Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.168 [Categoria DeCS]
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[PMID]:28384606
[Au] Autor:Sólyomváry A; Alberti Á; Darcsi A; Könye R; Tóth G; Noszál B; Molnár-Perl I; Lorántfy L; Dobos J; Orfi L; Béni S; Boldizsár I
[Ad] Endereço:Department of Pharmacognosy, Semmelweis University, 1085 Budapest, Ülloi út 26, Hungary.
[Ti] Título:Optimized conversion of antiproliferative lignans pinoresinol and epipinoresinol: Their simultaneous isolation and identification by centrifugal partition chromatography and high performance liquid chromatography.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1052:142-149, 2017 May 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:High amount of the valuable lignan pinoresinol (PR) was determined in Carduus nutans fruit (7.8mg/g) for the first time. A preparative separation method using two consecutive, identical steps of centrifugal partition chromatography (CPC) was developed in order (i) to isolate PR and (ii) to subsequently isolate PR and its 7' epimer epipinoresinol (EPR) simultaneously after an optimized acid treatment which resulted in PR epimerization forming equal amounts of PR and EPR, from C. nutans fruit. As optimal conditions, a two-phase solvent system consisting of methyl tert-butyl ether:acetone:water (4:3:3, v/v/v) for CPC separation, and an acid treatment performed at 50°C for 30min for the epimerization were applied. Thus, 33.7mg and 32.8mg PR and EPR, in as high as 93.7% and 92.3% purity, were isolated from 10.0gC. nutans fruit, representing 86.4% and 84.1% efficiency, respectively. Conversion characteristic of PR and EPR in acidic medium, determined as a function of time and temperature of acid treatment provides their unambiguous identification by on-line high performance liquid chromatography (HPLC). Antiproliferative assay of isolated PR and EPR in two different types of colon cancer cell lines (HCT116 and SW480) confirmed that both epimers caused a more significant decrease of viability in HCT116 cells than in SW480 cells, suggesting their similar mechanism of antiproliferative action.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/análise
Carduus/química
Cromatografia Líquida de Alta Pressão/métodos
Furanos/análise
Lignanas/análise
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/tratamento farmacológico
Frutas/química
Furanos/isolamento & purificação
Furanos/farmacologia
Cromatografia Gasosa-Espectrometria de Massas/métodos
Células HCT116
Seres Humanos
Lignanas/isolamento & purificação
Lignanas/farmacologia
Extratos Vegetais/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Furans); 0 (Lignans); 0 (Plant Extracts); V4N1UDY811 (pinoresinol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE


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[PMID]:27092658
[Au] Autor:Gupta SM; Kumar K
[Ti] Título:Stinging plants: as future bio-weapon.
[So] Source:J Complement Integr Med;13(3):217-219, 2016 Sep 01.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In the present opinion paper, we have been introducing for the first time the stinging plants and/or their biological toxins as novel bio-threat agents that may be used for the development of bio-weapons for self-defence purpose. The selected studied stinging plants are having dual role as nutraceutical and ethno-pharmacological uses apart from their less explored stinging property. However, future detailed work is required for identification and characterization of the precise stinging chemical components that will be used for the formulation of novel bio-warfare agents for self-defence purpose.
[Mh] Termos MeSH primário: Dor/induzido quimicamente
Extratos Vegetais/farmacologia
Estruturas Vegetais
Plantas/química
Toxinas Biológicas/farmacologia
Armas
[Mh] Termos MeSH secundário: Carduus
Euphorbiaceae
Seres Humanos
Inflamação/induzido quimicamente
Mucuna
Prurido/induzido quimicamente
Urtica dioica
Guerra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Toxins, Biological)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE


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[PMID]:26988483
[Au] Autor:Esposito M; Di Pierro P; Dejonghe W; Mariniello L; Porta R
[Ad] Endereço:Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario di Monte Sant'Angelo, via Cintia 21, 80126 Napoli, Italy; Separation and Conversion Technology, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
[Ti] Título:Enzymatic milk clotting activity in artichoke (Cynara scolymus) leaves and alpine thistle (Carduus defloratus) flowers. Immobilization of alpine thistle aspartic protease.
[So] Source:Food Chem;204:115-21, 2016 Aug 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two different milk clotting enzymes, belonging to the aspartic protease family, were extracted from both artichoke leaves and alpine thistle flowers, and the latter was covalently immobilized by using a polyacrylic support containing polar epoxy groups. Our findings showed that the alpine thistle aspartic protease was successfully immobilized at pH 7.0 on Immobeads IB-150P beads and that, under these experimental conditions, an immobilization yield of about 68% and a recovery of about 54% were obtained. Since the enzyme showed an optimal pH of 5.0, a value very similar to the one generally used for milk clotting during cheese making, and exhibited a satisfactory stability over time, the use of such immobilized vegetable rennet for the production of novel dairy products is suggested.
[Mh] Termos MeSH primário: Ácido Aspártico Proteases/química
Carduus/enzimologia
Cynara scolymus/enzimologia
Leite/química
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Animais
Carduus/química
Bovinos
Cynara scolymus/química
Enzimas Imobilizadas/química
Flores/química
Flores/enzimologia
Folhas de Planta/química
Folhas de Planta/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzymes, Immobilized); 0 (Plant Proteins); EC 3.4.- (Aspartic Acid Proteases)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE


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[PMID]:25154105
[Au] Autor:Marchetto KM; Shea K; Kelly D; Groenteman R; Sezen Z; Jongejans E
[Ti] Título:Unrecognized impact of a biocontrol agent on the spread rate of an invasive thistle.
[So] Source:Ecol Appl;24(5):1178-87, 2014 Jul.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herbivores may significantly reduce plant populations by reducing seed set; however, we know little of their impact on seed movement. We show for the first time that the receptacle-feeding weevil Rhinocyllus conicus not only reduces seed production by the invasive thistle Carduus nutans but also inhibits release and subsequent wind dispersal of seeds. These effects generate large, though different, impacts on spatial spread and local abundance in two populations with differing demography, located in the United States and New Zealand. Furthermore, the mechanism is context dependent, with the largest effects through increased terminal velocity in the United States but through reduced seed production in New Zealand. Our results show that the benefit of biocontrol programs may have been underestimated; screenings of potential biocontrol agents should examine effects on pest dispersal and spread, as well as on abundance.
[Mh] Termos MeSH primário: Agentes de Controle Biológico
Carduus
Herbivoria
Gorgulhos
[Mh] Termos MeSH secundário: Animais
Demografia
Espécies Introduzidas
Nova Zelândia
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Biological Control Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140827
[St] Status:MEDLINE


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[PMID]:24557607
[Au] Autor:Silva FM; Donega MA; Cerdeira AL; Corniani N; Velini ED; Cantrell CL; Dayan FE; Coelho MN; Shea K; Duke SO
[Ad] Endereço:Faculty of Agronomic Sciences, Experimental Station Lageado, Laboratory of Weed Science, São Paulo State University, 18610-307, PB 237, Botucatu, SP, Brazil.
[Ti] Título:Roots of the invasive species Carduus nutans L. and C. acanthoides L. produce large amounts of aplotaxene, a possible allelochemical.
[So] Source:J Chem Ecol;40(3):276-84, 2014 Mar.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The invasive thistle Carduus nutans has been reported to be allelopathic, yet no allelochemicals have been identified from the species. In a search for allelochemicals from C. nutans and the closely related invasive species C. acanthoides, bioassay-guided fractionation of roots and leaves of each species were conducted. Only dichloromethane extracts of the roots of both species contained a phytotoxin (aplotaxene, (Z,Z,Z)-heptadeca-1,8,11,14-tetraene) with sufficient total activity to potentially act as an allelochemical. Aplotaxene made up 0.44 % of the weight of greenhouse-grown C. acanthoides roots (ca. 20 mM in the plant) and was not found in leaves of either species. It inhibited growth of lettuce 50 % (I 50) in soil at a concentration of ca. 0.5 mg g(-1) of dry soil (ca. 6.5 mM in soil moisture). These values gave a total activity in soil value (molar concentration in the plant divided by the molarity required for 50 % growth inhibition in soil = 3.08) similar to those of some established allelochemicals. The aplotaxene I 50 for duckweed (Lemna paucicostata) in nutrient solution was less than 0.333 mM, and the compound caused cellular leakage of cucumber cotyledon discs in darkness and light at similar concentrations. Soil in which C. acanthoides had grown contained aplotaxene at a lower concentration than necessary for biological activity in our short-term soil bioassays, but these levels might have activity over longer periods of time and might be an underestimate of concentrations in undisturbed and/or rhizosphere soil.
[Mh] Termos MeSH primário: Carduus/química
Feromônios/metabolismo
Polienos/metabolismo
[Mh] Termos MeSH secundário: Carduus/metabolismo
Cotilédone/citologia
Cotilédone/efeitos dos fármacos
Cucumis sativus/crescimento & desenvolvimento
Cromatografia Gasosa-Espectrometria de Massas
Espécies Introduzidas
Feromônios/análise
Feromônios/toxicidade
Folhas de Planta/química
Folhas de Planta/metabolismo
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Polienos/análise
Polienos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pheromones); 0 (Polyenes)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140222
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-014-0390-8


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[PMID]:24199567
[Au] Autor:Liu SK; Que S; Cheng W; Zhang QY; Liang H
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
[Ti] Título:[Chemical constituents from whole plants of Carduus acanthoides].
[So] Source:Zhongguo Zhong Yao Za Zhi;38(14):2334-7, 2013 Jul.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Fourteen compounds were isolated from wholeplants of Carduus acanthoides by various chromatographic techniques including column chromatography over HP-20 macroporous resin, MCI gel, silica gel, Sephadex LH-20 and ODS and reversed-phase HPLC. Their structures were identified as salidroside (1), 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (2), 3,5-di-hydroxyphenethyl alcohol-3-O-beta-D-glucopyranoside (3), p-coumaric acid (4), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl) propan-1-one (5), 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl) propan-1-one (6), syringin (7), p-hydroxybenzaldehyde (8), salicylic acid (9), tachioside (10), vanillic acid-4-O-beta-D-glucopyranoside (11), syringic aldehyde (12), 2,6-dimethoxy-4-hydroxyphenol-1-O-beta-D-glucopyranoside (13), and 2, 6-dimethoxy-p-hydroquinone-4-0-P-D-glucopyranoside (14) on the basis of spectroscopic data analysiS. All compounds were isolated from the genus Carduus for the first time except for compounds 4 and 7.
[Mh] Termos MeSH primário: Carduus/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Plantas Medicinais/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Extracts)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:131108
[Lr] Data última revisão:
131108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131109
[St] Status:MEDLINE


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[PMID]:24180213
[Au] Autor:Liu SK; Que S; Cheng W; Zhang QY; Ye M; Liang H
[Ad] Endereço:a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center , Beijing , 100191 , China.
[Ti] Título:Two new glycosides from Carduus acanthoides.
[So] Source:J Asian Nat Prod Res;15(12):1243-8, 2013.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new glycosides, syringic acid-4-O-ß-L-arabinopyranoside and kaempferol-3-O-α-L-rhamnopyranosyl-7-O-ß-D-glucuronopyranoside, were isolated from whole plants of Carduus acanthoides (Asteraceae), and their structures were elucidated on the basis of spectroscopic analysis.
[Mh] Termos MeSH primário: Carduus/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Ácido Gálico/análogos & derivados
Glicosídeos/isolamento & purificação
Quempferóis/isolamento & purificação
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Ácido Gálico/química
Ácido Gálico/isolamento & purificação
Glicosídeos/química
Quempferóis/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Kaempferols); 0 (kaempferol-3-O-alpha-L-rhamnopyranosyl-7-O-beta-D-glucuronopyranoside); 0 (syringic acid-4-O-beta-L-arabinopyranoside); 632XD903SP (Gallic Acid); 731P2LE49E (kaempferol)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:131216
[Lr] Data última revisão:
131216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131105
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2013.837452


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[PMID]:24122547
[Ti] Título:Inhibition of key enzymes linked to obesity by preparations from Mediterranean dietary plants: effects on α-amylase and pancreatic lipase activities.
[So] Source:Plant Foods Hum Nutr;68(4):340-46, 2013 Dec.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:One of the most important strategy in the treatment of obesity includes the development of nutrient digestion and absorption inhibitors. Inhibition of digestive enzymes is one of the most widely studied mechanisms used to determine the potential efficacy of natural products as hypolipidemic and hypoglycaemic agents. In vitro studies here reported were performed to evaluate the inhibitory activity of five species(as hydroalcoholic extracts) of edible plants from Calabria region (Italy) on amylase and lipase by monitoring the hydrolysis of p-NPC and the hydrolysis of glycoside bonds indigestible carbohydrate foods. The formulation obtained from Clematis vitalba L. exhibited the strongest inhibitory effect on pancreatic lipase (IC50=0.99 mg/ml) and on α-amylase(IC50=31.52 µg/ml). In order to explore metabolome production HPTLC analysis of the extracts was performed, revealing the predominance of (±)-catechin, caffeic acid and chlorogenic acid in C. vital ba formulation at concentration of 23.18±3.14,13.63±0.65 and 18.88±0.76 mg/g, respectively. GC/MS analysis was used to identify fatty acids and terpene composition.
[Mh] Termos MeSH primário: Amilases/antagonistas & inibidores
Inibidores Enzimáticos/farmacologia
Lipase/antagonistas & inibidores
Obesidade/enzimologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Plantas Comestíveis/química
[Mh] Termos MeSH secundário: Fármacos Antiobesidade/farmacologia
Fármacos Antiobesidade/uso terapêutico
Carduus/química
Clematis/química
Inibidores Enzimáticos/uso terapêutico
Seres Humanos
Itália
Lepidium/química
Magnoliopsida/química
Malva/química
Região do Mediterrâneo
Obesidade/dietoterapia
Fenóis/análise
Fenóis/uso terapêutico
Extratos Vegetais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Enzyme Inhibitors); 0 (Phenols); 0 (Plant Extracts); EC 3.1.1.3 (Lipase); EC 3.2.1.- (Amylases)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131015
[St] Status:MEDLINE


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[PMID]:23726069
[Au] Autor:Bohnenblust E; Egan JF; Mortensen D; Tooker J
[Ad] Endereço:Department of Entomology, 101 Merkle Bldg., The Pennsylvania State University, University Park, PA 16802, USA.
[Ti] Título:Direct and indirect effects of the synthetic-auxin herbicide dicamba on two lepidopteran species.
[So] Source:Environ Entomol;42(3):586-94, 2013 Jun.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herbicides are the most commonly applied pesticides in agroecosystems, and therefore pose potentially significant ecotoxicological risks to plants and insects. Glyphosate is the most common herbicide worldwide, and glyphosate-resistant weeds are quickly becoming serious challenges in some agroecosystems. Because of this resistance epidemic and the recent development of crops with resistance to dicamba or 2,4-D, herbicide-use patterns are likely to change. Presently, dicamba and 2,4-D cause most herbicide-drift damage to nontarget plants despite limited agricultural usage, but the effects of these synthetic auxin herbicides on insects have been poorly explored. To understand the influence of dicamba on insects, we applied several sublethal, drift-level rates of dicamba to soybean, Glycine max L., and Carduus thistle, and measured growth and survival of Helicoverpa zea (Boddie) and Vanessa cardui (L.) larvae, respectively. For thistle, we measured percent nitrogen content before and after dicamba application. We also performed direct toxicity bioassays on the two caterpillar species with several rates of dicamba. Dicamba was not directly toxic to larvae of either species, and H. zea showed no negative effects when feeding on soybeans dosed with dicamba. We did, however, detect significant negative, indirect effects of higher rates of dicamba on V. cardui larval and pupal mass, total nitrogen of thistles post application, and thistle biomass in the presence of V. cardui larvae. Notably, thistle biomass was not related to dicamba dose in absence of larvae. Our results indicate that dicamba can indirectly influence the performance of some caterpillar species, possibly by altering plant nutritional content.
[Mh] Termos MeSH primário: Borboletas/efeitos dos fármacos
Dicamba/toxicidade
Herbicidas/toxicidade
Mariposas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Borboletas/crescimento & desenvolvimento
Borboletas/fisiologia
Carduus/crescimento & desenvolvimento
Carduus/metabolismo
Relação Dose-Resposta a Droga
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Larva/fisiologia
Longevidade
Mariposas/crescimento & desenvolvimento
Mariposas/fisiologia
Feijão de Soja/crescimento & desenvolvimento
Feijão de Soja/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Herbicides); SJG3M6RY6H (Dicamba)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:130603
[Lr] Data última revisão:
130603
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130604
[St] Status:MEDLINE
[do] DOI:10.1603/EN13021


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[PMID]:23185886
[Au] Autor:Vaupel A; Matthies D
[Ad] Endereço:Plant Ecology, Department of Ecology, Faculty of Biology, University of Marburg, D-35032 Marburg, Germany. vaupelan@biologie.uni-marburg.de
[Ti] Título:Abundance, reproduction, and seed predation of an alpine plant decrease from the center toward the range limit.
[So] Source:Ecology;93(10):2253-62, 2012 Oct.
[Is] ISSN:0012-9658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biogeographic models predict that, because of increasingly unfavorable and stressful conditions, populations become less frequent, smaller, less dense, and less reproductive toward the range edges. These models have greatly influenced the thinking on geographical range limits and have broad implications for ecology, evolution, and conservation. However, empirical tests of the models have rarely investigated comprehensive sets of population properties. We studied population size and density and a broad set of fitness-related traits in 66 populations of the alpine thistle Carduus defloratus along a latitudinal (615 km) and altitudinal (342-2300 m) gradient from the European Alps in the south to the northern range limit in the low mountain ranges of central Germany. Regression analysis indicated that population size and plant density declined with decreasing altitude from the center to the range margin, but plant size increased. In spite of the larger size of plants, the number of seeds produced strongly declined toward the range margin, mainly due to an increase in seed abortion. The number of flowering plants in a population influenced all components of reproduction. Plants in large populations initiated more seeds, aborted fewer seeds, and produced more and larger seeds per plant. The probability that seeds were attacked by insect larvae and the proportion of seeds damaged decreased strongly from the center to the margin of the distribution. However, in spite of the much lower level of parasitization, plants at the range margin produced far fewer viable seeds. Fluctuating asymmetry of leaf width, an indicator of developmental instability, was similar across the range and not related to population size.
[Mh] Termos MeSH primário: Carduus/fisiologia
Sementes/fisiologia
[Mh] Termos MeSH secundário: Altitude
Animais
Demografia
Europa (Continente)
Flores
Insetos/fisiologia
Modelos Logísticos
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1212
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121129
[St] Status:MEDLINE



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