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[PMID]: | 27984757 |
[Au] Autor: | Jesus JA; Fragoso TN; Yamamoto ES; Laurenti MD; Silva MS; Ferreira AF; Lago JH; Gomes GS; Passero LF |
[Ad] Endereço: | Laboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455. Cerqueira César, São Paulo, 01246-903, SP, Brazil; Center of Natural Sciences and Humanities, Federal University of ABC, Santo Andre, São Paulo, 09210-180, B |
[Ti] Título: | Therapeutic effect of ursolic acid in experimental visceral leishmaniasis. |
[So] Source: | Int J Parasitol Drugs Drug Resist;7(1):1-11, 2017 Apr. | [Is] ISSN: | 2211-3207 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compounds. In the present study, the therapeutic potential and toxicity of ursolic acid (UA), isolated from the leaves of Baccharis uncinella C. DC. (Asteraceae), were evaluated in experimental visceral leishmaniasis. To evaluate the therapeutic potential of UA, hamsters infected with L. (L.) infantum were treated daily during 15 days with 1.0 or 2.0 mg UA/kg body weight, or with 5.0 mg amphotericin B/kg body weight by intraperitoneal route. Fifteen days after the last dose, the parasitism of the spleen and liver was stimated and the main histopathological alterations were recorded. The proliferation of splenic mononuclear cells was evaluated and IFN-γ, IL-4, and IL-10 gene expressions were analyzed in spleen fragments. The toxicity of UA and amphotericin B were evaluated in healthy golden hamsters by histological analysis and biochemical parameters. Animals treated with UA had less parasites in the spleen and liver when compared with the infected control group, and they also showed preservation of white and red pulps, which correlate with a high rate of proliferation of splenic mononuclear cells, IFN-γ mRNA and iNOS production. Moreover, animals treated with UA did not present alterations in the levels of AST, ALT, creatinine and urea. Taken together, these findings indicate that UA is an interesting natural compound that should be considered for the development of prototype drugs against visceral leishmaniasis. |
[Mh] Termos MeSH primário: |
Antiprotozoários/uso terapêutico Leishmaniose Visceral/tratamento farmacológico Fígado/efeitos dos fármacos Baço/efeitos dos fármacos Triterpenos/uso terapêutico
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[Mh] Termos MeSH secundário: |
Anfotericina B/administração & dosagem Anfotericina B/uso terapêutico Anfotericina B/toxicidade Animais Antiprotozoários/administração & dosagem Antiprotozoários/isolamento & purificação Antiprotozoários/toxicidade Baccharis/química Descoberta de Drogas Feminino Interferon gama/genética Interleucina-10/genética Interleucina-12/genética Interleucina-4/genética Leishmaniose Visceral/parasitologia Leucócitos Mononucleares/efeitos dos fármacos Leucócitos Mononucleares/imunologia Fígado/parasitologia Fígado/patologia Mesocricetus Baço/parasitologia Baço/patologia Triterpenos/administração & dosagem Triterpenos/isolamento & purificação Triterpenos/toxicidade
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Antiprotozoal Agents); 0 (Triterpenes); 130068-27-8 (Interleukin-10); 187348-17-0 (Interleukin-12); 207137-56-2 (Interleukin-4); 7XU7A7DROE (Amphotericin B); 82115-62-6 (Interferon-gamma); P3M2575F3F (ursolic acid) |
[Em] Mês de entrada: | 1710 |
[Cu] Atualização por classe: | 171024 |
[Lr] Data última revisão:
| 171024 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161217 |
[St] Status: | MEDLINE |
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