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Pesquisa : B01.650.940.800.575.912.250.100.137 [Categoria DeCS]
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[PMID]:29017485
[Au] Autor:Bilanda DC; Dzeufiet PDD; Kouakep L; Aboubakar BFO; Tedong L; Kamtchouing P; Dimo T
[Ad] Endereço:Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. bilandad@yahoo.comm.
[Ti] Título:Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats.
[So] Source:BMC Complement Altern Med;17(1):479, 2017 Oct 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate extract (Bp) on L-NAME induced hypertension and oxidative stress in rats. METHODS: Male Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). The others groups were receiving concomitantly L-NAME plus Bp extract (75 and 150 mg/kg/day) or losartan (25 mg/kg/day). All the treatments were given orally for 4 weeks. At the end of the treatment, the hemodynamic parameters were recorded using the direct cannulation method. The effects of the extract on lipid profile, kidney and liver functions as well as oxidative stress markers were evaluated by colorimetric method. Results were expressed as the mean ± SEM. The difference between the groups was compared using one-way analysis of variance (ANOVA) followed by the Duncan's post hoc test. RESULTS: Animals receiving L-NAME presented high blood pressure, normal heart rate and lipid profile as well as NO depletion, liver and kidney injuries and oxidative stress. The concomitant treatment with L-NAME and Bp or losartan succeeded to prevent the raised of blood pressure and all the other injuries without affecting the heart rate. CONCLUSION: These results confirm the antihypertensive effects of Bidens pilosa and highlight its protective properties in L-NAME model of hypertension in rat, probably due to the presence of Quercetin 3,3 '-dimethyl ether 7-0-ß-D-glucopyranoside.
[Mh] Termos MeSH primário: Bidens/química
Hipertensão/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Acetatos
Animais
Etilenos
Hipertensão/prevenção & controle
Rim/efeitos dos fármacos
Lipídeos
Fígado/efeitos dos fármacos
NG-Nitroarginina Metil Éster
Extratos Vegetais/química
Substâncias Protetoras/química
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Ethylenes); 0 (Lipids); 0 (Plant Extracts); 0 (Protective Agents); 91GW059KN7 (ethylene); V55S2QJN2X (NG-Nitroarginine Methyl Ester)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1972-0


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[PMID]:28700828
[Au] Autor:Wu J; Ma JJ; Liu B; Huang L; Sang XQ; Zhou LJ
[Ad] Endereço:Key Lab of Natural Pesticides & Chemical Biology, Ministry of Education, Department of Pesticide Science, South China Agricultural University , Guangzhou, Guangdong, China 510642.
[Ti] Título:Herbicidal Spectrum, Absorption and Transportation, and Physiological Effect on Bidens pilosa of the Natural Alkaloid Berberine.
[So] Source:J Agric Food Chem;65(30):6100-6113, 2017 Aug 02.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Berberine is a natural herbicidal alkaloid from Coptis chinensis Franch. Here we characterized its herbicidal spectrum and absorption and transportation in the plant, along with the possible mechanism. Berberine showed no effect on the germination of the 10 tested plants. The IC values of berberine on the primary root length and fresh weight of the 10 tested plants ranged from 2.91 to 9.79 mg L and 5.76 to 35.07 mg L , respectively. Berberine showed a similar herbicidal effect on Bidens pilosa as the commercial naturally derived herbicide cinmethylin. HPLC and fluorescence analysis revealed that berberine was mainly absorbed by B. pilosa root and transported through vascular bundle acropetally. Enzyme activity studies, GC-MS analysis, and SEM and TEM observations indicated that berberine might first function on the cell membrane indicated by variation of the IUFA percent and then cause POD, PPO, and SOD activity changes and cellular structure deformity, which was eventually expressed as the decrease of cell adaptation ability and abnormal cell function and may even result in cell death. Environmental safety evaluation tests revealed that berberine was low in toxicity to Brachydanio rerio. These indicate that berberine has the potential to be a bioherbicide and/or a lead molecule for new herbicides.
[Mh] Termos MeSH primário: Berberina/metabolismo
Berberina/farmacologia
Bidens/metabolismo
Coptis/química
Herbicidas/metabolismo
Herbicidas/farmacologia
Extratos Vegetais/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Bidens/efeitos dos fármacos
Transporte Biológico
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Plant Extracts); 0I8Y3P32UF (Berberine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01259


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[PMID]:28605187
[Au] Autor:da Silva BP; Nepomuceno MP; Varela RM; Torres A; Molinillo JMG; Alves PLCA; Macías FA
[Ad] Endereço:Department of Applied Biology to Agropecuary, São Paulo State University, UNESP , 14884-900 Jaboticabal, Brazil.
[Ti] Título:Phytotoxicity Study on Bidens sulphurea Sch. Bip. as a Preliminary Approach for Weed Control.
[So] Source:J Agric Food Chem;65(25):5161-5172, 2017 Jun 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Farmers of the Franca region in Brazil observed that Bidens sulphurea was able to eliminate the Panicum maximum weed, which infected coffee plantations, without affecting the crop. In an effort to determine if the inhibitory effects observed were due to the presence of phytotoxic compounds from leaves and roots, a biodirected isolation and spectroscopic characterization has been carried out. The leaf dichloromethane and root acetone extracts were the most active, and the former appeared to be more phytotoxic to the target species, including four weeds. A total of 26 compounds were isolated from leaves and roots, and four of them are described here for the first time. The major compounds in the leaf extract are the sesquiterpene lactones costunolide, reynosin, and santamarine, and these showed marked inhibition. Amaranthus viridis and Panicum maximum were the most sensitive species of the weeds tested. These three phytotoxic lactones were also evaluated on A. viridis and P. maximum under hydroponic conditions. A. viridis was the most affected species with the three lactones, and santamarine was the most phytotoxic compound on both. This is the first time that the phytotoxicity of sesquiterpene lactones has been evaluated on hydroponic culture. The work described here is a preliminary approach for the use of B. sulphurea for weed control in agriculture, both as a cover crop and by use of its components as natural herbicide leads.
[Mh] Termos MeSH primário: Bidens/química
Herbicidas/toxicidade
Extratos Vegetais/toxicidade
Plantas Daninhas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amaranthus/efeitos dos fármacos
Asteraceae/efeitos dos fármacos
Brasil
Herbicidas/química
Herbicidas/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Raízes de Plantas/química
Controle de Plantas Daninhas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01922


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[PMID]:26846318
[Au] Autor:Chen Z; Schmidt B; Schäffer A
[Ad] Endereço:Institute for Environmental Research (Biology V), RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany. zhongli.chen@bio5.rwth-aachen.de.
[Ti] Título:Uptake and decomposition of the herbicide propanil in the plant Bidens pilosa L. dominating in the Yangtze Three Gorges Reservoir (TGR), China.
[So] Source:Environ Sci Pollut Res Int;24(12):11141-11153, 2017 Apr.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Propanil (3',4'-dichloropropionanilide) is a selective post emergence herbicide for controlling broad leaf and grass weeds in rice (Oryza sativa L.). After being taken up by plants, the fate of propanil in decomposing plant material is of particular importance to the phytoremediation of the environment. Therefore, we investigated the biotransformation of propanil in the plant Bidens pilosa under conditions close to those present in the Three Gorges Reservoir (TGR), China. Plants pre-treated with C-ring-labeled propanil were either (treatment a) directly submerged in TGR water for 90 days or (treatment b) pre-extracted with organic solvents, and subsequently only insoluble materials and non-extractable residues (NER) of the pesticide fractions were similarly incubated. After incubation in TGR water (treatment a), 30 % of applied radioactivity was released into water and simultaneously, amounts of NER in the plant debris appeared to increase with time finally amounting to 40 % of applied C. The radioactivity contained in the extractable fractions were identified as propanil, 3,4-dichloroaniline (DCA), and N-ß-D-glucopyranosyl-3,4-dichloroaniline (DCA-Glu). In treatment b, significant C amounts were released to the water (6 % of applied C) and the solubilized radioactivity fractions were demonstrated to agree with those found in the extractable fractions. Therefore, if residues of the pesticide propanil are taken up by plants, it may enter again the aquatic environment after plant death and submergence. This phenomenon may have a potential impact on aquatic organisms, which to our knowledge has not been reported before. As plant uptake and degradation of xenobiotics are recognized as detoxification, we consider B. pilosa with its high uptake potential, at least for propanil, as suitable species for phytoremediation.
[Mh] Termos MeSH primário: Bidens/metabolismo
Herbicidas/metabolismo
Propanil/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Compostos de Anilina/metabolismo
Biodegradação Ambiental
Radioisótopos de Carbono/análise
China
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Carbon Radioisotopes); 0 (Herbicides); 0 (Water Pollutants, Chemical); 20KR9WJ4NS (3,4-dichloroaniline); 709-98-8 (Propanil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6068-8


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[PMID]:27664442
[Au] Autor:Kinuthia DG; Muriithi AW; Mwangi PW
[Ad] Endereço:Department of Medical Physiology, School of Medicine, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya. Electronic address: gachkin@gmail.com.
[Ti] Título:Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea.
[So] Source:J Ethnopharmacol;193:416-422, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE OF THE STUDY: Diarrhea remains one of the main killers of children aged below five years. Traditional antidiarrheal remedies form a potentially viable source of novel low cost efficacious treatments in low resource settings. There is therefore a pressing need to scientifically evaluate these remedies. AIM OF THE STUDY: This study aimed to investigate the in vivo and in vitro antidiarrheal activity of freeze dried Bidens biternata, a herb used in traditional Ayurvedic medicine in the management of diarrhea. MATERIALS AND METHODS: In the castor oil test, twenty (20) adult Sprague-Dawley rats were randomized to a negative control (normal saline, n=5), a positive control (5mg/kg loperamide, n=5), and two test groups. The low dose test group received 200mg/kg Bidens biternata extract (n=5) while the high dose test group received 400mg/kg B. biternata extract (n=5). Castor oil (4ml/kg) was then administered to the animals one hour after administration of the respective treatments after which the total mass of fecal output excreted after four (4) hours was determined. In the charcoal meal test fifteen (15) Sprague Dawley rats were randomized to a control group (normal saline 5ml/kg orally, n=5), a positive control group (atropine sulfate 0.1mg/kg i.p., n=5) and a test group (400mg/kg B. biternata extract, n=5). Charcoal meal was then administered via oral gavage to each rat thirty (30) minutes after the administration of the various treatments. The distance covered by the charcoal meal from the pylorus was then determined after sacrifice of the animals thirty minutes after the meal. In the enteropooling test twenty (20) Sprague-Dawley rats were randomized to a control group (5% v/v ethanol in normal saline, n=5), a positive control group (5mg/kg loperamide, n=5) and a test group (400mg/kg B. biternata extract, n=5). For each group prostaglandin E2 (PGE2) (100µg/kg) was administered immediately after the treatments. The animals were then sacrificed half an hour later and the volume of the small intestine contents determined. The effects of different concentrations of B. biternata extract (0.5. 1.0, 2.0, 3.0 and 5.0mg/ml) on jejunal contraction were investigated and a dose-response curve constructed using the experimental data after which The ED50 dose was determined. The effect of tamsulosin (α1 adrenergic blocker), yohimbine (α2 adrenergic blocker), propranolol (ß adrenergic blocker) and naloxone (µ opioid blocker) on the contractile activity of the extract were also investigated. The experimental data were expressed as mean±standard error of mean (SEM) and then analyzed using one-way ANOVA followed by Tukey's post hoc test in cases of significance (set at p<0.05). RESULTS: The freeze dried extracts of B. biternata had significant antidiarrheal effects in the castor oil induced diarrhea model (p<0.01) with the highest activity being observed at the 400mg/kg dosage level (1.66±0.81g vs. 4.54±0.51g control, p=0.01). B. biternata extract had significant effects on intestinal motility in the charcoal meal test compared to the control group (43.61±4.42% vs. 60.54±3.33%: p<0.05). B. biternata extract had a significant effect on PGE2 induced enteropooling (3.06±0.07ml vs. 4.74±0.10ml; p<0.001). The freeze dried extracts of B. biternata had a significant negative effect on the contractility of the isolated rabbit jejunum (p<0.001). The effects of the extract were significantly attenuated by tamsulosin (53.94±4.20% vs. 80.57±4.09%; p<0.01) and naloxone (53.94±4.20% vs. 73.89±7.26%; p<0.05). Yohimbine (p>0.05) and propranolol (p>0.05) however did not have any significant effect on the contractile activity of the extract. CONCLUSIONS: The freeze dried extract of B. biternata possess significant antidiarrheal activity in both in vitro and in vivo models which appears to be mediated by modulating both the intestinal motility as well as the secretory activity. The results of this study also validate its traditional use as an antidiarrheal remedy.
[Mh] Termos MeSH primário: Antidiarreicos/farmacologia
Bidens/química
Defecação/efeitos dos fármacos
Diarreia/tratamento farmacológico
Liofilização
Motilidade Gastrointestinal/efeitos dos fármacos
Jejuno/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos/farmacologia
Animais
Antidiarreicos/química
Antidiarreicos/isolamento & purificação
Óleo de Rícino
Diarreia/induzido quimicamente
Diarreia/metabolismo
Diarreia/fisiopatologia
Dinoprostona/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Técnicas In Vitro
Secreções Intestinais/metabolismo
Jejuno/metabolismo
Jejuno/fisiopatologia
Loperamida/farmacologia
Masculino
Antagonistas de Entorpecentes/farmacologia
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Coelhos
Ratos Sprague-Dawley
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic Antagonists); 0 (Antidiarrheals); 0 (Narcotic Antagonists); 0 (Plant Extracts); 6X9OC3H4II (Loperamide); 8001-79-4 (Castor Oil); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


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[PMID]:27631003
[Au] Autor:Kouitcheu Mabeku LB; Eyoum Bille B; Nguepi E
[Ad] Endereço:Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:In Vitro and In Vivo Anti-Helicobacter Activities of Eryngium foetidum (Apiaceae), Bidens pilosa (Asteraceae), and Galinsoga ciliata (Asteraceae) against Helicobacter pylori.
[So] Source:Biomed Res Int;2016:2171032, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was performed to evaluate the antimicrobial activities of extracts of Bidens pilosa, Galinsoga ciliata, and Eryngium foetidum against 6 clinical strains of Helicobacter pylori in vitro and in vivo. Broth microdilution method was used in vitro. In vivo, Swiss mice were inoculated with H. pylori and divided into 5 groups; the control group received the vehicle and the four others received 125, 250, and 500 mg/kg of methanol extract of Eryngium foetidum and ciprofloxacin (500 mg/kg) for 7 days, respectively. Helicobacter pylori colonization and number of colonies in gastric biopsies culture were assessed on days 1 and 7 after treatment. The lowest MIC value (64 µg/mL) and the best spectrum of bactericidal effect (MBC/MIC = 1) were obtained with the methanol extract of Eryngium foetidum. The number of H. pylori infected animals was 17% (plant-extract) and 0% (ciprofloxacin) compared to 100% for the infected untreated group. Plant-extract (381.9 ± 239.5 CFU) and ciprofloxacin (248 ± 153.2 CFU) significantly reduced bacterial load in gastric mucosa compared to untreated, inoculated mice (14350 ± 690 CFU). Conclusion. The present data provided evidence that methanol extract of Eryngium foetidum could be a rich source of metabolites with antimicrobial activity to fight Helicobacter pylori infections.
[Mh] Termos MeSH primário: Antibacterianos/química
Asteraceae/química
Bidens/química
Eryngium/química
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Biópsia
Ciprofloxacino/química
Meios de Cultura/química
Mucosa Gástrica
Camundongos
Testes de Sensibilidade Microbiana
Compostos Fitoquímicos/química
Extratos Vegetais/química
Células-Tronco
Estômago/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Culture Media); 0 (Phytochemicals); 0 (Plant Extracts); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1155/2016/2171032


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[PMID]:27337217
[Au] Autor:Zhang C; Li K; Yang Z; Wang Y; Si H
[Ad] Endereço:Department of Ophthalmology, the First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
[Ti] Título:The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats.
[So] Source:Cell Physiol Biochem;39(1):266-77, 2016.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Bidens pilosa L. (Bp) is widely distributed in China and has been widely used as a traditional Chinese medicine. The aim of this study was to examine the effect of the extract of Bp on androgen deficiency dry eye and determine its possible mechanisms. METHODS: Twenty-four rats were randomly divided into four groups: Group Con (control), Group Sal (physiological saline), Group Fin (oral finasteride), and Group Bp (oral finasteride and Bp). The dry eye model was established in group Fin and group Bp. Aqueous tear quantity was measured with phenol red-impregnated cotton threads with anesthesia. Tear film breakup time (BUT) and corneal epithelial damage were evaluated by fluorescein staining. Animals were sacrificed at 28 days, and ocular tissues (lacrimal gland and cornea) were evaluated with light microscopy; gene microarray analysis for inflammatory cytokines and Western blot were also performed. RESULTS: Finasteride administration effectively induced dry eye in rats by 14 days after administration. Group Fin rats had significantly higher fluorescein staining scores and lower aqueous tear quantity and BUT than the group Con rats, and notable inflammatory cell infiltrates were observed in the lacrimal gland of group Fin rats. The fluorescein staining score, aqueous tear quantity and BUT significantly improved with Bp treatment in the group Bp rats, and the structures of the lacrimal gland were well maintained without significant lymphocyte infiltration. Cytokine antibody array data identified the cytokines B7-2/Cd86, IL-1ß, IL-4, IL-6, IL-10, MMP-8, FasL, TNF-α and TIMP-1 as candidates for validation by Western blot. Expression levels of pro-inflammatory cytokines, including IL-1ß, IL-6, and TNF-α, in group Fin were upregulated compared with group Con. Levels of anti-inflammatory cytokines, such as IL-4 and IL-10, in group Fin were also upregulated compared with those in group Con. Compared with group Fin, IL-1ß, FasL, and TNF-α were significantly decreased in group Bp. CONCLUSION: The extract of Bp appears to be effective for the treatment of androgen deficiency dry eye in rats by improving aqueous tear quantity, maintaining tear film stability, and inhibiting the inflammation of the lacrimal gland.
[Mh] Termos MeSH primário: Androgênios/deficiência
Bidens/química
Síndromes do Olho Seco/prevenção & controle
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Inibidores de 5-alfa Redutase/administração & dosagem
Inibidores de 5-alfa Redutase/farmacologia
Animais
Western Blotting
Córnea/efeitos dos fármacos
Córnea/metabolismo
Córnea/patologia
Citocinas/genética
Citocinas/metabolismo
Síndromes do Olho Seco/genética
Síndromes do Olho Seco/metabolismo
Feminino
Finasterida/administração & dosagem
Finasterida/farmacologia
Perfilação da Expressão Gênica/métodos
Mediadores da Inflamação/metabolismo
Aparelho Lacrimal/efeitos dos fármacos
Aparelho Lacrimal/metabolismo
Aparelho Lacrimal/patologia
Análise de Sequência com Séries de Oligonucleotídeos/métodos
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Distribuição Aleatória
Ratos Wistar
Lágrimas/metabolismo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Androgens); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Plant Extracts); 059QF0KO0R (Water); 57GNO57U7G (Finasteride)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1159/000445622


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[PMID]:27231727
[Au] Autor:Sliwa K; Sikora E; Ogonowski J; Oszmianski J; Kolniak-Ostek J
[Ad] Endereço:Faculty of Chemical Engineering and Technology, Cracow University of Technology, Kraków, Poland.
[Ti] Título:A micelle mediated extraction as a new method of obtaining the infusion of Bidens tripartita.
[So] Source:Acta Biochim Pol;63(3):543-8, 2016.
[Is] ISSN:1734-154X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:In this paper, the extracts of three-part beggarticks (Bidens tripartita) were prepared using ultrasonic assisted micelle-mediated extraction method (UAMME). Different kind of surfactants and WPC (whey protein concentrate) were applied. In the B. tripartita extracts twenty polyphenols were identified by UPLC-DAD-MS. Both aqueous and UAMME extracts mainly contained chlorogenic acid, caftaric acid and its derivatives as well as luteolin 7-O-glucoside. The luteolin was extracted with Rokanol B2 and Triton X-100. Furthermore, antioxidative properties of the extracts were analyzed with two methods: reactions with di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) reagent and Follin's method. The DPPH radical scavenging by micellar extracts was in general comparable with the antioxidant activity of conventional extracts. The most active was sample with Tego Care CG90, reducing about 73% of the radical. Obtained results confirmed that the UAMME might be an alternative method, to the liquid-liquid or solid-liquid extraction, of obtaining specified extracts rich in active compounds. Selecting a suitable surfactant may thus provide the expected composition of the extract.
[Mh] Termos MeSH primário: Bidens/química
Depuradores de Radicais Livres/isolamento & purificação
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Depuradores de Radicais Livres/química
Radicais Livres/química
Interações Hidrofóbicas e Hidrofílicas
Micelas
Picratos/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Micelles); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.18388/abp.2015_1223


  9 / 147 MEDLINE  
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[PMID]:27166532
[Au] Autor:Njume C; Gqaza BM; Rozani C; Goduka NI
[Ad] Endereço:Centre for Rural Development, Nkululekweni, Walter Sisulu University, Mthatha, South Africa / Department of Medical Microbiology, Walter Sisulu University, Mthatha, South Africa.
[Ti] Título:Studies on bioactivity and secondary metabolites of crude extracts of Bidens pilosa L. (Asteraceae): A medicinal plant used in the Transkei region of South Africa.
[So] Source:Pak J Pharm Sci;29(3):877-85, 2016 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Whole plant-parts of Bidens pilosa were powdered and extracted in concentrated hexane, acetone, ethanol, methanol and water. The extracts were tested for antimicrobial activity against Escherichia coli (25922), Bacillus subtilis (ATCC 6051), Enterococcus faecalis (51299) Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC127853), using standard microbiological techniques. Active crude extracts were macerated in concentrated methanol and tested for secondary metabolites including tannins, saponins, alkaloids, cardiac glycosides, anthraquinones, steroids and flavonoids using standard phytochemical procedures. Hexane and methanol extracts demonstrated similar activity producing 8-17 mm and 11-18 mm inhibition zone-diameter ranges respectively. Further analysis for minimum inhibitory concentrations (MIC(50)) recorded 1.25-20mg/mL and 2.5-20mg/mL for hexane and methanol extracts respectively. The highest zones of inhibition diameters (22-36mm) and lowest MIC(50) values (0.0002-0.0006mg/mL) were recorded for Gentamicin, the positive control. Minimum bactericidal concentration (MBC) ranges were between 10-80mg/mL and 0.001-0.005mg/mL for extracts and control antibiotic respectively. With the exception of anthraquinones, the plant crude extracts tested positive for all secondary metabolites analyzed. These results provide scientific basis for the use of B. pilosa in South African traditional medicine. The antibacterial activity reported herein may be attributed to one or more of the 6 secondary metabolites detected in the plant crude extracts.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bidens/metabolismo
Medicamentos de Ervas Chinesas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antibacterianos/metabolismo
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Fracionamento Químico
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/metabolismo
Estrutura Molecular
Fitoterapia
Plantas Medicinais
Solventes/química
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drugs, Chinese Herbal); 0 (Solvents); 0 (plant extract, Bidens pilosa)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160512
[Lr] Data última revisão:
160512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


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[PMID]:27098674
[Au] Autor:Chang CL; Yang CY; Muthamilselvan T; Yang WC
[Ad] Endereço:Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taiwan.
[Ti] Título:Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers.
[So] Source:Sci Rep;6:24692, 2016 Apr 21.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eimeriosis is a severe protozoan disease in poultry. Because of increasing concern about drug residue and drug resistance with the use of anticoccidial drugs, natural products are emerging as an alternative and complementary approach to control avian eimeriosis. Our previous publication showed that feed supplemented with B. pilosa (BP) was effective at combating chicken eimeriosis in experimental settings. However, its efficacy against chicken eimeriosis under field conditions is not known. Here, we investigated the efficacy of BP against eimeriosis on an organic chicken farm. We found that feed supplemented with BP, at the dose of 0.025% of feed or more, significantly reduced Eimeria infection. This treatment increased body weight gain and reduced feed conversion ratio, leading to superior growth performance. It lowered morbidity/mortality rate, decreased oocysts per gram of feces and gut pathology and augmented the anticoccidial index. Collectively, these data demonstrated the potential of BP to control chicken eimeriosis on chicken farms. BP can, therefore, be used as an effective means to control eimeriosis.
[Mh] Termos MeSH primário: Ração Animal
Bidens/química
Coccidiose/veterinária
Eimeria
Plantas Medicinais/química
Doenças das Aves Domésticas/tratamento farmacológico
Doenças das Aves Domésticas/parasitologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Galinhas
Fezes/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1038/srep24692



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