentes (UNIT), Aracaju-SE, Brazil. Scientific and intellectual content of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis,
[Ti] Título:Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats.
[So] Source:Acta Cir Bras;32(4):263-269, 2017 Apr.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Purpose:: To evaluate the effect of aqueous extract of Baccharis trimera leaves on the proliferative capacity of the liver after partial hepatectomy (PH) in rats. Methods:: Twenty Wistar rats weighing between 300 and 450g were divided into two groups: control (HP) and test (HP100-rats that received the aqueous extract of Baccharis trimera for four days at a dose of 100 mg / kg / day). On the fifth day, animals from both groups underwent resection of 70% of the liver. Twenty-four hours later, they were sacrificed and the remnant liver was removed and prepared for studied through PCNA immunohistochemistry. Data analysis for comparison between the two groups was made through the non-parametric statistical test Mann-Whitney test. Results:: In all the animals studied was found most abundant nuclear immunostaining positive hepatocytes interlobular located in regions of the liver. Quantitative analysis of PCNA-positive cells revealed positivity rate significantly higher mean (p = 0.02) in HP100 group (77.1 ± 13.6) compared to the HP group (45.8 ± 12.9). Conclusion:: DAdministration of aqueous extract of the leaves of Baccharis trimera 100 mg/kg of animal has a significant positive effect on liver regeneration in rats, 24 hours after hepatectomy (70%).
[Mh] Termos MeSH primário: Baccharis
Hepatectomia
Regeneração Hepática/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Antígeno Nuclear de Célula em Proliferação/análise
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Fígado/efeitos dos fármacos
Fígado/patologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Proliferating Cell Nuclear Antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


  3 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28103717
[Au] Autor:de Araújo GR; Rabelo AC; Meira JS; Rossoni-Júnior JV; Castro-Borges W; Guerra-Sá R; Batista MA; Silveira-Lemos DD; Souza GH; Brandão GC; Chaves MM; Costa DC
[Ad] Endereço:1 Center for Research in Biological Sciences - NUPEB, Federal University of Ouro Preto, 35400-000 Ouro Preto, Brazil.
[Ti] Título:Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phosphorylation of NADPH oxidase in SK Hep-1 cells.
[So] Source:Exp Biol Med (Maywood);242(3):333-343, 2017 Feb.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved in this process. So, the aim of the present study was to assess the influence of B. trimera on the modulation of PKC signaling pathway and to characterize the effect of the nicotinamide adenine dinucleotide phosphate oxidase enzyme (NOX) on the generation of reactive oxygen species in SK Hep-1 cells. SK-Hep 1 cells were treated with B. trimera, quercetin, or rutin and then stimulated or not with PMA/ionomycin and labeled with carboxy H DCFDA for detection of reactive oxygen species by flow cytometer. The PKC expression by Western blot and enzyme activity was performed to evaluate the influence of B. trimera and quercetin on PKC signaling pathway. p47 and p47 phosphorylated expression was performed by Western blot to evaluate the influence of B. trimera on p47 phosphorylation. The results showed that cells stimulated with PMA/ionomycin (activators of PKC) showed significantly increased reactive oxygen species production, and this production returned to baseline levels after treatment with DPI (NOX inhibitor). Both B. trimera and quercetin modulated reactive oxygen species production through the inhibition of PKC protein expression and enzymatic activity, also with inhibition of p47 phosphorylation. Taken together, these results suggest that B. trimera has a potential mechanism for inhibiting reactive oxygen species production through the PKC signaling pathway and inhibition subunit p47 phosphorylation of nicotinamide adenine dinucleotide phosphate oxidase.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Baccharis/química
NADPH Oxidases/metabolismo
Proteína Quinase C/metabolismo
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular
Hepatócitos/metabolismo
Seres Humanos
Ionomicina/farmacologia
NADPH Oxidases/antagonistas & inibidores
Estresse Oxidativo/efeitos dos fármacos
Fosforilação/efeitos dos fármacos
Preparações de Plantas/farmacologia
Quercetina/farmacologia
Rutina/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Preparations); 0 (Reactive Oxygen Species); 56092-81-0 (Ionomycin); 5G06TVY3R7 (Rutin); 9IKM0I5T1E (Quercetin); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.1 (neutrophil cytosolic factor 1); EC 2.7.11.13 (Protein Kinase C)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216672749


  4 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28066967
[Au] Autor:Veiga RS; De Mendonça S; Mendes PB; Paulino N; Mimica MJ; Lagareiro Netto AA; Lira IS; López BG; Negrão V; Marcucci MC
[Ad] Endereço:Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
[Ti] Título:Artepillin C and phenolic compounds responsible for antimicrobial and antioxidant activity of green propolis and Baccharis dracunculifolia DC.
[So] Source:J Appl Microbiol;122(4):911-920, 2017 Apr.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: This study investigates the antimicrobial activity in Staphylococcus aureus isolates (methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA)) and antioxidant activity of green propolis, Baccharis dracunculifolia DC extracts and Artepillin C™. METHODS AND RESULTS: The amount of Artepillin C in different extracts was determined by high performance liquid chromatography analysis. Minimum inhibitory concentration 90 (MIC90) was determined using 40 isolates of S. aureus inoculated in Müeller-Hinton agar culture medium containing the green propolis and B. dracunculifolia DC extracts. PVEE (green propolis ethanolic extract) and BDEH (B. dracunculifolia hexanic extract) showed the greatest antimicrobial activity with MIC90 values of 246·3 and 295·5 µg ml respectively. Green propolis ethanolic and hexanic extracts (PVEE and PVEH respectively) showed the greatest antioxidant activity assessed by DPPH (1,1-diphenyl-2-picryl hydrazyl radical) with IC values of 13·09 and 95·86 µg ml respectively. CONCLUSIONS: Green propolis ethanolic displays better antimicrobial and antioxidant activities compared to other extracts. These activities may be related to the presence of Artepillin C in synergism with the other constituents of the extracts. SIGNIFICANCE AND IMPACT OF THE STUDY: In this study, the antimicrobial activity of the extracts of green propolis and B. dracunculifolia DC demonstrated in MRSA and MSSA clinical isolates indicated that they can be important tools to treat infections caused by these bacteria.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Baccharis/química
Fenóis/farmacologia
Fenilpropionatos/farmacologia
Própole/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/análise
Antioxidantes/análise
Fenilpropionatos/análise
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Própole/química
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Phenols); 0 (Phenylpropionates); 0 (Plant Extracts); 72944-19-5 (artepillin C); 9009-62-5 (Propolis)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13400


  5 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28000211
[Au] Autor:Barbosa M; Fernandes GW; Lewis OT; Morris RJ
[Ad] Endereço:Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK.
[Ti] Título:Experimentally reducing species abundance indirectly affects food web structure and robustness.
[So] Source:J Anim Ecol;86(2):327-336, 2017 Mar.
[Is] ISSN:1365-2656
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Studies on the robustness of ecological communities suggest that the loss or reduction in abundance of individual species can lead to secondary and cascading extinctions. However, most such studies have been simulation-based analyses of the effect of primary extinction on food web structure. In a field experiment we tested the direct and indirect effects of reducing the abundance of a common species, focusing on the diverse and self-contained assemblage of arthropods associated with an abundant Brazilian shrub, Baccharis dracunculifolia D.C. (Asteraceae). Over a 5-month period we experimentally reduced the abundance of Baccharopelma dracunculifoliae (Sternorrhyncha: Psyllidae), the commonest galling species associated with B. dracunculifolia, in 15 replicate plots paired with 15 control plots. We investigated direct effects of the manipulation on parasitoids attacking B. dracunculifoliae, as well as indirect effects (mediated via a third species or through the environment) on 10 other galler species and 50 associated parasitoid species. The experimental manipulation significantly increased parasitism on B. dracunculifoliae in the treatment plots, but did not significantly alter either the species richness or abundance of other galler species. Compared to control plots, food webs in manipulated plots had significantly lower values of weighted connectance, interaction evenness and robustness (measured as simulated tolerance to secondary extinction), even when B. dracunculifoliae was excluded from calculations. Parasitoid species were almost entirely specialized to individual galler species, so the observed effects of the manipulation on food web structure could not have propagated via the documented trophic links. Instead, they must have spread either through trophic links not included in the webs (e.g. shared predators) or non-trophically (e.g. through changes in habitat availability). Our results highlight that the inclusion of both trophic and non-trophic direct and indirect interactions is essential to understand the structure and dynamics of even apparently discrete ecological communities.
[Mh] Termos MeSH primário: Baccharis/crescimento & desenvolvimento
Hemípteros/fisiologia
Hemípteros/parasitologia
Interações Hospedeiro-Parasita
Vespas/fisiologia
[Mh] Termos MeSH secundário: Animais
Biota
Brasil
Cadeia Alimentar
Folhas de Planta/crescimento & desenvolvimento
Dinâmica Populacional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1111/1365-2656.12626


  6 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27984757
[Au] Autor:Jesus JA; Fragoso TN; Yamamoto ES; Laurenti MD; Silva MS; Ferreira AF; Lago JH; Gomes GS; Passero LF
[Ad] Endereço:Laboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455. Cerqueira César, São Paulo, 01246-903, SP, Brazil; Center of Natural Sciences and Humanities, Federal University of ABC, Santo Andre, São Paulo, 09210-180, B
[Ti] Título:Therapeutic effect of ursolic acid in experimental visceral leishmaniasis.
[So] Source:Int J Parasitol Drugs Drug Resist;7(1):1-11, 2017 Apr.
[Is] ISSN:2211-3207
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compounds. In the present study, the therapeutic potential and toxicity of ursolic acid (UA), isolated from the leaves of Baccharis uncinella C. DC. (Asteraceae), were evaluated in experimental visceral leishmaniasis. To evaluate the therapeutic potential of UA, hamsters infected with L. (L.) infantum were treated daily during 15 days with 1.0 or 2.0 mg UA/kg body weight, or with 5.0 mg amphotericin B/kg body weight by intraperitoneal route. Fifteen days after the last dose, the parasitism of the spleen and liver was stimated and the main histopathological alterations were recorded. The proliferation of splenic mononuclear cells was evaluated and IFN-γ, IL-4, and IL-10 gene expressions were analyzed in spleen fragments. The toxicity of UA and amphotericin B were evaluated in healthy golden hamsters by histological analysis and biochemical parameters. Animals treated with UA had less parasites in the spleen and liver when compared with the infected control group, and they also showed preservation of white and red pulps, which correlate with a high rate of proliferation of splenic mononuclear cells, IFN-γ mRNA and iNOS production. Moreover, animals treated with UA did not present alterations in the levels of AST, ALT, creatinine and urea. Taken together, these findings indicate that UA is an interesting natural compound that should be considered for the development of prototype drugs against visceral leishmaniasis.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Leishmaniose Visceral/tratamento farmacológico
Fígado/efeitos dos fármacos
Baço/efeitos dos fármacos
Triterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Anfotericina B/administração & dosagem
Anfotericina B/uso terapêutico
Anfotericina B/toxicidade
Animais
Antiprotozoários/administração & dosagem
Antiprotozoários/isolamento & purificação
Antiprotozoários/toxicidade
Baccharis/química
Descoberta de Drogas
Feminino
Interferon gama/genética
Interleucina-10/genética
Interleucina-12/genética
Interleucina-4/genética
Leishmaniose Visceral/parasitologia
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/imunologia
Fígado/parasitologia
Fígado/patologia
Mesocricetus
Baço/parasitologia
Baço/patologia
Triterpenos/administração & dosagem
Triterpenos/isolamento & purificação
Triterpenos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Triterpenes); 130068-27-8 (Interleukin-10); 187348-17-0 (Interleukin-12); 207137-56-2 (Interleukin-4); 7XU7A7DROE (Amphotericin B); 82115-62-6 (Interferon-gamma); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


  7 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27756550
[Au] Autor:Lívero FA; Martins GG; Queiroz Telles JE; Beltrame OC; Petris Biscaia SM; Cavicchiolo Franco CR; Oude Elferink RP; Acco A
[Ad] Endereço:Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
[Ti] Título:Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice.
[So] Source:Chem Biol Interact;260:22-32, 2016 Dec 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Ethanol abuse is a serious public health problem that is associated with several stages of alcoholic liver disease (ALD) and a high incidence of morbidity and mortality. Alcoholic fatty liver disease (AFLD), the earliest stage of ALD, is a multifactorial injury that involves oxidative stress and disruptions of lipid metabolism. Although benign and reversible, no pharmacological treatments are available for this condition. In the present study, we induced AFLD in mice with 10% ethanol and a low-protein diet and then orally treated them with a hydroethanolic extract of Baccharis trimera (HEBT; 30 mg kg ). HEBT reversed ethanol-induced oxidative stress in the liver, reduced lipoperoxidation, normalized GPx, GST, SOD and Cat activity, and GSH and total ROS levels. The reverser effect of HEBT was observed upon ethanol-induced increases in the levels of plasma and hepatic triglycerides, plasma cholesterol, plasma high-density lipoprotein, and plasma and hepatic low-density lipoprotein. Moreover, HEBT increased fecal triglycerides and reduced the histological ethanol-induced lesions in the liver. HEBT also altered the expression of genes that are involved in ethanol metabolism, antioxidant systems, and lipogenesis (i.e., CypE1, Nrf2, and Scd1, respectively). No signs of toxicity were observed in HEBT-treated mice. We propose that HEBT may be a promising pharmacological treatment for AFLD.
[Mh] Termos MeSH primário: Baccharis/química
Etanol/química
Fígado Gorduroso Alcoólico/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Água/química
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Peso Corporal/efeitos dos fármacos
Modelos Animais de Doenças
Fígado Gorduroso Alcoólico/sangue
Fígado Gorduroso Alcoólico/genética
Fígado Gorduroso Alcoólico/patologia
Fezes/química
Comportamento Alimentar/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Lipídeos/sangue
Fígado/efeitos dos fármacos
Fígado/patologia
Fígado/ultraestrutura
Masculino
Camundongos
Modelos Biológicos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Lipids); 0 (Plant Extracts); 059QF0KO0R (Water); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  8 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27423764
[Au] Autor:Cabrera J; Saavedra E; Del Rosario H; Perdomo J; Loro JF; Cifuente DA; Tonn CE; García C; Quintana J; Estévez F
[Ad] Endereço:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, Spain.
[Ti] Título:Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.
[So] Source:Chem Biol Interact;256:220-7, 2016 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Flavonoids have attracted great interest due to their possible anticancer activities. Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 µM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. These effects on viability were accompanied by the concentration- and time-dependent appearance of apoptosis as evidenced by DNA fragmentation, formation of apoptotic bodies and a sub-G1 ratio increase. Comparative studies with the best-studied bioflavonoid quercetin indicate that gardenin B is a more cytotoxic and more apoptotic inducer than quercetin. Cell death induced by gardenin B was associated with: (i) a significant induction of caspase-2, -3, -8 and -9 activities; (ii) cleavage of the initiator caspases (caspase-2, -8 and -9), of the executioner caspase-3, and of poly(ADP-ribose) polymerase; and (iii) a concentration-dependent reactive oxygen species generation. In conclusion, apoptosis induced by gardenin B is associated with activation of both the extrinsic and the intrinsic apoptotic pathways of cell death and occurs through a mechanism that is independent of the generation of reactive oxygen species.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Caspases/metabolismo
Flavonas/farmacologia
Leucemia/tratamento farmacológico
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Baccharis/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Flavonas/química
Células HL-60
Seres Humanos
Leucemia/metabolismo
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/metabolismo
Poli(ADP-Ribose) Polimerases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Flavones); 0 (Reactive Oxygen Species); 313E89KN5E (gardenin B); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160718
[St] Status:MEDLINE


  9 / 160 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27395706
[Au] Autor:Stonis JR; Diskus A; Remeikis A; Remeikis A; Davis DR; Solis MA; Torres NC
[Ad] Endereço:Lithuanian University of Educational Sciences and Baltic-American Biotaxonomy Institute, Studentu St. 39, Vilnius LT-08106, Lithuania; Email: stonis@leu.lt.
[Ti] Título:The first record of Baccharis L. (Asteraceae) as a host-plant genus for Nepticulidae (Lepidoptera), with description of new Stigmella species from South America.
[So] Source:Zootaxa;4136(1):101-28, 2016 Jul 05.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:We record the first Nepticulidae species found to feed on Baccharis L. (Asteraceae). Despite the high species richness of Baccharis in the Western Hemisphere, no nepticulid has ever been recorded feeding on Baccharis. In this paper we describe six new Stigmella Schrank species feeding on Baccharis: S. emarginatae Diskus & Stonis, sp. nov., S. bipartita Diskus & Stonis, sp. nov., S. tripartita Diskus & Stonis, sp. nov., S. latifoliae Remeikis, Diskus & Stonis, sp. nov., S. baccharicola Diskus & Stonis, sp. nov., and S. confertae Diskus & Stonis, sp. nov. The remaining two taxa are left unnamed. All taxa are illustrated with photographs of adults, their genitalia, and their leaf-mines. Additionally, leaf-mines on Baccharis salicifolia are documented.
[Mh] Termos MeSH primário: Baccharis/parasitologia
Mariposas/classificação
[Mh] Termos MeSH secundário: Distribuição Animal
Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Tamanho Corporal
Ecossistema
Feminino
Especificidade de Hospedeiro
Masculino
Mariposas/anatomia & histologia
Mariposas/crescimento & desenvolvimento
Mariposas/fisiologia
Tamanho do Órgão
Folhas de Planta/parasitologia
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160711
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4136.1.4


  10 / 160 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27382921
[Au] Autor:Medina-López CF; Plascencia-Jatomea M; Cinco-Moroyoqui FJ; Yépiz-Gómez MS; Cortez-Rocha MO; Rosas-Burgos EC
[Ad] Endereço:a Department of Food Science Research and Graduate Studies , University of Sonora , Hermosillo , Sonora , Mexico.
[Ti] Título:Potentiation of antifungal effect of a mixture of two antifungal fractions obtained from Baccharis glutinosa and Jacquinia macrocarpa plants.
[So] Source:J Environ Sci Health B;51(11):760-8, 2016 Nov.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present work was to evaluate the effect of mixtures of antifungal fractions extracted from Baccharis glutinosa and Jacquinia macrocarpa plants on the development of the filamentous fungi Aspergillus flavus and Fusarium verticillioides. The minimal inhibitory concentration that inhibited 50% of growth (MIC50) of each plant antifungal fraction was determined from the percentage radial growth inhibition of both fungi. Binomial mixtures made with both plant fractions were used at their MIC50 to determine the Fractional Inhibitory Concentration index (FIC index) for each fungus in order to evaluate their synergistic effect. Each synergistic mixture was analyzed in their effect on spore germination, spore size, spore viability, mitotic divisions, hyphal diameter and length, and number of septa per hypha. Some antifungal mixtures, even at low concentrations, showed higher antifungal effect than those of the individual antifungal fraction. The FIC indices of mixtures that showed the highest antifungal activity against A. flavus and F. verticillioides were 0.5272 and 0.4577, respectively, indicating a synergistic effect against both fungi. Only 12% and 8% of the spores of A. flavus and F. verticillioides, respectively, treated with the synergistic mixtures, were able to germinate, although their viability was not affected. An increase in the number of septa per hypha of both fungi was observed. The results indicated that the synergistic mixtures strongly affected the fungal growth even at lower concentrations than those of the individual plant fractions.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus flavus/efeitos dos fármacos
Baccharis/química
Fusarium/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Primulaceae/química
[Mh] Termos MeSH secundário: México
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2016.1198641



página 1 de 16 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde